Principles of Immunology
Infectious Process
4/13/06
”If we had no winter, the spring would not be so
pleasant: if we did not sometimes taste of adversity,
prosperity would not be so welcome”
Anne Bradstreet
Word/Terms List
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Antigenemia
Antigenic drift
Antigenic shift
Disease
Infection
Intoxication
Normal flora
Toxoid
Infectious Process
 Infectious Disease Triangle
 Microbe/Agent
 Host
 Environmental conditions
Categories of Microbes/Agents
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Viruses
Bacteria
Fungi
Parasites
Prions
Pathogenicity
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Virulence factors
Infectious Dose
Route of infection
Mode of transmission
Microbe stability
Host Defenses
 Innate
 Adaptive
Things to remember
 Host range
 Infectious process as direct or indirect
cause of disease
 Infection vs. disease
Pathogenicity
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Virulence factors
Infectious Dose
Route of infection
Mode of transmission
Microbe stability
Viral diseases
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Obligate intracellular parasites
Enveloped vs. non enveloped
Latency
Host range
Tissue/cell specificity
Antigenic changes
Immunity to Viral diseases
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Interferon
NK cells
Neutralizing Ab
Secretory IgA
C fixation
Cell mediated immunity
Bacterial diseases
 Extracellular vs. intracellular
 Toxins
 Cell associated
 Extracellular
 Enzymes
 Capsules
 Fimbriae/pili
Immunity to Bacterial Diseases
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Antibodies
Opsonization
Phagocytes
Cell-mediated immunity
Fungal diseases
 Opportunism
 Capsules
 Spores
Immunity to Fungal diseases
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Innate
Normal flora
Antibodies
Cell mediated immunity
Parasitic diseases
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Large complex agents
Range of diseases
Environmental factors
Immunity is complex