Donald Olding Hebb (1904-1985)
Hebb’s Postulate:
“When an axon of cell A is near enough to
excite cell B and repeatedly or persistently
takes part in firing it, some growth process or
metabolic change takes place in one or both
cells such that A’s efficiency, as one of the cells
firing B, is increased”.
Hebbian Synaptic Rule
FrogRetinotectal
Visual System
Frog
System
Two-Eyed Frog
Three-Eyed Frog
Three-Eyed Frog OD Columns
Eye-Specific Segregation
Synaptic Stabilization Model
NMDA Receptor
Weak Glutamate Activation
Strong Glutamate Activation
Strong Glutamate Activation
X
NMDA
Receptor-Dependent
Synaptic
Rearrangement
Plasticity of Peripheral Synapses
Maturation of NMJ Function
Synapse Elimination at NMJ
Heterosynaptic Suppression at NMJ
Ach-Mediated Suppression
Axonal Sprouting at Mature NMJ
S-Laminin Addressing of Basal Lamina
Postsynaptic Maintenance of Synapses
Pre-Ach Receptor Clustering
Post-Ach Receptor Clustering
Aggregation of Ach Receptors
Immobilization of ACh Receptors
Electrical Input Patterning
Electrical Input Patterning
Electrical Input Patterning
Proto-Oncogenes fos and jun
c-fos Induction