BIO. 323 INTRODUCTORY MOLECULAR AND CELL BIOLOGY 002C LECTURER: Dr. Lisa Dorn Fall 2006 OFFICE: HS45, HS47, HS50 PHONE: 3064 E-MAIL: dorn@uwosh.edu. OFFICE HOURS: 10:20-12:20am Monday & Friday or by appointment. LECTURE HOURS: 4:10-5:10am MWF in Halsey Science 175. TEXT (lecture): Alberts, Bray, Hopkin, Johnson, Lewis, Raff, Roberts,Walter (2004) Essential Cell Biology, 2nd edition, Garland Science, Taylor and Francis Group, New York & London. ATTENDANCE POLICY: I will not take role in lecture. Attending lecture and good note-taking skills will increase your ability to do well in class. I will not repeat lectures nor do I publish lecture notes. Lecture number 1 2 Day Wed Friday Date 6-Sep 8-Sep Protein Structure & Function Protein Structure & Function Topics Book Ch. 4 Ch. 4 3 Monday 11-Sep Protein Structure & Function Ch. 4 2 4 Wed 13-Sep Membrane Structure Ch. 11 2 5 Friday 15-Sep Membrane Structure Ch. 11 2 6 Monday 18-Sep Membrane Transport Ch. 12 3 7 Wed 20-Sep Membrane Transport Ch. 12 3 8 Friday 22-Sep Membrane Transport Ch. 12 3 9 Monday 25-Sep Membrane Transport Ch. 12 4 10 Wed 27-Sep Cell Communication Ch.16 4 11 Friday 29-Sep Cell Communication Ch.16 4 12 Monday 2-Oct Cell Communication Ch.16 5 13 Wed 4-Oct Cell Communication Ch.16 5 Friday 6-Oct 14 Monday 9-Oct Intracellular Compartments and Transport; 15 Wed 11-Oct 16 Friday 17 Exam 1 5 Paper #1 Handout Discuss Handout Week 1 1 Ch. 15 6 Intracellular Compartments and Transport Ch. 15 6 13-Oct Intracellular Compartments and Transport Ch. 15 6 Monday 16-Oct Intracellular Compartments and Transport: Paper #1 First Draft Due Ch. 15 7 18 Wed 18-Oct Cytoskeleton Ch. 17 7 19 Friday 20-Oct Cytoskeleton; Ch. 17 7 20 Monday 23-Oct Cytoskeleton Ch. 17 8 21 Wed 25-Oct Cytoskeleton Ch. 17 8 22 Friday 27-Oct Cytoskeleton; Ch. 17 8 23 Monday 30-Oct Cytoskeleton Ch. 17 9 24 Wed 1-Nov Energetics Ch. 14 9 25 Friday 3-Nov Energetics Ch. 14 9 26 Monday 6-Nov DNA structure Ch. 5 10 27 Wed 8-Nov DNA structure Ch. 5 10 Critique First Drafts Final Draft Paper #1 due 28 Friday 10-Nov DNA structure Ch. 5 Monday 13-Nov 29 Wed 15-Nov DNA replication 30 Friday 17-Nov DNA replication & repair 31 Monday 20-Nov Transcription Wed 22-Nov Thanksgiving 12 Friday 24-Nov Thanksgiving 12 32 Monday 27-Nov Transcription 33 Wed 29-Nov Translation 34 Friday 1-Dec 35 Monday 36 Exam 2 11 Paper #2 Handout Discuss Handout 10 Ch. 6 11 Ch. 6 11 Ch. 7 12 Ch. 7 13 Ch. 7 13 Translation Ch. 7 13 4-Dec Gene Regulation Ch. 8 14 Wed 6-Dec Gene Regulation Ch. 8 14 37 Friday 8-Dec Gene Regulation Ch. 8 14 38 Monday 10-Dec Gene Regulation Ch. 8 15 Wed 13-Dec Friday 15-Dec Paper #2 First Draft Due Paper #2 Final Draft Due Exam 3 15 15 GRADING: Each exam is worth 100 pts, and each paper 50 points for a total of 400 points. 92-100% = A, 89-91 = AB, 82-88 = B, 79-81 = BC, 72-78 = C, 68-71 = CD, 60-67 = D, below 60% = F. Grades will only be “curved”, if necessary. Cheating in any form (including plagiarism, excessive and/or undocumented paraphrasing) will NOT be tolerated. Students caught cheating will receive an F in the course and will be reported to the Dean of Students. MAKE-UP EXAMS: If you cannot be present for an exam, it is your responsibility to get in touch with me before the rest of the class writes the exam. Make-up exams will be available only if the student suffers a life-threatening illness and has a medical excuse to support that claim. WRITING ASSIGNMENTS: General Instructions I will provide you with selected data from the literature that are relevant to theories discussed in class. You are to treat the data as though they were your own and as though you wanted to present the data to others in your field as a publishable research paper. Consequently, you must (1) capture the interest of the reader by developing some background and explaining the significance of the hypothesis tested in your paper; (2), explain clearly the results so that the reader understands their meaning and draws the same conclusions as you as the paper is read, and, (3), discuss how your results expand upon knowledge published to date. Each paper will have: - Introduction that gives some background information but mostly outlines questions in the field (that will be addressed by your data) and the significance of the work presented, i.e. what makes the study important. A rationale statement is often useful. - Results section that explains the data. What do the data show? (To answer this question, you may also have to explain a bit about the techniques used and the rationale for doing specific experiments.) Why were certain controls done? - Discussion section in which a reasonable new hypothesis for future work is formulated from the data. This sounds like a lot of writing, but, in fact, the maximum page length will be no more than two typewritten, double-spaced pages (font no less than 12 point). The key is to think clearly, write concisely and say exactly what you mean…no more, no less. You may discuss the data (and interpretations of the data) among themselves. You can also ask me questions, preferably in class where all can profit from the questions and answers.