CBA Unit Details as at 13th June, 2002 Biochemistry 2 (Medicine) Enrolment code: CBA200 Offered: Hobart: semesters 1 & 2 Special note: restricted to students enrolled in Medicine; taught by Discipline of Biochemistry Gives medical students an understanding of: (a) structure and function of important biological macromolecules, such as nucleic acids and proteins; (b) structure, function and metabolism of amino acids, carbohydrates and lipids; (c) the integration and control of metabolism, by hormonal and other means; (d) nutrition – energy, roles of macro- and micro-nutrients, dietary guidelines; (e) metabolic and genetic basis of disease states. Relevance to human health and disease is highlighted. Staff Dr SM Richards, Dr AK West, Dr DR Woodward (Coordinator) Unit weight 25% Teaching pattern 2–3x1-hr lectures weekly, 1-hr tutorial fortnightly focusing on integrative problems; 3 to 4 hrs of self-directed learning projects fortnightly Prerequisites 1st year Medicine Corequisites CHG210, CJA212, CAM205 Assessment mode 3-hr written paper at end of sem 1; 3-hr written paper and a 10-min viva voce at end of sem 2; self-directed learning projects will also be assessed Required texts etc either Meisenberg G and Simmons WH, Principles of Medical Biochemistry, Mosby, St Louis, 1998, ISBN 0815144105 or Elliott WH and Elliott DC, Biochemistry and Molecular Biology, 2nd edn, OUP, Oxf, 2001, ISBN 0198700458 Recommended texts etc Alberts B, Bray D, Johnson S, et al, Essential Cell Biology: An Introduction to Molecular Biology of the Cell, Garland, NY, 1998, ISBN 0815329717 Brownie AC and Kernohan JC, Biochemistry: A Core Text with Self-Assessment, Churchill Livingstone, Edin, 1999, ISBN 0443056935 Garrow JS, James WPT and Ralph A, Human Nutrition and Dietetics, 10th edn, Churchill Livingstone, Edin, 2000, ISBN 0443056277 Marks DB, Marks AD and Smith CM, Basic Medical Biochemistry: A Clinical Approach, Williams & Wilkins, Baltimore, 1996, ISBN 0683230107 Stryer L, Biochemistry, 4th edn, Freeman, NY, 1995, ISBN 0716720094 Mueller RF, Young ID, Emery’s Elements of Medical Genetics, 11th edn, Churchill Livingstone, Edin, 2000, ISBN 044307125X Nelson DL and Cox MM, Lehninger Principles of Biochemistry, 3rd edn, Worth, NY, 2000, ISBN 1572599316 Courses [M3A] [M3B] [M4B] Faculty website <http://www.healthsci.utas.edu.au/> ________________________________________ University of Tasmania unit details July 11, 2016, 18:39 PM, page –1 CBA Unit Details as at 13th June, 2002 Biochemistry (Pharmacy) Enrolment code: CBA220 Offered: Hobart: semesters 1 & 2 Gives pharmacy students an understanding of the following core areas of biochemistry and molecular biology: (a) structure and function of important biological macromolecules, such as nucleic acids and proteins; (b) structure, function and metabolism of amino acids, carbohydrates and lipids; (c) the integration and control of metabolism, by hormonal and other means; (d) nutrition – energy, macro- and micro-nutrients, dietary guidelines; (e) metabolic and genetic basis of disease states. Relevance to human health and disease is highlighted. Staff Dr SM Richards, Dr AK West, Dr DR Woodward (Coordinator) Unit weight 12.5% Teaching pattern 2–3x1-hr lectures weekly; 1-hr tutorial fortnightly Prerequisites KRA160, CHG101 Assessment mode 3-hr written paper at end of sem 1, 2-hr written paper at end of sem 2 Required texts etc either Meisenberg G and Simmons WH, Principles of Medical Biochemistry, Mosby, St Louis, 1998, ISBN 0815144105 or v Recommended texts etc Alberts B, Bray D, Johnson S, et al, Essential Cell Biology: An Introduction to Molecular Biology of the Cell, Garland, NY, 1998, ISBN 0815329717 Brownie AC and Kernohan JC, Biochemistry: A Core Text with Self-Assessment, Churchill Livingstone, Edin, 1999, ISBN 0443056935 Garrow JS, James WPT and Ralph A, Human Nutrition and Dietetics, 10th edn, Churchill Livingstone, Edin, 2000, ISBN 0443056277 Marks DB, Marks AD and Smith CM, Basic Medical Biochemistry: A Clinical Approach, Williams & Wilkins, Baltimore, 1996, ISBN 0683230107 Stryer L, Biochemistry, 4th edn, Freeman, NY, 1995, ISBN 0716720094 Mueller RF, Young ID, Emery’s Elements of Medical Genetics, 11th edn, Churchill Livingstone, Edin, 2000, ISBN 044307125X Nelson DL and Cox MM, Lehninger Principles of Biochemistry, 3rd edn, Worth, NY, 2000, ISBN 1572599316 Courses [M3F] Faculty website <http://www.healthsci.utas.edu.au/> Biochemistry (Agriculture) Enrolment code: CBA235 Offered: Hobart: semester 1 ________________________________________ University of Tasmania unit details July 11, 2016, 18:39 PM, page –2 CBA Unit Details as at 13th June, 2002 Special note: restricted to Agricultural Science students; taught by Discipline of Biochemistry Gives agricultural science students an introduction to: (a) structure and function of important biological macromolecules, such as nucleic acids and proteins; (b) structure, function and metabolism of amino acids, carbohydrates and lipids; (c) the integration and control of metabolism, by hormonal and other means; (d) molecular biology; (e) nutrition. Staff Dr SM Richards, Dr DR Woodward (Coordinator) Unit weight 12.5% Teaching pattern 3x1-hr lectures weekly; 1-hr tutorial fortnightly Prerequisites KRA120 and KPZ120 Mutual exclusions may not be included in BAgSc with CBA230 Assessment mode 3-hr written paper at end of sem 1 Required texts etc Elliott WH and Elliott DC, Biochemistry and Molecular Biology, 2nd edn, OUP, Oxf, 2001, ISBN 0198700458 Recommended texts etc Alberts B, Bray D, Johnson S, et al, Essential Cell Biology: An Introduction to Molecular Biology of the Cell, Garland, NY, 1998, ISBN 0815329717 Campbell MK, Biochemistry, 3rd edn, Saunders, Philadelphia, 1999, ISBN 0030244269 Hanes BD and Hooper NM, Instant Notes Biochemistry, 2nd edn, Bios, Oxf, 2000, ISBN 1859961428 Stryer L, Biochemistry, 4th edn, Freeman, NY, 1995, ISBN 0716720094 Brownie AC and Kernohan JC, Biochemistry: A Core Text with Self-Assessment, Churchill Livingstone, Edin, 1999, ISBN 0443056935 Nelson DL and Cox MM, Lehninger Principles of Biochemistry, 3rd edn, Worth, NY, 2000, ISBN 1572599316 Courses [S3A] Faculty website <http://www.healthsci.utas.edu.au/> Biochemistry: Metabolism & Nutrition Enrolment code: CBA260 Offered: Hobart: semester 1 Special note: restricted to students enrolled in Science Provides students with a broad introduction to metabolic and nutritional aspects of biochemistry. Major topics include structure, function and metabolism of amino acids, carbohydrates and lipids; the integration and control of metabolism, by hormonal and other means; roles of selected nutrients in health and disease. Students whose career aspirations are in the biomedical area are encouraged to include both KZA150 and CHG100, as well as a first-year chemistry unit. Students whose career aspirations are in the life sciences area are strongly encouraged to include both KZAI 51 and KPA150, as well as a first-year chemistry unit. (Please note that BSc rules do not allow students to include both KZA150 and KPA150) ________________________________________ University of Tasmania unit details July 11, 2016, 18:39 PM, page –3 CBA Unit Details as at 13th June, 2002 Students who do not have these prerequisites MAY be accepted after consultation with the unit coordinator; for example, a student who has not done a first-year chemistry unit will be considered if they have good marks in TCE Chemistry 12C, and have done one of the prerequisite first-year biology units. Staff Dr SM Richards, Dr DR Woodward (Coordinator) Unit weight 12.5% Teaching pattern 2–3x1hr lectures, 3hrs lab weekly; 1-hr tutorial fortnightly Prerequisites ONE of (KRA110 Chemistry IA, KRA130 Chemistry IB) and ONE of (KZA150 Zoology IG, KPA150 Botany 1 G) Mutual exclusions this unit may NOT be included in BSc with CBA250 or CBA211 Assessment mode 3-hr written end-of-sem paper (90%), practicals (10%) Required texts etc either Elliott WH and Elliott DC, Biochemistry and Molecular Biology, 2nd edn, OUP, Oxf, 2001, ISBN 0198700458 or Meisenberg G and Simmons YM, Principles of Medical Biochemistry, Mosby, St Louis, 1998, ISBN: 0815144105 Recommended texts etc All of the above, plus Campbell MYC, Biochemistry, 3rd edn, Saunders, Philadelphia, 1999, ISBN: 0030244269 Garrow JS, James WPT and Ralph A, Human Nutrition and Dietetics, 10th edn, Churchill Livingstone, Edin, 2000 ISBN: 0443056277 Stryer L, Biochemistry, 4th edn, Freeman, NY, 1995, ISBN: 0716720094 Wahl.qvist ML, Food and Nutrition: Australia Asia and the Pacific, Allen & Unwin, St Leonards, 1997, ISBN: 1864482206 Brownie AC and Kernohan JC, Biochemistry: A Core Text with Self-Assessment, Churchill Livingstone, Edin, 1999, ISBN: 0443056935 Nelson DL and Cox IM, Lehninger Principles of Biochemistry, 3nd edn, Worth, NY, 2000, ISBN: 1572599316 Courses [S3G] [S3Gc1] [S3Gc2] Faculty website <http://www.healthsci.utas.edu.au/> Molecular Biology in Health & Disease Enrolment code: CBA265 Offered: Hobart: semester 2 Special note: restricted to students enrolled in Science Provides students with a broad introduction to molecular biology. The focus is primarily on humans and other mammals, but most of the matters discussed apply to a much broader range of species. Major topics include protein structure and function; DNA structure, replication and transcription; protein synthesis; molecular biology of cancer; genetics of human disease; DNA technology and its applications. ________________________________________ University of Tasmania unit details July 11, 2016, 18:39 PM, page –4 CBA Unit Details as at 13th June, 2002 Students whose career aspirations are in the biomedical area are encouraged to include both KZA150 and CHG100, as well as a first-year chemistry unit. Students whose career aspirations are in the life sciences area are strongly encouraged to include both KZA151 and KPAI 50, as well as a first1year chemistry unit. (Please note that BSc rules do not allow students to include both KZA150 and KPA150) Students who do not have these prerequisites MAY be accepted after consultation with the unit coordinator; for example, a student who has not done a first-year chemistry unit will be considered if they have good marks in TCE Chemistry 12C, and have done one of the prerequisite first-year biology units. Staff Dr SM Richards, Dr AK West, Dr DR Woodward (Coordinator) Unit weight 12.5% Teaching pattern 2x1-hr lectures, 3 hrs lab weekly; 1-hr tutorial fortnightly Prerequisites ONE of (KRA110 Chemistry IA, KRA130 Chemistry IB) and ONE of (KZA150 Zoology IG, KPA150 Botany 1 G). Mutual exclusions This unit may not be included in BSc with CBA250 or CBA211 Assessment mode 3-hr written end-of-sem paper (90%), practicals (10%) Required texts etc either Elliott WH and Elliott DC, Biochemistry and Molecular Biology, 2nd edn, OUP, Oxf, 2001, ISBN 0198700458 or Meisenberg G and Simmons YM, Principles of Medical Biochemistry, Mosby, St Louis, 1998, ISBN: 0815144105 Recommended texts etc All of the above, plus Campbell MYC, Biochemistry, 3rd edn, Saunders, Philadelphia, 1999, ISBN: 0030244269 Garrow JS, James WPT and Ralph A, Human Nutrition and Dietetics, 10th edn, Churchill Livingstone, Edin, 2000 ISBN: 0443056277 Stryer L, Biochemistry, 4th edn, Freeman, NY, 1995, ISBN: 0716720094 Wahl.qvist ML, Food and Nutrition: Australia Asia and the Pacific, Allen & Unwin, St Leonards, 1997, ISBN: 1864482206 Brownie AC and Kernohan JC, Biochemistry: A Core Text with Self-Assessment, Churchill Livingstone, Edin, 1999, ISBN: 0443056935 Nelson DL and Cox IM, Lehninger Principles of Biochemistry, 3nd edn, Worth, NY, 2000, ISBN: 1572599316 Courses [S3G] [S3Gc1] [S3Gc2] Faculty website <http://www.healthsci.utas.edu.au/> Molecular Biochemistry: Techniques and Theory Enrolment code: CBA327 Offered: Hobart: semesters 1 & 2 ________________________________________ University of Tasmania unit details July 11, 2016, 18:39 PM, page –5 CBA Unit Details as at 13th June, 2002 Provides students with (i) an understanding and application of contemporary techniques in protein biochemistry and molecular biology and (ii) an understanding of contemporary developments in the areas of biochemistry relating to hormones, signal transduction and molecular biology, particularly advanced related to geneomics, transgenesis, cloning and the Human Genome Project Lectures cover: techniques in protein biochemistry and molecular biology including isolation of organelles and membrane proteins; measurement of membrane transport processes; isolation and purification of proteins and enzymes; determination of kinetic constants of enzymes; isolation of nucleic acids (DNA and RNA) from cells; in vitro manipulation of nucleic acids; detection of sequences of defined composition and reintroduction of genes into bacterial and eukaryotic cells; transformation, transfection, transgenic animals, microarrays, bioninformatics, control of gene expression; mechanisms of free radical action in cells and its consequences; mammalian cloning by nuclear transfer; hormonal control systems; adrenergic control systems; insulin and insulin-like growth factors; receptors; phosphoinositol turnover and control of intracellular calcium; protein kinases; phosphoprotein phosphatases; covalent modification. Practicals emphasise ‘hands-on’ experience with contemporary biochemical techniques. The unit features a 10-week research project in the second semester. Staff Prof MG Clark, Dr AK West Unit weight 50% Teaching pattern 3 lectures, 1-hr tutorial, 11 hrs practicals weekly Prerequisites CBA250 or equiv Assessment mode 2-hr written exam in June, 3-hr written exam in Nov, with 30% of final mark from practical assignments and projects Required texts etc Rapley R, Walker JM, Molecular Biomethods Handbook, ISBN 0896035018 Recommended texts etc Alberts B, Bray D, Lewis J, Raff M, Roberts K and Watson J, Molecular Biology of the Cell, ISBN 0815316208 Lewin B, Genes VII, ISBN 0198792778 other appropriate material will be indicated during the year. Courses [S3G] Faculty website <http://www.healthsci.utas.edu.au/> Biochemistry 4 (BSc Honours) Enrolment code: CBA410 Offered: Hobart: semesters 1 & 2 Special note: for Science students only Aims: (a) to provide students with the opportunity to plan, execute, interpret and analyse purposeful experiments, appropriate to their research project, and to communicate their results; and to investigate and present on two areas, unrelated to their own research topic, but representing important contemporary biochemical research in order to demonstrate their skills in providing a condensed account of these areas of research and in communicating their essential features in written and oral form; and (b) to provide a year’s ________________________________________ University of Tasmania unit details July 11, 2016, 18:39 PM, page –6 CBA Unit Details as at 13th June, 2002 training in research, in order to give successful students a competitive edge in seeking employment in biochemical research laboratories. The unit tests abilities which were largely ignored in the earlier years. Students who excel in this Honours year are well organised, plan carefully, are intensely motivated, are innovative thinkers, and express their ideas and findings clearly. Staff Prof MG Clark, Dr AK West, Dr DR Woodward, Dr SM Richards (Coordinator) Unit weight 100% Prerequisites BSc including CBA327 or equiv Assessment mode the year’s performance is assessed from the research topic (thesis, 60%; project seminar, 10%), and 2 assignments (10% for the essay and 10% for the reading topic seminar presentation), supervisor’s assessment (10%). There are no written exams or additional lectures, but students are expected to attend Discipline of Biochemistry seminars and those of their own research group Courses [S4E] Faculty website <http://www.healthsci.utas.edu.au/> ________________________________________ University of Tasmania unit details July 11, 2016, 18:39 PM, page –7