Supplementary Electronic File I. Control variables and summary statistics Table A1 Definition of Control Variables Variable Coding Age =Child’s age Number of children categories 2 children =1 if the number of children below age of 18 in the household is 2. 3 or more children =1 if the number of children below age of 18 in the household is 3 or more. Mother’s age categories Mother below 34 =1 if mother’s age is below 34 Mother below 44 =1 if mother’s age is below 44 and above 34 and above 34 Race/Ethnicity Hispanic =1 if the child is Hispanic Black =1 if the child is Black Income =1 if the household annual income is above 20,000$ Mother’s marital status =1 if mother is currently married Mother’s education =1 if mother has 13 years of education or more People in the household =Number of people in the household Health insurance status Private =1 if person holds employer or union provided health insurance. Public =1 if person Medicaid, S-CHIP, or American-Indian health insurance. Military =1 if person holds TRICARE, CHAMPUS, or CHAMPUS-VA. =1 if there is any period of the time after age 11 that teen did not have any No Insurance Since 11 health insurance coverage No doctor visit last year =1 if person has not visited a doctor in the past 12 months =1 if teen has already lung condition rather than asthma, heart condition, diabetes, a kidney condition, sick cell anemia or other anemia, weakened Teen health status immune system because of chronic illness or caused by medicine taken by chronic illness =1 if any other members of teen’s household have lung condition rather than asthma, heart condition, diabetes, a kidney condition, sick cell anemia Household health status or other anemia, weakened immune system because of chronic illness or caused by medicine taken by chronic illness Tdap uptake status =1 if teen has had at least one shot of Tdap since age 10 years Table A2 Summary Statistics Physician recommendation 0.537 (0.499) Education for parents state 0.519 (0.500) Age 14.972 (1.387) 14.997 (1.393) 15.004 (1.394) 0.498 (0.500) 0.069 (0.253) 0.510 (0.500) 0.096 (0.295) 0.502 (0.500) 0.095 (0.293) 0.074 (0.262) 0.354 (0.478) 0.0794 (0.270) 0.430 (0.495) 0.0759 (0.264) 0.429 (0.495) 0.066 (0.248) 0.378 (0.485) 0.226 (0.418) 0.135 (0.341) 0.108 (0.311) 0.096 (0.295) 0.857 (0.350) 0.846 (0.361) 0.883 (0.321) 0.545 (0.498) 0.718 (0.450) 0.628 (0.483) 0.686 (0.464) 0.620 (0.485) 0.705 (0.456) 4.057 (1.305) 4.285 (1.262) 4.251 (1.274) 0.299 (0.458) 0.073 (0.260) 0.045 (0.208) 0.115 (0.319) 0.315 (0.464) 0.0471 (0.212) 0.083 (0.275) 0.160 (0.367) 0.289 (0.453) 0.054 (0.227) 0.078 (0.268) 0.155 (0.362) 0.039 (0.195) 0.335 (0.472) 0.037 (0.190) 0.340 (0.474) 0.037 (0.189) 0.343 (0.475) 0.618 (0.486) 0.626 (0.484) 0.607 (0.488) School mandate states 2 children 3 or more children Mother below 34 Mother below 44 and above 34 Hispanic Black Income Mother’s marital status Mother’s education People in the household Public health insurance Military health insurance No Insurance Since 11 No doctor visit last year Teen health status Household health status Tdap uptake status 1 Other state 0.539 (0.498) II. Robustness of policy effects We want to be sure that null effects of existing policies is a fair conclusion, so we engage in several robustness checks in Table A3. First, the strong impact of physician recommendations might be attenuating the impact of the policies if those recommendations are more likely in states with mandates and educational programs than those in our control group. In panel A, we remove the recommendation variable as a control and find that there is still no discernable effect of either policy. In fact, the effects weaken. In panel B, we combine school mandates and education for parents, considering it as one policy to promote HPV vaccination. In the case of DC, the policies were concurrent so this is sensible. School entry requirements for HPV vaccines in Virginia are also not strict, and they offer a very liberal opt out. As a result, one might expect that school mandates would only affect the vaccine decision through the educational content they provide anyway. Regardless, there is no impact in considering both policies together. As a next attempt to assess policies, we note that using the entire set of states that failed to enact a policy as control states is problematic if those states that focus on HPV are simply more health conscious to begin with and perhaps more likely to promote HPV both before and after official policy enactment. We test for this by limiting our control group to only those states that at least introduced a state mandate that ultimately failed. It is these states that are likely more comparable prior to the enactment of the vaccine. In panel C, we see that for at least initiation of the vaccine, the results are more promising. However, it is only education for parents that is a significant predictor of vaccine take-up and even this effect does not hold for vaccine completion. Moreover, the effect is essentially zero for the 13 and under targeted group. We cautiously note here that this provides some support for educational material as a policy to at 2 least initiate the vaccine sequence but again cannot see any meaningful support for school mandates. Only two jurisdictions had a school mandate. We focus on Virginia and more systematically assess the impact of that state’s school mandate through a synthetic control approach. The synthetic control method is a data-driven procedure that provides a single control unit as a weighted average of characteristics of several potential comparison units. The weights determine the relative contribution of each control unit to the counterfactual of interest. Despite the many benefits, this method is designed for aggregate level panel data while we are using an individual level repeated cross section database. However, the Center for Disease Control and Prevention utilizes the same individual level database in order to estimate the HPV vaccination rate among girls between 13-17 years old. We use the data on vaccination rate, along with aggregate state level data on different characteristics to build our synthetic group and obtain the weights. Then, we use these weights in the basic specification to estimate the effect of school mandates.1 Panel D presents these results and again show no influence of the Virginia school mandates. Finally, only Missouri and DC enacted their educational programs for parents after 2008. For that reason, we engage in a final test where we repeat the synthetic control approach to identify the effect of educational programs for parents. We drop all the jurisdictions that either 1 The synthetic control is created by matching on the unemployment rate, median income, the relative percentage of urban population, the relative percentage of Hispanic population, the relative percentage of Black population, population density, the percentage of the female population above age 25 with a bachelor degree or higher, the percentage of the under age 18 population with public health insurance plans, and the percentage of married households. The weights yielded by this approach indicate that vaccination rate trends in Virginia prior to enactment of school mandate is best reproduced by a combination of Alaska (1.7%), Maryland (61.1%), Minnesota (7.7%), North Dakota (7.2%), and Utah (21.8%). 3 enacted school mandates, or enacted their educational programs for parents before 2008.2 Panel E presents these results. Education for parents is a significant predictor of vaccine initiation and this effect does not hold for vaccine completion. Table A3 Robustness Checks on policy impacts- Marginal effects from probit models Vaccine Initiation VARIABLES (1) Panel A-Robustness Check for Multi-collinearity School mandates 0.0252 (0.0410) Education for parents 0.0282 (0.0203) Vaccine Completion (2) Uptake Before Age 13 (3) 0.0369 (0.0386) 0.0175 (0.0327) 0.0053 (0.0184) -0.0196 (0.0203) Observations 35,624 35,624 Panel B- Consider School Mandates and Educational Programs Together as HPV promotion HPV vaccine promotion Observations 0.0278 (0.0194) 0.0096 (0.0177) -0.0109 (0.0196) 35,624 35,624 25,799 Panel C- Using As Control Groups Only Those States that Introduced a Mandate School mandate 0.0595 0.0516 (0.0426) (0.0405) Education for parents 0.0907*** (0.0312) Observations 17,758 Panel D- Synthetic control for School Mandate in Virginia School mandate 0.0296 (0.0672) Observations 3,562 Panel E- Synthetic control for education for parents in Missouri Education for parents 25,799 0.0736* (0.0442) 0.0244 (0.0347) 0.0463 (0.0294) -0.0082 (0.0297) 17,758 13,060 0.0269 (0.0621) -0.0225 (0.0402) 3,562 2,578 0.0325 (0.0383) 0.0249 (0.0421) Observations 5,350 5,350 3,774 Note: Regressions include state and year fixed effects as well as the interactions of age and year. The numbers in parenthesis are robust standard errors. *** p<0.01, ** p<0.05, * p<0.1 2 Synthetic of Missouri is the combination of Alabama (22.4%), Alaska (12.6%), Hawaii (15.1%), Kentucky (7.8%), Montana (14.6%), Ohio (12.6%), South Carolina (3.2%), and Tennessee (11.7%). 4