Supplement 1: Definition of Post-chemotherapy Adverse Events.
From the date to initiate a chemotherapy regimen to the date of one month later after chemotherapy ends, or from the beginning of chemotherapy to the initiation of next cycle of chemotherapy, if anyone of the following events happens during this period in a given case, we regard that there is a post-chemotherapy adverse event. In addition, it will only be counted once even if a patient has multiple adverse events after a cycle of chemotherapy.
1, Infection : either of the following situations happens: a newly-emerged clinically comfirmed or highly possible infection, and antibiotics, anti-viral or anti-fungal treatment are prescribed; or the previous unresolved pre-chemothearpy infection exacerbates, and a change of anti-infectives or an additional anti-infective agent are implemented.
2, Bleeding: any clinical signs of bleeding, and the transfusion of blood products such as platelets, plasma, cryoprecipitate or other hemostatic drug were prescribed in the clinical.
3, Anemia: a newly emerged anemia or the pre-existing anemia exacerbates, and a transfusion of
RBC is prescribed in the clinical setting.
4, Impaired liver function: either of the following situations happens: serum ALT or bilirubin higher than the upper limit of normal, and a medical intervention is prescribed; or for a case already has liver impairment before a cycle of chemotherapy, serum ALT or bilirubin increase more than twice as high as the basic value after the chemotherapy; or the copy number of HBV-DNA or HCV-RNA increased after chemotherapy, and antiviral treatment is prescribed; or hepatic encephalopathy occurred.
5, Renal dysfunction: either of the following situations happens: serum Ccr level goes above
ULN, and diuretic or water intake restriction is implemented, or serum Ccr increases more than

twice as high as the basic value before chemotherapy and diuretic or water intake restriction is implemented,, or acute renal failure occurred,
6, Cardiac events: either of the following situations happens: Newly emerged acute cardiac insufficiency and a medical intervention is prescribed for the treatment; or a pre-existing cardiac dysfunction aggravates and a medical intervention is prescribed for the treatment; or newly emerged atrial fibrillation and a medical intervention is prescribed for the treatment; or the pre-existing atrial fibrillation became a rapid ventricular rate type of atrial fibrillation and a medical intervention is prescribed for the treatment; or a newly emerged paroxysmal supraventricular tachycardia, and a medical intervention is prescribed for the treatment.
7, Nervous system events: new onset of ischemic stroke, and medical intervention is implemented for the treatment. Intracranial lesion results from hematological malignancies invasion is excluded as an adverse event.
8, Respiratory events: newly emerged dyspnea, which is not relative to cardiac dysfunction, and a medical intervention such as ventilation, bronchodilators, steroids, etc. is needed for the treatment.
9, Mucositis occurs on digestive tract and/or urogenital tract, and needed a medical intervention for the treatment.
10, For a case that a planed chemotherapeutic regimen ceases prematurely because of a severe adverse event, it is still regarded as the effective data in our study.