DEVELOPMENT OF FACE Dr. Saleem Shaikh Introduction The development of face is a very complex process which involves the interaction of many factors. The face develops during the 5th to 7th week of intrauterine life. Two prominent bulgings can be seen on the ventral aspect of the embryo – developing brain and the pericardial bulge. These two bulgings are seperated by the stomatodaeum. The floor of the stomatodaeum is formed by the buccopharyngeal membrane. Mesoderm covering the developing brain proliferates and forms a downward projection that overlaps the upper part of stomatodaeum – frontonasal process. The pharyngeal arches are also very closely located. The first pharyngeal arch - mandibular arch forms the lateral wall of the stomatodaeum . This arch gives a bud on its dorsal surface – forms the maxillary process The remaining part of the arch is now called as mandibular process. The ectoderm overlying the frontonasal process shows bilateral localized thickenings – nasal placodes These placodes soon sink below the surface to form nasal pits, these pits are continuous with stomatodaeum. The edges of the pit are raised and the medial edge is known as mesial nasal process and the distal is known as distal nasal process. Lower lip The mandibular process on both sides grow towards each other and meet at the midline. This gives rise to lower lip and mandible Upper lip The maxillary process grows medially and fuses first with the the lateral nasal process and then with the medial nasal process. The medial and lateral nasal process also fuse with each other. The maxillary process grows considerably and the frontonasal process becomes narrower – the nares come close to each other The nose The nose is formed by the frontonasal, medial nasal and lateral nasal process. The frontonasal process becomes narrower and forms the nasal septum. A groove appears between the nose and forebrain. The nasal pits deepen to form nasal sacs and communicates with the stomatodaeum. The lateral wall of the nose is derived from lateral nasal process Cheeks After formation of the upper and lower lips the stomatodaeum is very broad. the maxillary and the mandibular process fuse with each other to form the cheeks. The maxillary process fuses with the lateral nasal process, this fusion extends to the medial angle of the developing eye; naso-optic furrow or nasolacrimal sulcus contains the nasolacrimal duct. Eye It is first seen as an ectodermal thickening - lens placode. The lens placode sinks below the surface and forms a bulging The bulgings of the eye are directed laterally and later then they come to face forwards.