BE 481 and ChE 476
Introduction to Biomedical Engineering- Current Topics in Bionanotechnology
Instructor: Nehal I. Abu-Lail, Ph.D.
EME 59, (509) 335-4961, nehal@wsu.edu
Meeting Time and Location: Spring Semester 2013
Lecture: MWF 11:10 – 12 a.m. Bryan 324
Office hours: will be determined in class based on students’ availability
Course Description: This course aims at introducing students to currents topics of applications of
nanotechnology in biology as well as to using biology to develop new nanostructures.
Prerequisites: None
Text/Other Required Material: None
Course Objectives: At the completion of this course you should be able to:
1. Appreciate the differences between macro- and nano- scales
2. List the properties of nanoscale materials
3. Be familiar with technologies used to characterize material at the nanoscale
4. Define ways to utilize nanoscale materials in the biomedical field
5. Improve their written and oral communication skills
6. Improve the student’s ability to work individually and in a team
Class Scheduling/Policies: The class meets for three 50-minute class periods per week for the 15 weeks
duration of the semester. There will be a daily short homework assignment. We will have guest lectures during
the semester as well as student presentations. Students are required to write a short summary about each
presentation in class. Each student is required to write a project paper. Topics will be randomly assigned to
students. Students will be required to as well present their project paper. There will be no exams in this class.
Students are expected to attend scheduled class periods and to participate actively. Class discussions will count
toward your grade. If you have to miss a class, please inform me in advance.
Grading
Grades will follow the following structure: 93-100 A, 90-92 A-, 85-89 B+, 80-84 B, 75-79 B-, 70-74 C+, 65-69
C, 60-64 C-, 55-59 D+, 50-54 D, below 50 will get an F. Grades will be divided as:
20% for homework assignments, 25% for project paper, 10% for in class presentation, 5% for the poster
presentation at the end of class, 20% for summaries of presentations in class, 15% for in class discussions and
5% for attendance.
Homework assignments
Homework assignments will be given daily to help you reflect on a concept or an issue we covered in class.
Solutions of homework problems are due at 11:10 a.m. in the following class. No late homework will be
accepted. For all your assignments, there must be a clear presentation of the problem and a solution
understandable by another engineer including:
1) Problem statement with a diagram
4) Answers underlined with appropriate units
2) Approaches and equations used
5) A discussion of implications of the answer
3) Values with units used for the solution
6) Computer graphics, linear regressions, etc.
Project Paper
Randomly, each student will be assigned a topic for his/her project. These topics will not be covered in class.
The student will be required to write a literature review on the topic. The review should cover between 10 peer
refereed papers. The project paper should be around 10 pages, single spaced, 1” page dimensions and 12 points
Times News Roman. Project papers are due on 3/29/13. The paper should discuss as many aspects of the
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proposed topic as possible. Subtopics may include but not limited to: manufacturing, characterization,
applications, limitations, challenges, future, status of current research, toxicity and modeling.
Project Topics
# Project
1 Biopolymeric nanoparticles
2 Cellular uptake of nanoparticles
3 Nanotechnology for water treatment
4 Functional scaffolds with nanoparticles
5 Viral nanoparticles
6 Carbon nanotubes applications in biology
7 Nanosensors
8 Nanotechnology and food safety
9 Nanobacteria
10 Personalized nanomedicine
11 Diagnostic nanoparticles
12 Nanomachines
13 Nanotechnology in cosmetics
14 Nanoparticles for sustained drug delivery
15 Nanopatterning
16 Biomimetic nanotechnology
17 Lipid nanoparticles
18 Bacterial nanowires
19 Nanoreactors
20 Nanotools
21 Nanoparticles for rapid detection
22 Nanoarrays
23 Carbon nanotubes in medicine
24 Scanning tunneling microscopes applications at the nanoscale
25 Characterization of nanoparticles
26 Applications of nanotechnology in biofuels
27 Applications of nanotechnology in agriculture
28 Applications of nanotechnology in tissue engineering
29 Nanochannels
Project Presentation
Each student will present his/her topic of project paper to class. The presentation will be for 20 minutes and 5
minutes for questions. The format of the power point will be left to student. Schedules of presentations will be
determined early on and will take place between March 29th and April 24th. The student is responsible for
providing a handout for his/her classmates. Other students are responsible for writing a summary of the given
talk. Power points should be clear.
Project poster
All students in class will present a poster to students in the school. The poster will be on the last day of class
(April 26th 2013). Location of presentation of poster will be determined later on.
Students with Disabilities
Reasonable accommodations are available for students with a documented disability. If you have a disability
and need accommodations to fully participate in this class, please either visit or call the Access Center
(Washington Building 217; 509-335-3417) to schedule an appointment with an Access Advisor. All
accommodations MUST be approved through the Access Center. I MUST be notified of this documented
disability at the beginning of the semester.
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Plagiarism and Cheating
All information from outside sources shall be properly cited. Failure to do so will be considered plagiarism.
Cases of plagiarism and cheating will result in a grade of “0” for that assignment. For addition information on
the university’s policy regarding cheating and plagiarism, refer to the Schedule of Courses (Legal Notices on
Cheating and Plagiarism) or the University Catalog (Policies and Regulations).
Safety
Washington State University is committed to maintaining a safe environment for its faculty, staff, and students.
Safety is a priority in which the university invests significant time and resources. The university has emergency
plans and procedures that are reviewed regularly and that can be implemented quickly in a crisis or emergency.
Safety is a shared responsibility of every one on campus. Students should know the appropriate actions to take
when an emergency arises. The Campus Safety Plan, which can be found at http://safetyplan.wsu.edu, contains
a comprehensive listing of university policies, procedures, statistics, and information relating to campus safety,
emergency management, and the health and welfare of the campus community. In addition to the safety plan,
the emergency management plan can be found online at http://oem.wsu.edu/Emergencies. Everyone should also
become familiar with the WSU ALERT site (http://alert.wsu.edu) where information about emergencies and
other issues affecting WSU will be found. This site also provides information on the communication resources
WSU will use to provide warning and notification during emergencies. It should be bookmarked on
computers. Finally, all students should go to the myWSU portal at http://my.wsu.edu and register their
emergency contact information for the Crisis Communication System (CCS). Enter your network ID and
password and you will be taken to the myWSU main webpage. Look for the Emergency Notification box on
the right side of the page and click on Register to be taken to the registration page where you can enter your
cell, landline, and email contact information. Essential to WSU’s preparatory efforts is ensuring that all
members of the university community follow appropriate preventative measures to minimize the impact
influenza like illness will have on our daily learning, teaching, research, and service mission. These measures,
and other important information to help everyone stay informed, can be found at www.h1n1flu.wsu.edu.
Programmatic Objectives Met (denoted by: √):
√ 1. Application of Math/Science/Engineering: Use foundational knowledge in mathematics, physics,
chemistry, biology, and engineering sciences
2. Experimentation: Design and conduct experiments and analyze and interpret data for scientific
investigation and for evaluating designs
√
3. Bioengineering Design: Creatively design engineering solutions to meet needs recognizing
constraints of biology and society
√
4. Teamwork: Work in teams comprised of scientists, engineers, and others
5. Systems Solutions: Use analogous thinking, engineering synthesis and analysis, and integrative
system approaches in solving problems
√
6. Professional Ethics: Apply ethical principles to professional decision-making
√
7. Communication: Communicate effectively in an interdisciplinary world of engineers, healthcare
professionals, and scientists
√
8. Critical Thinking: Critically analyze issues of engineering practice in relevant global, economic,
environmental and societal contexts
√
9. Independent Learning: Identify professional development needs and learn independently
√
10. Career Awareness: Aware of career opportunities in the context of personal preparation and
contemporary issues
11. Bioengineering Tools: Use modern tools important to understanding and solving problems at the
interface of biology and engineering
12. Bioengineering Measurements: Perform measurements to appropriately characterize living
systems for engineering purposes
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Tentative weekly schedule:
Week
Jan. 7-11
Jan. 14-18
Jan. 21-25
Jan.28-Feb. 1
Feb. 4-8
Feb. 11-15
Feb. 18-22
Feb. 25 - Mar. 1
Mar. 4-8
Mar. 11-15
Mar. 18-22
Mar. 25-29
Apr. 1 –5
Apr. 8-12
Lecture #
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5
6
7
8
9
10
11
12
13
14
15
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25
26
27
28
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32
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36
37
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Apr. 15-19
Apr. 22-26
Apr. 29-May 3
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45
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Lecture Topics (MWF)
Introduction
What is so special about nano?
Bionanotechnology versus nanobiotechnology
Nanoparticles
NPs synthesis
Guest lecture-Dr. Luigi Giancarlo Corti, ME, WSU, “Surface engineering and functionalization of
nanomaterials for sensing applications”
Martin Luther King Jr. Day
Physico-chemical characteristics dependent toxicity of nanoparticles
Physico-chemical characteristics dependent toxicity of nanoparticles
NPs toxicity completed
Self-assembly of NPs
Guest lecture-Dr. Qiang, Physics, UI, “Magnetic NPs in biomedical applications”
Self-assembly of NPs completed
Functionalization of NPs
Functionalization of NPs completed
QDs
QDs applications in biology
Guest lecture-Dr. W. Dong, BE, WSU, “Sensor design based on quantum-dots fluorescence quenching by
gold nano-particles”
Class Holiday-President’s Day
QDs for cancer therapy
Stability of NPs
Guest lecture-Chemistry-Mike Ramsey-we will go there to Fulmer
Stability of NPs completed
Guest lecture, Neil Ivory, MEMS and NEMS
AFM
Guest lecture-Susmita Bose-Drug delivery and functional tissues
AFM on bacteria
Spring break
Guest lecture-Dr. Ananth Kalyanaraman from EECS, WSU “DNA Origami”
Nanomedicine
Muhammedin guest lecture
Guest Lecture-Subra Murali- physical-biochemical model for cancer progression
4D microscope
Complete Nanomedicine and Carbon nanotubes
Me too
Carbon nanotubes in medicine (Sarah), nanochannels (Damon)
Biopolymeric nanoparticles (Maureen), Lipid nanoparticles (Brennan) and viral NPs (Derek)
NPs for rapid detection (Tyler), NPs for sustained drug delivery (Benjamin), and diagnostic NPs (Edward)
Nanotechnology for water treatment (Troy), Personalized nanomedicine (Christian) and Cellular uptake of
nanoparticles (Samantha)
Nanotechnology in cosmetics (Tao), Applications of nanotechnology in agriculture (Chris McClean), and
nanotechnology and food safety (Kadin)
Nanomachines (Afshin), carbon nanotubes applications in biology (Brian), and Nanosensors (Jia)
Nanopatterning (Lindsey), and biomimetic nanotechnology (Mitch)
Functional scaffolds with nanoparticles (Moataz), applications of nanotechnology in tissue engineering
(Chrystal), and Nanoreactors (Adan)
Nanobacteria (Matt), characterization of nanoparticles (Wentao), and bacterial nanowires (Trent)
Nanotools (Isaac), applications of nanoparticles in biofuels (Sara)
Poster presentation (with BMES and AIChE)
No Final exam
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