UNIVERSCITY OCF PENNSYLVANIA CENTER FOR BIOETHICS Mind Wars: Brain Research and National Defense Jonathan D. Moreno David and LynDate Silfen University Professor National Research Council, August 13, 2008 “Committee on Military and Intelligence Methodology for Emergent Physiological and Cognitive/Neural Science Research in the Next Two Decades” Client: Defense Intelligence Agency Henry A. Murray Father of personality theory Director of Harvard Psychological Clinic Explorations in Personality, 1938 Developed Thematic Apperception Test for the US Army during WWII First chief psychologist in the OSS Assessment of Men, 1948 Allen Dulles Legendary CIA director Commissioned WolfHinkle report on “brain washing”, 1953 Subsequently supported various hallucinogenic and innovative human experiments Sidney Gottlieb CIA spymaster Developed toxic items for assassination (Castro, Patrice Lumumba) Funded hallucinogen experiments Architect of MKUltra program Frank Olson CIA anthrax expert assigned to Fort Detrick Given LSD Descended to his death from a Manhattan hotel, 1953 The Case of Harold Blaur NY tennis pro, 42 y.o. Admitted to NY State Psychiatric Institute for depression, January 1953 Unconsented mescaline experiment funded by US Army Chemical Corps Died after overdose Covered up, LSD aspect revealed in Ford administration, compensation to adult children 1978 Henry Beecher Icon of human research ethics Harvard anesthesiology professor Work on LSD supported by CIA Reported foreign science contacts to CIA through the 1950s “Harvard and the Unibomber” Experiment in personality deconstruction of Harvard undergrads Humiliation technique Ted Kaczynski was a subject The Professor and the Unibomber Kurt Lewin Founder of modern social psychology Advised OSS on psychological warfare Perhaps up to a third of major research university faculty were supported by security agencies after WWII J.B. Rhine Distinguished Duke U. parapsychology researcher ESP studies CIA supported starting in 1952 “Psiops” U.S. Test of Simulated NonLethal Mortar Round, 2002 (Image from Project Sunshine) The Moscow Theater Tragedy, October 2002 Chechen terrorists occupy Russian theater during play Fentanyl pumped into the heating ducts Emergency teams not informed of the nature of the agent 128 die Reading Hidden Intentions in the Human Brain Haynes, J. -D. et al. Current Biology 17, 323-328 (2007) Kay, K. N., Naselaris, T., Prenger, R. J. & Gallant, J. L. Nature advanced online publication doi:10.1038/nature067, 15 March 2008). “In the experiment, the brain activity of two subjects was monitored while they were shown 1,750 different pictures. The team then selected 120 novel images that the subjects hadn’t seen before, and used the previous results to predict their brain responses. When the test subjects were shown one of the images, the team could match the actual brain response to their predictions to accurately pick out which of the pictures they had been shown. With one of the participants they were correct 72% of the time, and with the other 92% of the time; on chance alone they would have been right only 0.8% of the time.” Non-invasive Brain Imaging Uses fMRI (oxygenation) or PET scans (glucose) Correlations of neurochemistry with behavior NIRS (Near Infrared Spectroscopy) cheaper and portable, also records oxygenation but poor temporal resolution Transcranial Magnetic Stimulation Induces changes in brain activation Could be used to alter a person’s social behavior or attitudes Influence brain functions including physical movement, visual perception, memory, reaction time, speech and mood $3 billion budget Developed internet, stealth bomber Dedicated to long-range innovation through speculative technical possibilities Various current neuroscience projects Neuroimaging and the “Head Web” Noninvasive brain monitoring devices Contract: “Head Access Laminar Optoelectronic Neuroimaging System” Contract: “Wireless Near-Infrared Devices for Neural Monitoring in Operational Environments” Security and medical uses “Neuromics”: DARPA’s MindMachine Interface Programs Training honeybees to detect explosives and other “odors of interest” The “electronic dog’s nose” to develop electronic devices that can sniff out explosives as well as dogs. Improved battlefield vision technology based on fly eyes “Enhanced Human Performance” project to make warfighter more endurant, better able to heal “Continuous Assisted Performance” project to enable fighters to stay awake and alert 24/7 “AugCog”, DARPA, 2002 will develop the technologies needed to measure and track a subject’s cognitive state in real-time enhance operational capability, support reduction in the numbers of persons required to perform current functions, and improve human performance in stressful environments E.g., cockpit design: a computer-based command environment (working memory), an unmanned combat vehicle (executive function), a combat vehicle (sensory input), and an integrated individual combat system (attention). Cognitive Threat Warning System “Luke’s Binoculars” Cyborgs At a certain point the neural system integrates the information encoded on an implanted chip What does this mean for the research participant’s capacity? Has the participant’s identity been altered? The Roborat No Bull: Jose Delgado’s “Stimoceiver”, 1958 Modafinil (Provigil) Possible replacement for amphetamines The “Anti-Conscience” Pill Beta blockers can be used to treat stress, prevent PTSD Suppress release of hormones like norephinephrine that help encode memory Might also reduce guilt feelings The trust drug? Natural oxytocin production is associated with trust behavior May be artificially administered in a spray to encourage cooperation Use in interrogations? Scientists’ Use of Brain Enhancers Nature 450, 1157–1159 ; 2007 20% of readers reported using at least one of these for non-medical reasons: Ritalin (62%) Modafinil (44% Beta blockers (15%) Emerging Cognitive Neuroscience and Related Technologies (National Academies Press, 2008) 1. 2. 3. The Big Picture: Bridging the Science and Technology for the Decision Maker Current Cognitive Neuroscience Research and Technology: Selected Areas of Interest 1. Challenges to the Detection of Psychological States and Intentions via Neurophysiological Activity 2. Neuropsychopharmacology 3. Functional Neuroimaging Emerging Areas of Cognitive Neuroscience and Neurotechnologies Summary “The intelligence community (IC) faces the challenging task of analyzing extremely large amounts of information on cognitive neuroscience and neurotechnology, deciding which of that information has national security implications, and then assigning priorities for decision makers. It is also challenged to keep pace with rapid scientific advances that can only be understood through close and continuing collaboration with experts from the scientific community, from the corporate world, and from academia. The situation will become more complex as the volume of information continues to grow. The Committee … was tasked by the Technology Warning Division of the Defense Intelligence Agency’s (DIA’s) Defense Warning Office to identify areas of cognitive neuroscience and related technologies that will develop over the next two decades and that could have military applications that might also be of interest to the IC.” Tasks Review the current state of today's work in neurophysiology and cognitive/ neural science, select the manners in which this work could be of interest to national security professionals, and trends for future warfighting applications that may warrant continued analysis and tracking by the intelligence community, Use the technology warning methodology developed in the 2005 National Research Council report Avoiding Surprise in an Era of Global Technology Advances (NRC, 2005) to assess the health, rate of development, and degree of innovation in the neurophysiology and cognitive/neural science research areas of interest, and Amplify the technology warning methodology to illustrate the ways in which neurophysiological and cognitive/neural research conducted in selected countries may affect committee assessments. Thank you! University of Pennsylvania Center for Bioethics Center for Cognitive Neuroscience Department of History and Sociology of Science Dana Foundation Howard Hughes Medical Institute National Research Council