2014 Annual Report
Center for Health Policy and Health Services Research
OVERVIEW
2014 was an excellent year for the Center – the best year in our history in terms of peerreviewed publications. We expanded the scope of our activity in two significant areas – health
policy analysis and pharmacogenomics – and were able to support research and demonstration
projects in a number of clinical departments in addition to those based directly in CHPHSR. We
received funding for some significant new research projects while continuing work and publishing
findings from previously-funded studies. The year featured publications in all of the top-tier journals
read widely in our field (New England Journal of Medicine, JAMA, Health Affairs, BMJ) and
presentations to prominent groups like the National Health Policy Forum.
HEALTH SERVICES RESEARCH
Investigators in CHPHSR continued work in five major program areas: diabetes, cancer
prevention and control, pharmacogenomics and chronic disease, mental health services, and
screening and treatment of chronic hepatitis. Highlights in the five areas included:
Pharmacogenomics and Chronic Disease
The Center has been actively involved in research to improve the tailoring of medications to
individuals (i.e., personalized medicine) through the identification of the genetic predictors of
treatment response (i.e., pharmacogenomics). Over the past decade, CHPHSR has been a leader
in measuring medication use and relating this to patient outcomes pertaining to asthma, diabetes,
hypercholesterolemia, hypertension, congestive heart failure, and depression; support for this work
has come from grants from the National Institute of Allergy and Infectious Diseases (NIAID), the
National Heart Lung and Blood Institute (NHLBI), and the National Institute of Diabetes and
Digestive and Kidney Disorders (NIDDK) of the National Institutes of Health (NIH) and other
sources, such as the American Asthma Foundation. Investigators in the Center have pioneered
methods of combining electronic medical records data with high throughput genomics to perform
large-scale pharmacogenomic studies. This work has already resulted in identifying a number of
genetic predictors of asthma medication response. Research from these projects has also
produced high-profile publications in The New England Journal of Medicine, Nature Genetics,
Circulation, American Journal of Respiratory and Critical Care Medicine, The Journal of Allergy and
Clinical Immunology, and Journal of the American College of Cardiology.
Mental Health Services
CHPHSR has been very active in psychiatric research in 2014. We remain core members of the
Mental Health Research Network (MHRN). Our group has become a national leader in suicide
research, including studies examining of patterns of health care use before suicide and suicide
attempt as well as an investigation of suicide attempts/deaths before and after FDA warnings on
antidepressants and continued publications on the Behavioral Health Services’ award-winning
Perfect Depression Care initiative. We recently received funding to implement mental health,
substance use, and suicide screening as well as proactive psychiatric consultation services within
the Henry Ford Macomb Hospital. We’ve also collaborated with the Office of Clinical Quality and
Safety to evaluate implementation of an online cognitive behavioral therapy focused depression
intervention as an adjunct to usual care. We have continued our work studying treatment adherence
among patients with depression, and have become active in research on the misuse of prescription
opioids. In addition, as part of our continued collaboration with Behavioral Health Services, we now
lead instruction of the research methods curriculum for all psychiatry medical residents. Our strong
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collaborations have positioned us to participate in several other mental health services projects in
the coming years.
Chronic Viral Hepatitis
CHPHSR is involved in two research studies, CHeCS and BEST-C, investigating chronic viral
hepatitis testing, treatment, and outcomes. Both studies are sponsored by the CDC Foundation.
The Chronic Hepatitis B & C Cohort Study (CHeCS) is a prospective, longitudinal observational
cohort study created to assess the impact of chronic viral hepatitis in the United States. Henry Ford
Health System, via a collaborative effort between CHPHSR, the HFMG Division of
Gastroenterology/Hepatology, and the HFHS Public Health Sciences department, serves as the
lead site and data coordinating center for this multicenter study. Among recent findings – that
approximately 40% of CHeCS patients are susceptible to or have no documented immunity or
vaccination against hepatitis A (patients with hepatitis B or C) or hepatitis B (patients with hepatitis
C); also that 17% of CHeCS patients with hepatitis C already had advanced liver disease at the
time of their initial HCV diagnosis, and these patients had higher long-term rates of hospitalization
and mortality compared to patients diagnosed at an earlier stage. The BEST-C project includes a
retrospective study and a prospective study. The retrospective study documented relatively low
rates of hepatitis C screening, and the prospective study showed that rates could be significantly
increased with a reminder system tailored to patients in the highest-risk age band.
Diabetes Management
Findings from the AHRQ-funded 11-site retrospective cohort diabetes study SUPREME-DM
continued to be published in journals such as Annals of Pharmacotherapy and the American
Journal of Epidemiology in 2014. The SUPREME-DM study has found that overall diabetes
incidence has not significantly increased in recent years, but increases in hemoglobin A1c testing
may have contributed to rising diabetes incidence among nonwhite patients. In addition, patients
newly diagnosed with diabetes face an increased burden of medications used to control diabetes
and other comorbidities as well as an increased focus on cardiovascular disease risk factor control
after diagnosis of diabetes.
Cancer Prevention & Control
Several CHPHSR studies focused on cancer prevention and control in 2014. Findings from the
observational Preventive Health Discussions study indicate that physician use of the 5 As
communication technique (Assess, Advise, Agree, Assist and Arrange) when discussing colorectal
cancer screening with patients is associated with increased screening uptake (Patient Education
and Counseling, 2014). Results from a tailored intervention to increase colorectal cancer screening
among African American patients found that patient communication preference moderated the
effect of the intervention; patients with a more autonomous style were more likely to be screened
following the intervention compared to others.
HEALTH POLICY
In March of 2010, CHSR was asked to take on the role of leading and coordinating health
policy analysis for Henry Ford Health System. This decision was driven in part by the passage of
the Patient Protection and Affordable Care Act (ACA), but also driven by the increasing number of
opportunities for Medicare demonstration projects that might include HFHS as a participant. The
specific tasks taken on by CHPHSR under the "Health Policy" heading include: monitoring of
regulatory developments following ACA; monitoring announcements of CMS and other federal
demonstration projects; coordinating HFHS applications to CMS and other demonstration projects;
analysis of HFHS and other relevant data sets to have background information for HFHS
communications on health policy; preparation of white papers and other forms of communication
about health policy issues; attendance at health policy meetings and conference calls as HFHS
representatives.
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Two Research Associates provide staff support for the health policy activity. CHPHSR has
played a key role in the preparation of several demonstration project applications based in other
clinical departments of HFHS business units; for example, a CMS demonstration project by the
HFMG Department of Radiology for a project on computerized decision support for ordering of
imaging studies and the CMMI Bundled Payments for Care Improvement Initiative.application led
by the Henry Ford Physician Network. Staff also conducted analyses and developed reports on the
status of “dual eligible” (patients who are covered under both Medicare and Medicaid) in support of
Henry Ford’s participation in a state-wide demonstration project about coordination of care for the
dual eligible population..
In May of 2012, Dr. Nerenz of CHPHSR was appointed to the Medicare Payment Advisory
Commission (MedPAC) as one of 17 Commissioners. MedPAC is an influential policy-setting body
that advises Congress on a variety of payment issues in the context of the Medicare program. Dr.
Nerenz also co-chaired an Expert Panel for the National Quality Forum working on the issue of
adjustment of health care performance measures on the basis of socioeconomic and demographic
factors. This is an issue of great significance to Henry Ford Hospital, other parts of the System, and
providers across the country who serve economically and demographically “vulnerable”
populations.
NEW AWARDS
Combined Transcriptomics and Genomics to Find Asthma Genes in Admixed Populations
P.I.: Keoki Williams, M.D., M.P.H.
Funding Source: NIH
Funding: $2,911,122 (total cost)
This project leverages both recent technological advancements in measuring gene expression (i.e.,
RNA‐sequencing) and the ancestral diversity of African American individuals to identify
asthma‐related genes. By combining these transcriptomic and genomic approaches, we anticipate
having greater statistical power to detect asthma genes and their regulatory elements, thereby
identifying new biomarkers and therapeutic targets to better diagnose and manage asthma.
Mental Health Research Network II
Site PI: Brian Ahmedani, Ph.D. (PI: Greg Simon, M.D.)
Funding Source: NIH (Subcontract with Group Health Research Institute)
HFHS Funding Amount: $277,978 (total cost)
Henry Ford Health System will work with other MHRN investigators to identify patient cohorts for
future studies, conduct infrastructure work and preliminary analyses, gather other preliminary data
needed to design MHRN studies, and will work with clinicians and others at HFHS to prepare for
specific studies carried out by the MHRN.
Integrating Behavioral Health Screening and Consultation into a Medical Hospital
P.I.: Brian Ahmedani, Ph.D.
Funding Source: Flinn Foundation
Funding Amount: $200,000 (total cost)
This project seeks to integrate proactive psychiatric consultation services into routine care within a
large general medical hospital. This proposed intervention is an evidence-based mental health
substance use, and suicide screening, assessment, treatment, and referral model.
*Comparing Engagement Techniques for Incorporating Patient Input
Site P.I.: David Nerenz, Ph.D. (PI: Jeffrey Jarvik, MD)
Funding Source: PCORI (Subcontract with University of Washington)
Funding Amount: $31,459 (total cost)
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This project involves working with patients and patient advocates to identify the best ways of
eliciting preferences for back pain care. The project will use quantitative and qualitative methods to
compare ways of eliciting preferences, with the ultimate goal of making care more patient-centered
and more responsive to patients’ balancing of risks and benefits.
INPHAASE: A Temporal Data Driven Approach to Estimate the Risk of Heart Failure Events
HFHS P.I.: David Lanfear, MD, Badri Padhukasahasram, Ph.D.
HFHS Funding: $17,000 (total cost)
In this project, we propose to develop novel computational algorithms that can efficiently utilize
large volumes of genetic data and various longitudinal and clinical variables to improve and
individualize risk prediction under the Cox Proportional Hazards framework. Developing such
comprehensive and integrative models will be an important step towards maximizing the accuracy
of predictive tests so that it can eventually become clinically relevant and bring us closer to the
exciting possibility of personalized diagnosis, treatment and prevention.
INPHAASE: Effects of the Affordable Care Act on Preventive Care Use and Disparities in Use
HFHS P.I.: Jianhui Hu, Ph.D. (WSU PI: Wassim Tarraf, Ph.D.)
HFHS Funding: $9,396 (total cost)
Using both nationally representative data and data from Henry Ford Health System (HFHS), this
study examines the national and local impact of the newly mandated preventive service benefits,
enacted under the Affordable Care Act (ACA), on service utilization and healthcare disparities for
such services.
Prescription Opioid Analgesics and Risk of Major Depression
Subcontract with St Louis University
Site PI: Brian Ahmedani, Ph.D. (PI: Jeffrey Scherrer, PhD)
Funding Source: NIH
HFHS Funding Amount: $2,500 (total cost)
Using large claims databases, this project proposes to determine if prescription opioid use is
associated with risk of depression, treatment resistant depression and re-occurrence.
* Funding for noted project is through other HFHS Department.
PUBLICATIONS
1. Abouljoud MD, Brown KA, Nerenz DR. Sicker patients with end-stage liver disease cost more:
A quick fix? (Editorial) Am J Transplant 2014 Jan:14(1):9-10]. PMID: 24165228.
2. Amiri L, Cassidy-Bushrow AE, Dakki H, Li J, Wells K, Phillips S, Thomas A, Lanfear DE. Patient
characteristics and participation in a genetic study: A type 2 diabetes cohort. J Investigative Med
2014 Jan:62(1):26-32. PMID: 24379022
3. Ahmedani BK, Crotty N, Abdulhak MM, Ondersma SJ. Pilot feasibility study of a brief, tailored
mobile health intervention for depression among patients with chronic pain. Behav Med 2013
Dec 7. [Epub ahead of print]. PMID: 24313728
4. Ahmedani BK, Simon GE, Stewart C, Beck A, Waitzfelder BE, Rossom R, Lynch F, OwenSmith A, Hunkeler EM, Whiteside U, Coffey MJ, Solberg LI. Health care contacts in the year
before suicide death. J Gen Intern Med 2014 June;29(6):870-7. PMID: 24567199
5. Ahmedani BK, Peterson EL, Wells KE, Lanfear DE, Williams LK. Policies and events affecting
prescription opioid use for non-cancer pain among an insured patient population. Pain
Physician. 2014 May-Jun;17(3):205-16. PMID: 24850102
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6. Ahmedani BK, Solberg LI, Copeland LA, Fang Y, Stewart C, Hu J, Nerenz DR, Williams LK,
Cassidy-Bushrow A, Waxmonsky J, Lu CY, Waitzfelder BE, Owen-Smith A, Coleman KJ, Lynch
F, Ahmed A, Beck A, Rossom R, Simon GE. Psychiatric Comorbidity and 30-Day Readmissions
After Hospitalization for Heart Failure, AMI, and Pneumonia. Psychiatric Services. 2014 Nov 5.
[Epub ahead of print].
7. Ahmedani BK, Vannoy S. National pathways for suicide prevention and health services
research. American Journal of Preventive Medicine, 47(3S2):S222–S228. PMID: 25145743.
8. Amiri L, Cassidy-Bushrow AE, Dakki H, Li J, Wells K, Oliveria SA, Yood MU, Thomas
A, Lanfear DE. Patient characteristics and participation in a genetic study: a type 2 diabetes
cohort. J Investig Med. 2014 Jan;62(1):26-32. PMID: 24379022
9. Boscarino JA, Sitarik A, Gordon SC, Rupp LB, Nerenz DR, Vijayadeva V, Schmidt MA, Henkle
E, Lu M. Risk factors for hepatitis C infection among Vietnam era veterans versus nonveterans:
results from the Chronic Hepatitis Cohort Study (CHeCS). J Community Health 2014
Oct;39(5):914-21. PMID: 24682941
10. Boscarino JA, Lu M, Moorman AC, Gordon SC, Rupp LB, Spradling PR, Teshale EH,
Schmoidt MA, Vijayadeva V, Holmberg SD, for the Chronic Hepatitis Cohort Study (CHeCS)
Investigators, Predictors of poor mental and physical health status among patients with
chronic hepatitis C infection: the Chronic Hepatitis Cohort Study (CHeCS). Hepatology 2014
Sept 9. PMIC: 25203533
11. Bunyavanich S, Schadt EE, Himes BE, Lasky-Su J, Qiu W, Lazarus R, Ziniti JP, Cohain A,
Linderman M, Torgerson DG, Eng CS, Pino-Yanes M, Padhukasahasram B, Yang JJ, Mathias
RA, Beaty TH, Li X, Graves P, Romieu I, del Rio Navarro B, Salam MT, Vora H, Nicolae DL,
Ober C, Martinez FD, Bleecker ER, Meyers DA, Gauderman WJ, Gilliland F, Burchard EG,
Barnes KC, Williams LK, London S, Zhang B, Raby BA, Weiss ST. Integrated Genome-wide
Association, Coexpression Network, and Expression Single Nucleotide Polymorphism Analysis
Identifies Novel Pathways in Allergic Rhinitis. BMC Med Genomics. 2014 Aug 2;7(1):48. [Epub
ahead of print]. PMID:25085501
12. Cresci S, Depta JP, Lenzini PA, Li AY, Lanfear DE, Province MA, Spertus JA, Bach RG.
Cytochrome p450 gene variants, race, and mortality among clopidogrel-treated patients after
acute myocardial infarction. Circ Cardiovasc Genet. 2014 Jun;7(3):277-86. PMID: 24762860
13. Depta JP, Lenzini PA, Lanfear DE, Wang TY, Spertus JA, Bach RG, Cresci S. Clinical
outcomes associated with proton pump inhibitor use among clopidogrel-treated patients within
CYP2C19 genotype groups following acute myocardial infarction. Pharmacogenomics J. 2014
Jul 8. [Epub ahead of print]. PMID: 25001880
14. El-Refai M, Hrobowski T, Peterson EL, Wells K, Spertus JA, Williams LK, Lanfear DE. Race
and association of angiotensin converting enzyme/angiotensin receptor blocker exposure with
outcome in heart failure. J Cardiovasc Med. 2014 May 16. [Epub ahead of print]. PMID:
24842464
15. Friedly JL, Comstock BA, Turner JA, Heagerty PJ, Deyo RA, Sullivan SD, Bauer Z,
Bresnahan BW, Avins AL, Nedeljkovic SS, Nerenz DR, Standaert C, Kessler L, Jarvik JG,
and the LESS Investigators. A double-blind randomized controlled trial of lumbar epidural
steroid injections for spinal stenosis (LESS). N Engl J Med. 2014 Jul 3;371(1):11-21 PMID:
24988555
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16. Galanter JM, Gignoux CR, Torgerson DG, Roth LA, Eng C, Oh SS, Nguyen EA, Drake KA,
Huntsman S, Hu D, Sen S, Davis A, Farber HJ, Avila PC, Brigino-Buenaventura E, LeNoir MA,
Meade K, Serebrisky D, Borrell LN, Rodríguez-Cintrón W, Estrada AM, Mendoza KS, Winkler
CA, Klitz W, Romieu I, London SJ, Gilliland F, Martinez F, Bustamante C, Williams LK, Kumar
R, Rodríguez-Santana JR, Burchard EG. GWAS and admixture mapping identify different
asthma-associated loci in Latinos: The GALA II Study. J Allergy Clin Immunol. 2014
Aug;134(2):295-305. Epub 2014 Jan 7. PMID: 24406073
17. Gerbi GB, Rupp LB, Ko SC, Moorman AC, Holmberg SD, Xu F; CHeCS Investigators .
Reported reasons for testing among hepatitis B virus infected patients, Chronic Hepatitis Cohort
Study (CHeCS), United States, 2006–2010. Liver International 2014 Jul;34(6):e162-3. PMID:
24589333
18. Gordon S, Lamerato L, Rupp L, Holmberg S, Moorman A, Spradling P, Teshale E, Nakasato
C, Boscarino J, Henkle E, Nerenz D, Oja-Tebbe N, Lu M, for the CHeCS Investigators.
Hepatitis B therapy and incidence of hepatocellular carcinoma in a U.S. population, the Chronic
Hepatits Cohort Study (CHeCS). Clin Gastroenterol Hepatol 2014 May;12(5):885-93. PMID:
24107395.
19. Hawley S, Lillie S, Cooper G, Lafata JE. Managed care patients’ preferences, physician
recommendations and colon cancer screening. Am J Manag Care 2014 Jul;20(7):555-61.
PMID: 2529540
20. Henkle E, Lu M, Rupp LB, Boscarino JA, Vijayadeva V, Schmidt MA, Gordon SC, for the
CHeCS Investigators. Hepatitis A and B Immunity and Vaccination in Chronic Hepatitis B and C
Patients in a Large United States Cohort. Clin Infect Dis. 2014 Nov 3. PMID: 25371489
21. Hu J, Gonsahn M, Nerenz DR. Socioeconomic status and readmissions: Evidence from an
urban teaching hospital. Health Aff (Millwood). 2014 May;33(5):778-85. PMID: 24799574
22. Jarvik JG, Comstock BA, Heagerty PJ, Turner JA, Sullivan SD, Shi X, Nerenz DR, Nedeljkovic
SS, Kessler L, James K, Friedly JL, Bresnahan BW, Bauer Z, Avins AL, Deyo RA. Back pain in
seniors: The Back pain Outcomes using Longitudinal Data (BOLD) cohort baseline data. BMC
Musculoskelet Disord. 2014 Apr 23;15:134. PMID: 24755158
23. Jennings DL, Tita C, Williams C, Lanfear DE. Assessing the potential of email for
communicating drug-therapy recommendations to physicians in patients with heart failure and
ventricular-assist devices. J Pharm Pract 2014 Oct;27(5):478-80. PMID: 24319078
24. Jennings DL, Wagner JL, To L, Nemerovski CW, Kalus JS, Morgan JA, Lanfear DE.
Epidemiology and outcomes associated with anemia during long-term support with continuousflow left ventricular assist devices. J Card Fail. 2014 Jun;20(6):387-91. PMID: 24732723
25. Jennings DL, Jacob M, Chopra A, Nemerovski CW, Morgan JA, Lanfear DE. Safety of
Anticoagulation Reversal in Patients Supported with Continuous-flow Left-ventricular Assist
Devices. ASAIO J. 2014 Mar 20. [Epub ahead of print]. PMID:24658518
26. Jennings DL, Makowski CT, Chambers RM, Lanfear DE. Dosing of vancomycin in patients with
continuous-flow left ventricular assist devices: a clinical pharmacokinetic analysis. Int J Artif
Organs. 2014 Mar;37(3):270-4. PMID: 24619894
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27. Karrowni W, Li Y, Jones PG, Cresci S, Abdallah MS, Lanfear DE, Maddox TM, McGuire DK,
Spertus JA, Horwitz PA. Insulin resistance is associated with significant clinical atherosclerosis
in nondiabetic patients with acute myocardial infarction. Arterioscler Thromb Vasc Biol. 2013
Sep;33(9):2245-51. PMID: 23868937
28. Lafata JE, Cooper G, Divine G, Flocke S, Oja-Tebbe N. Patient-physician colorectal cancer
screening discussions and patient’s use of colorectal cancer screening, patient education and
counseling, Patient Educ Couns 2014 Jan;94(1):76-82. PMID:24094919
29. Lafata JE, Salloum RG, Fishman PA, Pearson Ritzwoller D, O’Keeffe-Rosetti MC, Hornbrook
MC. Preventive Care receipt and office visit use among breast and colorectal cancer survivors
relative to age-and gender-matched cancer-free controls. J Cancer Surviv 2014;Sept 25 [Epub
ahead of print]. PMID: 25252623
30. Lanfear DE, Chow S, Padhukasahasram B, Li J, Langholz D, Wilson Tang WH, Williams LK,
Sabbah HN Genetic and non-genetic factors influencing pharmacokinetics of B-type natriuretic
peptide. J Card Fail. 2014 Sep;20(9):662-8. PMID: 24983826
31. Lekura J, Tita C, Lanfear DE, Williams CT, Jennings DL. Assessing the potential of E-mail for
communicating drug therapy recommendations to physicians in patients with heart failure and
ventricular-assist devices. J Pharm Pract. 2014 Oct;27(5)478-80. PMID: 24319078
32. Levin AM, Wang Y, Wells KE, Padhukasahasram B, Yang JJ, Burchard EG, Williams LK.
Nocturnal asthma and the importance of race-ethnicity and genetic ancestry. Am J Respir Crit
Care Med. 2014 Aug 1;190(3):266-73. PMID: 24937318
33. Li J, Gordon S, Rupp L, Zhang T, Boscarino J, Vijayadeva V, Schmidt M, Lu M. Validity of
serum markers for fibrosis staging in chronic hepatitis B and C. J Viral Hepatitis 2014 Jan 29
[Epub ahead of print]. PMID: 24472062
34. Lu CY, Stewart C, Ahmed AT, Ahmedani BK, Coleman K, Copeland LA, Hunkeler E, Lakoma
MD, Madden JM, Penfold RB, Rusinak D, Soumerai SB, Zhang F. How complete are E-codes in
commercial plan claims databases? Pharmacoepidemiol Drug Saf 2014 Feb;23(2):218-20.
PMID: 24453020
35. Lu CY, Zhang F, Lakoma M, Madden J, Penfold RB, Simon G, Ahmedani BK, Clarke G,
Hunkeler E, Waitzfelder B, Owen-Smith A, Raebel M, Rossom R, Coleman KJ, Copeland LA,
Soumerai SB. Changes in youth antidepressant use by young people and suicidal behavior
after FDA warnings and media coverage: quasi-experimental study. BMJ 2014; 348:g3596.
PMID: 24942789
36. Lu M, Rupp LB, Moorman AC, Li J, Zhang T, Lamerato LE, Holmber SD, Spradling PR,
Teshale EH, Vijavadeva V, Boscarino JA, Schmidt MA, Nerenz DR, Gordon SC, for the
Chronic Hepatitis Cohort Study (CHeCS) Investigators. Comparative Effectiveness Research of
Chronic Hepatitis B and C Cohort Study (CHeCS): Improving Data Collection and Cohort
Identification. Digestive Diseases and Sciences 2014 Jul 17. [Epub ahead of print] PMID:
25030940
37. Mahajan R, Xing J, Liu S, Ly K, Moorman A, Rupp L, Holmberg S, for the CHeCS
Investigators. Rates and causes of mortality among people in care with hepatitis C virus
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infection - The Chronic Hepatitis Cohort Study (CHeCS), 2006–2010. Clin Infect Dis. 2014
Apr;58(8):1055-61. PMID: 24523214.
38. Miller AL, Gosch K, Daugherty SL, Rathore S, Peterson PN, Peterson ED, Ho PM, Chan
PS, Lanfear DE, Spertus JA, Wang TY. Failure to reassess ejection fraction after acute
myocardial infarction in potential implantable cardioverter/defibrillator candidates: insights from
the Translational Research Investigating Underlying disparities in acute Myocardial infarction
Patients' Health Status (TRIUMPH) registry. Am Heart J. 2013 Oct;166(4):737-43.. PMID:
24093855
39. Moorman A, Xing J, Ko S, Rupp L, Xu F, Gordon S, Lu M, Spradling P, Teshale E, Boscarino
J, Vijayadeva V, Schmidt M, Holmberg S, for the CHeCS Investigators. Late diagnosis of
hepatitis C virus infection in Chronic Hepatitis Cohort Study (CHeCS): Mixed opportunities for
intervention. Hepatology. 2014 Aug 13. PMID: 25131217
40. Morgan JA, Brewer RJ, Nemeh HW, Gerlach B, Lanfear DE, Williams CT, Paone G. Stroke
while on long-term left ventricular assist device support: incidence, outcome, and predictors.
ASAIO J. 2014 May-Jun;60(3):284-9. PMID: 24625532
41. Myers RA, Scott NM, Gauderman WJ, Qui W, Mathias RA, Romieu I, Levin AM, Pino-Yanes M,
Graves PE, Villarreal AB, Beaty TH, Carey VJ, Croteau-Chonka DC, del Rio Navarro B, Edlund
C, Hernandez-Cadena L, Navarro-Olivos E, Padhukasahasram B, Salam MT, Torgerson DG,
Van den Berg DJ, Vora H, Bleecker ER, Meyers DA, Williams LK, Martinez FD, Burchard EG,
Barnes KC, Gilliland FD, Weiss ST, London SJ, Raby BA, Ober C, Nicolae DL. Genome-wide
interaction studies reveal sex-specific asthma risk alleles. Hum Mol Genet. 2014 Oct
1;23(19):5251-9. Epub 2014 May 13. PMID: 24824216
42. Nichols GA, Schroeder EB, Karter AJ, Gregg EW, Desai J, Lawrence JM, O’Connor PJ, Xu S,
Newton KA, Raebel MA, Pathak RD, Waitzfelder B, Segal J, Elston Lafata J, Butler MG,
Kirchner HL, Thomas A, Steiner JF, On behalf of the SUPREME-DM Study Group. Trends in
diabetes incidence, 2006-2011, in seven million insured adults: The SUPREME-DM Project.
American Journal of Epidemiology, published online Dec 16, 2014.
43. Padhukasahasram B, Yang JJ, Levin AM, Yang M, Burchard EG, Kumar R, Kwok P-Y,
Lanfear DE, Williams LK. Gene-based association identifies SPATA13-AS1 as a
pharmacogenomic predictor of inhaled short-acting beta-agonist response in multiple population
groups. Pharmacogenomics J. 2014 Aug;14(4):365-71. Epub 2014 Jan 14. PMID: 24418963
44. Pino-Yanes M, Thakur N, Gignoux CR, Galanter JM, Roth LA, Eng C, Nishimura KK, Oh SS,
Vora H, Huntsman S, Nguyen EA, Hu D, Drake KA, Conti DV, Moreno-Estrada A, Sandoval K,
Winkler CA, Borrell LN, Lurmann F, Islam TS, Davis A, Farber HJ, Meade K, Avila PC,
Serebrisky D, Bibbins-Domingo K, Lenoir MA, Ford JG, Brigino-Buenaventura E, RodriguezCintron W, Thyne SM, Sen S, Rodriguez-Santana JR, Bustamante CD, Williams LK, Gilliland
FD, Gauderman WJ, Kumar R, Torgerson DG, Burchard EG. Genetic ancestry influences
asthma susceptibility and lung function among Latinos. J Allergy Clin Immunol. 2014 Sep 13.
[Epub ahead of print] PMID: 25301036
45. Ports KA, Barnack-Tavlaris JL, Syme ML, Perera RA, Elston Lafata J, Sexual Health
Discussions with Older Adult Patients During Periodic Health Exams. J Sex Med 2014 Feb 12.
PMID: 24517714
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46. Resnicow K, Davis R, Shires D, Hawley S, Jimbo M, Ruffin M, Lafata JE. Communication
Preference Moderates the Effect of a Tailored Intervention to Increase Colorectal Cancer
Screening among African Americans. Patient Education and Counseling. 2014 Dec;97(3):370-5.
PMID:25224317
47. Schmittdiel JA, Raebel MA, Dyer W, Xu S, Goodrich GK, Schroeder EB, Segal JB, O’Connor
PJ, Nichols GA, Lawrence JM, Kirchner HL, Karter AJ, Lafata JE, Butler MG, Steiner JF.
Prescription medication burden in patients with newly diagnosed diabetes: A SUrveillance,
PREvention, and ManagEment of Diabetes Mellitus (SUPREME-DM) study. J Am Pharm Assoc.
2014 Jul-Aug;54(4): 374-82. PMID: 24860866
48. Simon GE, Stewart C, Beck A, Ahmedani BK, Coleman KJ, Whitebird RR, Lynch F, OwenSmith AA Waitzfelder BE, Soumerai SB, Hunkeler EM. National prevalence of receipt of
antidepressant prescriptions by persons without a psychiatric diagnosis. Psychiatr Serv 2014
65(7):944-946. PMID: 24788368
49. Shore S, Maddox TM, Tang F, Jones PG, Lanfear DE, Ho PM. Gap between clinical guidelines
and practice: the case of aldosterone-antagonists in patients with myocardial infarction. Int J
Cardiol. 2014 Mar 1;172(1):e151-3.. PMID: 24411911
50. Spradling PR, Tong X, Rupp L, Moorman AC, Lu M, Teshale EH, Gordon SC, Vijayadeva V,
Boscarino JA, Schmidt MA, Holmberg SD; for the Chronic Hepatitis Cohort Study (CHeCS)
Investigators. Trends in HCV RNA testing among HCV antibody positive persons in care, 20032010. Clin Infect Dis. 2014 Oct;59(7):976-81. PMID: 24991025
51. Stachler R, Schultz L, Nerenz DR. PROMIS evaluation for head and neck cancer patients: A
comprehensive quality of life outcomes assessment tool. Laryngoscope 2014 Jun;124(6):136876. PMID:24719292
52. Srivastava AV, Hrobowski T, Krese L, Huang MA, Nemeh H, Tita C, Williams C, Brewer
R, Lanfear DE. High rates of false-positive hepatitis C antibody tests can occur after left
ventricular assist device implantation. ASAIO J. 2013 Nov-Dec;59(6):660-1. PMID: 24088900
53. Stults CD, Elston Lafata J, Diamond L, MacLean L, Stone AL, Wunderlich T, Tai-Seale M.
How do primary care physicians respond when patient cry during routine ambulatory visits?
Journal of Communication in Healthcare 2014;7(1):17-24.
54. Sun F, Stock EM, Copeland LA, Zeber JE, Ahmedani BK, Morissette SB. Polypharmacy ith
antipsychotic drugs in patients with schizophrenia: trends in multiple health care systems. Am J
Health Syst Pharm 2014 May 1;71(9):728-38. PMID: 24733136
55. Teshale E, Lu M, Rupp LB, Holmberg SD, Moorman AC, Spradling P, Vijayadeva V, Boscarino
JA, Schmidt MA, Gordon SC; the CHeCS Investigators. APRI and FIB-4 are good predictors of
the stage of liver fibrosis in chronic hepatitis B: the Chronic Hepatitis Cohort Study (CHeCS). J
Viral Hepat. 2014 Dec: 21(12):917-20. PMID: 25131445
56. Vijayadeva V, Spradling P, Moorman A, Rupp L, Lu M, Gordon S, Henkle E, Boscarino J,
Teshale E, Holmberg S, Nakasato C, for the CHeCS Investigators. Hepatitis B virus testing
and prevalence by country of origin among Asian/Pacific Islanders. Am J Manag Care 2014 Apr
1;20(4):e98-e104. PMID: 24884958
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57. Wang M, Gupta RC, Rastogi S, Kohli S, Zhang K, Lanfear DE, Sabbah HN. Acute intravenous
infusion of an adenosine regulating agent improves left ventricular function in dogs with
advanced heart failure. Cardiovasc Drugs Ther. 2013 Dec;27(6):489-98. PMID: 23907235
58. Williams LK, Ahmedani BK, Peterson EL, Wells K, Padhukasahasram B, Burchard EG,
Lanfear DE. Differing effects of metformin on glycemic control by race-ethnicity. J Clin
Endocrinol Metab. 2014 Sep;99(9):3160-8. PMID: 24921653
59. Yao TC, Du G, Han L, Sun Y, Hu D, Yang JJ, Mathias R, Roth LA, Rafaels N, Thompson EE,
Loisel DA, Anderson R, Eng C, Arruabarrena Orbegozo M, Young M, Klocksieben JM,
Anderson E, Shanovich K, Lester LA, Williams LK, Barnes KC, Burchard EG, Nicolae DL,
Abney M, Ober C. Genome-wide association study of lung function phenotypes in a founder
population. J Allergy Clin Immunol. 2014 Jan;133(1):248-255. Epub 2013 Aug 6. PMID:
23932459
Publications Accepted [In Press]
1. Coffey MJ, Coffey CE, Ahmedani BK. Suicide in a health maintenance organization
population. JAMA Psychiatry.
2. Lafata JE, Wunderlich T, Flocke S, Oja-Tebbe, N, Siminoff L. Physician Use of Persuasion and
Colorectal Cancer Screening. Translational Behavioral Medicine.
3. Lin JC, Nerenz DR, Migliore P, Young R, Shepard AD, Weaver WD. Cost analysis of
endovenous catheter ablation versus stripping for treatment of superficial venous insufficiency
and varicose vein disease. J Vasc Surg Venous Lymphat Disord (ePUB October 28)
Publications Under Revision
1. Ahmedani BK, Stewart C, Simon GE, Lynch F, Lu CY, Waitzfelder BE, Solberg LI, OwenSmith AA, Beck A, Copeland LA, Hunkeler EM, Rossom RC, Williams LK. Race/ethnic
differences in healthcare visits made prior to suicide attempt across the United States.
Medical Care.
2. Lafata JE, Shay LA, Brown R, Street R. Primary Care Office-based Tools and Patient-physician
Communication Behaviors, Visit Length, and the Delivery of Preventive Health Services, Health
Services Research.
3. Owen-Smith AA, Stewart C, Green C, Druss B, Ahmedani BK, Waitzfelder BE, Rossom R,
Copeland L, Simon GE. Adherence to Statin Medications in Patients with Schizophrenia vs.
Patients without Psychiatric Illness. General Hospital Psychiatry.
4. Shahawy OE, Shires DA, Lafata JE. Tobacco Cessation Counseling in Primary Care:
Identifying Opportunities to Improve Efficiency and Effectiveness. Evaluation and the Health
Professions.
Publications Submitted
1. Allison RD, Tong X, Moorman AC, Ly KN, Rupp LB, Xu F, Gordon SC, Holmberg SD, for the
Chronic Hepatitis Cohort Study (CHeCS). Incidence of Malignant Cancers and Cancer-related
Mortality Among Persons with Chronic Hepatitis C Infection, 2006-2010.
2. Coleman KJ, Stewart CC, Waitzfelder B, Zeber JE, Morales LS, Ahmed AT, Ahmedani BK,
Beck A, Copeland LA, Cummings JR, Hunkeler EM, Lindberg N, Lynch F, Lu CY, Owen-Smith
AA, Quinn VP, Trinacty CM, Whitebird RR, Simon G. Racial and Ethnic Differences in
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Diagnoses and Treatment for Mental Health Conditions across Healthcare Systems
Participating in the Mental Health Research Network.
3. Desai J, Vazquez-Benitez G, Xu Z, Schroeder EB, Karter AJ, Steiner JF, Nichols GA, Reynolds
K, Xu S, Newton KM, Schmittdiel J, Pathak RD, Waitzfelder B, Elston Lafata J, Butler MG,
Kirchner LH, Thomas A, O’Connor PJ, On behalf of the SUPREME-DM Study Group, Trends in
Cardiovascular Events and Mortality Among Adults With and Without Diabetes: The SUPREMEDM Project 2005-2011.
4. Fishman PA, O’Keeffe-Rosetti MC, Ritzwoller DP, Lafata JE, Salloum RG, Keast E, Hornbrook
MC. Cost of helical CT to diagnose lung cancer. JNCI
5. Gordon S, Lamerato L, Rupp L, Holmberg S, Moorman A, Spradling P, Teshale E, Xu F,
Vijayadeva V, Boscarino J, Schmidt M, Oja-Tebbe N, Lu M, for the CHeCS investigators.
Prevalence of cirrhosis in hepatitis C patients in the Chronic Hepatitis Cohort Study (CHeCS): A
Retrospective and Prospective Observational Study
6. Howell EA, Kleinman LC, Scholle S, Zaslavsky AM, Mistry K, Carle AC, Woods,D, Elliott MN,
Mosely K, Nerenz,DR, Silber JH, Schuster,MA. Conceptual and methodological challenges
when assessing equity and disparities in child health care quality. Acad Pediatr
7. Lafata JE, Morris HL, Schmittdiel JA, Karter A, Pathak R, Thomas A, Raebel MA, O’Connor PJ,
Lawrence JM, Butler M, Newton KM et al. Medication Management and Clinical Control among
Insured Patients with Diabetes
8. Lu M, Chacra W, Rabin D, Rupp L, Trudeau S, Li J, Gordon S. An ICD-9 based algorithm to
classify decompensated cirrhosis using electronic health records.
9. Vazquez Benitez G, Desai JR, Xu S, Goodrich GK, Schroeder EB, Nichols GA, Segal J, Kimes
TM, Butler MG, Karter AJ, Steiner JF, Newton KM, Morales LS, Pathak RD, Thomas A,
Reynolds K, Kirchner HL, Waitzfelder E, Elston Lafata J, Adibhatla R, Xu Z, O’Connor PJ.
Preventable major cardiovascular events associated with uncontrolled glucose, blood pressure,
lipids and active smoking in adults with diabetes with and without cardiovascular disease: A
contemporary analysis.
PRESENTATIONS
1. Boscarino J, Lu M, Gordon S, Rupp L, Schmidt M, Vijayadeva V. Predictors of Depression
and Poor Physical Health among Patients with Chronic Hepatitis C Infection: Results from the
Chronic Hepatitis Cohort Study. HMO Research Network 2014 Conference, Phoenix, AZ. April
1- 3.
2. Gordon S, Lamerato L, Rupp L, Holmberg S, Moorman A, Spradling P, Teshale E, Vijayadeva
V, Boscarino J, Schmidt M, Nerenz D, Oja-Tebbe N, Lu M. Estimated prevalence of HCV
cirrhosis in the Chronic Hepatitis Cohort Study (CHeCS). 49th meeting of the European
Association for the Study of the Liver: The International Liver Conference 2014, London, United
Kingdom, April 9-13.
3. Moorman A, Xu F, Tong X, Gordon S, Rupp L, Lu M, Spradling P, Teshale E, Boscarino J,
Vijayadeva V, Schmidt M, Holmberg S, for the CHeCS Investigators. Mortality and progression
to decompensated cirrhosis in chronic hepatitis C (CHC) patients with liver biopsy confirmed
fibrosis in the Chronic Hepatitis Cohort Study (CHeCS). Oral presentation at the 65th Annual
Meeting of the American Association for the Study of Liver Diseases (AASLD), Boston, MA.
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November 7-11.
4. Nerenz, DR. Sociodemographic Adjustment of Health Care Performance Measures. Presented
at the National Health Policy Forum, Washington, DC. September 26.
5. Owen-Smith A, Green C, Ahmedani BK, Waitzfelder BE, Rossom R, Copeland L, Simon GE.
Medication Adherence to Common Cardiovascular Medications in Patients with Schizophrenia
vs. Patients without Psychiatric Illness. Poster presentation at the 20th Annual HMO Research
Network Conference, Phoenix, AZ. April 1-3.
6. Rahm AK, Boggs JM, Martin CR, Beck A, Backer T, Pearson M, Ahmedani BK. Systematic
Stakeholder Assessment to Determine Facilitators of and Barriers to SBIRT Implementation in
Multiple Integrated Health Systems. Poster presentation at the 20th Annual HMO Research
Network Conference, Phoenix, AZ. April 1-3.
7. Simon G, Rossom R, Ahmedani B, Beck A, Solberg L. Mental Health Research Network: A
population-based approach to transform research. Symposium presentation at the 22nd NIMH
Conference on Mental Health Services Research (MHSR), Bethesda, MD, April.
8. Teshale E, Xing J, Holmberg S, Moorman A, Gordon S, Rupp L, Lu M, Spradling P, Boscarino
J, Vijayadeva V, Schmidt M, Xu F, for the CHeCS Investigators. Increased all-cause
hospitalization among hepatitis C virus (HCV)-infected persons: the Chronic Hepatitis Cohort
Study (CHeCS), 2006-2010. Poster presentation at the 65th Annual Meeting of the American
Association for the Study of Liver Diseases (AASLD), Boston, MA. November 7-11.
9. Xu F, Xing J, Moorman A, Gordon S, Rupp L, Lu M, Spradling P, Teshale E, Boscarino J,
Vijayadeva V, Schmidt M, Holmberg S, for the CHeCS Investigators. FIB4 score and gender
predict the incidence of hepatocellular carcinoma (HCC) among patients with chronic hepatitis C
virus (HCV) infection: Chronic Hepatitis Cohort Study (CHeCS). Poster presentation at the 65th
Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), Boston,
MA. November 7-11.
10. Zeber JE, Sun FF, Stock EM, Copeland LA, Ahmedani BK, Morissertte SB. Comparison of
Antipsychotic Polypharmacy Trends among Schizophrenia Patients across Multiple Healthcare
Systems. Poster presentation at the 20th Annual HMO Research Network Conference, Phoenix,
AZ. April 1-3.
SERVICE ACTIVITIES
Committees
 Abbott Health Policy Advisory Board (Elston Lafata J)
 ACC HI/TX Committee (Lanfear D)
 ACC Michigan Chapter Council (Lanfear DE)
 American Association for the Advancement of Science, Grant Reviewer (Williams LK)
 Addiction Research Network Steering Committee (Ahmedani BK)
 American Academy of Allergy, Asthma, and Immunology Adherence Committee (Williams
LK)
 American Heart Association, Functional Genomics and Translational Biology Professional
Education Council (Lanfear DE)
 Continuing Medical Education Policy Review Board (Williams LK)
 Henry Ford Medical Group Chairs Council (Nerenz DR)
 Henry Ford Hospital Pharmacy and Therapeutics Committee (Lanfear DE)
 Henry Ford Hospital Research Committee (Lanfear DE)
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 Henry Ford Health System Medication Management Committee (Lanfear DE)
 HFSA Research Committee (Lanfear DE)
 Italian Ministry of Health, Grant Reviewer (Williams LK)
Medicare Payment Advisory Commission (MedPAC) (Nerenz DR)
 Mental Health Research Network Steering Committee (Ahmedani BK)
 Merck Outcomes Research Advisory Panel (Williams LK)
 MHRN Suicide Prevention Scientific Interest Group, Chair (Ahmedani BK)
 National Quality Forum Risk Adjustment and Socioeconomic Status Expert Panel (Nerenz
DR)
 NIH Special Emphasis Panel, Immunology– Center for Scientific Review, 2005-2007
(Williams LK)
 NIH Special Emphasis Panel, Pharmacogenomics – Center for Scientific Review, 2009
(Williams LK)
 NIH Health Services Organization and Delivery Study Section – Center for Scientific Review,
2007-2011 (Elston Lafata J)
 NIH Infectious, Reproductive, Asthma and Pulmonary Conditions Study Section – Center for
Scientific Review, 2014 (Williams LK)
 NIH Special Emphasis Panel, Obesity, Asthma and Reproductive – Center for Scientific
Review, 2013 (Williams LK)
 National Committee for Quality Assurance (NCQA) CLAS/Disparities Expert Panel (Nerenz
DR)
 National Quality Forum Expert Panel on SES Adjustment for Performance Measures
(Nerenz DR)
 Physician Scientist Committee (Williams LK)
 NIH Health Services Organization and Delivery Study Section – Center for Scientific Review,
2007-2011 (Elston Lafata J)
 Society for Medical Decision Making Advisory Task Force (Elston Lafata J)
Reviewers
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Addiction (Ahmedani BK)
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Allergy (Williams LK)
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American Journal of Family Practice (Elston Lafata J)
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American Journal of Managed Care (Williams LK, Elston Lafata J, Shires DA, Ahmedani BK)
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American Journal of Pharmacy Benefits (Williams LK)
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American Journal of Preventive Medicine (Elston Lafata J, Ahmedani BK)
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American Journal of Respiratory and Critical Care Medicine (Williams LK)
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Annals of Internal Medicine (Nerenz DR, Williams LK)
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Annals of Family Medicine (Elston Lafata J)
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Archives of Disease in Childhood (Williams LK)
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BioMed Central Family Practice (Elston Lafata J)
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BMC Pediatrics (Williams LK)
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BMC Psychiatry (Ahmedani BK)
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BMJ (Ahmedani BK)
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Cancer (Elston Lafata J)
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Circulation (Lanfear DE)
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Comprehensive Psychiatry (Ahmedani BK)
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Diabetes Care (Nerenz DR, Williams LK)
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Drug and Alcohol Dependence (Ahmedani BK)
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Expert Opinion on Drug Delivery (Williams LK)
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Expert Review of Pharmacoeconomics & Outcomes Research (Williams LK)
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Health Affairs (Nerenz DR)
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Health Services Research (Elston Lafata J, Nerenz DR)
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Hormone and Metabolic Research (Pladevall M)
Human Genetics (Williams LK)
Human Immunology (Williams LK)
Human Molecular Genetics (Williams LK)
Inflammation Research (Williams LK)
Journal of Allergy and Clinical Immunology (Williams LK)
Journal of American College of Cardiology (Lanfear D)
Journal of American Medical Association (Elston Lafata J, Lanfear DE)
Journal of General Internal Medicine (Elston Lafata J)
Journal of Health Care for the Poor and Underserved (Williams LK)
Journal of Men’s Health (Williams LK)
Journal of Occupational and Environmental Medicine (Williams LK)
Journal National Cancer Institute (Elston Lafata J)
Lancet (Lanfear DE)
Medical Care (Elston Lafata J, Nerenz DR, Ahmedani BK)
Medical Care Research and Review (Nerenz DR)
New England Journal of Medicine (Williams LK, Ahmedani BK)
NCI, HSOD Study Section – Ad Hoc Member (Elston Lafata J)
NIH, Immunology IRG Special Study Section (Williams LK)
Pediatric, Allergy, Immunology and Pulmonology (Williams LK)
Pediatric Pulmonology (Williams LK)
Pediatrics (Williams LK)
Pharmacoepidemiology and Drug Safety (Williams LK)
Pharmacogenomics (Williams LK)
Population Health Management (Nerenz DR)
Psychiatric Services (Ahmedani BK)
Psychological Medicine (Ahmedani BK)
Respiratory Medicine (Williams LK)
Social Science & Medicine (Ahmedani BK)
Editorial Boards
 American Journal of Managed Care (Elston Lafata J)
 Medical Care Research and Review (Nerenz DR)
 Population Health Management (Nerenz DR)
Editorship
 Associate Editor, Journal of Cardiac Failure (Lanfear DE)
STAFF RECRUITMENT
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Anthony Jurayi (Student Research Assistant)
Diane Valade (Health Policy Analyst)
CONTINUING ADJUNCT APPOINTMENTS
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Christine Cole Johnson, Ph.D.
George Divine, Ph.D.
Stanton Elias, MD
Lois Lamerato, Ph.D.
Mouaz Al-Mallah, MD
Bruce Muma, MD
Ilan Rubinfeld, MD
Lonni Schultz, Ph.D.
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