Unit details [CBA] Biochemistry 2 (Medicine) Enrolment code: CBA200 Offered: Hbt: (fy) ie sem 1 & 2 Special note: restricted to students enrolled in Medicine; taught by Discipline of Biochemistry Unit description: Provides medical students an understanding of: (a) structure and function of important biological macromolecules, such as nucleic acids and proteins; (b) structure, function and metabolism of amino acids, carbohydrates and lipids; (c) the integration and control of metabolism, by hormonal and other means; (d) nutrition – roles of macro- and micro-nutrients in health and disease, dietary guidelines, food composition; (e) basic human genetics; (f) human molecular biology in health and disease; (g) metabolic and genetic basis of disease states. Relevance to human health and disease is highlighted. Staff: Dr DR Woodward (Coordinator), Dr SM Richards, Dr AK West, Dr AF Holloway Unit weight: 20% Teaching pattern: 59 hrs lectures; 13 hrs tutorials Prereq: 1st year Medicine Coreq: CHG210 Assess: 2-hr written paper at end of sem 1 (45%); 2-hr written paper at end of sem 2 (35%); assessments during sem (20%) Required: either Meisenberg G & Simmons WH, Principles of Medical Biochemistry, Mosby, St Louis, 1998, ISBN 0815144105 or Elliott WH & Elliott DC, Biochemistry and Molecular Biology, 2nd edn, OUP, Oxf, 2001, ISBN 0198700458 Recommend: Mann J & Truswell AS, Essentials of Human Nutrition, 2nd edn, OUP, Oxf, 2002, ISBN 0198508611. Courses: [M3J] [M3B] [M4B] Faculty website: <www.healthsci.utas.edu.au> Biochemistry (Pharmacy) Enrolment code: CBA220 ________________________________________ University of Tasmania unit details for 2004 academic year July 11, 2016, 18:55 PM, page –1 Unit details [CBA] Offered: Hbt: (fy) ie sem 1 & 2 Unit description: Gives pharmacy students an understanding of the following core areas of biochemistry and molecular biology: (a) structure and function of important biological macromolecules, such as nucleic acids and proteins; (b) structure, function and metabolism of amino acids, carbohydrates and lipids; (c) the integration and control of metabolism, by hormonal and other means; (d) nutrition – role of macro- and micro-nutrients in health and disease, food composition, dietary guidelines; (e) basic human genetics; (f) human molecular biology in health and disease; (g) metabolic and genetic basis of disease states. Relevance to human health and disease is highlighted. Staff: Dr AF Holloway, Dr SM Richards, Dr AK West, Dr DR Woodward (Coordinator) Unit weight: 12.5% Teaching pattern: 2–3x1-hr lectures weekly; 1-hr tutorial fortnightly Prereq: KRA160, CHG101 Assess: 2-hr written paper at end of sem 1 (45%), 2-hr written paper at end of sem 2 (35%), assessments during sem (20%) Required: either Meisenberg G & Simmons WH, Principles of Medical Biochemistry, Mosby, St Louis, 1998, ISBN 0815144105 or Elliott WH & Elliott DC, Biochemistry and Molecular Biology, 2nd edn, OUP, Oxf, 2001, ISBN 0198700458 Recommend: Berg JM, Tymoczko JL & Stryer L, Biochemistry, 5th edn, Freeman, NY, 2002, ISBN 0716746840 Murray RK, Granner DK, Mayes PA & Rodwell VW, Harper’s Biochemistry, 25th edn, McGraw-Hill, NY, ISBN 0838536905 Courses: [M3F] Faculty website: <www.healthsci.utas.edu.au> Biochemistry (Agriculture) Enrolment code: CBA235 Offered: Hbt: sem 1 Special note: restricted to Agricultural Science students; taught by Discipline of Biochemistry Unit description: Gives agricultural science students an introduction to: (a) structure and function of important biological macromolecules, such as nucleic acids and proteins; (b) structure, ________________________________________ University of Tasmania unit details for 2004 academic year July 11, 2016, 18:55 PM, page –2 Unit details [CBA] function and metabolism of amino acids, carbohydrates and lipids; (c) the integration and control of metabolism, by hormonal and other means; (d) molecular biology; (e) nutrition. Staff: Dr SM Richards, Dr DR Woodward (Coordinator) Unit weight: 12.5% Teaching pattern: 3x1-hr lectures weekly; 1-hr tutorial fortnightly Prereq: KRA120 and KPZ162 and KZA160; students who do not have these prereqs should consult unit coordinator M.excl: may not be included in BAgSc with CBA230 Assess: 3-hr written paper at end of sem 1 (80%); assessments during sem (20%) Required: Elliott WH & Elliott DC, Biochemistry and Molecular Biology, 2nd edn, OUP, Oxf, 2001, ISBN 0198700458 Recommend: Campbell MK & Farrell SO, Biochemistry, 4th edn, Thomson, 2003, ISBN: 0030348498 Gilbert HF, Basic Concepts in Biochemistry, 2nd edn, McGraw-Hill, NY, 2000, 0071356576 Courses: [S3A] Faculty website: <www.healthsci.utas.edu.au> Biochemistry: Metabolism & Nutrition Enrolment code: CBA260 Offered: Hbt: sem 1 Special note: restricted to students enrolled in Science Unit description: Provides students with a broad introduction to metabolic and nutritional aspects of biochemistry. Major topics include structure, function and metabolism of amino acids, carbohydrates and lipids; the integration and control of metabolism, by hormonal and other means; roles of selected nutrients in health and disease. Students whose career aspirations are in the biomedical area are encouraged to include both KZA150 and CHG100, as well as a first-year chemistry unit. Students whose career aspirations are in the life sciences area are strongly encouraged to include both KZA151 and KPA150, as well as a first-year chemistry unit. (Please note that BSc rules do not allow students to include both KZA150 and KPA150) Students who do not have these prerequisites MAY be accepted after consultation with the unit coordinator; for example, a student who has not done a first-year chemistry unit will be considered if they have good marks in TCE Chemistry 12C, and have done one of the prerequisite first-year biology units. Staff: Dr AF Holloway, Dr SM Richards, Dr DR Woodward (Coordinator) ________________________________________ University of Tasmania unit details for 2004 academic year July 11, 2016, 18:55 PM, page –3 Unit details [CBA] Unit weight: 12.5% Teaching pattern: 2–3x1hr lectures, 3hrs lab weekly; 1-hr tutorial fortnightly Prereq: ONE of (KRA110 Chemistry IA, KRA130 Chemistry IB) and ONE of (KZA150 Zoology IG, KPA150 Botany 1 G). See note above. M.excl: this unit may NOT be included in BSc with CBA250 or CBA211 Assess: 3-hr written end-of-sem paper (80%), practicals (10%), tests during sem (10%) Required: either Elliott WH & Elliott DC, Biochemistry and Molecular Biology, 2nd edn, OUP, Oxf, 2001, ISBN 0198700458 or Meisenberg G & Simmons YM, Principles of Medical Biochemistry, Mosby, St Louis, 1998, ISBN: 0815144105 Recommend: Mann J & Truswell AS, Essentials of Human Nutrition, 2nd edn, OUP, Oxf, 2002, ISBN 0198508611 Courses: [S3G] [S3Gc1] [S3Gc2] Faculty website: <www.healthsci.utas.edu.au> Molecular Biology in Health & Disease Enrolment code: CBA265 Offered: Hbt: sem 2 Special note: restricted to students enrolled in Science Unit description: Provides students with a broad introduction to molecular biology. The focus is primarily on humans and other mammals, but most of the matters discussed apply to a much broader range of species. Major topics include protein structure and function; DNA structure, replication and transcription; protein synthesis; molecular biology of cancer; genetics of human disease; DNA technology and its applications. Students whose career aspirations are in the biomedical area are encouraged to include both KZA150 and CHG100, as well as a first-year chemistry unit. Students whose career aspirations are in the life sciences area are strongly encouraged to include both KZA151 and KPA150, as well as a first-year chemistry unit. (Please note that BSc rules do not allow students to include both KZA150 and KPA150) Students who do not have these prerequisites MAY be accepted after consultation with the unit coordinator; for example, a student who has not done a first-year chemistry unit will be considered if they have good marks in TCE Chemistry 12C, and have done one of the prerequisite first-year biology units. Staff: Dr AF Holloway, Dr SM Richards, Dr AK West, Dr DR Woodward (Coordinator) ________________________________________ University of Tasmania unit details for 2004 academic year July 11, 2016, 18:55 PM, page –4 Unit details [CBA] Unit weight: 12.5% Teaching pattern: 2x1-hr lectures, 3 hrs lab weekly; 1-hr tutorial fortnightly Prereq: ONE of (KRA110 Chemistry IA, KRA130 Chemistry IB) and ONE of (KZA150 Zoology IG, KPA150 Botany 1 G). M.excl: This unit may not be included in BSc with CBA250 or CBA211 Assess: 3-hr written end-of-sem paper (90%), practicals, tests during sem (10%) Required: either Elliott WH & Elliott DC, Biochemistry and Molecular Biology, 2nd edn, OUP, Oxf, 2001, ISBN 0198700458 or Meisenberg G & Simmons YM, Principles of Medical Biochemistry, Mosby, St Louis, 1998, ISBN: 0815144105 Recommend: Alberts B, Bray D, Johnson S, et al, Essential Cell Biology: An Introduction to Molecular Biology of the Cell, Garland, NY, 1998, ISBN 0815329717 Courses: [S3G] [S3Gc1] [S3Gc2] Faculty website: <www.healthsci.utas.edu.au> Molecular Biochemistry: Techniques and Theory Enrolment code: CBA327 Offered: Hbt: (fy) ie sem 1 & 2 Unit description: Provides students with (i) an understanding and application of contemporary techniques in protein biochemistry and molecular biology and (ii) an understanding of contemporary developments in the areas of biochemistry relating to hormones, signal transduction and molecular biology, particularly advanced related to genomics, transgenesis, cloning and the Human Genome Project. Lectures cover: techniques in protein biochemistry and molecular biology including isolation of organelles and membrane proteins; predictive and actual structure of membrane proteins; measurement of membrane transport processes; relationship of structure and function of membrane proteins; isolation and purification of proteins and enzymes; proteomics; determination of kinetic constants of enzymes; isolation of nucleic acids (DNA and RNA) from cells; in vitro manipulation of nucleic acids, including PCR, site-directed mutagenesis, sequencing; cDNA libraries; detection of sequences of defined composition and reintroduction of genes into bacterial and eukaryotic cells; transformation, transfection, transgenic animals, microarrays, bioinformatics, mammalian cloning by nuclear transfer; mechanisms of gene regulation; programmed cell death in development and disease; hormonal control systems; signal transduction. Practicals emphasise ‘hands-on’ experience with contemporary biochemical techniques. The unit features a 10-week research project in the second semester. ________________________________________ University of Tasmania unit details for 2004 academic year July 11, 2016, 18:55 PM, page –5 Unit details [CBA] Staff: Prof MG Clark, Dr AF Holloway, Dr SM Richards, Dr AK West Unit weight: 50% Teaching pattern: 3 lectures, 1-hr tutorial, 11 hrs practicals weekly Prereq: CBA260 and CBA265 Assess: 2-hr written exam in June, 3-hr written exam in Nov, with 30% of final mark from practical assignments and projects Required: Alberts B, Johnson A, Lewis J, RaffM, Roberts K & Walter P, Molecular Biology of the Cell, 4th edn. Garland NY, 2002, ISBN 0815340729 Recommend: Rapley R & Walker JM, Molecular Biomethods Handbook, Humana Press, Totowa NJ, ISBN 0896035018 Courses: [S3G] Faculty website: <www.healthsci.utas.edu.au> Biochemistry for Biotechnology Enrolment code: CBA330 Offered: Hbt: sem 1 Unit description: Provides students with an understanding and application of contemporary techniques in protein biochemistry and molecular biology central to biotechnology, eg, genomics, transgenesis, cloning and the Human Genome project. Lectures cover: techniques in protein biochemistry and molecular biology including isolation of organelles and membrane proteins; predictive and actual structure of membrane proteins; measurement of membrane transport processes; relationship of structure and function of membrane proteins; isolation and purification of proteins and enzymes; proteomics; determination of kinetic constants of enzymes; isolation of nucleic acids (DNA and RNA) from cells; in vitro manipulation of nucleic acids, including PCR, site-directed mutagenesis, sequencing; cDNA libraries; detection of sequences of defined composition and reintroduction of genes into bacterial and eukaryotic cells; transformation, transfection; microarrays, bioinformatics. Practicals emphasise ‘hands-on’ experience with contemporary biochemical techniques. Staff: Prof MG Clark, Dr AF Holloway, Dr AK West Unit weight: 25% Teaching pattern: 3 lectures, 1-hr tutorial, 11 hrs practicals weekly Prereq: CBA260 and CBA265 M.excl: CBA327 Assess: 2-hr written exam in June (70%), practicals (30%) ________________________________________ University of Tasmania unit details for 2004 academic year July 11, 2016, 18:55 PM, page –6 Unit details [CBA] Required: Alberts B, Johnson A, Lewis J, Raff M, Roberts K & Walter P, Molecular Biology of the Cell, 4th edn, Garland NY, 2002, ISBN 0815340729 Recommend: Rapley R & Walker JM, Molecular Biomethods Handbook, Humana Press, Totowa NJ, 1998, ISBN 0896035018 Other appropriate material will be indicated during the year. Courses: [S3V] Faculty website: <www.healthsci.utas.edu.au> Advanced Biochemistry for Biotechnology Enrolment code: CBA335 Offered: Hbt: sem 2 Unit description: Provides students with in-depth coverage of selected topics relevant to biotechnology, with a major emphasis on research laboratory experience. This unit is an excellent preparation for students wishing to undertake a biomedically-oriented Honours degree. Lectures cover: transgenic animals; mammalian cloning by nuclear transfer, human gene therapy, stem cell technology; mechanisms of gene regulation; programmed cell death in development and disease; hormonal control systems; signal transduction. The practical component comprises a major research project which may be selected from any of the research themes in the Discipline of Biochemistry. Staff: Dr AF Holloway, Dr SM Richards, Dr AK West Unit weight: 25% Teaching pattern: 3 lectures, 1-hr tutorial, 11 hrs practicals weekly Prereq: CBA260 and CBA265 and CBA330 M.excl: CBA327 Required: Alberts B, Johnson A, Lewis J, Raff M, Roberts K & Walter P, Molecular Biology of the Cell, 4th edn, Garland NY, 2002, ISBN 0815340729 Recommend: Rapley R & Walker JM, Molecular Biomethods Handbook, Humana Press, Totowa NJ, 1998, ISBN 0896035018 Other appropriate material will be indicated during the year. Courses: [S3V] Faculty website: <www.healthsci.utas.edu.au> Biochemistry 4 (BSc Honours) ________________________________________ University of Tasmania unit details for 2004 academic year July 11, 2016, 18:55 PM, page –7 Unit details [CBA] Enrolment code: CBA410 Offered: Hbt: (fy) ie sem 1 & 2 Special note: for Science students only Unit description: Aims: (a) to provide students with the opportunity to plan, execute, interpret and analyse purposeful experiments, appropriate to their research project, and to communicate their results; and to investigate and present on two areas, unrelated to their own research topic, but representing important contemporary biochemical research in order to demonstrate their skills in providing a condensed account of these areas of research and in communicating their essential features in written and oral form; and (b) to provide a year’s training in research, in order to give successful students a competitive edge in seeking employment in biochemical research laboratories. The unit tests abilities which were largely ignored in the earlier years. Students who excel in this Honours year are well organised, plan carefully, are intensely motivated, are innovative thinkers, and express their ideas and findings clearly. Staff: Prof MG Clark, Dr AK West, Dr DR Woodward, Dr AF Holloway, Dr SM Richards (Coordinator) Unit weight: 100% Prereq: BSc including CBA327 or equiv Assess: the year’s performance is assessed from the research topic (thesis, 60%; project seminar, 10%), and 2 assignments (10% for the essay and 10% for the reading topic seminar presentation), supervisor’s assessment (10%). There are no written exams or lectures, but students are expected to attend Discipline of Biochemistry seminars and those of their own research group Courses: [S4E] Faculty website: <www.healthsci.utas.edu.au> ________________________________________ University of Tasmania unit details for 2004 academic year July 11, 2016, 18:55 PM, page –8