Quantitative Comparison of the Accuracy Between the OLAM ContinuousTracking Device and Commercial Monitoring Shannon Cahill-Weisser Mentor: Dr. Patrick Chiang Department of Electrical Engineering and Computer Science Oregon State University http://ase.iha.dk/Default.aspx?ID=9944 Why Make Vital Signs Monitors Wearable? One third of physicians make decisions with incomplete information. [1] In General... • Assists diagnosis/prognosis • Can indicate specific events • Promotes patient independence [1] PricewaterhouseCoopers’ Health Research Institute, 2011 [2] Hayes, et al., 2008 [2] What Doctors Want in Monitoring Digestive Health Acid Reflux/Indigestion Bladder Control Cardiac Rhythms Sleep Patterns Pain Level Caloric Intake Exercise/Physical Activity Vital Signs Blood Sugar Weight 0 10 20 30 40 Percent of Doctors Surveyed Based on PricewaterhouseCoopers Health Research Institute Physician Survey, 2010 50 60 70 Why Make Vital Signs Monitors Wearable? Specific Examples... Activity: • Energy expenditure [1] • Gait velocity to predict cognitive impairment [2] Electrocardiogram: 2006: 36.3% of Americans have heart disease [3] Contextual vs. clinical measurement [1] Chen et. al., 2005 [2] Buracchio et. al., 2010 [3] CDC, 2009 Linus Pauling Institute Collaboration •OLAM worn to study effects of micronutrient •Worn by 10 subjects in an 6 week trial •Study conducted with lab of Dr. Tory Hagen Albright, Goska, Hagen, Chi, Cauwenberghs, and Chiang EMBS Conference, 2011 Project Plan Objective: Evaluate performance of ECG against pulse oximeter Compare activity data to commercial monitor data Apply analysis to LPI study data Hypothesis: Activity data will be comparable to commercial sensing. ECG data will contain motion artifact. Considerations for Any Wearable Monitor Biocompatibility Durability Efficiency Data Quality Signal to noise ratio Particularly motion induced artefact Considerations for the OLAM OLAM [1] GT3X+ [2] ActiTrainer [3] Sensor Variety ECG, accelerometer, gyroscope Accelerometer, light sensor ECG accessory, accelerometer, light sensor Battery Life 15 days min. 31 days 7-14 days Memory 2 GB 512 MB 4 MB Rate/Sensitivity 100 Hz/ ±2-8 g 30-100 Hz/ ±6g 30 Hz/ ±3g Mounting Over or under Chest belt Polar heart strap [1] Albright, Goska, Hagen, Chi, Cauwenberghs, and Chiang EMBS Conference, 2011 [2] http://www.theactigraph.com/products/gt3x-plus/ [3] http://www.theactigraph.com/products/actitrainer/ Sampling and Analysis Block Diagram 3-D ADXL345 MEMS Accelerometer Capacitive ECG Sensor 100 Hz Sampling, 5 sec per minute MATLAB 2.5 Hz Low Pass Filter 0.25 Hz High Pass Filter Obtain and compare counts over minutes and hours Albright, Goska, Hagen, Chi, Cauwenberghs, and Chiang EMBS Conference, 2011 Counting Method SAMPLING SAMPLING sleep sleep 5 sec 54.5 sec 1. Average accelerometer magnitudes over number of samples. These are “counts”. 2. Add counts for desired time period. 3. Analysis code written to “window” continuous GT3X+ data. Albright, Goska, Hagen, Chi, Cauwenberghs, and Chiang EMBS Conference, 2011 Count Sum (gs) Comparison Between OLAM and ActiGraph GT3X+ OLAM 80 60 GT3X-plus 40 OLAM Filtered 20 0 1 2 3 4 5 GT3X-plus Filtered "Hours" (set of 66 minute-count sums) Hour Counts Minute Counts μ Difference (%), Unfiltered 6.92 7.84 σ Difference (%), Unfiltered 4.00 3.52 μ Difference (%), Filtered 5.67 315.79 σ Difference (%) Filtered 5.05 1072.05 • Agreement good in unfiltered and hourly data • Error high in filtered minute data • Sources: reaction time, window matching, extrapolation 1 11 21 31 41 51 61 71 81 91 101 111 121 131 141 151 161 171 181 191 201 211 221 231 241 251 261 271 281 291 301 311 321 331 341 351 361 371 381 391 401 411 421 Counts (g's) Comparison of "Minute" Scale Counts 0.5 0.45 0.4 0.35 Olam Filtered 0.3 0.25 GT3X+ Filtered 0.2 0.15 0.1 0.05 0 Epoch Number Stationary Walking on bench Working at Computer Heart Rate Data Taped to Skin In Belt Over Shirt Heart Data OLAM Pulse Ox. Absolute Difference 72 77 5.0 72 77 5.0 72 82 10. 72 88 16. 96 87 9.0 [1] • Compared to Crucial Medical Systems pulse oximeter • Avg. Difference: 9.0 bpm, Stdev: 4.5 bpm • Indicates higher sensitivity to cycling [1] http://www.crucialmedicalsystems.com/oled-cms50c-fingertip-pulse-oximeter-andoxygen-meter-p-220.html Conclusions 1. Duty-cycled activity data agrees highly with commercial data on an hourly scale. 2. Heart data is more sensitive to duty-cycle length. 3. Further post-processing is necessary to obtain accurate heart-rate data. References “Healthcare Unwired: New Business Models Delivering Care Anywhere” [Online], PricewaterhouseCoopers’ Health Research Institute, 2010, Available at: http://www.lindsayresnick.com/Resource_Links/Healthcare_Unwired.pdf, Accessed Sept 12, 2011. T. Buracchio, H.H. Dodge, D. Howieson, D. Wasserman, and J. Kaye, "The Trajectory of Gait Speed Preceding Mild Cognitive Impairment", Arch Neurol., 2010; 67(8):980-986. T. Hayes, M. Pavel, and J. Kaye, "An Approach for Deriving Continuous Health Assessment Indicators from In-Home Sensor Data" in Selected Papers from the 2007 International Conference on Technology and Aging, IOS Press, Amsterdam, Netherlands, 2008. US Census Bureau, State & County Quickfacts [Online], Available from: (http://quickfacts.census.gov/qfd/states/00000.html , Accessed: Feb. 24, 2011. American Heart Association, American Heart Disease and Stroke Statistics―2009 Update At-A-Glance (http://www.americanheart.org/presenter.jhtml?identifier=3037327), Accessed Feb. 24, 2011. R.K. Albright, B.J. Goska, T.M. Hagen, M.Y. Chi, G. Cauwenberghs, and P. Y. Chiang, “OLAM: A Wearable, Non-Contact Sensor for Continuous Heart-Rate and Activity Monitoring,” accepted, IEEE Engineering in Medicine and Biology Conference, 2011. ActiGraph, ActiTrainer Activity Monitor [Online], Available at: http://www.theactigraph.com/products/actitrainer/. Accessed: Sept 12, 2011. ActiGraph, ActiGraph GT3X+ Monitor [Online], Available at: www.theactigraph.com/wpcontent/uploads/ActiGraphCT3X+Specs.pdf, Accessed: Sept, 2011. K.Y. Chen, and D.R. Bassett, Jr., “The Technology of Accelerometry-Based Activity Monitors: Current and Future,” Medicine & Science in Sports & Exercise, American College of Sports Medicine, Indianapolis, IN, pp. S490-S500, 2005. Bonomi, A. G. Bonomi and K. R. , “Advances in physical activity monitoring and lifestyle interventions in obesity: a review.”, International Journal of Obesity, 1-11, 2011. MORE UPON REQUEST Acknowledgements • HHMI and URISC • Dr. Patrick Chiang • Dr. Stewart Trost • Ben Goska, Ryan Albright, Samuel House, Sean Connell, Daniel Austin, and Robert Pawlowski • The lab of Dr. Tory Hagen