PHARMACY DEPARTMENT
FACULTY OF TECHNOLOGY & ENGINEERING
THE MAHARAJA SAYAJIRAO UNIVERSITY OF BARODA
Scheme of Teaching and Examination of B.Pharm
4 year Degree course as per AICTE Guidelines
Subject
Teaching
Subject Code
T
FIRST SEMESTER B.Pharm
ACH111
Physical Chemistry
ACH112
Organic Chemistry-I
AM 113
Remedial Mathematics/
PHR114
Remedial Biology
ME 115
Engg Drawing
Total
SECOND SEMESTER B.Pharm
PHR121
Pharm.Chem – I ( Inorg)
ACH122
Organic Chemistry –II
PHR123
Pharmaceutics-I
PHR124
Human Anat & Physiology
AM 125
Mathematics
4
4
4
P
Pap
er
Dura
tion
P&T
M
3
3
3
3
1
1
1
3
3
3
100
100
100
-
3
-
Examination
TW/ Total
Pr
Mark
Viva
s
50
50
50
50
150
150
100
300
200/
150
450/
400
50
12
9
4
4
4
4
4
20
3
3
3
3
12
1
1
1
1
1
3
3
3
3
3
100
100
100
100
100
500
50
50
50
50
200
150
150
150
150
100
700
4
4
4
4
4
3
3
3
-
1
1
1
1
1
3
3
3
3
3
100
100
100
100
100
50
50
50
-
150
150
100
150
100
20
9
500
150
650
4
4
4
4
4
3
3
3
3
-
100
100
100
100
100
50
50
50
-
150
150
150
150
100
20
12
500
150
650
Total
THIRD SEMESTER B.Pharm
PHR231
Médicinal Chemistry -I
PHR232
Pharm.Analysis-I
PHR233
Pharmacology -I
AM234
Intro.Computer Application
ChE235
Pharm.Engg-I
Total
FOURTH SEMESTER B.Pharm
PHR 241
Pharmacognosy -I
PHR242
Pharm.Biochemistry
PHR243
Pharmaceutics II
Ch E 244
Pharm.Engg-II
CF 245
Industrial Management
Total
1
1
1
1
1
3
3
3
3
3
FIFTH SEMESTER B.Pharm
PHR351
Pharmaceutics-III( Hospi.Ph)
PHR352
Pharmaceutics-IV
PHR353
Medicinal Chemistry-II
PHR354
Pharm.Microbiology
PHR355
Pharmacology-II
Total
4
4
4
4
4
6
3
4
-
20
13
SIXTH SEMESTER B.Pharm
PHR361
Pharm.Analysis-II
PHR362
Pharmacognosy-II
PHR363
Pharmaceutics-V
PHR364
Pharm.Biotechnology
PHR365
Pharmacology-III
Total
4
4
4
4
4
3
3
3
3
20
12
4
4
4
4
4
16
6
3
3
12
1
1
1
1
1
4
4
4
4
6
6
3
-
16
15
SEVENTH SEMESTER B.Pharm
PHR471
Pharmaceutics-VI
PHR472
Pharmacology-IV
PHR473
Pharmacognosy-III
PHR474
Medicinal Chemistry-III
PHR475
Pharm.Jurisprudence
1
1
1
1
1
100
100
100
100
100
100
50
50
-
100
200
150
150
100
500
200
700
100
100
100
100
100
50
50
50
50
150
150
150
100
150
500
200
700
3
3
3
3
3
100
100
100
100
100
500
100
50
50
200
200
150
150
100
100
700
1
1
1
1
3
3
3
3
100
100
100
100
100
100
50
-
200
200
150
100
-
-
400
50
300
50
700
1
1
1
1
1
3
3
3
3
3
3
3
3
3
3
Total
EIGHTH SEMESTER B.Pharm
PHR481
Pharm.Analysis-III
PHR482
Medicinal chemistry-IV
PHR483
Pharmaceutics-VII
PHR484
Nanotechnology
& Nanobiotechnology
PHR 485 Comprehensive Evaluation
Total
FIRST SEMESTER
B.PHARM. I
Theory 4 hrs/week
ACH 111 PHYSICAL CHEMISTRY
Marks 100
1. Behavior of Gases : Kinetic theory of gases, deviation from behaviours and explanation.
2. The Liquid State : Physical properties (surface tension, viscosity, refractive index, optical rotation,
dipole movements and chemical constituents).
3. Solutions : Ideal and real solutions, solutions of gases in liquids, colligative properties, partition
coefficient, conductance and its measurement, Debye Huckel theory.
4. Thermodynamics : First, second, and third laws, zeroth law, absolute temperature scale, thermochemical
equations, phase equilibria and phase rule.
5. Adsorption : Fredlich and Gibbs adsorption, isotherms, Langmuir theory of adsorption.
6. Photochemistry : Consequences of light absorption, Jablenski diagram, Lambert-Beer Law, Quantum
efficiency.
7. Chemical Kinetics : Zero, first and second order reactions, complex reactions, theories of reaction
kinetics, characteristics of homogeneous and heterogeneous catalysis, acid base and enzyme catalysis.
8. Quantum Mechanics : Postulates of quantum mechanics, operators in quantum mechanics, the
Schrodinger wave equation.
Practicals
Marks 50
3 hrs/week
1. To determine molar mass by Rast method and cryoscopic method.
2. To determine refractive index of given liquids and find out the contribution of carbon, hydrogen and
oxygen in molar refraction of a compound.
3. To determine molar mass of volatile liquids by Victor-Meyer method.
4. To determine the specific rotation of sucrose at various concentrations and determine the intrinsic
rotation.
5. To determine the heat of solution, heat of hydration and heat of neutralization.
6. To determine the cell constant, verify Ostwald dilution law and perform conductometric titration.
7. To determine rate constant of simple reaction.
FIRST SEMESTER ACH 112 ORGANIC CHEMISTRY – I
B.PHARM I
Theory 4 hrs/week
100 marks
1. Structure and Properties : Atomic structure, Atomic orbitals, Molecular orbital theory, wave equation,
Molecular orbitals, Bonding and Antibonding orbitals, Covalent bond, Hybrid orbitals, Intramolecular
forces, Bond dissociation energy, Polarity of bonds, Polarity of molecules, structure and physical properties,
Intermolecular forces, Acids and bases.
2. Stereochemistry : Isomerism and nomenclature and associated physicochemical properties, optical
activity, stereoisomerism, specification of configuration, Reactions involving stereoisomers, chirality, chiral
reagents conformations.
3. Structure, nomenclature, Preparation and Reactions of : Alkanes, Alkenes, Akynes, Cycloalkanes,
Dienes, Benzene, Polynuclear aromatic compounds, Arenes, Alkyl halides, Alcohols, Ethers, Epoxides,
Amines, Phenols, Aldehydes and ketones, Carboxylic acids, Functional derivatives of carboxylic acids,
Reactive intermediates - carbocations, carbanions, carbenes, nitrene and nitrenium ions.
Practicals
Marks 50
3 hrs/week
1. The student should be introduced to the various laboratory techniques through demonstrations involving
synthesis of selected organic compounds (e.g. aspirin, p-bromoacetanilide, anthraquinone from anthracine,
reduction of nitrobenzene etc.).
2. Identification of organic compounds and their derivatisaton.
3. Introduction to the use of stereomodels.
FIRST SEMESTER
B.PHARM.-I
Theory
4 hrs
PHR 114 REMEDIAL BIOLOGY
Marks 100
1. Plant Taxonomy: Methods of classification of plants.
2. Plant Cell: its structure and non-living inclusions; mitosis and meiosis; different types
of Plant tissues and their functions.
3. Morphology and histology of root, stem, bark, wood, leaf, flower, fruit and seed.
Modification of root and stem.
4. Study of the following families with special reference to medicinally important plants
Apocynacae, Solanaceae, Rutaceae, Umbelliferae, Leguminosae, Rubiaceae,
Liliaceae, Grarninae, Labiatae, Cruciferae, Papaveraceae.
5. General Survey of Animal Kingdom; Structure and life history of parasites as
illustrated by amoeba, entamoeba, trypanosoma, plasmodium, taenia, ascaris,
schistosoma, oxyuris, and ancylostoma.
6. General Structure and life history of insects like mosquito, housefly, mites and
silkworm.
Practical
3hrs / week
Marks 50
1. Morphology of plant parts indicated in theory.
2. Gross identification of slides of structure and life cycle of lower plants / animals mentioned in theory.
3. Preparation, microscopic examination of stem, root and leaf of monocot and dicot plants
4. Structure of human parasites and insects mentioned in theory with the help of specimens
FIRST SEMESTER
B.PHARM I
ME 115
ENGINEERING DRAWING
Practicals 3 hrs/week
Marks 50
Elementary Knowledge of Engineering Drawing :
Concept of orthographic and isometric views of elevation and third angle projection. Notation and
abbreviation used in Engineering Drawing
Basic Engineering Drawing Practice :
Bolts, nuts, riveted fronts, screws, worn screws as per specification.
Drawing of simple pharmaceutical machinery parts.
.
SECOND SEMESTER
B. PHARM. I
Theory: 4hrs/week:
PHR 121. PHARMACEUTICAL CHEMISTRY
(Inorganic Pharmaceutical Chemistry)
Marks : 100
An outline of methods of preparation, uses, sources of impurities, tests for purity and identity, including
limit tests for iron, arsenic, lead, heavy metals, chloride, sulphate and special tests If any, of the following
classes of inorganic pharmaceuticals included in Indian Pharmacopoeia.
1. . Acids and Bases: Buffers, Water
2. Gastrointestinal Agents : Acidifying agents, Antacids, Protectives and Adsorbents, Cathartics.
3. Major Intra- and Extracellular Electrolytes : Physiological ions. Electrolytes used for replacement
therapy, acid-base balance and combination therapy.
4. Essential and Trace Elements Transition elements and their compounds of
Pharmaceutical importance: Iron and haematinics, mineral supplements.
5. Cationic and anionic components of inorganic drugs useful for systemic effects.
6. Topical Agents Protectives, Astringents and Anti-infectives.
7, Gases and Vapours: Oxygen, Anesthetics and Respiratory stimulants.
8. Dental Products : Dentifrices, Anti-caries agents.
9. Complexing and chelating agents used in therapy.
10. Miscellaneous Agents : Sclerosing agents, expectorants, emetics, poisons and antidotes, sedatives etc.
Pharmaceutical Aids Used in Pharmaceutical Industry. Anti-oxidants, preservatives, filter aids, adsorbents,
diluents, excipients, suspending agents, colorants etc..
11. Inorganic Radio pharmaceuticals : Nuclear radio pharmaceuticals, Reactions. Nomenclature,
Methods of obtaining their standards and units of activity, measurement of activity, clinical applications and
dosage, hazards and precautions.
Practicals : 3 Hrs/week
Marks : 50
The background and systematic qualitative analysis of inorganic mixtures of up to four radicals. Six
Mixtures to be analyzed, preferably by semi-micro methods. All identification tests for pharmacaopoeal
inorganic pharmaceuticals and qualitative tests for cations & anions should be covered.
SECOND SEMESTER
B.PHARM I
Theory3 hrs/week
ACH 122 ORGANIC CHEMISTRY-II
100 marks
Nucleophillic aromatic substitution : alpha, beta- unsaturated carbonyl compounds ; Conservation of
orbital symmetry and rules. Electrocyclic, Cycloaddition and sigmatropic reactions; Neighbouring group
effects, Catalysis by transition metal complexes, Stereoselective and stereospecific reactions.
Heterocyclic Compounds : Chemistry, preparations and properties of some important heterocycles
containing 3,4,5,6 & 7 atoms with one or two heteroatoms like O, N. S, fused ring heterocyles
(Quinoline,iso Quinoline, Indole).
Practicals
50 marks
3 hrs/week
At least five exercises in synthesis involving various heterocyclic ring system. An exercise involving
stereoselective synthesis of a compound. Resolution of recemic D,L-alanine or any other example.
Workshop on molecular modelling of primary, secondary and tertiary structures of proteins, molecular
modelling on double helical structure of nucleic acid showing hydrogen bonding.
SECOND SEMESTER
B.PHARM.I
PHR 123 PHARMACEUTICS-I
(Dispensing & Community Pharmacy)
Theory: 4 hrs/week
Marks: 100
Dispensing Pharmacy
1. Definition, scope and Ethics of dispensing practice.
2. Prescription, handling of Prescription, care required in dispensing prescription.
3. General dispensing procedure including packing and labeling of dispensed products.
4. Pharmaceutical calculations: enlarging and reducing recipes, percentage solutions, allegations, alcohol
dilution, proof spirit, Isotonic solutions and displacement values.
5 Incompatibility in prescriptions with examples.
6. Posology: Dose of commonly used drugs, alone and in combinations. Calculation of doses according to
age and other body functions.
Community Pharmacy:
1. Retail Pharmacy management: Organization and structure of retail pharmacy. Layout of retail pharmacy
and other legal aspects for establishment and management of retail pharmacy. Good pharmacy practices,
maintenance of records, dispensing of Proprietary products.
2. Community Pharmacy: Study of community health care system with special references to the areas like
Nutrition( Balanced diet, nutritional deficiency disorders , their treatment and prevention) , Family
planning and family Welfare, First Aid ( shock, snake bites, burns , poisoning , fractures) and
resuscitation methods, Communicable Diseases(brief outline , their causative agents,. Modes of
transmission and prevention ( chicken pox, measles, influenza, diphtheria, whooping cough ,
tuberculosis, poliomyelitis, helminthiasis, malaria, filariasis, rabies, trachoma, tetanus, leprosy,
leprosy, syphilis, gonorrhoea and AIDS ) Immunization and Disinfection.
3. Patient counselling.
Practicals 3 hrs./week
Marks:50
Dispensing of prescriptions belonging to - Mixtures, Solutions, Emulsions, Creams, Ointments,
Powders, Capsules, Pastes, Jellies, Suspensions, Ophthalmics, Pastilles, Lozenges, Pills, Liniments,
Inhalations, Paints, Sprays and Tablet triturates, Ear drops ,Incompatible mixtures
Demonstration & training of first aid.
SECOND SEMESTER
B. PHARM. I
PHR 124. HUMAN ANATOMY & PHYSIOLOGY
Theory: 4 hrs/week:
I. Introduction .
1. Scope of anatomy and physiology
2. Study of cell and elementary tissues of the body.
II. Skeletal Muscle
3. Gross anatomy and physiology of muscsle contraction.
4. Physiological properties of skeletal muscle.
III. Haemopoetic system
5. Composition and functions of blood.
Marks: 100
6. Blood groups and their significance
7. Mechanism of blood coagulation
IV. Digestive system
8. The Alimentary tract and its secretory functions.
9. Digestion and absorption in G.I.tract.
10. Functions of liver.
V. Respiratory system
11. The respiratory tract and pulmonary ventilation
12. Diffusion and transport of oxygen and carbon dioxide.
13. Regulation of Respiration
VI. Cardiovascular system
14. Basic anatomy and physiology of Heart
15. Specialized conducting system of Heart
¶6. Basic understanding of Heart sounds, Cardiac cycle and ECG.
17. Circulation of blood. Blood pressure and its regulation.
VII, Lymphatic system
18. Basic Physiology and functions of spleen
19. Composition and circulation of lymph.
VIII. Central Nervous System
20. Development and organization of nervous system
21. Neurone, synapse and transmitter substance
22. The cerebellum and overall motor control
23. The cerebral cortex and functions of specific cortical areas.
24. Limbic system, hypothalamus and spinal reflexes.
25. Cerebral blood flow, membranes, CSF and Brain metabolism
IX. Autonomic Nervous System
26. General organisations of ANS.
27. Basic characteristics of sympathetic and parasympathetic function and adrenal medulla.
X. Endocrine system
28. Introduction to endocrinology, the pituitary hormones and their control by hypothalamus.
29. Thyroid, parathyroid, adrenal, pancreas, their hormone and functions.
Xl. Excretory system
30. Structure and functions of kidney.
31. Physiology of urine formation.
32. Regulation of Acid base balance.
XIII. Sense organ
34. Basic anatomy and physiology of eye, ear, taste buds, nose and skin.
Practicals 3 hrs./week
Marks: 50
1. Study of Microscope and Preparation of blood smear and Identification of different cells.
2. Estimation of haemoglobin in blood.
3, Differential WBC count.
4. Total RBC and Total WBC count.
5. Determination of bleeding time and clotting time.
6. Study of Human skeleton.
7. Study of different systems with the help of models.
8. Blood pressure Recording
9. Microscopic study of different tissues and organs
10. Physiological experiments on Nerve-Muscle preparation.
11. Effect of osmotic pressure on RBC.
12. Identification of Blood group.
SECOND SEMESTER
B.PHARM. I
Theory 4 hrs/week
AM125
MATHEMATICS
Marks 100
MATHEMATICS
UNIT - 1 Ordinary Differential Equations :
Reorientation.
Modeling of Engineering system pertaining to first order differential equations (Pharmaceutical
applications), Exact differential equations, Integrating factors, Unified approach to first order ordinary
differential equation, equations of first order and higher degree.
UNIT - 2 Linear Differential Equations of Higher Order With Constant Co-efficient and with Variable
Coefficients : Homogeneous linear equation first method of solution only), Simultaneous differential
equations which are linear and of the first order, Pharmaceutical applications.
UNIT - 3 Laplace Transforms :
Laplace Transforms of elementary functions, Inverse Laplace Transforms, Linearity property, First and
Second shifting theorem. Laplace Transforms of derivative and integrals, Application of Laplace
Transform in solving ordinary and simultaneous
differential equations.
UNIT -4 Probability Theory
Review of Elementary concept in Probability, Random variable and discrete and continuous probability
distributions; Mean and variance of a distribution; Binomial and Poisson distribution and their properties;
Normal distribution curves and properties Kurtosis and skewness, sums of Independent normal random
variables, t-distribution and related results.
UNIT - 5 Statistical Inference :
Random and non-random sampling; sample size, data organization, diagrammatic representation of sample
data, bar, pie, 2-D, and 3-D diagrams, measures of central tendency, measures of dispersion, standard
deviation, Standard error of means, coefficient of variation, Parameter estimation, Testing of hypothesis,
Null hypothesis and kind of alternatives, Types of errors in tests, Tests in the case of the normal distribution
(For mean with known & unknown variance, for variance) comparison of means and variances of two
normal distributions.
UNIT - 6 Correlation and Regression :
Linear Coefficient of correlation, Methods of least-square, Regression of Yon X and X on Y, correlation
and regression analysis, elements of ANOVA, Applications in Pharmaceutical Sciences.
THIRD SEMESTER PHR 231. MEDICINAL CHEMISTRY-I
B. PHARM. II
Theory 3 hrs /week
Marks: 100
1. Strategies for synthesizing the medicinally active drug molecules to be dealt in detail taking selected
examples and utilising the knowledge gained from earlier papers of organic chemistry.
2. Newer organic reagents used in drug synthesis.
3. Chemistry of amino acids and nucleic acids covering the polypeptide drugs.
Practicals 3 hrs./week
Marks: 50
Exercises based on Identification of organic compounds / drugs on the basis of functional group
analysis and derivatization.
THIRD SEMESTER: PHR 232 . PHARMACEUTICAL ANALYSIS-I
B. PHARM. II
Theory: 4 hrs / week
Marks: 100
1. Significance of quantitative analysis In quality control, Different techniques of analysis, Preliminaries
and definitions, Significant figures, Rules for retaining significant digits, Types of errors, Mean deviation,
Standard deviation, Statistical treatment of small data sests, Selection of sample, Precision and accuracy.
Fundamentals of volumetric analysis, methods of expressing concentration, primary and secondary
standards. 6 hrs
2, Acid Base Titrations : Acid base concepts, Role of solvent, Hydrolysis of salts, Henderson-Hesselbach
equation, Buffer solutions, Neutralization curves, Acid-base indicators, Theory of indicators. Choice of
indicators, Mixed indicators, Polyprotic system, Polyamine and amino acid systems, Amino acid titration,
applications in assay of H3P04, NaOH, CaCO3 etc.
8 hrs
3. Oxidation Reduction Titrations : Concepts of oxidation and reduction, Redox reactions, Strengths and
equivalent weights of oxidizing and reducing agents, Theory of redox titrations, Redox indicators, Cell
representations, Measurement of electrode potential, Oxidation-reduction curves, lodimetry and lodometry,
Titrations involving ceric sulphate, potassium iodate, potassium brornate, potassium permanganate: titanous
chloride and Sodium 2,6-dichlorophenol indophenol.
6 hrs
4. Precipitation Titrations : Precipitation reactions, Solubility products, Effect of acids, temperature and
solvent upon the solubility of a precipitate. Argentometric titrations and titrations involving ammonium or
potassium thiocyanate. mercuric nitrate, and barium sulphate, indicators, Gay-lussac method; Mohr’s
method, Volhard’s method and Fajan’s method. 5 hrs
5. Gravimetric Analysis : Precipitation techniques, Solubility products; The colloidal state, Supersaturation
Go- precipitation, Post-precipitation, Digestion, washing of the precipitate, Filtration, Filter papers and
crucibles, Ignition, Thermogravimetric curves, Specific examples like benzyl penicillin, cholesterol and
histamine acid phosphate , aluminum as aluminum oxide, calcium as calcium oxalate and magnesium as
magnesium pyrophosphate, Organic precipitants.
6hrs
6. Solvent Extractions –Brief introduction , classification and theory of extraction, separation from
excipients using extraction.
5 hrs
7. Miscellaneous Methods of Analysis: Diazotisation titrations, Kjeldahl method of nitrogen estimation,
Karl-Fischer titration, Oxygen flask combustion, gasometry. 4 hrs
Practical 3 hrs /week
Marks - 50
The students should be introduced to the main analytical tools through demonstrations. They should have a
clear understanding of a typical analytical balance, the requirements of a good balance, weights, care and
use of balance, methods of weighing and errors in weighing. The students should also be acquainted with
the
general
apparatus
required
in
various
analytical
procedures.
1. Standardization of analytical
weights and
calibration of volumetric
apparatus.
2. Acid Base Titrations : Preparation and standardization of acids and bases; some exercises related with
determination of acids and bases separately or in mixture form, some official assay procedures e.g. boric
acid should also be covered.
3. Oxidation Reduction Titrations : Preparation and standardization of some redox titrants e.g. potassium
permanganate, potassium dichromate, iodine, sodium thiosuiphate, etc. Some exercises related to
determination of oxidizing and reducing agents in the sample shall be covered. Exercises involving
potassium odate, potassium bromate, iodine solution, titanous chloride, sodium 2,6-dichlorophenol
indophenol,
and
ceric
amnionium
sulphate.
4. PrecIpitation titrations Preparation and standardization of titrants like silver nitrate and, arnmonium
thiocyanate,
Titrations
acording
to
Mohr’s,
Voihard’s
and
Fajan’s
methods.
5. Gravlmetric Analysis Preparation of gooch crucible for filtration and use of sintered glass crucible,
determination of water of hydration, Some exercises related to gravimetric analysis should be covered.
THIRD SEMESTER: PHR 233 PHARMACOLOGY-I
B.PHARM.II: (Pharmacokinetics, Pharmacolynamics & Toxiology)
Theory: 4 hrs/week
Marks: 100
I. Introduction:
1. Development and scope of pharmacology
2. Modern and other system of medicine
3. Definition, sources and routes of administration of drugs
II. Drug Absorption:
4. Mechanism of drug absorption
5. Absorption from vascular and non-vascular sites
6. Factors affecting drug absorption
III. Drug Distribution:
7. Factors affecting drug distribution
8. Binding of drugs to blood and tissue component
9. Protein binding and factors affecting protein binding
10. Physiological barrier to drug distribution
11. Volume of distribution and its significance
IV, Drug Biotransformation
12. Chemical pathway of drug biotransformation
13. Microsornal and non microsonial enzyme system \14. Factor affecting biotransformation
15. Prodrug and its application
V. Drug Excretion:
16. Renal drug excretion and concept of clearance
17. Factors affecting renal excretion
18. Non-renal route of drug excretion
19. Enterohepatic cycling of drug
VI. Principles of Pharmacokinetlcs:
20. Basic concept and rate and order of reaction
21. Plasma concentration time profile and urinary excretion data
22. Bioavailability and bioequivalence and their clinical significance
23. Application of pramacokinetic principles
24. Prologned release medication
VII. Mechanism of action of drugs:
25. Types of receptors, receptor proteins and drug receptor interaction —
26. Molecular aspect of drug action 27. Factors modifying the effects of drug in individuals,.28. Pharmacokinetic and pharmacodynamic drug interaction;,
VIII. Toxicology: — —
29. Adverse drug reactions (Pharmacogenetics, hypersensitivity, teratogenicity etc.)
30 Pre clinical evaluation of drugs. (Acute, sub acute & chronic toxicity Testing)
31 New drug development and clinical trials
32. Poisons and the treatment of poisoning.
33. Non therapeutic toxicants including heavy metals and heavy metal antagonists.—
THIRD SEMESTER AM 234 INTRODUCTION TO COMPUTER APPLICATION
B.PHARM II
Theory: 4 hrs/week
Marks: 100
1. Introduction to Computers :
History of Computer development, computer classification, Calculator, computers and Human burin,
Computer organization, RAM, ROM, Virtual memory, I/O devices, Hardware & Software, Computer
Languages, Low level & High level Languages, Concept of operating systems, Basic commands in MSDOS, UNIX and windows, Computer Networks.
2. Introduction to PC Software :
MS-Word, Excel, Power Point etc. (More stress in practical)
3. C Programming Language:
1. Data types, Operators, Expressions.
2. Control flow statements : If-Else, Else-if, Switch, While, for and do while statements.
3. Pointers, Arrays.
4. Functions : Built in functions, User-defined functions, I/O functions;
5. Computer applications in pharmaceutical and clinical studies.
Practical 3 hrs /week
Marks - 50
1. DOS, UNIX and windows (Basic commands)
2. Study of PC software packages like MS-Word, Excel, Power Point etc.
3. Simple programs in 'C'.
THIRD SEMESTER Ch E 235 PHARM ENGINEERING-I
B.PHARM II
Theory 3hours/week
Marks : 100
1. Unit Operations : Introduction, basic laws.
2. Fluid Flow : Types of flow, Reynold's number, Viscosity, Concept of boundary layer, basic equations of
fluid flow, valves, flow meters, manometers and measurement of flow and pressure.
3. Material Handling Systems :
(a) Liquid handling - Different types of pumps.
(b) Gas handling - Various types of fans, blowers and compressors.
(c) Solid handling - Bins, Bunkers, Conveyers, Air transport.
4. Filtration and Centrifugation : Theory of filtration, filter aids, filter media, industrial filters including
filter press, rotary filter, edge filter, etc. Factors affecting filtration, mathematical problems on filtration,
optimum cleaning cycle in batch filters. Principles of centrifugation, industrial centrifugal filters, and
centrifugal sedimenters.
5. Crystallization : Characteristics of crystals like-purity, size, shape, geometry, habit, forms size and
factors affecting them, Solubility curves and calculation of yields. Material and heat balances around
Swenson Walker Crystallizer. Supersaturation theory and its limitations, Nucleation mechanism, crystal
growth. Study of various types of Crystallizer, tanks, agitated batch, Swenson Walker, Single vacuum,
circulating magma and crystal Crystallizer, Caking of crystals and its prevention. Numerical problems on
yields.
6. Dehumidification and Humidity Control : Basic concepts and definition, wet bulb and adiabatic
saturation temperatures, Psychrometric chart and measurement of humidity, application of humidity
measurement in pharmacy, equipments for dehumidification operations.
7. Refrigeration and Air Conditioning : Principles and applications of refrigeration and air conditioning.
8. Material of Construction : General study of composition, corrosion, resistance, Properties and
applications of the materials of construction with special reference to stainless steel and glass.
9. Industrial Hazards and Safety Precautions : Mechanical, Chemical, Electrical, fire and dust hazards.
Industrial dermatitis, Accident records etc.
FOURTH SEMESTER
B.PHARM –II
Theory: 4 hrs /week
PHR 241 PHARMACOGNOSY- I
Marks : 100
1.Introduction to Pharmacognosy. Classification of crude drugs & their sources. Cultivation, collection,
processing and storage of crude drugs. .Plant hormones and their applications. Pesticides and Insecticides.
4hrs.
3.Quality control of crude drugs: Different types of Adulteration. Methods of evaluation . Including
quntitative microscopic determinations.
2hrs
4.Classification, Chemical and spectral approaches to simple molecules of natural origin.
Concept of sterioisomerisms taking examples of natural products.
4hrs.
5. Chemistry including isolation of Carbohydrates, Lipids, Proteins & Terpenoides. 10hrs
6.Physico chemical properties of Volatile oils , Resins, Tannins.
4hrs
7. Systematic pharmacognostic study of following drugs and pharmaceutical aids:. 12hrs.
Colophony, podophyllum, jalap, cannabis, capsicum, myrrh, asafoetida, balsam of tolu, balsam of peru,
benzoin, turmeric, ginger. Garnbir, black catechu, gall and myrobalan.
Mentha, Coriander, Cinnamon, Cassia, Lemon peel, Orange peel, Lemon grass, Citronella, Caraway. Dill,
Spearmint, Clove. Fennel, Nutmeg, Eucalyptus, Chenopodium, Cardamom, Valerian, Musk, Palmarosa,
Gaultheria, Sandal wood.. Agar, Guargum, Acacia, Honey, Isabgol, Pectin, Starch, Lactose, Sorbitol,
Sterculia, Tragacanth, Cellulose and its products, Sodium Alginate, Talc, and Bentonite. Besswax, Castor
oil, Qliveoil, Cocoa butter, Chaulmogra oil, Lard, Sharkliveroil, Codliver oil, Woolfat, Spermecetiwax ,
8. Studies of traditional drugs like:Amala, Kantksri, satavari, Guduchi, Giloya, Punarnava,
Chitrak,Apamarg, Gokhru, Shanlchsp ushpi, Adusa, Arjuna, Ashoka, Brahmi, Satavari, Methi, Lasun,
Guggula, Nagarmotha, Neem, Shilajit.
Practicals
3 Hours / week
Marks : 50
1. Chemical tests for general and specific constituents like carbohydrates lipids, protines.
3. Preparation of herbarium sheets.
4. Experiments on isolation & evaluation of lipids, volatile oils.
5. Morphologic, Microscopic and Chemical evaluation of crude drugs mentioned in theory.
FOURTH SEMESTER: PHR 242 PHARMACEUTICAL BIOCHEMISTRY
B.PHARM II
Theory: 4 hrs/week
Marks: 100
1. Biochemical organisation of the cell and transport processes across cell membrane.
2. The concept of free energy, determinational of change in free energy from equilibrium constant and
reduction potential , bioenergetics, production of ATP and its biological significance.
3. Enzymes : Nomenclature, enzyme kinetics and its mechanism of action, mechanism of inhibition,
enzymes and iso-enzymes In clinical diagnosis.
4. Co-enzymes : Vitamins as co-enzymes and their significance. Metals as co-enzymes and their
significance.
5. Carbohydrate Metabolism; Conversion of polysaccharide to glucose- 1- phosphate, Glycolysis and
fermentation and their regulations, Giuconeogenesis and glycogenolysis, Metabolism of galactose and
galactosemia, Role of sugar nucleotides in biosynthesis and pentosephosphate pathway.
6. The citric Acid cycle: Significance, reactions and energetic of the cycle, Amphibolic role of the cycle,
and Glyoxalic acid cycle.
7. Lipids Metabolism : Oxidiatio of fatty acids, B-oxidation & energetic, a- oxidation of fatty acids, Boxidation & energetic , a-oxidation, w-oxidation, Biosynthesis of ketone bodies and their utilization,
Biosynthesis of saturated and unsaturated fatty acids, control of lipid metabolism, Essential fatty acids &
eicosanoids (Postagglandian, thromboxanes and leukotrienes), phoapholipids, and spshingolipids.
8. Biological Oxidation: Redox- potential, enzymes and co-enzyzmes involved in oxidation reduction & its
control. The respiratory chain, its role in energy capture and its control. Energies of oxidative
phosphorylation, Inhibitors of respiratory chain and oxidative phosphorylation, Mechanism of oxidative
phosphorylation.
9. Nitrogen & Sulphur cylce: Nitrogen fixation, ammonia assimilation, nitrification and nitrate assimilation,
sulphate activitation, sulphate reduction, Incorporation of sulphur in organic compounds, release of sulphur
from organic compounds.
10. Metabolism of Ammonia and Nitrogen containing Monomers: Nitrogen balance, Biosynthesis of amino
acids, catabolism of amino acids, conversion of amino acids, to specialezed products. Assimilation of
ammonia, Urea cycle, metabolic disorders or urea cycle. Metabolism of sulphur containing amino acids,
porpphyrin biosynthesis ,formation of bile pigments, hyperbiliruninemia, purine biosynthesis, purine
nucleotide intereconversion, pyrimidine biosynthesis, and formation of deoxyribounucleotides.
ii. Biosynthesis of Nucleic Acids: Brief introduction of genetic organisation of the mammalian genome,
alteration and rearrangements of genetic material, Biosynthesis of DNA and its replication. Mutation,
physical & chemical mutagenesis/carcinogenesis, DNA repair mechanism, Biosynthesis of RNA.
12. Genetic code and protein synthesis: Genetic code components of protein synthesis, brief account of
genetic
engineering and polymerase chain reactions.
13. Regulations of gene expression.
Practicals 3 hrs/week
* Practical based on theory will be conducted
THIRD SEMESTER
B.PHARM.II
Theory: 4 hrs/week
Marks: 50
PHR 243 -PHARMACEUTICS-Il
(Physical Pharmacy)
Marks: 100
1. Solubility and Distribution Phenomena:
Definitions, expressions, solute-solvent interactions. Solubility of gases, liquids and solids-factors affecting
their solubility. Distribution -law, coefficient, pharmaceutical applications of partition coefficient.
2. Micrometrics:
Particle size and distribution, average particle size, particle size distribution, number and weight
distribution, particle number, methods for determining particle size, optical microscopy, sieving,
sedimentation, particle volume measurement, particle shape, specific surface, methods for determining
surface area, permeability method, adsorption method; Derived properties of powders-porosity-packing
arrangement- densities bulkiness, flow properties.
3, Surface and Interfacial phenomena
Liquid interfaces- surface and interfacial tensions, surface free energy, measurement of surface and
interfacial tensions, spreading coefficient, adsorption at liquid interfaces, surface active agents-HLB
classification, solubilization-detergency, adsorption at solid interfaces, solid -gas and solid -liquid
interfaces, complex films. Electrical properties of interfaces.
4. Viscosity and Rheology;
Newtonian systems- Low of flow, kinematic viscosity, effect of temperature, Non-newtonian systemspseudoplastic dilatant, plastic- thixotropy, measurement thixotropy, thixotropy in formulation ,
determination of viscosity- capillary, falling ball- rotational viscometers.
5. Disperse systems:
(a) Colloidal Dispersions- pharmaceutical applications, types- lyophilic, lyophobic, association colloids,
properties of colloids.
(b) Coarse dispersions- Suspensions and Emulsions;
Interfacial properties of suspended particles, settling in suspensions- theory of sedimentation-effect of
Brownian movement -sedimentation of flocculated particles, sedimentation parameters, wetting of particles,
controlled flocculation.
Emulsions- types- theories of emulsification, physical stability of emulsions.
6. Complexation:
Classification, methods of preparation and analysis, Applications.
7. Kinetics and drug stability :
General consideration and concepts, orders of reaction, half life determination, influence of temp. , light,
solvent, catalytic species and other factors, accelerated stability study, expiration dating.
Practical : 3 hrs week
Marks :50
Experiments devised to determine complexation and complex stability, kinetics and orders of reaction,
average particle size, particle size distribution, particle surface areas. bulk density of powders, flow
properties of powders, solubility of solids, partitioning of salutes in immiscible solvents, surface and
interfacial tensions, HLB values, adsorption of solutes on solids, viscosity, Rheological properties of
liquids, optical and electrical properties of colloids, gelling property, sedimentation rates of non-flocculated
and flocculated systems, creaming and cracking of emulsions etc, and other
experiments of illustrate the topics covered in theory.
FOURTH SEMESTER
PHR 244 PHARM ENGINEERING – II
B.PHARM II
Theory: 4 hrs/week
Marks: 100
1. Stoichiometry : Unit processes material and energy balances, molecular units, mole fraction, tie
substance, gas laws, mole volume, primary and secondary quantities, equilibrium state, rate process, steady
and unsteady states, dimensionless equations, dimensionless foumulae, dimensionless formulae,
dimensionless groups, different types of graphic representation, mathematical problems.
2. Heat Transfer : Source of heat, heat transfer, steam and electricity as heating media, determination of
requirement of amount of steam/electrical energy, steam pressure, Boiler capacity, Mathematical problems
on heat transfer.
3. Evaporation : Basic concept of phase equilibria, factor affecting evaporation, evaporators, film
evaporators, single effect and multiple effect evaporators, Mathemical problems on evaporation.
4. Distillation : Raoult's law, phase diagrams, volatility; simple steam and flash distillations, principals of
rectification, Mc. Cabe Thiele method for calculations of number of theoretical plates, Azeotropic and
extractive distillation. Mathematical problems on distillation.
5. Drying : Moisture content and mechanism of drying calculations; classification and types of dryers,
dryers used in pharmaceutical industries and special drying methods. Mathematical problems on drying.
6. Size Reduction and Size Separation : Definition, objectives of size reduction, factors affection size
reduction, laws governing energy and power requirements of a mills including abll mill, hammer mill, fluid
energy mill etc.
7. Mixing : Theory of mixing, solid-solid, solid-liquid and liquid-liquid mixing equipments.
8. Automated Process Control Systems : Process variables, temperature, pressure, flow, level and their
measurements. Elements of automatic process control and introduction to automatic process control
systems. Elements of computer aided manufacturing (CAM).
9. Reactors and fundamentals of reactors design for chemical reactions.
Practicals:
Practicals 4 hrs / week
1. Determination of overall heat transfer coefficient.
2. Determination of rate of evaporation.
3. Experiments based on steam, extractive and azeotropic distillations.
Marks: 50
4. Determination of rate of drying, free moisture content and bound moisture content.
5. Experiments to illustrate the influence of various parameters on the rate of drying.
6. Experiments to illustrate principles of size reduction, Laws governing energy and power requirements
of size Reduction.
7. Experiments to illustrate solid-solid mixing, determination of mixing efficiency using different types
of mixers.
FOURTH SEMESTER CF PHR 245 INDUSTRIAL MANAGEMENT
B.Pharm II ( taught by commerce faculty)
FIFTH SEMESTER PHR 351 . PHARMACEUTICS-III
B.PHARM.IV (Hospital Pharmacy)
Theory 4 hrs./week
Marks : 100
1, Organisation and Structure: Organisation and structure of Hospital and Hospital Pharmacy
Responsibilities of a Hospital Pharmacist. Pharmacy and therapeutic committee.
2. Drug distribution systems in Hospitals: Inpatient and out patient drug distribution, Dispensing of
Narcotic and other controlled substances, ancillary substances and articles. Changing policy and systems for
hospital supplies and drugs.
3. Manufacture of Hospital products and sterile extemporaneous preparations:
a) Intra venous fluids: Facility requirements, formulation, preparation and packing
b) Special electrolytes
c) Blood products and plasma expanders
d) Surgical dressings: Ligature and sutures.
5. Handling and administration of sterile products: Injections-IMIIV, Catheters, IV Infusions Volume
control sets, Over the needle catheters (ONC), Intermittent IV therapy. Complications in IV therapy. Other
parenteral and implantable devices. Parenteral Admixtures and incompatibilities.
6. Hospital formulary and other hospital publications.
7. Drug information services.
Sources of information and procurement, computerization of services like prescription filling, drug profile,
patient medication profile, drug interaction and adverse reaction, idiosyncratic cases etc.
8. Medication errors, documentation and preventive measures.
9. Central sterile supply unit and its management.
10. Nuclear Pharmacy : Introduction to radiopharmaceuticals, preparation of radiopharmaceuticals in
hospital and their standardization. Radiation dosimetry radiation hazards and their prevention.
Specifications for radio isotope laboratory.
FIFTH SEMESTER
PHR 352 ( PHARMACEUTICS-IV)
B. PHARM.III (Pharm. Technology-I)
Theory 4 hrs/week
Marks : 100
1. Liquid Dosage Forms
Introduction, type, additives used in formulations, vehicles, stabilizers, preservatives, suspending agents,
emulsifying agents, solubilizers, colours, flavours and others. Manufacturing, packing and evaluation of
clear liquids, suspensions and emulsions for oral and topical administration. Liquid preparation official in
Pharmacopoeia.
2. Semisolid dosage forms
Definitions, types, mechanism of drug penetration through skin, factors influencing penetration. Semisolid
bases and their selection.
General formulation of semisolids, manufacturing procedures, evaluation and packaging.
3. Suppositories
Ideal requirements, bases, manufacturing procedure, packaging and evaluation.
5. Pharmaceutical Aerosols
Definitions, propellents, formulation, manufacturing and packaging, evaluation and applications.
6. Cosmeticology and Cosmetics:
Fundamentals of cosmeticology, materials and additives used in cosmetics and their specifications,
structure and functions of skin, hair, nails , eyes, preparation and packing of cosmetics for skin, hair,
dentifrices, manicure preparations, nail polish, lipsticks, eye cosmetics, baby care products etc.
7. Packing, levels of packaging, Raw materials in packaging and their specifications and testing
Practicals 6 hrs/week
Marks : 100
1. To study the influence of emulsifier, HLB and formulation method on the stability of emulsions.
2. To prepare various liquid orals like solutions, syrups, elixirs, gels, mixtures, suspensions, emulsions etc.
3. To prepare various topical formulations like lotions, liniments, glycerites, paints, applications etc.
4. To prepare various semisolid preparations like ointments, pastes, jellies, poultices etc.
5. To prepare suppositories.
6. To prepare various cosmetics like cold creams, vanishing cream, hair cream, shampoo, deodorants, nail
polish, eye shadow, mascara, tooth paste, tooth powers, mouth wash, lipsticks, shampoo, face powder,
shaving cream, after shave lotion etc.
7. Other practicals covering the theory.
FIFTH SEMESTER PHR 353. MEDICINAL CHEMISTRY-Il
B. PHARM. III
Theory 3hrs/week
Marks: 100
1. Basic Principles of Medicinal Chemistry : Physico-chemical aspects (Optical, geometric and
bioisosterism) of drug molecules and biological action, Drug-receptor interaction including transduction
mechanisms.
2. Amino acids, peptide, nucleotides and related drugs.
i) Thyroid and Anti thyroid drugs
ii) Insulin and oral hypoglycaemic agents.
iii) Peptidomimetics and nucleotidomimetics.
iv) Diagnostic agents.
v) Pharmaceutical Aids.
3. Synthetic procedures of selected drugs, mode of action, uses, structure activity relationship including
physicochemical properties of the following classes of drugs
A. Drugs acting at Synaptic and neuro-effector junction sites
i. Cholinergics and Anticholinesterases
ii. Adrenergic drugs
iii. Antispasmodic and anti ulcer drugs
iv. Neuromuscular blocking agents.
B. Autocoids
i. Antihistamines ii. Eicosanoids
ii. Analgesic-antipyretics, anti-inflammatory (non-steroidal) agents
C. Drugs affecting uterine motility
Oxytocics (including oxytocin, ergot alkaloids and prostaglandins)
Biochemical approaches in drug designing wherever applicable should be discussed.
Practicals 3 hrs / week
Marks: 50
1. Workshop on stereomodel use of some selected drugs.
2. Synthesis of selected drugs from the course content.
3. Spectral analysis of the drugs synthesized.
4. Establishing the pharmacopoeial standards of the drugs synthesized.
5. Determination of partition, coefficient, dissociation constant and molar refractivity of compounds for
OSAR analysis.
FIFTH SEMESTER PHR 354. PHARMACEUTICAL MICROBIOLOGY
B. PHARM. III
Theory 4 hrs I week
Marks: 100
I. Introduction to the scope of microbiology.
2. Bacterial cell cytology.
3. Classification of microbes and their taxonomy; bacteria, fungi.
4. Identification of Microbes: stains and types of staining techniques, electron microscopy.
5. Nutrition, cultivation, isolation and enumeration of bacteria, fungi, viruses, etc.
6. Microbial genetics and variation.
7. Control of microbes by physical and chemical methods.
a) Disinfection, factors influencing disinfectantion, dynamics of disinfection, disinfectants and antiseptics
and their evaluation.
b) Sterilization, different methods, validation of stserilization methods & equipments.
8. Sterility testing of all pharmaceutical products.
9. Immunity, primary and secondary, defensive mechanisms of body, microbial resistance, interferon.
10. Microbial assays of Antibiotics, Vitamins and amino acids.
Practicals 4 hrs / week
Marks: 50
Experiments devised to prepare various types of culture media, subculturing of common aerobic and
anaerobic bacteria, fungus and yeast, various staining methods, various methods of isolation and
identification of microbes, sterilization techniques and their validation evaluation of antiseptics and
disinfectants, testing the sterility of pharmaceutical products as per l.P. requirements, microbial assay of
antibiotics and vitamins total microbial counts in raw materials and pharmaceutical preparations.
FIFTH SEMESTER PHR 355. PHARMACOLOGY-II
B.PHARM.III (Pharmacological Studies of Chemical Mediators)
Theory 4 hrs/week
Marks: 100
I Chemical Mediators and Autonomic Nervous System:
I. Introduction
2. Some general principles of chemical transmission
3. Mechanism of transmitter release
4. Basic steps in neurochemical transmission-site of drug action
II. Cholinergic Transmission:
5. Muscarnic and nicotinic actions of cholinergic agonists.
6 Effects of drugs on cholinergic transmission (anti- cholinesterases).
7. Drugs affecting muscarnic receptors ( anti musarnic agents)
8. Drugs affecting autonomic ganglion.
9. Neuromuscular -blocking drugs.
III. Noradrenergic Transmission:
10. Classification of adrenoceptors.
11. Drugs acting on adrenoceptors.
12. Drugs affecting adrenoceptors ( a and b blockers)
13. Drugs that affect adrenergic neurones.
IV. Other Peripheral Mediators:
14. 5-hydroxytryptarnine & the treatment of migraine
15. purines.
V. Peptides and Proteins as Mediators:
16. General principals of peptide pharmacology
17. Biosynthesis and regulation of peptides
18. Peptide antagonists.
19. Protein and peptide as drugs.
VI. Nitric Oxide:
20. Biosynthesis of nitric oxide and control.
21. Effect of nitric oxide.
22. Therapeutic use of nitric oxide and nitric oxide donors.
23. Clinical condition in which nitric oxide may play a part.
VII. Local Hormones, Inflammation and allergy:
24. The acute inflammatory reaction and immune response.
25. Outcome of inflammatory response.
26. Mediators of inflammation and allergy (Prostaglandins, histamine etc.)
27. Non-steroidal and inflammatory drugs.
28. Antirheumatoid drugs.
29. Drugs used in gout.
30. Antagonists of histamine.
31. Immnosuppresant drugs & immunomodulators.
SIXTH SEMESTER PHR 361. PHARMACEUTICAL ANALYSIS - II
B. PHARM. III
Theory 4 hrs / week
Marks: 100
Theoretical considerations, and application in drug analysis and quality control of the following analytical
techniques
1. Non-aqueous titrations
4hrs
2. Complexometric titrations
4 hrs
3. Chromatography –Theoretical aspects and simple chromatographic techniques
Column, paper, TLC and HPTLC .
6 hrs
Theory instrumentation and applications of the following techniques :
4. Potentiometry
5 hrs
5. Conductometry
4 hrs
6. Coulometery
3 hrs
7. Polarography and amperometery
6 hrs
8. R.I.A
4 hrs
9. X-ray Diffraction
4 hrs
Practicals 3 hrs / week
Marks 50
I. Non aqueous Titrations : preparation and standardization of perchioric acid and sodium/potassium/lithium
methoxides solutions; Estimations of some pharmacopoeial products.
2. Complexometric Titrations : Preparations and standardization of EDTA solution, some exercises related
to pharmacopoeial assays by complexometric titrations.
3. Miscellaneous Determinations Exercises involving diazotisation, Kjeldahl, Karl-Fischer, Oxygen flask
combustion and gasometry methods. Determination of alcohol content in liquid galenicals, procedure (BPC)
shall be covered.
4. Experiments involving separation of drugs from excipients.
5. Chromatographic analysis of some pharmaceutical products.
6. Exercises based of acid base titration in aquqeous and non-aqueous media, oxidation-reduction titrations
using potentiometric technique, Determination of acid-base disassociation constants and plotting of titration
curves using pH meter.
7. Exercises involving Polarimetery.
8. Exercises involving conductometric and polarographic techniques.
SIXTH SEMESTER PHR 362. PHARMACOGNOSY- II
B. PHARM. III
Theory 4 hrs/week
Marks: 100
1. General techniques of biosynthetic studies including radio-tracer techniques. Basic
metabolic pathways. Description of schemes of biosynthesis of secondary metabolites of pharmaceutical
importance.
6 hrs.
2. Phytochemical screening: different extraction methods.Screening the extracts for presence of alkaloids,
saponins, cardenolides and bufadienolides, flavonoids , leucoanthocyanidins, tannins , polyphenols,
anthraquinones, cynogenetic glycosides, and amino acids etc. 4 hrs.
3. Nature, distribution, classification, general methods of isolation and properties of
Alkaloids & Glycosides.
4 hrs.
4. Chemistry, including biogenesis,isolation and pharmacological activity of atropine,
reserpine, ephedrine, ergometrine, quinine,morphine, digitoxin, sennosides, diosgenin,
carotenoides, flavanoides and related compounds.
12 hrs.
5. Systematic pharmacognostic study of drugs like: Tobacco, Belladonna, Hyoscyamus,
Datura, Coca, Withania, Cinchona, Ipecac, Opium, Ergot, Rauwolfia, Vinca, Nuxvomica,
Physostigma, Pilocarpus, Veretrum, Kurchi, Epedra, Solanum, Tea, Colchicum ,Digitalis, Rhubarb,
SolanumSpp., Cascara, Scilla, Liquorice,Senna, Aloes, Wild cherry, Bitter Almond.
12 hrs.
6. Natural allergens and photosensitizing agents and fungal toxins.
Herbs as hearth foods.
2hrs.
Practical
3 hrs/week
Marks: 50
1. General chemical tests for alkaloids, glycosides, steroids, flavonoids and tannins.
2. Evaluation of crude drugs listed in theory including Study of powdered drugs.
3. Isolation of few alkaloid and glycosides.
SIXTH SEMESTER
B.PHARM.III
PHR 363 PHARMACEUTICS-V
(Biopharmaceutics & Pharmacokinetics)
Theory . 4 hrs/week
Marks: 100
1. Introduction to Biopharmaceutics and Pharmacokinetics, various terms used and their role in related
discipline.
2. Bio-pharmaceutics.
Definition, physico-chemical factors altering biological performance of drugs with special emphasis on pH,
partition hypothesis, dissolution rate. Physiological considerations including membrane, gastro-intestinal
physiology arid environment like presence of food, motility etc. Influence of formulation factors on
absorption of drugs.
3. Bio-availability and bio-equivalence; concept and significance; Methods of determination of bioavailability using blood level and urinary excretion data. Parameters and protocols used to evaluate bioequivalence.
3. Pharmaco-kinetlcs
(i) Absorption, distribution, metabolism and excreation of drugs, protein binding, Pharmacokinetic
parameters, determinations and their significance.
(U) Compartment kinetics: One and two compartment models, pharmacokinetics of single dose
administration as applied to intravenous bolus and oral administration. Pharmacokinetic basis for sustained
release formulations. Micheelis-Menten elimination kinetics.
(Ni) Two compartmental model: elimination kinetics, pharmacokinetics of single, multiple and sustained
release formulations Wagner-Nelson methods of estimation. Curve fitting, method of residuals as applied to
plasma concentration profile for two compartment model. Area under the curve estimations.
(iv) Brief Introduction to non -linear pharmacokinetics: Concepts and applications.
(v) Kinetics of multiple dosing and dosage regimen.
(vi) Urinary excretion, computation of pharmacokirietic parameters from urine data. Dosage regimen
adjustment in pateints with and without renal failure.
Practlcals 3 hrs/week
Marks; 50
1. Experiments designed to determine bioavailability, bioequivalence of selected drug(s) by urinary salivary
excretion or blood level data.
2. Experiments designed to determine pharmacokinetic parameters of selected drug(s) from blood
level/urinary excretion data.
3. Mathematical modeling, curve fitting, area under the curve determination etc.
SIXTH SEMESTER PHR 364. PHARMACEUTICAL BIOTECHNOLOGY
B. PHARM. III (Biological Pharmacy and Fermentation)
Theory 4 hrs/week
Marks: 100
1. Immunology & Immunological preparations:
Immune systems, cellular, humoral immunity, antigens, antibody, antigen-antibody reactions and their
applications:
hypersensitivity, active and passive immunization, vaccines - their preparation, standardization and storage.
Hybridoma technology; monoclonal antibody production & its applications.
2. Genetic Reconibinatlon
Transformation, transduction, conjugation, protoplast fusion, Gene cloning and its applications.
3. Fermentation
Types, design of fermenter, nutrients, sterilization of media and equipments, Production and recovery of
Penicillin, citric acid, vitamins and enzymes etc.
4. Microbial Transformation : Introduction, types of reactions mediated by microorganisms, design of
biotransformation processes, selection of organisms, biotransformation process and its improvements with
special reference to steroids.
5. Enzymes:
Study of enzymes; hyaluronidase, penicillinase, streptokinase, streptodornase, amylases, proteases etc.
Immobilization of enzymes, bacteria and plant cells.
SIXTH SEMESTER PHR 365 PHARMACOLOGY-III
B.PHARM.III (Clinical & Pharmacological Study of Major Organ Systems)
Theory 4 hrs/week
Marks : 100
I. The Heart
1.Pathophysiology of C.C.F.
2. Drugs used in C.C.F.
3. Pftthophysiology of cardiac arrhythmia.
4. Anti arrhythrnic drugs.
II. The Vascular System:
5. Pathophysiology of hypertension.
6. Anti- hypertensive drugs.
7. Pathophysiology of isehemic heart disease.
8. Drugs used in the treatment of angina and myocardial infaction.
9. Pathophysiolo9y of atherosclerosis.
10. Lipoprotein transport in the blood & lipid lowering drugs.
III. The Haemopoietic system:
11. Disorders of blood coagulation.
12. Drugs that act on coagulation cascade
13. Anti-platelet nd ttwombolytic agents.
14. lron,folic acid and vitamin B-12
15. Haemopoietic growth factors.
IV. The Respiratory system:
16. Disorders of respiratory function.
17. Drugs used in bronchial asthma and other respiratory disorders.
V. The kidney 18. Diuretics and their clinical application.
VI. The Gastrointestinal system:
19. Pathophysiology of peptic ulcer.
20. Drugs used in the treatment of acid-peptic disorders.
21. Drugs used in vomiting.
22. Drugs affecting the gastrointestinal motility & billiary system.
23. Drugs for the chronic inflammatory bowel disease.
VII. The Central Nervous system:
24. Neurotransmitters of central nervous system.
25. Neurodegenarative disorders and their treatment
26. General and local anaesthetic drugs.——
27. Pharmacotherapy of anxiety and Insomnia.
28. Pathophysiology and management of schizophrenia.
29. The nature of affective disorders and antidepressant drugs.
30.Different forms of epileptic disorders and the management of epilepsy.
31. 4pioIds and other analgesics.
32 Respiratory stimulants, psychomotor stimulants and psychomimetic drugs.
33. Alcohol, Drug dependence and drug abuse.
Practicals : 3 hrs/week
Marks 50
1. Introduction to experimental pharmacology.
2. Study of concentration response curve of acetyladine on Frog rectus abdoniinis muscle preparation.
3. Modification of responses to acotnjcraline on Frog Rectus by atropine, neostigmine and pancuronium.
4. Modification of responses to acetyladine Histamine and Bad2 by atropine and antihistaminic on smooth
muscle preparation.
5. Estimation of concentration of acetyladine Histamine and Adrenaline using suitable biological
preparation from Frog, Rat, Guinea pig and Rabbit by log dose or matching method.
6. Study of competitive and non- competitive antagonism.
7. calculation of EC 50 and PA2 values and its significance.
8. Study of Mydriatics and miotics on Rabbit eye.
9. Study of lnotropic and chronotropic effects of drugs on perfused Frog heart and its modification by
Atropine and propranolol.
SEVENTH SEMESTER PHR 471 PHARMACEUTICS VI
B. PIIARM (Pharmaceutical Technology-Il)
Theory 4 hrs/week
100 Marks
1. Capsules:
Formulation, production and evaluation and packing of hard and soft capsules including quality control,
stability testing and storage.
2. Tablets:
(a) Formulation of different types of tablets, Granulation, technology of production of granules on large
scale by various techniques. Physics of tablets making, tablet compression machinery of different types of
tablets.
(b) Coating of Tablets: Types of coating , film formers, formulation of coating solution, coating
equipments, coating process , evaluation of coated tablets.
(C) Packaging of tablets: Raw materials in packing tablets, specifications and evaluation. Strip
packing and blister packing of solid formulations
3. Parenterals ( Sterile products):
a) Preformulation factors, routes of administration.
b) Vehicles: Water for injection, pyrogenicity, non aqueous vehicles.
c) Formulation details
d) Containers, closures, their selection, specification and testing.
e) Prefilling treatment, washing of containers and closures
e) Preparation and filling of solutions, suspensions, ampoules, vials, infusion fluids, sterile and lyophilised
powders, equipment for large scale manufacture.
f) Evaluation of sterile products
g) Aseptic techniques,- sources of contamination, methods of prevention, design of aseptic area, laminar
flow bench services and maintenance.
4. Opthalmic preparations:
Requirement, formulation, Methods of preparation, packing and evaluation.
5. Sustained and Controlled Release Products:
(a) Design, development and evaluation of oral and injectable sustained release products
(b) Microencapsulation- Importance, techniques, application.
Practicals 6 hrs/week
Marks: 100
Preparation and evaluation of various types of:
(i) Capsules
(H) Tablets, conventional, sugar coated, film coated, dispersible etc.
(iii) Parenterals - Small volume injectables, Large volume parenterals, Aqueous and oily based injections.
(iv) Ophthalmic products - eye drops, eye ointments.
(v) Sustained and controlled release formulations of various types.
(vi) Microcapsules by various techniques.
(vii) Novel drug delivery systems like implants, inserts etc.
SEVENTH SEMESTER PHR 472. PHARMACOLOGY-lV
B.PHARM.IV (Clinical & Pharmacological Study of Hormones, Neoplastic &
Infectious Disease)
Theory 4 hrs/week
Marks: 100
I. Hormones:
1. Hormones of hypothalamus
2. Pharmacology of anterior and posterior pituitary hormones.
3. Papthophysiology of diabetes mellitus.
4. Insulin and oral hypoglycemic agents.
5. Adrenocorticosteroids and synthetic analogs.
6. Female sex hormones and oral contraceptives.
8.. Androgens and anabohc steroids
9. Oxytocics and uterine relaxants.
10. Thyroid and anti-thyroid drugs.
11. Caicitonin, parathyroid hormone and the treatment of osteoporosis.
II Chemotherapy of Malignant Disease:
12. Basic principal of chemotherapy
13. The biology of cancer.
14. Drugs used in cancer chemotherapy
15. Resistance to anti-cancer drugs.
16. Possible future strategies for cancer chemotherapy.
III. Chemotherapy of Infectious disease:
17. Antimicrobial agents which interfere with the synthesis of folate.
13. Beta-lactam antibiotics.
19. Antimicrobial affecting bacterial protein synthesis
20. Antimicrobial affecting topoisomerase V.
21. Miscellaneous antibacterial agents.
22. chemotherapy of tuberculosis and leprosy.
23. Antiviral drugs.
24. Treatment of AIDS
25. Antifungal drugs.
26. Antiprotozol drugs.
27. Anthelminthic drugs.
IV. Vitamins & Minerals:
28. Vitamin deficiency diseases and their management.
29. Role of minerals in health &diseases.
Practicals 4 hrs/week
Marks : 50
1. Estimation of the concentration of Oxytocin, 5HT and Histmine using suitable biological preparation by log dose or
three point assay method.
2. Estimation of concentration of pancuronium using Frog rectus abdominis preparation by percentage inhibition
method.
3. Demonstration of the effect of various drugs on cad blood pressure and its modification by antagonists.
4. Study of mucarinic and micotinic acations of acetylcholine on cat blood pressure.
5. Study of anticonvuslant effect of phenytoin against maximal elctroshock induced convulsions in mice.
6. Study of anti-inflammatory effect of NSAIDs against hind paw edema in rat.
7. Study of antipsychotic effect of phenothiazine in rats using Cook’s pole climbing apparatus.
8. Study of analgesic effect In mice using tail flick or acetic acid induced writhing.
9. Study of drug affecting locomotor activity using actophotometer.
10. Basic consideration and procedure involved in pyrogen testing.
SEVENTH SEMESTER
PHR 473. PHARMACOGNOSY - III
B. PHARM. IV
Theory 4 hrs/week
Marks: 100
1 Brief account of plant based Industry and Institutions involved in work on medicinal and aromatic plants in India.
2 hrs
2. Phyto Pharmaceuticals : Detailed method of isolation/ estimation of following in plant extracts and formulations:
Atroptine ,Quinine, Ephedrine, digoxin, Ca-Sennosides, Diosgënin, Glycerrhizin, Citrus Bioflavanoids, Rutin
Andrographolides, Phyllanthin Guggul Lipids, Gimnemic acid, Asiaticosidè Withanoloides, Wedelolactone.
8 hrs.
3.Basic principles of Therapy in alternative systems of medicine like Ayurveda, Siddha, Unani, Chinese and
Homeopathy.
4 hrs.
4. Herbal Formulations: Basic principles involved in the preparation of formulation in Ayurveda like Aristas, Asava,
Ghutika, Churna Avalehas Bhasmas, etc. and their evaluation.Determination of alcohol content in Aristas and asavas
4 hrs.
5.Herbal Cosmetics : Study of role of herbs like : Soapnut,: Amla, Henna, Hybiscus, Tea,: Amla, Henna, Aloe-vera,
Glycyrrhiza, Turmeric, Sandalwood.etc.
2 hrs.
6. Standardisation of Herbals : GMP IN Ayurveda.and salient features of Schedule T of Drugs and Cosmetics act of
India. Details of WHO guidelines for the assessment of Herbal products including study of newer analytical
techniques including (HPLC, HPTLC). Study of methods used to detect and estimate the amount of heavy metals in
Herbal Preparations (Mg, Cu, Zn, As etc.). Patenting of Natural Products.
8 hrs.
7. Plant Biotechnology:Plant genetics (Polyploidy, Mutation & Hybridization).Tissue Culture: (a) Callus &
Suspension cultures,(b) Production of Secondary metabolites.
(c) Biotransformation, imrnobilisation of cells and enzymes. Gene transfer in plants using vectors and physical
delivery methods. Applications of plant biotechnology.
4 hrs.
8. Plant bitters and sweeteners. Novel medicinal agents from marine sources.
2 hrs.
9. Enzyme Biotechnology (a) Introduction, General methods of Isolation and purification of enzymes, enzyme
reactors. (b) Source, method of preparation, chemical nature and uses of Papaine, Bromelaine.
4 hrs.
Practicals
3 hrs/week
Marks50
Isolation of some Phyto constituents mentioned in theory and their estimation in natural sources using
chromatographic or other recommended methods.
Determination of heavy metals in crude drugs. Some experiments on plant tissue culture.
Evaluation of herbal drug preparation using Thin layer and paper chromatography.
SEVENTH SEMESTER PHR 474. MEDICINAL CHEMISTRY III
B. PHARM. IV
Theory 4 hrs/week
Marks : 100
Synthetic procedures of selected drugs, mode of action, uses, structure activity relationship including PhysicoChemical properties of the following classes of drugs:
1. Steroids and related drugs : Steroidal nomenclature and stereochemistry, androgens and anabolic agents, estrogens,
and progestational agents, adrenocorticoids.
2. Drugs acting on the Central Nervous System: General Anesthetics, Local Anesthetics, Hypnotics and Sedatives,
Opioicl analgesics, antitussives, anticonvulsants, Antiparkinsonisrn drugs, CNS stimulants, Psychopharmacological
agents (neuroleptics, antidepressants, anxiolytics).
3. Diuretics, Cardiovascular drugs (Antihypertensiv , antiarrythmic, antihyperlipidemic agents , Cardiotonics and
antianginal agents), Anticoagulant and anti platelet drugs.
Biochemical approaches in drug designing wherever applicable should be discussed.
SEVENTH SEMESTER PHR475 PHARMACEUTICAL JURISPRUDENCE
B.PHARM.III :
THEORY: 4 hrs/week
Marks: 100
1. Introduction:
a) Evolution of drugs, Pharmacy, Pharmaceutical Industry
b) Drug legislation in India
c) Overview of Pharmaceutical Education.
2. Elaborate study of
a) Pharmaceutical ethics
b) Pharmacy Act 1948.
c) Drugs and Cosmetics Act 1940 and Rules 1945.
d) Medicinal and Toilet preparations (Excise Duties) Act 1955.
e) Essential Commodities Act and price Control order.
f) Narcotic and psychotropic substances Act 1985 and Rules.
3. Brief study of:
a) Dangerous Drugs Acts and Rules.
b) Drugs and Magic Remedies ( Objectionable Advertisement) Act 1954.
c) Poisons Act 1919 and Rules.
d) State shops and Establishment Act and Rules.
a) Patents Act 1968. As amended bill 1998 rules.
f) Factories Act 1948.
g) Air Act,1988
h) Medical Termination of Pregnancy Act 1970 and Rules 1975.
I) Prevention of Cruelty to Animals Act 1960.
j) Water Act 1968.
k) Solid waste management act
4. A brief study of various Prescription/Non-prescription products, Medical/ Surgical Accessories,
Diagnostic aids. appliances available in market.
EIGHTH SEMESTER PHR 481. PHARMACEUTICAL ANALYSIS III
B. PHARM. IV
Theory 4 hrs./week
Marks :100
A. Quality Assurance:
( A+ B) 20 hrs
1. GLP, ISO 9000, TOM, Quality Review and Quality Documentation.
2. Regulatory control, regulatory drug analysis, interpretation of analytical data.
3. Validation, quality audit: Quality of equipment, validation of equipment, validation of
analytical procedures.
B. Theoretical aspects, basic instrumentations and applications of the following chromatographic
techniques should be discussed - HPLC and GC
C. Theoretical aspects, basic instrumentations, elements of spectra and applications of the following
analytical techniques should be discussed
( C) 20 hrs
c.1. UV Visible
c.2 Infra Red Spectroscopy
c.1 Fluorimetery
c 2 Flame Photometry and Atomic Absorption Spectroscopy
c.3 Emission Spectroscopy
c.4 Nuclear Magnetic resonance spectroscopy including 13c NMR.
c 5. Mass Spectrometry
Practicals 6 hrs./week
Marks: 100
1. Quantitative estimation of at least ten formulations containing single drug or more than one drug, using
instrumental techniques.
2. Estimation of Na+, K+, Ca++ ions using flame photometry
3. IR of samples with different functional groups (-COOH, -COOR, -CQNHR -NH2, NHR, -OH, etc.)
4. Workshop to interpret the structure of simple organic compounds using UV, IR, NMR and MS.
EIGHTH SEMESTER PHR 482. MEDICINAL CHEMISTRY - IV
B. PHARM. IV
Theory 4 hrs./week
Marks: 100
1. Drug metabolism and Concepts of Prodrugs.
2. Synthetic procedures of selected drugs, mode of action, uses, structure activity relationship (including
physicochemical aspects) of the following classes of drugs. (Biochemical approaches in drug designing
wherever applicable should be discussed).
i) Antimetabolites (including sulfonamides).
ii) Chemotherapeutic agents used in Protozoal, Parasitic and other infections.
iii) Antineoplastic agents
iv) Anti-viral including anti-HIV agents.
v) Immunosuppressives and immunostimulants.
3. Principles of Drug Design (Theoretical Aspects) Traditional analog (QSAR) and mechanism based
approaches (Introduction to graph theory), applications of quantum mechanics, Computer aided drug
designing (CADD) and molecular modeling.
Practicals 6 hrs./week
Marks : 100
1. Exercises based on QSAR: Hansch & Free-Wilson methods.
2. Synthesis of selected drugs from the course content involving two or more steps and their spectral
analysis.
3. Establishing the Pharmacaopoelal standards of the drugs synthesized.
EIGHTH SEMETER PHR 483. PHARMACEUTICS-VIl
B.PHARM. IV (Formulation Design & Development)
Theory 4 hrs./week
Marks 100
1. Pre-formulation studies; Detailed study of the following pre-formulation parameters;
(a) Physical properties of drugs like physical form, particle size, shape, density, wetting solutiblity, dielectric
constant, dissolution and organoleptic properties.
(b) Chemical properties of drugs-hydrolysis, oxidation, reduction, racemization, polymerization etc. and their
influence on the stability.
(c) Study of prodrugs, complexex and conjugates of drugs in solving problems related to stability, bioavailability andelegance of the products.
2. Design, development and process validation for pharmaceutical operations involved in the production of
solid and liquid dosage forms.
3. Stability testing protocols and procedure as per ICH guidelines
4. Performance evaluation methods for pharmaceutici products:
(a) In-Vivo dissolution studies- Methods and interpretation of results.
(b) Bio-availability studies-protocols and procedures. Result Interpretations.
(c) In-Vivo studies-methods and statistical methods in the interpretation of results.
5. Introduction to Novel and controlled Drug Delivery Systems: (a) Implants and Inserts for
Opthalrnic, Intravaginal, Intrauterine, Subcutaneous administration.(b) liposomes, niosomes,
erythrosomes (c) micro-emulsions and multiple emulsion.
Practicals 3 hrs./week
Marks ; 50
Experiments devised to study the preformulation of dosage forms, stability testing, formulation of dosage
forms, avaluation of dosage forms, evaluation of dosage form necessities in the stable formualtion of dosage
forms, process validation dissolution and bioavaialbility testing, and others to illustrate the topics mentioned
in theory. Preparation and evaluation of selected NDDS products.
EIGHT SEMESTER PHR 484 NANO TECHNOLOGY AND NANO BIOTECHNOLOGY
B.PHARM IV
Theory 4 hrs/ week
Marks: 100
1. Introduction , definition and scope classification
2. Applications of Nanotechnology in Drug Discovery
2.1 A Historical Overview of the Drug Discovery Process
2.2 An Introduction to Nanotechnology in Drug Discovery and Development
2.3 Fundamentals of Nano-enabled Drug Discovery Tools : Atomic Force
Microscopy ,(AFM) and the Congruent Force Intermolecular Test, Field-Ion
Microscope , Near -field Scanning Optical Microscope (SNOM or NSOM) ,
Surface Plasmon Resonance , Nano-Mass Spectroscopy , Dip-Pen
Nanolithography (DPN)
2.4 Microarrays and Nanoarrays
2.5 Microfluidics and Nanofluidics
2.6 Nanoparticles for Drug Discovery :Quantum Dots (QDots) and Gold
Nanoparticles for High-Content and Initial Drug Screening , Nanoshells for
Raman Spectroscopy , Nanobarcode Particles
2.7 Nanomaterial Drugs : Abraxane , RenaZorb , Antimicrobial Emulsions ,
Antioxidant and Anti-HIV Fullerenes
2.8 Future Developments
3. Nano Technology in Drug Delivery
3.1 Nano Particles :- Definitions, classifications,
3.2 Polymeric nanoparticle:- Types, synthesis, purification, characterization,
property, bio degradation.
3.3 Lipid nanoparticles : Types, preparation, purification, characterization,
properties, bio degradation
3.4. Hydrogel Nanoparticles:- Synthesis & properties
3.5 Peptide nano particle:
3.6 Toxicity and toxicity evaluation of nanoparticles .
PHARMACY DEPARTMENT
FACULTY OF TECHNOLOGY & ENGINEERING
THE MAHARAJA SAYAJIRAO UNIVERSITY OF BARODA
Scheme of Teaching and Examination of B.Pharm
4 year Degree course as per AICTE Guidelines
Subject Code
Subject
Teaching
T
P
Pap
er
Dura
tion
P&T
M
3
3
3
3
1
1
1
3
3
3
100
100
100
-
3
-
Examination
TW/ Total
Pr
Mark
Viva
s
FIRST SEMESTER B.Pharm
ACH111
ACH112
AM 113
PHR114
ME 115
Physical Chemistry
Organic Chemistry-I
Remedial Mathematics/
Remedial Biology
Engg Drawing
Total
4
4
4
12
9
50
50
50
50
150
150
100
50
50
300
150/
200
450/
500
100
100
100
100
100
50
50
50
50
-
150
150
150
150
100
500
200
700
SECOND SEMESTER B.Pharm
PHR121
ACH122
PHR123
PHR124
AM 125
Pharm.Chem – I ( Inorg)
Organic Chemistry –II
Pharmaceutics-I
Human Anat & Physiology
Mathematics
Total
4
4
4
4
4
3
3
3
3
-
20
12
1
1
1
1
1
3
3
3
3
3
PHARMACY DEPARTMENT
FACULTY OF TECHNOLOGY & ENGINEERING
THE MAHARAJA SAYAJIRAO UNIVERSITY OF BARODA
Scheme of Teaching and Examination of B.Pharm
4 year Degree course as per AICTE Guidelines
Subject
Teaching
Subject Code
T
P
Pap
Dura- P& TW/ Total
tionTM
Pr
Mark
Viva s
er
FIRST SEMESTER B.Pharm
ACH111
Physical Chemistry
ACH112
Organic Chemistry-I
AM 113
Remedial Mathematics/
OR
PHR114
Remedial Biology
ME 115
Engg Drawing
Total
Examination
CreditsCredits
4
4
4
3
3
-
1
1
1
3
3
3
100
100
100
50
50
-
150
150
100
8
8
4
4
3
3
1
-
3
3
100
-
50
50
50
2
2
12
9/
12
300
200/
150
450/
400
22/24
4
4
4
4
4
20
3
3
3
3
12
1
1
1
1
1
3
3
3
3
3
100
100
100
100
100
500
50
50
50
50
200
150
150
150
150
100
700
8
8
8
8
4
36
THIRD SEMESTER B.Pharm
PHR231
Médicinal Chemistry -I
PHR232
Pharm.Analysis-I
PHR233
Pharmacology -I
AM234
Intro.Computer Application
ChE235
Pharm.Engg-I
4
4
4
4
4
3
3
3
-
1
1
1
1
1
3
3
3
3
3
100
100
100
100
100
50
50
50
-
150
150
100
150
100
8
8
4
8
4
Total
20
9
500
150
650
32
4
4
4
4
4
3
3
3
3
-
100
100
100
100
100
50
50
50
50
-
150
150
150
150
100
8
8
8
8
4
20
12
500
200
700
36
SECOND SEMESTER B.Pharm
PHR121
Pharm.Chem – I ( Inorg)
ACH122
Organic Chemistry –II
PHR123
Pharmaceutics-I
PHR124
Human Anat & Physiology
AM 125
Mathematics
Total
FOURTH SEMESTER B.Pharm
PHR 241
Pharmacognosy -I
PHR242
Pharm.Biochemistry
PHR243
Pharmaceutics II
Ch E 244
Pharm.Engg-II
CF 245
Industrial Management
Total
1
1
1
1
1
3
3
3
3
3
FIFTH SEMESTER B.Pharm
PHR351
Pharmaceutics-III(Hospi.Ph)
PHR352
Pharmaceutics-IV
PHR353
Medicinal Chemistry-II
PHR354
Pharm.Microbiology
PHR355
Pharmacology-II
Total
4
4
4
4
4
6
3
4
-
20
13
SIXTH SEMESTER B.Pharm
PHR361
Pharm.Analysis-II
PHR362
Pharmacognosy-II
PHR363
Pharmaceutics-V
PHR364
Pharm.Biotechnology
PHR365
Pharmacology-III
Total
4
4
4
4
4
3
3
3
3
20
12
4
4
4
4
4
16
6
3
3
12
1
1
1
1
1
4
4
4
4
6
6
3
-
16
15
`
SEVENTH SEMESTER B.Pharm
PHR471
Pharmaceutics-VI
PHR472
Pharmacology-IV
PHR473
Pharmacognosy-III
PHR474
Medicinal Chemistry-III
PHR475
Pharm.Jurisprudence
Total
1
1
1
1
1
100
100
100
100
100
100
50
50
-
100
200
150
150
100
4
12
8
8
4
500
200
700
36
100
100
100
100
100
50
50
50
50
150
150
150
100
150
8
8
8
4
8
500
200
700
36
3
3
3
3
3
100
100
100
100
100
500
100
50
50
200
200
150
150
100
100
700
12
8
8
4
4
36
1
1
1
1
3
3
3
3
100
100
100
100
100
100
50
-
200
200
150
100
12
12
8
4
-
-
400
50
300
50
700
2
38
1
1
1
1
1
3
3
3
3
3
3
3
3
3
3
Total
EIGHTH SEMESTER B.Pharm
PHR481
Pharm.Analysis-III
PHR482
Medicinal chemistry-IV
PHR483
Pharmaceutics-VII
PHR484
Nanotechnology
& Nanobiotechnology
PHR 485 Comprehensive Evaluation
Total
Subject Code
Subject
Teaching
T
P
Pap
Dura- P& TW/ Total
tionTM
Pr
Mark
Viva s
er
FIRST SEMESTER B.Pharm
ACH111
Physical Chemistry
ACH112
Organic Chemistry-I
AM 113
Remedial Mathematics/
OR
PHR114
Remedial Biology
ME 115
Engg Drawing
Total
Examination
CreditsCredits
4
4
4
3
3
-
1
1
1
3
3
3
100
100
100
50
50
-
150
150
100
10
10
4
4
3
3
1
-
3
3
100
-
50
50
50
6
6
12
9/
12
300
200/
150
450/
400
30/36
4
4
4
4
4
20
3
3
3
3
12
1
1
1
1
1
3
3
3
3
3
100
100
100
100
100
500
50
50
50
50
200
150
150
150
150
100
700
10
10
10
10
4
34
THIRD SEMESTER B.Pharm
PHR231
Médicinal Chemistry -I
PHR232
Pharm.Analysis-I
PHR233
Pharmacology -I
AM234
Intro.Computer Application
ChE235
Pharm.Engg-I
4
4
4
4
4
3
3
3
-
1
1
1
1
1
3
3
3
3
3
100
100
100
100
100
50
50
50
-
150
150
100
150
100
10
10
4
10
4
Total
20
9
500
150
650
38
4
4
4
4
4
3
3
3
3
-
100
100
100
100
100
50
50
50
50
-
150
150
150
150
100
10
10
10
10
4
20
12
500
200
700
34
SECOND SEMESTER B.Pharm
PHR121
Pharm.Chem – I ( Inorg)
ACH122
Organic Chemistry –II
PHR123
Pharmaceutics-I
PHR124
Human Anat & Physiology
AM 125
Mathematics
Total
FOURTH SEMESTER B.Pharm
PHR 241
Pharmacognosy -I
PHR242
Pharm.Biochemistry
PHR243
Pharmaceutics II
Ch E 244
Pharm.Engg-II
CF 245
Industrial Management
Total
1
1
1
1
1
3
3
3
3
3
FIFTH SEMESTER B.Pharm
PHR351
Pharmaceutics-III(Hospi.Ph)
PHR352
Pharmaceutics-IV
PHR353
Medicinal Chemistry-II
PHR354
Pharm.Microbiology
PHR355
Pharmacology-II
Total
4
4
4
4
4
6
3
4
-
20
13
SIXTH SEMESTER B.Pharm
PHR361
Pharm.Analysis-II
PHR362
Pharmacognosy-II
PHR363
Pharmaceutics-V
PHR364
Pharm.Biotechnology
PHR365
Pharmacology-III
Total
4
4
4
4
4
3
3
3
3
20
12
4
4
4
4
4
16
6
3
3
12
1
1
1
1
1
4
4
4
4
6
6
3
-
16
15
SEVENTH SEMESTER B.Pharm
PHR471
Pharmaceutics-VI
PHR472
Pharmacology-IV
PHR473
Pharmacognosy-III
PHR474
Medicinal Chemistry-III
PHR475
Pharm.Jurisprudence
Total
1
1
1
1
1
100
100
100
100
100
100
50
50
-
100
200
150
150
100
4
12
10
10
4
500
200
700
40
100
100
100
100
100
50
50
50
50
150
150
150
100
150
10
10
10
4
10
500
200
700
44
3
3
3
3
3
100
100
100
100
100
500
100
50
50
200
200
150
150
100
100
700
12
10
10
4
4
40
1
1
1
1
3
3
3
3
100
100
100
100
100
100
50
-
200
200
150
100
12
12
10
4
-
-
400
50
300
50
700
6
44
1
1
1
1
1
3
3
3
3
3
3
3
3
3
3
Total
EIGHTH SEMESTER B.Pharm
PHR481
Pharm.Analysis-III
PHR482
Medicinal chemistry-IV
PHR483
Pharmaceutics-VII
PHR484
Nanotechnology
& Nanobiotechnology
PHR 485 Comprehensive Evaluation
Total