Graybill VII:
Biopharmaceutical Statistics
Some History of the Graybill
Conference Series
 2001 Graybill Conference on Linear, Nonlinear, and Generalized
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Linear Models.
2003 Graybill II: Microarrays, Bioinformatics and Related Topics.
2004 Graybill III: Spatial Statistics
2005 Graybill IV: Statistics in Information Technology
2006 Graybill V: Multi-Scale Methods and Statistics-A
Productive Marriage
2007 Graybill VI: Symposium on Applied Probability and Time
Series: A Conference in Honour of Peter J. Brockwell
2008 Graybill VII: Biopharmaceutical Statistics
2009 Graybill VIII: 6th International Conference on Extreme
Value Analysis
…2049 Graybill XLVIII: To Be Announced
Short Course Preceding Graybill
 2003, Steen Knudsen, Microarray Data
Analysis
 2004, Jay ver Hoef, Applied Spatial Statistics
 2005 Bin Yu and Mark Hansen, Minimum
Description Length
 2006 Thomas Lee, Xiao-Li Meng, Patrick
Wolfe, Multiscale Methods
 2007 Warren Ewens, BLAST
Short Courses for Graybill VII
 Hot Topics in Clinical Trials, Scott
Evans, Lingling Li, L.J. Wei, and Marvin
Zelen
 Statistical Graphics for Clinical Data
Analysis, Michael O’Connell and Matt
Austin
Reminders
 Banquet speaker for tonight: Marvin Zelen
(Harvard)
 “Biostatisticians, Biostatistical Scientists and
the Future”
 Social hour/Cash bar: 6-30pm
 Banquet: 7pm
Thanks to the Organizers
 Program Committee :
 Co-Chair: Naitee Ting (Pfizer)
 Co-Chair: Hari Iyer (Colorado State)
 Fred Balch ( Bristol-Myers Squibb)
 Scott Evans (Harvard University)
 Jim Whitmore (Gilead)
 Brian Wiens (Gilead)
 Local Organizers:
 Hari Iyer (Colorado State)
 Jim zumBrunnen (Colorado State)
 Courtney Sykes (Chesapeake College)
Thanks to the Sponsors
 Industry Sponsors (thanks to Dr. Naitee Ting for fundraising)
Amarex Clinical Research (Dr. Kazem Kazempour/student of
Graybill)
 AMGEN (Thanks to Dr. Rick Burdick)
 Eisai Medical Research, Inc.
 Gilead Colorado, Inc. (Dr. Brian Wiens)
 Takeda Pharmaceuticals N. America, Inc.
 Thanks also to SAS Inc for supporting several of the past
Graybill Conferences (Dr. Maura Stokes, Dr. Robert Lucas,
Dr. Larry Stewart)
 Academic and Professional Sponsors
 American Statistical Association
 Biopharmaceutical Section of the ASA
 CSU Bioinformatics Center
 CSU Department of Statistics
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Thanks to the Participants
 Short course instructors
 Keynote and invited speakers
 Poster presenters
 Audience!
Thanks to the Volunteers
 Student volunteers from CSU
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Derek Sonderegger, Stacey Hancock, Ming
Ying Wang, Zonglin He, Brandy Sinco, Yan Tu,
Hsin-Wen Chang, Tingjin Chu
 Student volunteers not from CSU
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ENSAI: Vincent Chambon, Erwan LeComte,
Paul Bui Quang
CUHK: Matt Yang
Frank Graybill
 Hired at CSU in 1960 to develop a
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graduate program in statistics
1961: launched the statistical
laboratory, now the Franklin A. Graybill
Statistical Laboratory
1965: first PhD in the mathematical
sciences at CSU, in Statistics!
1971: founded the Department of
Statistics
1976: president of the American
Statistical Association
1976: publication of now-classic text
on linear models
1997: retired from CSU
Less Formal Pictures
One more picture…
• Great advising, teaching,
and service to the
profession
• Honored with Graybill
Stat Lab, Graybill Award for
Excellence in Linear
Models, Graybill
Conference Series
•(Conjecture) Honored with
accomplishments of his
students and other alumni
of CSU
Naitee Ting: Conference Co-Chair
 Pfizer, Global Research and
Development
 PhD, 1987, under the direction of Frank
Graybill
Official Opening of the Conference
 Dr. Hank Gardner, Associate Vice
President for Research
First Session
 Robert O’Neill
 US Food and Drug Administration
 Director, Office of Biostatistics, Center for
Drug Evaluation and Research
 Emerging trends in regulatory
biostatistics: what might be their impact?
 Robb Muirhead
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Pfizer Global Research and Development
Recent Developments in the analysis of QT
interval data