4th Quadrennial Meeting of the World Federation of Neuro-Oncology
held in conjunction with the
2013 Scientific Meeting and Education Day of the Society for Neuro-Oncology
November 21-24, 2013
San Francisco, California
Marriott Marquis Hotel
http://www.soc-neuro-onc.org/2013-annual-meeting/
Case CCC Members indicated in BOLD
PLENARY SESSIONS: AWARD WINNING ABSTRACTS
RTOG 0825: Primary outcome results from a phase III randomized, placebo controlled trial evaluating
bevacizumab in newly diagnosed glioblastoma
Mark Gilbert*1, Stephanie Pugh2, Minhee Won2, Deborah Blumenthal3, Michael Vogelbaum4, Ken
Aldape1, Howard Colman5, Arnab Chakravarti6, Robert Jeraj7, James Dignam2, Terri Armstrong8,1, Jeffrey
Wefel1, Paul Brown1, Kurt Jaeckle9, David Schiff10, David Brachman12, Maria Werner-Wasik13, Ivo
Tremont-Lukats1, Erik Sulman1, Minesh Mehta14
1M.
D. Anderson Cancer Center, USA, 2Radiation Therapy Oncology Group, USA, 3Tel Aviv Medical Center, Israel, 4Cleveland Clinic
Foundation, USA, 5University of Utah Health Science Center, USA, 6Ohio State University Medical Center, USA, 7University of
Wisconsin-Madison, USA, 8University of Texas Health Science Center, USA, 9Mayo Clinic, USA, 10University of Virginia, USA,
11Southeast Cancer Control Consortium, USA, 12Arizona Oncology Services Foundation, USA, 13Thomas Jefferson University
Hospital, USA, 14University of Maryland, USA, 15Emory University, USA
Friday, November 22, Scientific Meeting: Plenary Session - Award Winning Abstracts - 8:15am - 10:15am
CONCURRENT SESSION PRESENTATIONS
Roles of glioblastoma stem cell-derived vascular pericytes
Lin Cheng, Zhi Huang, Wenchao Zhou, Qiulian Wu, Jeremy Rich, Shideng Bao*
Lerner Research Institute, Cleveland Clinic, USA
Friday, November 22, Scientific Meeting: Concurrent Session 3A - Angiogenesis and Invasion - 3:15pm - 5:00pm
POSTER PRESENTATIONS
Adult medulloblastoma: survival, recurrence, and prognostic factors
Andrew J. Song*2, Aryavarta M.S. Kumar1, Erin S. Murphy1, Tanya Tekautz1, John H. Suh1, Violette
Recinos1, Samuel T. Chao1
1Rose
Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Department of Radiation Oncology, Cleveland Clinic, USA, 2Case
Western Reserve University School of Medicine, USA
Friday, November 22, Scientific Meeting: Poster session - 7pm - 9:00pm
An open-label, multi-center, phase II study of patupilone (EPO906), in the treatment of recurrent or
progressive brain metastases in patients with non-small cell lung cancer (NSCLC)
Lakshmi Nayak*1, Antonio Omuro2, Lisa DeAngelis2, H. Ian Robins3, Ramaswamy Govindan4, Shirish
Gadgeel5, Karen Kelly6, James Rigas7, Hans-Joachim Reimers8, David Peereboom9, Steven Rosenfeld10,
Jennifer Garst11, Nithya Ramnath12, Patricia Wing13, Ming Zheng13, Patrick Urban13, Lauren Abrey2,
Patrick Wen1
1Dana-Farber
Cancer Institute, USA, 2Memorial Sloan-Kettering Cancer Center, USA, 3University of Wisconsin Hospital and
Clinics, USA,
University School of Medicine, Siteman Cancer Center, USA, 5Wayne State University, Wertz Clinical
6
Cancer Center, USA, University of California Davis Cancer Center, USA, 7Darmouth Hitchcock Medical Center, USA, 8St. Louis
University Cancer Center, USA, 9Cleveland Clinic Foundation, USA, 10Columbia University Medical Center-New York Presbyterian
Hospital, USA, 11Duke University Medical Center, USA, 12Roswell Park Cancer Institute, USA, 13Novartis Pharmaceuticals, USA
4Washington
Friday, November 22, Scientific Meeting: Poster session - 7pm - 9:00pm
Bevacizumab salvage therapy for glioblastoma refractory to monoclonal antibodies targeting VEGF and
PDGF pathway
Saurabh Dahiya*, Glen Stevens, David Peereboom, Manmeet Ahluwalia
Cleveland Clinic, USA
Friday, November 22, Scientific Meeting: Poster session - 7pm - 9:00pm
Differences in internalization of bevacizumab by normal brain endothelial cells and endothelial cells
isolated from GBM tumors
Gaelle Muller-Greven*1, Cathleen Carlin2, Candece Gladson3
1Kent
State University, USA, 2Case Western Reserve University, USA, 3Cleveland Clinic, USA
Friday, November 22, Scientific Meeting: Poster session - 7pm - 9:00pm
Historical benchmarks for medical therapy trials in surgery and radiation refractory meningioma: a
RANO review
Thomas Kaley*1, Igor Barani2, Marc Chamberlain3, Michael McDermott2, Jeffrey Raizer4, Leland Rogers5,
David Schiff6, Michael Vogelbaum7, Damien Weber8, Patrick Wen9
1Memorial
Sloan-Kettering Cancer Center, USA, 2University of California San Francisco, USA, 3University of Washington, USA,
University, USA, 5Gamma West Cancer Services, USA, 6University of Virginia, USA, 7Cleveland Clinic, USA, 8Geneva
University Hospital, Switzerland, 9Dana-Farber Cancer Institute/ Brigham and Women's Center, USA
4Northwestern
Friday, November 22, Scientific Meeting: Poster session - 7pm - 9:00pm
Laser Interstitial Thermal Therapy (LITT) as a treatment modality for difficult-to-access high grade
gliomas: a multi-center study
Alireza Mohammadi*1, Ammar Hawasli2, Analiz Rodriguez3, Jason Schroeder1, Adrian Laxton3, Paul
Elson1, Stephen Tatter3, Gene Barnett1, Eric Leuthardt2
1Cleveland
Clinic, USA, 2Washington University, USA, 3Wake Forest University, USA
Friday, November 22, Scientific Meeting: Poster session - 7pm - 9:00pm
Phase II trial of triple receptor tyrosine kinase receptor inhibitor nintedanib in recurrent high-grade
gliomas
Andrew Norden*1, David Schiff2, Manmeet Ahluwalia3, Glenn Lesser4, Lakshmi Nayak1, Eudocia Lee1,
Alona Muzikansky5, Jorg Dietrich5, Katrina Smith1, Sarah Gaffey1, Christine McCluskey1, Keith Ligon1,
David Reardon1, Patrick Wen1
1Dana-Farber/Brigham
4Wake
and Women's Cancer Center, USA, 2University of Virginia School of Medicine, USA, 3Cleveland Clinic, USA,
Forest Baptist Medical Center, USA, 5Massachusetts General Hospital, USA
Friday, November 22, Scientific Meeting: Poster session - 7pm - 9:00pm
Thinking outside the box: intractable seizures in the glioma patient, is seizure surgery the answer?
Kathleen Lupica*, Glen Stevens
Cleveland Clinic, USA
Friday, November 22, Scientific Meeting: Poster session - 7pm - 9:00pm
Treatment of GBM xenograft tumors with a thrombospondin mimetic peptide, ABT-898: comparison to
bevacizumab
Eunnyung Bae*1, Luke Smith3, Gaelle Muller-Greven1, Ryosuke Yamada3, Mariko Nakano-Okuno3, Xi
Feng2, Dolores Hambardzumyan2, Ichiro Nakano3, Candece L. Gladson1
1Department
of Cancer Biology, Cleveland Clinic, USA, 2Department of Neuroscience, Cleveland Clinic, USA, 3Department of
Neurosurgery, Ohio State University, USA
Friday, November 22, Scientific Meeting: Poster session - 7pm - 9:00pm
Treatment of large brain metastases with stereotactic radiosurgery (SRS)
Amy L. Zimmerman*2, Michael A. Vogelbaum1, Gene H. Barnett1, Erin S. Murphy1, John H. Suh1, Lilyana
Angelov1, Chandana A. Reddy1, Samuel T. Chao1
1Cleveland
Clinic, USA, 2Case Western Reserve University, USA
Friday, November 22, Scientific Meeting: Poster session - 7pm - 9:00pm
Atopic conditions, antihistamine use, and glioma risk: Preliminary results from the Glioma International
Case-Control Study
E. Susan Amirian*1, Michael E. Scheurer1, Margaret Wrensch3, Sara H. Olson4, Rose Lai5, Daniel
Lachance7, Georgina Armstrong1, Renke Zhou1, Joseph Wiemels3, Ching Lau1, Elizabeth Claus8, Jill
Barnholtz-Sloan9, Dora Il'yasova10, Joellen Schildkraut10, Richard Houlston11, Sanjay Shete12, Jonine
Bernstein4, Robert Jenkins7, Faith Davis13, Ryan Merrell14, Christoffer Johansen15, Siegal Sadetzki6, The
Gliogene Corsortium16, Beatrice Melin2, Melissa Bondy1
1Baylor
College of Medicine, USA, 2Umeå University, Sweden, 3University of California San Francisco, USA, 4Memorial SloanKettering Cancer Center, USA, 5University of Southern California, USA, 6Chaim Sheba Medical Center, Israel, 7Mayo Clinic, USA,
8Yale University School of Medicine, USA, 9Case Western Reserve University, USA, 10Duke University Medical Center, USA,
11Institute of Cancer Research, UK, 12The University of Texas MD Anderson Cancer Center, USA, 13University of Illinois at Chicago,
USA, 14North Shore University Health System, USA, 15Unit of Survivorship, Danish Cancer Society Research Center, Denmark
Saturday, November 23, Scientific Meeting: Poster session - 5:00pm - 7:00pm
Computerized image analysis of texture descriptors in multi-parametric MRI to distinguish recurrent
glioblastoma multiforme from radiation necrosis
Pallavi Tiwari*1, Lisa Rogers2, Leo Wolansky2, Andrew Sloan2, Jill Barnholtz-Sloan2, Curtis Tatsauka2,
Mark Cohen2, Anant Madabhushi1
1Case
Western Reserve University, USA, 2University Hospitals, Case Medical Center, USA
Saturday, November 23, Scientific Meeting: Poster session - 5:00pm - 7:00pm
New prognostic scoring system for single brain metastasis patients utilizing clinical and radiological
factors
Saurabh Dahiya*, Volodymyr Statsevych, Paul Elson, Hao Xie, Samuel Chao, David Peereboom, Glen
Stevens, Gene Barnett, Manmeet Ahluwalia
Cleveland Clinic, USA
Saturday, November 23, Scientific Meeting: Poster session - 5:00pm - 7:00pm
Sunitinib suppresses myeloid derived suppressor cells (MDSCs) and induces T cell infiltration into murine
gliomas
Baisakhi Raychaudhuri*, Patricia Rayman, Pengjing Huang, Mathew Grabowski, Dolores
Hamburdzumyan, Jim Finke, Michael Vogelbaum
Cleveland Clinic, USA
Saturday, November 23, Scientific Meeting: Poster session - 5:00pm - 7:00pm
Targeting glioblastoma cancer stem cells via mitotic kinesins
Monica Venere*1, Cathleen Chang1, Qiulian Wu1, Matthew Summers2, Steven Rosenfeld2, Jeremy
Rich1,3
1Department
of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, USA, 2Department of
Cancer Biology, Lerner Research Institute, Cleveland Clinic, USA, 3Molecular Medicine, University Hospital-Case Medical Center
and Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, USA
Saturday, November 23, Scientific Meeting: Poster session - 5:00pm - 7:00pm
The frequency of the rs55705857 risk allele is elevated and similar in familial and sporadic glioma
patients.
Robert Jenkins*1, Margaret Wrensch2, Thomas Kollmeyer1, Georgina Armstrong3, Sara Olson4, Rose Lai5,
Daniel Lachance1, Ching Lau3, Elizabeth Claus6, Jill Barnholtz-Sloan7, Dora Il'yasova8, Joellen Schildkraut7,
Richard Houlston9, Sanjay Shete15, Jonine Bernstein4, Faith Davis10, Ryan Merrell11, Christoffer
Johansen12, Siegal Sadetzki13, The GLIOGENE Consortium3, Beatrice Melin14, Melissa Bondy3
1Mayo
Clinic, USA, 2University of California, USA, 3Baylor College of Medicine, USA, 4Memorial Sloan-Kettering Cancer Center,
USA, 5University of Southern California, USA, 6Yale University School of Medicine, USA, 7Case Western Reserve University School
of Medicine, USA, 8Duke University School of Medicine, USA, 9The Institute of Cancer Research, UK, 10University of Illinois at
Chicago, USA, 11NorthShore University HealthSystem, USA, 12Unit of Survivorship Danish Cancer Society Research Center,
Denmark, 13Tel-Aviv University, Israel, 14Umeå University, Sweden, 15MD Anderson Cancer Center, USA
Saturday, November 23, Scientific Meeting: Poster session - 5:00pm - 7:00pm
Tumors of the pituitary: is incidence rising?
Haley Gittleman*1,2, Carol Kruchko2, Quinn Ostrom1,2, Yanwen Chen1,2, Paul Farah4, Annie Ondracek3,
Yingli Wolinsky1,2, Jill Barnholtz-Sloan1,2
1
Case Comprehensive Cancer Center, CWRU School of Medicine, USA, 2Central Brain Tumor Registry of
the United States, USA, 3The Ohio State University, USA, 4Case Western Reserve University, USA
Saturday, November 23, Scientific Meeting: Poster session - 5:00pm - 7:00pm
What can radiographic diagnosis tell us about meningioma?
Quinn Ostrom*1, Carol Kruchko2, Haley Gittleman1,2, Yanwen Chen1,2, Annie Ondracek3, Paul Farah4,
Yingli Wolinsky1,2, Jill Barnholtz-Sloan1,2
1Case
Comprehensive Cancer Center, USA, 2Central Brain Tumor Registry of the United States, USA, 3The Ohio State University,
USA,
Western Reserve University, USA
4Case
Saturday, November 23, Scientific Meeting: Poster session - 5:00pm - 7:00pm