Table S1. Top 25 of genes expressed 1.5-fold or more (p<0.01) by WC-Co than by CoCl2 in PBMC (15 min).
Gene Name
Description
Function
HMOX1
Systematic
Name
NM_002133
Fold
change
16,00
Heme oxygenase (decycling) 1
Essential enzyme in heme catabolism and strong anti-oxidant
PHLDA3
NM_012396
Pleckstrin homology-like domain, family Involved in extrinsic death receptor pathway, induction of Fas
A, member 3
pathway
VASN
NM_138440
Vasorin.
Type I membrane protein that binds TGF-β and attenuates
TGF-β signaling
4,03
NAP1L2
NM_021963
Nucleosome assembly protein 1-like 2
Participates in DNA replication and contributes to cell
proliferation
3,86
NQO1
NM_000903
NAD(P)H dehydrogenase, quinone 1
Flavoprotein that catalyzes the two electron reduction and
stabilizes p53
3,76
HSPA1A
NM_005345
Heat shock 70kDa protein 1A
Chaperone stabilizing existing proteins and mediating folding of
new translated proteins
3,50
CALCB
NM_000728
Calcitonin-related polypeptide, beta
Reduces Ca2+ levels
3,48
HTRA3
NM_053044
HtrA serine peptidase 3
Serine protease that inhibits TGF-β signalling
3,35
PIR
NM_003662
Pirin (iron-binding nuclear protein)
Fe (II) containing nuclear protein which may act as
transcriptional cofactor and may be involved in regulation of
DNA transcription and replication
3,25
ZFAND2A
NM_182491
Zinc finger, AN1-type domain 2A
Unclear function
2,98
UCHL1
NM_004181
Ubiquitin carboxyl-terminal esterase L1
(ubiquitin thiolesterase)
Protein with hydrolase activity and ligase activity. Involved in
degradation of ubiquitinated proteins
2,92
PSAT1
NM_058179
Phosphoserine aminotransferase 1
Involved in synthesis of phosphoserine
2,85
RGS3
NM_017790
Regulator of G-protein signalling 3
GTPase activating protein which inhibits G-protein mediated
signal transduction
2,81
DNAJB4
NM_007034
DnaJ (Hsp40) homolog, subfamily B,
member 4
Co-chaperone
2,78
6,73
FDXR
NM_024417
Ferredoxin reductase
Flavoprotein that initiates electron transport for cytochrome
P450 and sensitizes cells to oxidative stress induced apoptosis
2,66
GCLM
NM_002061
Glutamate-cysteine ligase, modifier
subunit
First rate limiting enzyme for glutathione synthesis
2,65
TXNRD1
NM_003330
Thioredoxin reductase 1
Pyridine nucleotide oxidoreductase which reduces thioredoxins
and protects against oxidative stress
2,64
SPG3A
NM_015915
Spastic paraplegia 3A (autosomal
dominant)
Unclear function
2,59
RRM2
NM_001034
Ribonucleotide reductase M2
polypeptide
Enzyme controlling the concentration of deoxynucleotides and
which assembles deoxynucleotides into DNA
2,58
GPT2
NM_133443
Glutamic pyruvate transaminase
(alanine aminotransferase) 2
Enzyme responsible for glutamate metabolism
2,55
CTH
NM_001902
Cystathionase (cystathionine gammalyase)
Enzyme involved in cystathionine breakdown
2,52
E2F8
NM_024680
E2F transcription factor 8
Transcription factor involved in cell cycle regulation and DNA
synthesis
2,49
ORC6L
NM_014321
Origin recognition complex, subunit 6
like (yeast)
Member of the complex essential for initiation of DNA
replication
2,49
BRF2
NM_018310
BRF2, subunit of RNA polymerase III
transcription initiation factor, BRF1-like
Subunit of RMA pol II transcription factor complex
2,47
FBXW10
NM_031456
F-box and WD-40 domain protein 10
Protein-ubiquitin ligase
2,42