Entrepreneurial Leadership Academy Fellows 2010-2011 Minou Bina, Chemistry Over ten years ago, Dr. Bina and a colleague developed an inexpensive, miniaturized, rapid DNA sequencing system. She is interested in: (1) identifying strategies to use a miniaturized DNA sequencing system to expand undergraduate science education in the area of biotechnology; and (2) developing the system further for commercialization. Thomas H. Brush, Krannert School of Management Interests for Project: I would like to know more about how established and startup CRO’s (Contract Research Organizations) develop over time as they improve contracting with partners and intend to carry this learning to contracting with other partners. I would like to interview managers in CRO firms involved in the Purdue Research Park who interface with pharmaceutical firms to design contracts and examine the record of past contracts at these firms to determine what they can do differently to benefit from designing better contracts. Barrett Caldwell, Industrial Engineering Barrett is exploring how to improve the opportunities for engaging innovation between companies with identified problems and undergraduates in non-research contexts. Beyond undergraduate research project coordination with specific faculty research grants, there are multiple opportunities for students to participate in emergent real-world projects for class projects, extracurricular activities, and campus outreach. These relationships represent distinct challenges for balancing university IP concerns, the academic mission to educate students in cutting edge areas, and the engagement mission to demonstrate involvement with the economic and social needs of the State. The focus of this project is to create a supportive and dynamic partnership for student "intrapreneurship," or providing innovative solutions to identified needs within existing companies. Daniel DeLaurentis, Aeronautics and Astronautics System of systems can be considered both a way of thinking and a computational modeling approach to answer questions that are asked at the top of the pyramid of aggregation: How to solve a problem or meet a generational challenge that requires many systems, some yet to be designed, and most under control of different owners/operators. SoS is motivated by the recent leaps in the ability for information exchange between systems in aerospace and defense, but also with implications in healthcare, transportation, etc. Purdue researchers have completed considerable research on systems-of-systems and the recently completed College of Engineering Strategic Plan has called for the creation of a System-of-Systems Institute. Dr. DeLaurentis would like to uncover the recent and not-so-recent history of large scale systems research at Purdue and look outside campus to find models for best structure and behavioral features for such an institute and strategies to actualize it. Jennifer Dennis, Horticulture and Landscape Architecture and Agricultural Economics Dr. Dennis would like to obtain the skills to lead a Specialty Crop project center/interdisciplinary team and is also interested in the skills necessary for administrative leadership positions. Jessica Huber, Speech Hearing and Language Sciences Dr. Huber has been developing a wearable device aimed at improving communication in individuals with Parkinson’s Disease. She would like assistance with the commercialization of this technology. She is interested in developing more technologies to behaviorally treat common PD related symptoms, in particular speech, balance, and cognitive issues. She is also interested in how to develop and manage large scale interdisciplinary studies. Chang Kim, Comparative Pathobiology Dr. Kim is interested in establishing a new superresolution-multiphoton imaging facility to enhance the research environment at Purdue university. The activities involve selection of a right instrument, preparation of the space, installation, management planning, and advertisement. Dr. Kim is interested also in enhancing his capabilities to lead interdisciplinary research programs and to increase technology commercialization of products deriving in his lab. Steven Landry, Industrial Engineering Dr. Landry is interested in organizing a "Rapid Deployment Task Force" that would focus on developing lab-to-field military applications based on the most up-todate technology and science within 6-18 months, and that would be tightly integrated with the various branches of the military. For example, he has a concept for a 3D controller that is flight-certifiable and could be used to control UAVs in the field by dismounted soldiers. Such a device, with the proper support and interest, could be fielded in a few months. Sophie Lelièvre, Basic Medical Sciences Dr. Lelièvre is interested in developing an international project on breast cancer prevention research with a global effort to identify the link between diet, the epigenome and breast cancer types and establish a research network across continents. The project was initiated last year when Dr. Lelièvre was an ELA fellow with the task of organizing a first international breast cancer prevention symposium. This symposium took place at Purdue University in October 2011 and brought together potential scientist and public health expert partners from different continents to discuss the organization of the project. The project subsequently received funding from the Global Policy Research Institute at Purdue to develop a framework based on cultural and public policy analyses of countries from different regions of the world. As an ELA scholar, Dr Lelièvre’s goal is to develop the infrastructure and funding plan for the project, possibly as a Center or a part of a Center. Currently the project is under the Oncological Sciences, the Discovery Park arm of the Purdue Center for Cancer Research Omid Nohadani, Industrial Engineering Dr. Nohadani is developing a multi-institutional research group to study cancer radiation therapy at the systems level. Conventional therapy is divided into three independent stages of imaging, planning, and delivery. Dr. Nohadani intends to optimize this process as a whole by connects the stages directly with each other and engineering an adaptive and individualized treatment flow that can benefit the patient care. He is building a team of experts in all three areas. Michael S. Nolan, Aviation Technology Interests for Project: The Aviation Technology department has completed the process of an aircraft fleet replacement program. As part of this project, the department will operate these aircraft using economic models and operations similar to those used by the airlines. Prof. Nolan plans to use this new equipment and direction in a way that encourages and develops entrepreneurial activity in the students enrolled in the undergraduate degree within the department. Prof. Nolan will develop a corporate structure within the department that will enable students to develop their organizational, management and entrepreneurial talents through the operation of a student/faculty operated, corporately structured entity. This entity will focus directly on products and IP that can be used by the industry to enhance both efficiency and safety in the aviation industry while also providing a learning environment for the students enrolled in the program. Suranjan Panigrahi, Electrical and Computer Engineering Technology Dr. Panigrahi’s project is entitled “Linking Invention to Innovation through Entrepreneurship: A Strategic Model for Enhancing Economical Impact of a Research University”. This study will adopt a system-based strategic approach to analyze the current practices among different selected research universities with respect to innovation and commercialization. This study postulates that invention and innovation are different and can be linked via entrepreneurship. Based on literature search and interview of different stakeholders, analysis will be conducted on how to incorporate innovation-based approaches for solving societal problems in a University setting. Focus will be provided on how to train undergraduate and graduate students to be engaged in innovative framework of thinking. A new web-based interactive platform “PIL: Purdue Innovation Link” will be created as one of the platforms for enhancing innovation among students and faculty. This study will help us know more about methods and process of incorporating innovation and creativity in a University setting. PREPP Fellows Hamsa Jaganathan Goal of project: The goal of the PREPP project is to license out the DNA-templated nanoparticle chain technology to interested MRI agent companies. DNA-templated nanoparticle chains serve as an agent to aid in visualizing clearer MRI images. The linear arrangement of magnetic and gold nanoparticles on DNA has exhibited enhanced magnetic relaxation properties that would potentially improve magnetic resonance imaging, and thereby, improve in disease detection. Current focus of work: My current focus of work is to examine the utility of the DNAtemplated nanoparticle chains under tissue environments in MRI. In addition, we are focusing on planning out in vivo experiments in collaboration with IUPUI. Jianming Li: Project description: My work focuses on the development of novel treatments for acute and chronic wounds. Our platform technology uses a patent- pending mechanism for killing bacteria. My goal is to test in vitro properties as well as profile the safety and efficacy of these wound dressings in live animals. Ultimately, my mission is to incorporate this technology into products that are applicable to the clinic. We have formed a startup company and are negotiating with Purdue for a potential licensing agreement. Current focus: Basic research regarding the bactericidal activity and in vivo work with animal models. I’m also performing market research, applying for continued funding and compiling a business plan. Our team (another Ph.D and MBA student) recently competed in the Idea to Product Global competition and received 3rd place. We will be entering in other business plan competitions in the near future. Shaili Sharma: Goal of project: The goal of the research project is to develop a unique fabrication technology that has the ability to align collagen fibers in specific directions. The technology utilizes magnetic fields to engineer scaffolds that can be used for regeneration of tissues that have very precise architecture and spatial arrangements. As a PREPP project the technology is directed to reengineer the stratified architecture seen in articular cartilage in an effort to treat tissue damage seen during osteoarthritis. Current focus of work: In vitro mechanical testing of the three dimensional scaffold to determine mechanical capabilities and compare with scaffolds prepared without aligned collagen fibers. On successful completion of these tests, the scaffold will be used in a pilot animal study. Also, involved in writing a business plan for the Burton Morgan Competition, spelling out the commercialization opportunities for this technology.