Surveillance Dona Schneider, PhD, MPH Surveillance is the ongoing, systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice, closely integrated with the timely feedback of these data to those who need to know. Centers for Disease Control Surveillance can… Estimate the magnitude of a problem Determine geographic distribution of illness Detect epidemics/outbreaks Generate hypotheses, stimulate research Evaluate whether control measures work Monitor changes in infectious agents Detect changes in health practices 30 25 CASES 20 15 10 5 0 TIME Examples: Morbidity and Mortality Weekly Report http://www.cdc.gov/mmwr/ SEER Cancer Registry http://seer.cancer.gov/ US Vital Statistics http://wonder.cdc.gov/welcome.html National Notifiable Diseases Surveillance System (NNDSS) – produces the data in the MMWR The reportable diseases list is revised periodically by the Council of State and Territorial Epidemiologists (CSTE) and the Centers for Disease control (CDC) States report their cases to the CDC Internationally quarantinable diseases (i.e., cholera, plague and yellow fever) must be reported to the World Health Organization (WHO) The Epidemic and Pandemic Alert and Response (EPR) Program at the WHO Monitors… Anthrax Avian influenza Crimean-Congo haemorrhagic fever (CCHF) Dengue/dengue haemorrhagic fever Ebola haemorrhagic fever Hepatitis Influenza Lassa fever Marburg haemorrhagic fever Meningococcal disease Plague Rift Valley fever Severe Acute Respiratory Syndrome (SARS) Smallpox Tularaemia Yellow fever Surveillance for communicable diseases is important… The world population is highly mobile International travel and troop movements increase the risk of communicable disease transmission Forced migration for war and famine, and voluntary immigration increase communicable disease risk Types of Surveillance Passive Inexpensive, provider-initiated Good for monitoring large numbers of typical health events Under-reporting is a problem Active More expensive, Health Department-initiated Good for detecting small numbers of unusual health events Enhanced Rapid reporting and communication between surveillance agencies and stakeholders Best for detecting outbreaks and potentially severe public health problems Syndromic surveillance Allows us to identify groups of signs and symptoms that precede diagnosis and signal a sufficient probability of a case or an outbreak that warrants a further public health response Example: EBOLA VIRUS Sentinel Surveillance Monitors Sites – volcanos Events – 9/11 Providers – ERs Vectors/animals • Rabies • West Nile SENTINEL EVENT Nov 12, 2001 - 9:17 am Flight AA 587 Crashes in Rockaways 7-Zip Surveillance showed: 27 Obs / 10 Exp Resp Emergencies p<0.001 31 Obs / 16 Exp Hospital Events p<0.05 10 /2 5 10 /20 /2 01 7 10 /20 /2 01 9 10 /20 /3 01 1/ 2 11 00 /2 1 /2 11 00 /4 1 /2 11 00 /6 1 /2 11 00 /8 1 11 /20 /1 01 0 11 /20 /1 01 2 11 /20 /1 01 4 11 /20 /1 01 6 11 /20 /1 01 8 11 /20 /2 01 0 11 /20 /2 01 2 11 /20 /2 01 4 11 /20 /2 01 6 11 /20 /2 01 8 11 /20 /3 01 0/ 2 12 00 /2 1 /2 12 00 /4 1 /2 12 00 /6 1 /2 12 00 /8 1 12 /20 /1 01 0 12 /20 /1 01 2 12 /20 /1 01 4 12 /20 /1 01 6 12 /20 /1 01 8/ 20 01 Resp/None Syndromes 40 35 Rockaways 30 Rest of City 25 20 15 10 5 0 Date Investigation Chart review in one hospital (9 cases) Smoke Inhalation (1 case) Atypical Chest Pain / Anxious (2 cases) Shortness of Breath - Psychiatric (1 case) Asthma Exacerbation (3 cases) URI/LRI (2 cases) Checked same-day logs at 2 hospitals Increase not sustained Cipro and Doxycycline Prescriptions 250000 40000 Cipro Doxycycline 35000 200000 30000 25000 First anthrax case reported, 10/4/01. 150000 20000 100000 15000 CDC recommends doxycyline 10/28/01. 9/11 10000 50000 5000 0 7/1/2001 0 7/29/2001 8/26/2001 9/23/2001 10/21/2001 11/18/2001 12/16/2001 1/13/2002 Blood Lead Measurements 1975-1981 110 18 Predicted blood lead 100 Lead used in 90 gasoline (thousands of tons) 80 16 Mean blood lead 14 levels g/dl Gasoline lead 70 Observed blood lead 12 60 50 10 40 30 1975 1976 1977 1978 1979 1980 1981 8 Year Source: Pirkle et al JAMA 272:284-91, 1994 Reported Salmonella Isolates,* United States, 1976-2001 *Data from Public Health Laboratory Information System (PHLIS). Source: CDC. Summary of notifiable diseases. 2001. 8/ 12 / 9/ 20 0 9 10 /20 0 /7 0 11 /20 0 /4 0 12 /20 0 12 /2/2 00 /3 0 0 0 1/ /2 0 0 27 0 2/ /20 0 24 0 3/ /20 1 24 0 4/ /20 1 21 0 5/ /20 1 19 0 6/ /20 1 16 0 1 7/ /20 14 01 8/ /20 11 0 / 1 9/ 20 0 8 10 /20 1 /6 0 11 /20 1 /3 0 12 /20 1 12 /1/2 01 /2 0 0 9 1/ /2 0 1 26 0 2/ /20 1 23 0 3/ /20 2 23 0 4/ /20 2 20 0 5/ /20 2 18 0 6/ /20 2 15 0 2 7/ /20 13 02 /2 00 2 Units per 100,000 prescriptions Tobacco Cessation Aids Sold at a Large Pharmacy Chain $0.39 400 $1.42 increase in City increase in tax State tax 350 300 250 200 150 100 50 0 Week Ending Recent Occupational Monitoring Efforts for Sentinel Events Include… Biodetection Systems (BDS) in NJ post offices to detect anthrax and soon, ricin Biowatch, an air monitoring system in New York City and 30 other cities Free Resources World Health Organization DISMOD Software http://www.who.int/healthinfo/boddismod/en/ Centers for Disease Control Epi Info and Epi Map http://www.cdc.gov/epiinfo/ Good surveillance does not necessarily ensure the making of right decisions, but it reduces the chances of wrong ones. Alexander D. Langmuir NEJM 1963;268:182-191