LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
M.Sc. DEGREE EXAMINATION – BIOTECHNOLOGY
FIRST SEMESTER – NOV 2006
BT 1815 - CELL & MOLECULAR GENETICS
AE 16
(Also equivalent to BT 1808)
Date & Time : 31-10-2006/1.00-4.00
Dept. No.
Max. : 100 Marks
PART A (20 marks)
Answer all the questions.
I. Choose the correct answer:
(5 x 1=5)
1. The organism with the largest number of chromosome is
(a) Ostrich (b) Fern (c) Chimpanzee (d) Elephant
2.
Who proposed the lac operon?
(a) Jacob and Monad (b) Beadle and Tatum (c) Crick and Watson (d) Francis Collins
3.
Who discovered jumping genes?
(a) Barbara Mcclinctok (b) Stanley Cohen (c) Stahl (d) Kornberg
4.
Which cell division occurs in germ cells?
(a) Equational division only (b) Mitosis (c) Reduction division only (d) Meiosis
5.
Which is the inducer in lac operon?
(a) Glucose (b) Fructose (c) Mannose (d) Lactose
II. State True or False, if false give reasons
(5 x 1=5)
6.
Only chloroplast DNA contains no histones.
7.
All mitochondrial genes contain introns
8.
Protofilament is present in microtubules.
9.
Shine-Dalgarno sequence is 5’ AGGT3’.
10. The generation time of E.coli is 30 minutes at 37 degree C
III. Complete the following:
11.
12.
13.
14.
15.
Sugar specificity of concanavalin A is __________________.
Cell communication is most often done by ___________________.
________________ leads to a confirmation change in receptor.
Ratio of DNA/Protein is ___________ or _______________.
________________ are the predominant proteins in Chromatin
IV. Answer the following, each with 50 words only
16.
17.
18.
19.
20.
(5 x 1=5)
Define G-protein
Define cell theory
What is Turner’s syndrome?
What is a genome?
What is transformation?
(5 x 1=5)
PART B
V. Answer any five of the following, each within 350 words only:
(5 x 8=40)
21.
Write the nuclear and cytoplasmic genes interaction and protein synthesis,
cite an example
22.
Write a brief note on endocrine signalling
23.
Write a brief note on mobile elements
24.
What is transduction and what are the different types?
25.
Write a brief note on bacterial conjugation
26.
What is linkage? How does it differ from Mendelian inheritance?
27.
Describe briefly the chromosomal mutations or aberrations
28.
How does protein sorting takes place in a cell?
PART C
VI. Answer the following in detail, not more than 1500 words each:
(2 x 20=40 marks)
29.
(a) Describe transcriptional control mechanism in prokaryotes
OR
(b) Describe translational control mechanism in prokaryotes
30.
(a) Explain replication in prokaryote and eukaryote
OR
(b) Enumerate the extra chromosomal inheritances seen and Explain them
______________________