Parkinson's disease ♦ Is a neurodegenerative disorder ♦ Develops around age 50 * incidence rises with age * affects 1-2% of population > age 65 ♦ Higher incidence in men (62%) compared to women (38%) Early Signs and Symptoms Cardinal Characteristics Resting tremor Bradykinesia Rigidity Postural instability Other Micrographia Masked face Slowing of ADLs Stooped, shuffling gait Decreased arm swing when walking Additional Signs and Symptoms Difficulty arising from a chair Difficulty turning in bed Hypophonic speech Sialorrhea Loss of the sense of smell Foot dystonia Criteria for Diagnosis At least two of three: rest tremor, bradykinesia, rigidity Absence of a secondary cause—drugs, metabolic, etc. Definitive diagnosis can only be made by autopsy Pathophysiology : Deficiency of the brain chemical dopamine occurs in the basal ganglia. Degeneration of nigrostriatal pathway (Substantia Nigra to corpus striatum. Drug Classes in PD Dopaminergic agents Levodopa Dopamine agonists Anticholinergics Amantadine Surgical Treatments for Parkinson’s Disease Ablative thalamotomy pallidotomy Electrical stimulation VIM thalamus, globus pallidus internus, sub-thalamic nucleus Transplant human fetal, genetically engineered transplants Treatment Plan Maintain or increase ROM in all joints Efforts to improve postural control and standing balance Prevent disuse atrophy and muscle weakness Improve motor function and mobility Physical Therapy: Goal Maintain or increase activity level Decrease rigidity and bradykinesia Facilitate movement and flexibility; optimize gait Maximize gross motor coordination and balance Maximize independence, safety, function Rehabilitation Hoehn and Yahr Rating scale Divided into five stages Stage 0 = no visible disease; Stage I = disease that involves only one side of the body; Stage II = disease that involves both sides of the body. but does not impair balance: Stage III = disease that impairs balance or walking; Stage IV = disease that markedly impairs balance or walking: and Stage V = disease that results in complete immobility. Cardiopulmonary Impairment The patient's flexed posture can lead to kyphosis, cause a reduction in pulmonary capacity, and produce a restrictive lung disease pattern. Breathing exercises, postural reeducation, and trunk exercises may be helpful. Institution of a general conditioning program can increase the patient's endurance. If pulmonary function progressively worsens, assisted coughing techniques, incentive spirometry, and respiratory therapy intervention may be required. Physical Therapy Static and dynamic postural controls emphazing whole body movements sitting and standing Stationary bike training to help reciprocal movements Exercise: walking(1+mile/day),swimming,golf,dancing Use of assistive devices, mobility aids, orthotics Family training and home program Proper and energy conservation techniques After 6 mths benefit of therapy if not coninued will be gone Aerobic activities such as: Using a treadmill Using a stationary bike or rowing machine Walking Swimming MAKE GOOD POSTURE A HABIT Stand against a wall and be sure your lower back and shoulder BLADES are touching the wall MAKE GOOD POSTURE A HABIT lie flat on your back, with just enough support to keep your head and neck from tipping back for 5 minutes. FLEXIBILITY OR STRETCHING FLEXIBILITY OR STRETCHING STRENGTHENING EXERCISES STRENGTHENING EXERCISES Alzheimer's Disease Alzheimer’s disease is an irreversible, progressive brain disease that slowly destroys memory and thinking skills, symptoms first appear after age 60.