COMPLICATIONS OF BURNS CHANDRASEKAR.L LECTURER, MAJMA’AH UNIVERSITY PHT 331 – SECTION - 1422 Lecture outline 2 This lecture deals about the complications of burns in the following subcategories; 1. Cardiorespiratory complications 2. Septic complications 3. Gastrointestinal complications 4. Other complications PHT 331 – SEC 1422 1-Jul-16 Lecture Objective 3 At the end of this lecture the students will be able to; Explain the complications of burn in different systems level. Compare & contrast the complications of burns between different systems. PHT 331 – SEC 1422 1-Jul-16 Cardiorespiratory complications: 4 Acute Lt ventricular failure Congestive cardiac failure Myocardial infarction Pneumonia Pulmonary embolism. PHT 331 – SEC 1422 1-Jul-16 Septic complications 5 Burn wound sepsis Virus infection Bacteremia Septic shock PHT 331 – SEC 1422 1-Jul-16 Gastrointestinal complications 6 Hepatic dysfunction Pancreatitis Calculus cholecystitis Renal complications PHT 331 – SEC 1422 1-Jul-16 Other complications 7 Neurological complications Vascular complications Skeletal complications Amputation PHT 331 – SEC 1422 1-Jul-16 VASCULAR CHANGES RESULTING FROM BURN INJURIES 8 Circulatory disruption occurs at the burn site immediately after a burn injury Blood flow decreases or cease due to occluded blood vessels Damaged macrophages within the tissues release chemicals that cause constriction of vessel Blood vessel thrombosis may occur causing necrosis Macrophage: A type of white blood that ingests (takes in) foreign material. Macrophages are key players in the immune response to foreign invaders such as infectious microorganisms. PHT 331 – SEC 1422 1-Jul-16 Infectious complications 9 The most frequent complications of the major burn are due to bacterial, fungal infection. Burn wound sepsis is an imbalance in the equilibrium between bacterial and host resistances resulting in numerical increase in bacteria. As bacteria increase from normal level of 103 organism per gram of tissue to level of greater than 105 organism per gram of tissue. So they break out the hair follicles and the glands and migrate through colonizing a long dermal subcutaneous interface. Level of growth in excess of 105 organism per gram. Of tissue constitute ( burn wound sepsis). Level of 108 to 109 organism per gram may be associated with lethal burn. In rare cases, an infected burn can cause blood poisoning (sepsis) or toxic shock syndrome (TSS). These are serious conditions that can be fatal if not treated. Signs of sepsis and toxic shock syndrome include a high temperature, dizziness and vomiting. PHT 331 – SEC 1422 1-Jul-16 10 PHT 331 – SEC 1422 1-Jul-16 Renal failure: 11 Un treated hypovolemia leads to acute renal failure. Acute renal failure that may occur if the principles of fluid resuscitation are not understood Following an acute burn, oliguria or anuria shouldn't be diagnosed as renal failure but only ( insufficient volume replacement). To be sure that patient takes adequate fluid resuscitation, the amount of urine output must be ( 30-50 ml per hour). PHT 331 – SEC 1422 1-Jul-16 Inhalation injury: 12 First group of patients are die at site of fire within moments of injury because of: Asphyxia ( as the o2 will be consumed) At concentration of 2%, the death ensues in 45 sec. The inspired air contain co that can reach to 3000 ppm, combine with Hb and decrease availability of tissue to o2 . Inhalation of HCN contained in smock, this cause rapid tissue hypoxia plus hyperventilation. Inhalation of sulphur dioxide and hydrochloric acid that cause bronchospasm. The edematous response of larynx. PHT 331 – SEC 1422 1-Jul-16 Inhalation injury: cont…… 13 The next group of patients with pulmonary complications develop respiratory symptoms several hours after admission. These group of patients develop hypoxia and hypercapnia and high levels of carboxyhaemoglobin, restlessness, wheezing. PHT 331 – SEC 1422 1-Jul-16 Hepatitis 14 It is a leading cause of death in burn victim. Multiple blood transfusions add to risk of infection. Several anesthesia may be required during the course of management, exposing the patient to the dangers of drug induced hepatitis. PHT 331 – SEC 1422 1-Jul-16 Musculoskeletal complications : 15 Complications Exposed PERIARTICULAR CLASCIFICATION involving bone bone Fractures Osteoporosis Bone spurs Bone growth retardation Heterotopic ossifications: - Formation of new bone in tissue that manually don't ossify PHT 331 – SEC 1422 1-Jul-16 Musculoskeletal complications : Cont….. 16 Complications involving joint Septic arthritis Capsular tightness Dislocations Complications Exposed involving tendon tendon Tendonitis Structural TENDON DESTRUCTION FOOT DROP CONTRACTURE deformities subsequent to scarring and scar management. PHT 331 – SEC 1422 1-Jul-16 Scarring 17 A scar is a patch or line of tissue that remains after a wound has healed. Most minor burns only leave minimal scarring. You can try to reduce the risk of scarring after the wound has healed by: applying an emollient, such as aqueous cream or emulsifying ointment, two or three times a day using sunscreen with a high sun protection factor (SPF) to protect the healing area from the sun when you are outside PHT 331 – SEC 1422 1-Jul-16 18 Hypertrophic scar = continued production of collagen Keloid = ….with extension into surrounding tissues Scar contracture PHT 331 – SEC 1422 1-Jul-16 19 The hypertrophic scar is defined as a widened or unsightly scar that does not extend beyond the original boundaries of the wound. Unlike keloids, the hypertrophic scar reaches a certain size and subsequently stabilizes or regresses. Keloid scars are defined as an abnormal scar that grows beyond the boundary of the original site of a skin injury. It is a raised and ill defined growth of skin in the area of damaged skin. PHT 331 – SEC 1422 1-Jul-16 Burn Scars - Hypertrophic 20 PHT 331 – SEC 1422 1-Jul-16 Burn Scars - Keloid 21 PHT 331 – SEC 1422 1-Jul-16 Burn Scars - Contracture 22 PHT 331 – SEC 1422 1-Jul-16 Burn Scars - Contracture 23 PHT 331 – SEC 1422 1-Jul-16 Peripheral neuropathy 24 Weakness of muscles Lack of sensations Types: Generalized peripheral neuropathy (poly neuropathy) - Patient complains of fatigue and lack of endurance, distal weakness in upper and lower extremity. Local neuropathy: - It is caused by a stretch or compression injury to a single nerve. PHT 331 – SEC 1422 1-Jul-16 Shock After a serious injury, it is possible to go into shock. Shock is a life-threatening condition that occurs when there is an insufficient supply of oxygen to the body. It's possible to go into shock after a serious burn. Signs and symptoms of shock include: a pale face cold or clammy skin a rapid pulse fast, shallow breathing yawning unconsciousness 25 PHT 331 – SEC 1422 1-Jul-16 COMPLICATIONS OF BURNS 26 Heart problems Inhalation injuries Pneumonia Adult respiratory distress syndrome - ARDS (shock lung) Infection of the wound site Infection of the urinary tract Septicemia Renal and liver failure Joint effusion and periarticular swelling Calcification of periarticular tissues Contraction of scar tissue causing joint deformity Psychological trauma to the patient PHT 331 – SEC 1422 1-Jul-16