By
Dr. Mohammed Golam Rasul
COLLEGE OF DENTISTRY
MAJMAAH UNIVERSITY

• Biochemistry is the science concerned with the chemical basis of life.
• It is the application of the principles and methods of chemistry to the field of biology and physiology.
• It is the language of biology basic to the understanding of the different phenomena both in the biological and medical sciences.

 Upon completion of this course, students should be able to:
 Define the basic constituents of macromolecules (carbohydrates, proteins, lipids, nucleic acids) and enzymes
 Describe the classification, structure and functions of macromolecules and enzymes
 Discuss the nutrition/ effects of nutrient deficiencies and their relationship to body structure
 Demonstrate the ability to conduct basic biochemical laboratory test

Time-Table
Lecture : 1hr/week
• Sunday : 1pm – 2.00 pm
Practical: 3hrs/week
• Tuesday: 10 am– 1 pm
• Venue: Biochemistry Lab
Tutorials: 1 hr/ 3 week

st
• Theoretical part ……………………….…………..………………50%
• Practical part ………….…..………………………………………50%
• Incourse assessments……………………………………….... 60%
• o Midterm written examination ……..…20%
• o practical assessments ………. ……..30%
• o Behavior and attitude ………..……….5%
• o Research ……………………………...2%
• o Home work …………………………...1%
• o Presentation …………………………..1%
• o Quiz….. ……………………………..…1%
• Final examination …………..…………………………………….40 %
• o Final practical examination …………10%
• o Final written examination ……………30%

• Biochemistry is a branch of medical science that seeks to describe the structure, organization and functions of living matter in molecular terms.
• It is the chemistry of life . It is divided into
3 principal areas:
• 1. Structural chemistry
• 2. Metabolism
• 3. Chemistry of molecular genetics

• Medicine
• Agriculture
• Industrial applications
• Environmental applications

• Physiology overlaps with biochemistry almost completely
• Pharmacology and pharmacy rest on sound knowledge of biochemistry in the creation of
“designer drugs” or drug architecture
• Invention of new drugs in Pharmacy, Medicine ,
Agriculture and other fields
• Biochemical approaches are employed in
Pathology
• Poisons act on biochemical reactions and this is the subject matter in toxicology .

The aims, attitudes and techniques of biochemistry are as relevant to dentistry as to medicine or to any aspect of biology.
1.
To understand the true nature of dental disease .
All diseases have a biochemical basis.
2.
To give dental patients the necessary or appropriate dietary advice to prevent dental disease.
3.
Special relevance to dentists are areas of blood coagulation and effects of drugs and other injected substances on tissue and cells.

4. Understanding the physicochemical process of resorption and deposition of bone minerals and its matrix is essential to orthodontics
5.As for the future, methods to prevent or cure tooth decay are likely to involve a biochemical approach, like caries vaccine .

?
• Biomolecules are molecules found in living matter.
• Two broad types: Small molecules and macromolecules
• Importance of Macromolecules: a) Essential structures for the basis of life b) Control and regulate these processes c) Responsible for energy exchanges, irritability, metabolism, mobility and reproduction

Many Important Biomolecules are Polymers monomer lipids fatty acid polymer phospholipid supramolecular structure membrane proteins amino acid protein subunit protein complex carbo nucleic acids glucose nucleotide cellulose cell wall
DNA chromosome

monomer fatty acid polymer phospholipid supramolecular structure membrane

monomer amino acid polymer protein subunit supramolecular structure Enzyme complex

monomer glucose polymer cellulose supramolecular structure cell wall

monomer nucleotide polymer supramolecular structure
DNA chromatin

Common theme:
Monomers form polymers through condensations
Polymers are broken down through hydrolysis.

www.m.rasul@mu.edu.sa

• Basic Biochemical reactions
• Acid-Base relationship