Minnesota Department of Health Tuberculosis Prevention and Control Program (651) 201-5414 Tuberculosis surveillance data for Minnesota are available on the Web at: www.health.state.mn.us/tb Year 2010 No. Cases 135 Rate* 2.5 2011 2012 2013 2014 137 162 151 147 2.6 3.0 2.8 2.7 * Cases per 100,000 population. Rates were calculated using state population estimates from the U.S. Census Bureau. Year of Diagnosis Percentage of Cases Year 2010 2011 No. Cases 135 137 No. Deaths* (%) 3 (2%) 9 (7%) 2012 2013 2014 162 151 147 4 (2%) 2 (1%) 3 (2%) *Represents only deaths due to TB disease or TB drug-induced toxicity Location of Residence 2010 No. (rate)* 2011 No. (rate)* 2012 No. (rate)* 2013 2014 No. (rate)* No. (rate)* Hennepin County 67 (5.8) 59 (5.0) 71 (6.1) 51 (4.3) 51 (4.3) Ramsey County 34 (6.7) 31 (6.0) 39 (7.6) 39 (7.5) 26 (4.9) Suburban Twin Cities Metro† 16 (1.3) 12 (0.7) 27 (2.2) 20 (1.6) 24 (2.0) Olmsted County 6 (4.2) 9 (6.2) 3 (2.1) 10 (6.8) 16 (10.7) Other counties 12 (0.5) 26 (1.1) 22 (1.0) 31 (1.3) 30 (1.3) Total 135 (2.5) 137 (2.6) 162 (3.0) 151 (2.8) 147 (2.7) * Rate per 100,000 population. Rates were calculated using population estimates from U.S. Census Bureau data. † Anoka, Carver, Dakota, Scott, and Washington counties Location of Residence 2010 No. (rate)* 2011 No. (rate)* 2012 No. (rate)* Hennepin County 67 (50) 59 (43) 71 (44) 51 (34) 51 (35) Ramsey County 34 (25) 31 (22) 39 (24) 39 (26) 26 (18) Suburban Twin Cities Metro† 16 (12) 12 ( 9) 27 (17) 20 (13) 24 (16) Olmsted County 6 ( 4) 9 ( 7) 3 ( 2) 10 ( 7) 16 (11) Other counties 12 ( 9) 26 (19) 22 (13) 31 (21) 30 (20) 135 (100) 137 (100) 162 (100) 151 (100) 147 (100) Total 2013 2014 No. (rate)* No. (rate)* * Rate per 100,000 population. Rates were calculated using population estimates from U.S. Census Bureau data. † Anoka, Carver, Dakota, Scott, and Washington counties Hennepin: 51 Ramsey: 26 Suburban metro: 24 Greater MN: 46 Total: 147 Hennepin: 299 Ramsey: 169 Suburban metro: 99 Greater MN: 165 Total: 732 Place of Birth Percentage of Cases N = 732 Cases per 100,000 † * Race categories do not include persons of Hispanic/Latino origin. † Rates were calculated using population estimates from the U.S. Census Bureau. ** The 2014 patient with multiple races is not represented in this graph. Race / Ethnicity* Foreign-Born Cases No. (%) U.S.-Born Cases† No. (%) White 15 (2) 59 (42) Black 308 (52) 35 (25) Asian 211 (36) 14 (10) Native American / Alaska Native 0 17 (12) Multi-racial 0 1 (<1) 59 (10) 13 (9) 593 (100) 139 (100) Hispanic/Latino Total *Race categories do not include persons of Hispanic/Latino origin. †Includes U.S.-born children of foreign-born parents Risk Category* 2010 (N=135) No. (%) 2011 (N=137) No. (%) 2012 (N=162) No. (%) 2013 (N=151) No. (%) 2014 (N=147) No. (%) Cumulative (N=732) No. (%) Foreign-born 110 (81) 116 (85) 136 (84) 123 (81) 108 (73) 593 (81) Substance abuse† 7 (5) 7 (5) 7 (4) 9 (6) 7 (5) 37 (5) Homeless 3 (2) 2 (1) 2 (1) 4 (3) 7 (5) 18 (2) HIV-infected 6 (4) 3 (2) 6 (4) 4 (3) 4 (3) 23 (3) 23 (17) 27 (20) 20 (12) 35 (23) 37 (25) 142 (19) Incarcerated 4 (3) 2 (1) 0 (0) 0 (0) 1 (1) 7 (1) Long-term care resident 3 (2) 2 (1) 1 (1) 2 (1) 0 (0) 8 (1) Other medical condition** * Risk categories are not mutually exclusive Alcohol abuse and/or illicit drug use ** Conditions or therapies that increase risk for progression from latent TB infection to active TB disease, not including HIV/AIDS † N=732 * Risk categories are not mutually exclusive † Alcohol abuse and/or illicit drug use ** Conditions or therapies that increase risk for progression from latent TB infection to active TB disease, not including HIV/AIDS Medical conditions** Cases (N=732) No. (%) Diabetes 81 (11) End stage renal disease 19 (3) Weight loss/undernutrition/malabsorption 6 (1) Other: silicosis, hematologic disease 3 (<1) Other immunosuppressive condition or immunosuppressive therapy*** 56 (8) *Conditions or therapies that increase risk for progression from latent TB infection to active TB disease, not including HIV/AIDS **Patients could have > 1 medical condition ***Includes TNF α antagonist therapy and post-organ transplantation * Risk categories are not mutually exclusive ** Conditions or therapies risk for progression to active TB disease, not HIV † Alcohol abuse and/or illicit drug use Foreign-Born Cases No. (%) U.S.-Born Cases No. (%) Total No. (%) Negative 546 (92) 126 (91) 672 (92) Positive 21 (4) 2 (1) 23 (3) Refused 4 (1) 2 (1) 6 (1) Not Offered 22 (4) 9 (6) 31 (4) 593 (100) 139 (100) 732 (100) HIV Status Total Percent co-infected No. of TBHIV cases in MN: 2005 – 12 2006 – 8 2007 – 12 2008 – 11 2009 – 7 2010 – 6 2011 – 3 2012 – 6 2013 – 4 2014 – 4 No. of eligible TB cases* Percent of eligible TB cases with HIV result * Alive at diagnosis School/Setting No. (%) Preschool 2 (<1) Elementary 36 (5) Secondary 31 (4) Post-secondary 51 (7) Other* 52 (7) None 560 (77) Total 732 (100) *Includes: daycare, ESL/ELL, and other schools Number of Cases Year * “Other” includes: Eastern Europe, North Africa/Middle East, and Western Europe Number of Cases Region of Birth * “Other” includes: Eastern Europe, North Africa/Middle East, and Western Europe N = 593 N = 593 N = 71 * Per results of pre-immigration screening performed overseas N = 593 % of foreign-born cases N= 175 203 155 129 110 116 136 123 108 Technical instructions for overseas exams revised N = 732 * Includes cases with or without concurrent pulmonary disease Site of disease** Cases (N=356) No. (%) Lymphatic 192 (54) Musculoskeletal 51 (14) Pleural 40 (11) Peritoneal 22 (6) Genitourinary 14 (4) Brain 14 (4) Meningeal 11 (3) Other 26 (7) * Includes TB cases with or without concurrent pulmonary disease ** Patients may have multiple extrapulmonary sites of disease N = 460 * From initial chest x-ray or chest CT scan N = 460 *53% of pulmonary cases without sputum smear results were under 15 years of age N = 732 N = 732 *Based on the public health surveillance definition for TB [CDC. (2009, June) CDC Tuberculosis Surveillance Data Training: Report of Verified Case of Tuberculosis (RVCT) Instruction Manual. Atlanta, GA: U.S. Department of Health and Human Services, CDC. (Appendix A - Tuberculosis Case Definition for Public Health Surveillance)] Year Cases With Susceptibility Results* Any Drug Resistance† No. (%) INHResistant** No. (%) MDR-TB‡ No. (%) 2010 109 13 (12) 5 (5) 0 (0) 2011 101 22 (22) 12 (12) 3 (3) 2012 124 23 (19) 12 (10) 1 (1) 2013 113 24 (21) 13 (21) 0 (0) 2014 105 25 (24) 19 (18) 1 (1) Total 552 107 (19) 61 (11) 5 (1) * Culture-confirmed cases with drug susceptibility results available † Resistance to at least one first-line anti-TB drug [i.e., isoniazid (INH), rifampin, pyrazinamide (PZA), or ethambutol] ** INH-resistant cases may also be resistant to other drugs ‡ Multi-drug resistant TB, defined as resistance to at least INH and rifampin Place of birth Cases With Any Drug Susceptibility Resistance† Results* No. (%) INHResistant** No. (%) MDR-TB‡ No. (%) Foreign-Born Cases 456 94 (21) 53 (12) 4 (1) U.S.-Born Cases 96 13 (14) 8 (8) 1 (1) Total 552 107 (19) 61 (11) 5 (1) * Culture-confirmed cases with drug susceptibility results available † Resistance to at least one first-line anti-TB drug [i.e., isoniazid (INH), rifampin, pyrazinamide (PZA), or ethambutol] ** INH-resistant cases may also be resistant to other drugs ‡ Multi-drug resistant TB, defined as resistance to at least INH and rifampin N = 732 Overseas TB class follow-up 2% * “Other” includes: other immigration exam – 1.3%, and employment screening (including health care worker screening) – 1.6% 90% 90% N=722 Type of provider * DOT = Directly Observed Therapy started on treatment Year Started Treatment* Completed Within 12 mos.** No. (%) Completed Overall** No. (%) 2010 116 105 (91) 115 (99) 2011 101 96 (95) 97 (96) 2012 133 127 (95) 130 (98) 2013 125 116 (93) 123 (98) Total 475 444 (93) 465 (98) * Patients for whom < 12 months of therapy is indicated. This excludes: patients with rifampin resistance, meningeal TB, TB in bone or skeletal system, TB in CNS, children 14 years of age or younger with disseminated TB, patients who died or moved out of US within 366 days of starting treatment. ** Treatment completion data as of 9/14/2015 * Some patients are managed by multiple providers throughout disease course