Intercalation opportunities for external students available at the University of Exeter Academic Year 2016-2017 Note: All information in the document below is correct at the time of writing but students are strongly advised to verify all information with the appropriate course convenor before enrolling. It is a student’s responsibility to be clear on the final title of the award, prior to enrolling on the programme. Students who wish to use their award for F1 application points will need to be aware that the degree must be ratified by the Exam Board and a degree certificate OR degree confirmation letter provided by the institution must be uploaded by the close of application deadline in October (please refer to the FP/AFP Applicant’s Handbook which can be found on the Foundation Programme website at: http://www.foundationprogramme.nhs.uk/) With a few exceptions, the University of Exeter will consider students for intercalation on to any of its courses on a case-by-case basis, provided all academic prerequisites are met. Click here for a link to the entire undergraduate course catalogue. If you are interested in a course that is not listed below please contact the University of Exeter Intercalated Degrees Lead, Dr Kate Ellacott (ICD@exeter.ac.uk), to discuss your interests before contacting any course convenor directly. 1|Page Table of Contents 1. 2. Bachelor’s Degree programmes ......................................................................................................................4 1.1. BSc (Hons) Intercalated Biosciences .................................................................................................................... 4 1.2. BSc (Hons) Intercalated Exercise & Sports Science ........................................................................................ 5 1.3. BA or BSc (Hons) Intercalated Flexible Combined Honours (FCH) ......................................................... 6 1.4. BA (Hons) Intercalated Medical Humanities (via Flexible Combined Honours) ................................ 7 1.5. BSc (Hons) Intercalated Human Biosciences .................................................................................................... 9 1.6. BSc (Hons) Intercalated Infectious Disease .................................................................................................... 10 1.7. BSc (Hons) Intercalated Medical Sciences ....................................................................................................... 11 1.8. BSc (Hons) Intercalated Molecular & Cellular Science ............................................................................... 12 1.9. BSc (Hons) Intercalated Psychological Studies ............................................................................................. 13 Master’s Degree Programmes ....................................................................................................................... 15 2.1. MSc Applied Health Services Research ............................................................................................................. 15 2.2. MSc Bioarchaeology .................................................................................................................................................. 17 2.3. MSc by Research Biosciences ................................................................................................................................ 19 2.4. MSc Environment & Human Health (Cornwall) ............................................................................................ 20 2.5. MRes Health and Wellbeing ................................................................................................................................... 21 2.6. MSc by Research Medical Imaging ...................................................................................................................... 22 2.7. MSc by Research Medical Studies........................................................................................................................ 23 2.8. MSc Paediatric Exercise and Health ................................................................................................................... 24 2.9. MSc Sports & Health Sciences ............................................................................................................................... 25 2.10. MSc by Research Sport & Health Sciences ....................................................................................................... 26 2.11. MSc International Management .............................................................................................................................. 27 3. MSc by Research – Portfolio of Available Projects 2016-2017 .......................................................... 29 3.1. MSc by Research Medical Studies – Diabetes, Cardiovascular risk and Aging.......................... 30 3.1.1. Functional Characterisation of Genes Involved in Type 2 Diabetes ..................................................... 30 3.1.2. Role of STAT signalling in the regulation of pancreatic beta-cell viability ........................................ 31 3.1.3. Persistent enteroviral infection as a mechanism promoting islet autoimmunity in type 1 diabetes......................................................................................................................................................................................... 32 3.1.4. Glucagon and glucose lowering therapy in type 2 diabetes ..................................................................... 33 3.1.5. Predicting response to treatment in Type 2 diabetes ................................................................................. 34 3.1.6. Pathogenesis and prediction of rapid progression to insulin requirement in Type 2 diabetes 35 3.2. MSc by Research Medical Studies – Neuroscience and Mental Health ...................................... 36 3.2.1. Systematic Review of medication adherence in children with attention-deficit/hyperactivity disorder ........................................................................................................................................................................................ 36 2|Page 3.3. MSc by Research Medical Studies – Environment and Human Health .......................................... 37 3.3.1. Antimicrobial resistance: a global issue, requiring cross-disciplinary research ............................. 37 3.3.2. Stress, sleep and the symptoms of Meniere’s disease................................................................................. 38 3.3.3. Do pollen levels influence symptom severity in Meniere’s disease? .................................................... 39 3.3.4. Dust inhalation and the risk of rheumatoid arthritis .................................................................................. 40 3.4. MSc by Research Medical Studies – Health Services Research .......................................................... 41 3.4.1. How can medical clinical-academic practice be informed by ‘engaged scholarship’? .................. 41 3.4.2. Accelerating the diffusion of innovations in acute medical practice: How can Normalisation Process Theory inform diffusion strategies? ................................................................................................................ 42 3.4.3. Accelerating the diffusion of innovations in public health: How can Normalisation Process Theory inform diffusion strategies? ................................................................................................................................. 43 3.4.4. Accelerating the diffusion of innovations in surgical practice: How can Normalisation Process Theory inform diffusion strategies? ................................................................................................................................. 44 3.5. MSc by Research Medical Studies – Medical Education......................................................................... 45 3.5.1. How might we improve the preparedness of new medical graduates for medical practice? .... 45 3.6. MSc by Research Biological Sciences – Environmental Biology ........................................................ 46 3.6.1. Colour Change and Metabolics of Chameleon Prawns................................................................................ 46 3.6.2. Effects of Colour Change and Rearing Conditions on Lobster Release Success ............................... 47 3.6.3. Ageing in its natural context .................................................................................................................................. 48 3.6.4. Citizen Science – real research by real people ............................................................................................... 49 3|Page 1. Bachelor’s Degree programmes 1.1. BSc (Hons) Intercalated Biosciences Contact: Dr. Helen Dawe (H.R.Dawe@exeter.ac.uk) Description: In this broad programme you will be able to explore diverse aspects of the fundamental molecular and cellular biology that underpins many of our recent advances in the treatment of disease. You will have the opportunity to consider how drugs are discovered and subsequently modified to achieve a better therapeutic outcome, how the immune system protects itself again pathogens and how they in turn pathogens (bacterial and fungal) adapt and defend themselves in response to host defences and drug therapy. You will be able to examine how science is conducted through practical investigation and look at how science is communicated to both specialist and lay audiences. The programme provides access to our specialist modules delivered to students in the second or final year of our three year undergraduate programmes. Many of these are seminar modules which provide valuable new perspectives to topics you may already have completed as part of your main programme of study, allowing you to explore complementary areas in greater detail. Modules: The following table describes the programme and constituent modules. Constituent modules may be updated, deleted or replaced as a consequence of the annual programme review of this programme. The following list should be considered as indicative rather than definitive. You may take optional modules as long as any necessary prerequisites have been satisfied, where the timetable allows and if you have not already taken the module in question or an equivalent module. Details of the modules may be http://biosciences.exeter.ac.uk/current/modules/ obtained from the College website: 45 credits of compulsory modules, 75 credits of optional modules Code Title Credits Compulsory Noncondonable BIO3096 Biosciences Research Project 45 Yes Yes BIO2066 Forensic Science 15 No No BIO3041 Pharmacology and Medicinal Chemistry 15 No No BIO3077 Frontiers in Molecular Cell Biology 15 No No BIO3078 Cellular Basis of Immunity 15 No No BIO3079 Molecular Basis of Infection 15 No No BIO3080 Microbial Effectors of Disease 15 No No BIO3082 Science Communication 15 No No BIO3085 Horizons of Biochemical Research 15 No No BIO3086 Cell Biology of Disease 15 No No BIO3091 Animal Developmental Biology 15 No No PAM2901 Medical Imaging: Principals and Applications 15 No No PHL3018 Sex and death 15 No No 4|Page 1.2. BSc (Hons) Intercalated Exercise & Sports Science Contact: Alison Hume (A.Hume@exeter.ac.uk) Description: The programme is designed to give you a balanced understanding of both sport and exercise sciences across the range of sub-disciplines. This is delivered through learning about the psychology, physiology and biomechanics of sport and exercise, with a focus on research. Optional modules reflect the application of this scientific knowledge in a variety of populations from athletes, to children and the general public. Alongside the subject specific knowledge, there is also a commitment to enhancing your learning and personal development skills. Modules: The following table describes the programme and constituent modules. Constituent modules may be updated, deleted or replaced as a consequence of the annual programme review of this programme. You may take optional modules as long as any necessary prerequisites have been satisfied, where the timetable allows and if you have not already taken the module in question or an equivalent module. Details of the modules currently offered http://sshs.exeter.ac.uk/students/modules/ may be obtained from the College website: 15-45 credits of compulsory modules, 75-105 credits of optional modules (subject to an overall total of 120 credits) NonCode Title Credits Compulsory condonable a ESS3302a Dissertation 45 Yes Yes ESS3303a Independent Research Review 15 Yes No ESS2900 Employability and Career Development 15 No No ESS3703 Paediatric Exercise Physiology 15 No No ESS3705 Sport, Physical Activity and Health 15 No No ESS3706 Integrated Physiology and Adaptation to Physical (in)activity 15 No No ESS3707 Physiological Determinants of Exercise Performance 15 No No ESS3804 Clinical Exercise Prescription 30 No No ESS3805 Biomechanical Analysis of Human Movement 30 No No ESS3808 Sport Psychology 30 No No You must choose one of ESS3302 or ESS3303. 5|Page 1.3. BA or BSc (Hons) Intercalated Flexible Combined Honours (FCH) Contact: Dr Mike Dobson (FCH@exeter.ac.uk) or call 01392 725270 Description: Intercalated Flexible Combined Honours (iFCH) gives you the freedom to explore two (or more) subjects during your Intercalated year. You can study them in a very flexible manner and customise your degree programme to match your personal interests, making it distinctive and different. The degree offers you the widest possible access to modules from range of subject disciplines. Uniquely, you can also create your own subject by combining related modules from across departments; to produce what is called a ‘themed pathway’. Examples that may be of particular interest to medical students include “Medical Humanities”, “Ancient Medicine” or “Bioarchaeology” (see section 1.4. BA or BSc (Hons) Intercalated Medical Humanities). Your final degree title will reflect the combination of modules you take. You will receive the best quality teaching experience, and have support from dedicated academic advisers (the FCH Director and the FCH subject co-ordinators) to oversee your academic progress and help you develop your academic potential during your studies. Modules: Due to the highly flexible nature of the FCH programme it is not possible to list all of the available options. Details of the details of the programme can be found at: http://www.exeter.ac.uk/fch/the-degree.php If you are interested in this programme please contact the FCH team directly to discuss your interests. 6|Page 1.4. BA (Hons) Intercalated Medical Humanities (via Flexible Combined Honours) Contact: Dr Mike Dobson (FCH@exeter.ac.uk) or call 01392 725270 Description: From Hippocrates and Galen, to Nightingale and Lister, our current medical practices have been shaped by our ancient and more recent past. In this flexible programme you will have the opportunity to explore the origins and evolution of human life, science, culture and medicine from different academic perspectives combined with the opportunity to investigate how humanities influence medical practice today. You will have the freedom to choose a combination of modules from the table below to satisfy your individual interests. The final combination of modules taken will determine which degree title is awarded. Modules: The following tables describe the programme and its potential constituent modules. The constituent modules may be updated, deleted or replaced as a consequence of the annual programme review of this programme. You may take optional modules as long as any necessary prerequisites have been satisfied, where the timetable allows and if you have not already taken the module in question or an equivalent module. Details of the modules currently offered may be obtained from the College website: http://www.exeter.ac.uk/fch/thedegree.php Stage 1: 30 credits of compulsory modules, 90 credits of optional modules Code Title Credits Compulsory Noncondonable ARC3000a Dissertation (Archaeology) 30 Yesa Yes CLA3009a Dissertation (Classics) 30 Yesa Yes EAS3003a Dissertation (English) 30 Yesa Yes HIH3005a Dissertation (History) 30 Yesa Yes ARC2504 Zooarchaeology 15 No No ARC2514 Forensic anthropology 15 No No ARC3127 Human Origins 15 No No ARC3512 Paleobotany 15 No No ARC3611 Funerary Osteoarchaeology 15 No No BIO3082 Science Communication 15 No No CLA3112 Medicine in Antiquity 15 No No CLA3264 Ancient Science and Society 15 No No CSC4011 Living with Environmental Change 15 No No CSC4013 Frontiers in Global Health 15 No No CSC4018 Health Economics 15 No No EAS3179 Life and Death in Early Modern Literature 15 No No EAS3230 Prostitutes, Pornographers, and Inverts: Sex in the Long Nineteenth Century 30 No No 7|Page EAS3237 The Rise of Science 30 No No EAS3239 Cultures of Neuroscience 30 No No GEO3138 Geographies of Health 15 No No HIH2181A The Witchcraze in Europe and its Colonies 30 No No HIH2202A Sexuality in c19th and c20th Britain 30 No No HIH2207B History of Science in Society 30 No No HIH2229A Culture, Class and Gender 30 No No HIH3133b The Body in Early Modern England: Context 30 No No HIH3134b The Body in Early Modern England: Sources 30 No No HIH3267c Magic in the Middle Ages: Context 30 No No HIH3266c Magic in the Middle Ages: Sources 30 No No HIH3619 Sexualities 30 No No HIH3629 Disease 30 No No LAW3066 Medical Ethics & Law 15 No No THE3152 Evolution, God and Gaia 30 No No THE3179 'Deviant Bodies': Disability Studies and the New Testament 30 No No Choice of ARC3000, CLA3009, EAS3003 or HIH3005. The dissertation must be on a topic related medical humanities which must be agreed with the FCH team prior to commencing. a b,c Modules with the same letter (b or c) are co-requisite and must be taken together. In order to obtain a named subject specialism in the degree title a dissertation plus a minimum of 60 credits must be taken in that subject. 8|Page 1.5. BSc (Hons) Intercalated Human Biosciences Contact: Alison Hume (A.Hume@exeter.ac.uk) Description: The programme is taught jointly by Biosciences and Sport and Health Sciences. The programme represents an innovative, collaborative teaching response to a broadening demand for graduates with skills in fields of study relating to biological and sport science. It allows you to study scientific aspects of health, physical activity and biotechnology and recognises the importance that exercise can play in the prevention and treatment of disease. You will receive a thorough grounding in the study of human and molecular biology together with the various sub-disciplines of exercise and sport sciences, including biomechanics, kinesiology, human and applied physiology, molecular biology, genetics and microbiology. Modules: The following table describes the programme and constituent modules. Constituent modules may be updated, deleted or replaced as a consequence of the annual programme review of this programme. You may take optional modules as long as any necessary prerequisites have been satisfied, where the timetable allows and if you have not already taken the module in question or an equivalent module. Details of the modules currently offered may be obtained from the Colleges websites: http://sshs.exeter.ac.uk/students/modules/ or http://biosciences.exeter.ac.uk/current/modules/ 15-45 credits of compulsory modules, 75-105 credits of optional modules (total=120 credits) Code Title Credits Compulsory Noncondonable BIO3096a Biosciences Research Project 45 Yes Yes ESS3302a Dissertation 45 Yes Yes ESS3303a Independent Research Review 15 Yes No BIO3077b Frontiers in Molecular Cell Biology 15 No No BIO3078b Cellular Basis of Immunity 15 No No BIO3079b Molecular Basis of Infection 15 No No BIO3080b Microbial Effectors of Disease 15 No No BIO3082b Science Communication 15 No No BIO3092b Bioinformatics 15 No No ESS2506c Sports Nutrition 15 No No ESS2900c Employability and Career Development 15 No No ESS3703c Paediatric Exercise Physiology 15 No No ESS3706c Integrated Physiology and Adaptation to Physical (in)activity 15 No No ESS3707c Physiological Determinants of Exercise Performance 15 No No ESS3804c Clinical Exercise Prescription 30 No No ESS3805c Biomechanical Analysis of Human Movement 30 No No You must choose one of BIO3096, ESS3302 or ESS3303 You must choose 30-75 credits modules starting with the code BIO3 c You must choose 30-75 credits from modules starting with the code ESS a b 9|Page 1.6. BSc (Hons) Intercalated Infectious Disease Contact: Dr Helen Dawe (H.R.Dawe@exeter.ac.uk) Description: Understanding of the molecular basis of infection and the interaction between microorganisms and their hosts is critical if we are to conquer the threat they pose to public health and food security. In this programme you will explore the diverse repertoire of cellular strategies that microbes use to defend themselves against host immune systems and gain better insight into the therapeutic agents we currently employ to control infections. In parallel, you will explore how the immune system defends the host against pathogen invasion and consider the fundamental cellular processes that contribute to the expression of disease. To give a broad overview, the topics will be explored in the context of both bacterial and fungal pathogens. The programme provides access to our specialist modules delivered to students in the final year of our three year undergraduate programme, and module availability closely reflects the research strengths of Bioscience academics. Many modules are seminar-based, and these provide valuable new perspectives to topics you may already have completed as part of your main programme of study, allowing you to explore complementary areas in greater detail. The overall programme offers an innovative-approach to learning that includes supportive small-group learning and tutorials as well as the chance to engage with research at a practical level in our laboratories. Modules: The following table describes the programme and constituent modules. Constituent modules may be updated, deleted or replaced as a consequence of the annual programme review of this programme. The following list should be considered as indicative rather than definitive. You may take optional modules as long as any necessary prerequisites have been satisfied, where the timetable allows and if you have not already taken the module in question or an equivalent module. Details of the modules may be http://biosciences.exeter.ac.uk/current/modules/ obtained from the College website: 45 credits of compulsory modules, 75 credits of optional modules a Code Title Credits Compulsory Noncondonable BIO3096a Biosciences Research Project 45 Yes Yes BIO3041 Pharmacology and Medicinal Chemistry 15 No No BIO3077 Frontiers in Molecular Cell Biology 15 No No BIO3078 Cellular Basis of Immunity 15 No No BIO3079 Molecular Basis of Infection 15 No No BIO3080 Microbial Effectors of Disease 15 No No BIO3082 Science Communication 15 No No BIO3086 Cell Biology of Disease 15 No No BIO3093 Energy Metabolism 15 No No The research project must be on a topic related to infectious disease. 10 | P a g e 1.7. BSc (Hons) Intercalated Medical Sciences Contact: Dr Kate Ellacott (K.Ellacott@exeter.ac.uk) Description: At present, many scientific discoveries never leave the laboratories in which they are made. At the same time the needs of frontline clinicians – and their patients – often go unheard by those doing research. Our BSc Intercalated Medical Sciences programme prepares you to be able to fill these gaps, and thereby enhance the lives of patients. Our intercalated Medical Sciences programme aims to provide a firm foundation in the core biomedical and biomolecular sciences. You will develop an integrated, scientific knowledge that you can put into practice in a clinical setting, plus creative and inquisitive communication, leadership, critical appraisal, and problem-solving skills. Students will also have the option of completing a research project and writing up a dissertation. These key skills will prepare you for a career helping to progress scientific discovery into clinical and medical practice, ultimately to improve human health. Modules: The following table describes the programme and constituent modules. Constituent modules may be updated, deleted or replaced as a consequence of the annual review of this programme. Details of the modules currently offered may be obtained from the Colleges web site: http://medicine.exeter.ac.uk/education/medicalsciences/ or http://biosciences.exeter.ac.uk/current/modules/ 75 credits of compulsory modules, 45 credits of optional modules Code Title CSC4001 Integrated Clinical Sciences 4 30 Yes Yes CSC4002 Expanding Horizons 4 (Independent Research Project + personal development portfolio) 45 Yes Yes CSC3905 Employability 0 Yes N/A CSC4003 Psychology applied to health 15 No No CSC4004 Managing Clinical Trials: Putting Science into Practice 15 No No CSC4011 Living with Environmental Change 15 No No CSC4013 Frontiers in Global Health 15 No No CSC4018 Health Economics 15 No No PAM2901 Medical Imaging-Principles and Applications 15 No No BIO3041 Pharmacology and Medicinal Chemistry 15 No No BIO3077 Frontiers in Molecular Cell Biology 15 No No BIO3078 Cellular Basis of Immunity 15 No No BIO3079 Molecular Basis of Infection 15 No No BIO3080 Microbial Effectors of Disease 15 No No BIO3085 Horizons of Biochemical Research 15 No No Total credits (core + optional): 120 11 | P a g e Credits Compulsory Noncondonable 1.8. BSc (Hons) Intercalated Molecular & Cellular Science Contact: Dr Helen Dawe (H.R.Dawe@exeter.ac.uk) Description: Molecular and cellular biology is one of the most fast-moving and important areas of biomedical research. Major human diseases such as cancer, inflammation, and pathogen infections are all fundamentally diseases of cells, and without a thorough understanding of the molecular mechanisms that underlie each disorder, directed therapeutic intervention is impossible. In this one year intercalated Molecular and Cellular Science programme, you will develop a molecular understanding of cell function and behaviour that complements your BMBS studies and allows you to gain an appreciation for the core biological science that underpins clinical practice. The programme provides access to our specialist modules delivered to students in the second or final year of our three year undergraduate programmes, and module availability closely reflects the research strengths of Biosciences academics. Many modules are seminar-based, and these provide valuable new perspectives to topics you may already have completed as part of your main programme of study, allowing you to explore complementary areas in greater detail. The overall programme offers an innovative-approach to learning that includes supportive small-group learning; lectures, and interactive seminars alongside a tutorial programme designed to give you the skills you need to succeed in your degree. Modules: The following table describes the programme and constituent modules. Constituent modules may be updated, deleted or replaced as a consequence of the annual programme review of this programme. The following list should be considered as indicative rather than definitive. You may take optional modules as long as any necessary prerequisites have been satisfied, where the timetable allows and if you have not already taken the module in question or an equivalent module. Details of the modules may be http://biosciences.exeter.ac.uk/current/modules/ obtained from the College website: 45 credits of compulsory modules, 75 credits of optional modules a Code Title Credits Compulsory Noncondonable BIO3096a Biosciences Research Project 45 Yes Yes BIO3041 Pharmacology and Medicinal Chemistry 15 No No BIO3077 Frontiers in Molecular Cell Biology 15 No No BIO3078 Cellular Basis of Immunity 15 No No BIO3082 Science Communication 15 No No BIO3085 Horizons of Biochemical Research 15 No No BIO3086 Cell Biology of Disease 15 No No BIO3091 Animal Developmental Biology 15 No No BIO3093 Energy Metabolism 15 No No PAM2901 Medical Imaging: Principals and Applications 15 No No The dissertation/research project must be on a topic related to molecular and cellular science. 12 | P a g e 1.9. BSc (Hons) Intercalated Psychological Studies Contact: Dr. Cris Burgess (C.N.W.Burgess@exeter.ac.uk) Description: Psychologists are interested in why we do things, how we do them and how we relate to others as well as to the world at large. As a result, Psychology plays an important role in drawing together techniques, theories, findings and professional practice from several areas of expertise to address complex and socially and economically important questions about behaviour. Psychologists study people at all stages in their lives from birth to old-age, assessing how people perceive the physical and social world around them, how they think and use ideas, how they vary in intelligence and personality and how they are influenced by particular environments such as work, school and family. Psychology is the systematic and scientific study of behaviour and experience. As such it has a wide range of applications, such as in industry and commerce, in education and in health and social services. Modules: The following table describes the programme and constituent modules. Constituent modules may be updated, deleted or replaced as a consequence of the annual programme review of this programme. The following list should be considered as indicative rather than definitive. You may take optional modules as long as any necessary prerequisites have been satisfied, where the timetable allows and if you have not already taken the module in question or an equivalent module. Details of the modules may be obtained from the College website: www.exeter.ac.uk/psychology/currentstudents/modules/ You must choose three 15 credit seminar modules in the series starting PSY3410. Seminars are arranged into three groups: Group 1, Group 2 and Group 3. The groupings may vary slightly from one year to the next and so prospective students should contact Psychology before making any firm decisions. You must take one seminar from each group and the three seminars cannot all be taken in the same term. You are also permitted to take the five credit module PSY3906 Psychology Research Internship in the second or final years. Registration on this module is subject to a competitive application process. If taken, this module will not count towards progression or award calculation. 75 credits of compulsory modules, 45 credits of optional modules Code Title Credits Compulsory Noncondonable PSY3401 Psychology Research Project 45 Yes Yes PSY3402 Methods and Statistics in Psychology III 15 Yes Yes PSY3403 Contemporary Issues in Psychology 15 Yes No PSY3410 Stereotypes and Stereotyping 15 No No PSY3411 Psychology and Law 15 No No PSY3412 The Psychology of Gender 15 No No PSY3413 Communication and Social Groups 15 No No PSY3415 Social Psychology of Prosocial and Antisocial Behaviour 15 No No PSY3416 Work and Organisational Psychology 15 No No PSY3417 The Associative Mind 15 No No PSY3418 Processes of Human Memory 15 No No PSY3419 Studying Cognition and Emotion with Brain Imaging 15 No No 13 | P a g e PSY3420 Brain Plasticity and Language Learning Across the Lifespan 15 No No PSY3422 Comparative Cognition 15 No No PSY3423 The Evolution of Social Behaviour and Social Organisation 15 No No PSY3424 Applied Social Psychology: Health, Environment and Society 15 No No PSY3425 Cognitive Behavioural Approaches to Mood Disorders 15 No No PSY3426 Parental Psychological Disorders and Children's Development 15 No No PSY3427 Compulsive Behaviour 15 No No PSY3429 Associative Mechanisms Underpinning Human Addictive Behaviour 15 No No PSY3430 Women’s Mental Health 15 No No PSY3435 Transdiagnostic Approaches to Psychological Disorders 15 No No 14 | P a g e 2. Master’s Degree Programmes Please note that all Master’s programmes are a full 12months in duration which may affect your planned electives. You are strongly advised to contact the department to confirm that the degree will be completed and ratified by the time you have to return to the BMBS programme or soon after. In order for the degree to count towards additional FP/AFP application points it must be ratified by the University prior to the application deadline. 2.1. MSc Applied Health Services Research Contact: medicine@exeter.ac.uk Website: http://www.exeter.ac.uk/postgraduate/taught/medicine/health-services-research-msc/#Overview Overview: The global burden of disease and challenges of safe and accessible health services means that more than ever practitioners and researchers need skills for developing, testing, evaluating and implementing evidencebased health care in highly complex situations. This programme provides you with the skills and knowledge to tackle these challenges. You will be taught by a multi-disciplinary team of expert tutors and guest lecturers from a diverse range of clinical and research backgrounds, with a blend of tutorials, work-based training and research exchange visits. Topics such as patient and public involvement, collaborative working, evidence-based practice, complex interventions, health economics, clinical trials and medical statistics will provide a common thread that runs throughout the programme. Structure: The programme has been designed to be flexible and well-defined with four integrated and mandatory modules (each 30 Masters level credits) plus a dissertation (60 Masters level credits) that can be studied on a part-time or full-time basis. A blended approach to learning will be achieved through taught sessions, bespoke tutorials, research exchange visits and practical exercises. All learning will be supported by online resources and moderated activities on the University of Exeter’s electronic learning environment (ELE). Expert tutors and guest lecturers will represent an appropriately diverse range of clinical and research backgrounds. Teaching for the programme takes place over one full day (Tuesdays -year 1, Wednesdays - year 2) for the parttime route, or two full days (Tuesday and Wednesday) for the full-time route. Teaching will take place between 9am and 5pm, however specific times may vary from module-to-module. Each module runs over 1 academic term, with 11 contact days per module timetabled with teaching staff. Module Core concepts & paradigms Implementation Sciences Fundamentals of Health Services Research Methods 15 | P a g e What will be covered Health services & systems Complex interventions Systematic Reviews Qualitative and quantitative research Evidence-based practice Patient & public involvement Diffusion of innovations Behaviour change Quality improvement and indicators Surveillance & intervention mapping Environmental impact and sustainability Ethics & governance Research questions Outcome measures & survey design Qualitative methods Statistics Health Economics Advanced Health Services Methods Independent Study 16 | P a g e Modelling in Health and Social care Observational study designs Clinical trials design Adapting methods to complex situation Process evaluation Statistics Advanced health economics Qualitative methods – secondary data analysis and qualitative synthesis Designing a research protocol Undertake a piece of empirical or theoretical research using secondary or primary data supported by a named supervisor 2.2. MSc Bioarchaeology Contact: archaeology@exeter.ac.uk Website: http://www.exeter.ac.uk/postgraduate/taught/archaeology/bioarch/#Contact Overview: Bioarchaeology is an exciting and fast-advancing field which combines archaeology with branches of the natural sciences to study key topics such as past health and well-being, diet, ecology, subsistence strategies and environmental impacts. Our MSc in Bioarchaeology aims to develop a broad understanding of these issues through the study of human remains. Students on this programme will also have the opportunity to study animal remains, as well as floral and faunal evidence depending which pathway they choose to follow. The two available Bioarchaeology pathways are: MSc Bioarchaeology: Human Osteology MSc Bioarchaeology: Zooarchaeology The programme develops advanced practical skills in skeletal analysis, making use of the department’s wellprovisioned specialist laboratories and reference collections. A particular strength of our provision is that we are able to address the bioarchaeology of both the New and Old Worlds. Those completing the programme acquire the skills necessary to continue into academic research or employment, as an osteologist in field units, museums or CRM companies. It allows you to specialise in one of two named pathways: Human Osteology (physical anthropology and funerary archaeology) or Zooarchaeology (animal bones and other faunal remains). Structure: Our programme includes 135-150 credits of compulsory modules: 30 credits of research methods, 45 60 credits of specialist modules and 60 credits of dissertation. You must also choose 45 credits of optional modules from those available from other Masters programmes within the department of Archaeology, or other Masters programmes within the University, or from Level 3 undergraduate modules in Archaeology (as appropriate and subject to the agreement of the programme director.) The two available Bioarchaeology pathways are: MSc Bioarchaeology: Human Osteology (compulsory modules marked with a-suffix below) MSc Bioarchaeology: Zooarchaeology (compulsory modules marked with b-suffix below) Code Module Credits ARCM100ab Research methods and archaeological theory 30 ARCM414ab Musculo-skeletal anatomy 30 ARCM403b Advanced Zooarchaeology 15 ARCM405a Advanced Human Osteology 15 ARCM407b Zooarchaeology 15 ARCM408a Bioarchaeology dissertation 60 ARCM409b Bioarchaeology dissertation Zooarchaeology 60 ARCM007 Advanced project 15 17 | P a g e ARCM102B Experimental archaeology in practice 1 30 ARCM102C Experimental archaeology in practice 2 30 ARCM200 Field Study 15 ARCM225 Landscape Archaeology: Understanding the historic environment 15 ARCM300 Material culture 15 ARCM411 Palaeobtoany 15 ARCM412 Funeral Osteoarchaeology 15 ARCM501 Researching the historic environment online 15 The modules we outline here provide examples of what you can expect to learn on this degree course based on recent academic teaching. The precise modules available to you in future years may vary depending on staff availability and research interests, new topics of study, timetabling and student demand. 18 | P a g e 2.3. MSc by Research Biosciences Contact: Please contact the PI of the project(s) that you are interested in directly (see portfolio of available projects below) Website: http://www.exeter.ac.uk/postgraduate/research-degrees/biosciences/mastersstreatham/ Overview: The University of Exeter offers a Masters by Research in an outstanding international research-active environment. With the recent technological developments in Biological Sciences, in particular post-genomic technologies leading to data rich research environments, many students are finding that conventional taught courses cannot adequately cover their research needs and ambitions. Our MSc by Research is offered in response to this situation and can be studied in any of our research areas at our Streatham Campus: Cellular and Chemical Biology Environmental Biology Microbes and Disease Structure: The programme gives you the flexibility to shape your own research in an area of particular interest to you. Like other research degrees you will be required to work independently, but with the support and guidance of an appropriate supervisor. We are committed to ensuring that its research students are given the training and support to develop high-level professional skills required for careers in academia, commercial or public sectors. A wide range of training is available to Masters by Research students, including traditional, transferable skills and research specific training. This is either provided by Biosciences staff, or by colleagues from the University's Researcher Development Programme, which offers an extensive choice of training and development events exclusively designed for our PhD students. There are a number of events, workshops and sessions available every year. These include quantitative biology and statistics, demonstrator training and various aspects of safety, research management, personal effectiveness, communication skills, networking, teamworking, and career management. Research seminars featuring internal and external speakers are organised each week during term time. You will be encouraged to attend additional optional courses, graduate schools and conferences and these are arranged through discussion with supervisors on an individual basis. Assessment: You will be assessed by a written thesis or scientific paper of up to 40,000 words in length. 19 | P a g e 2.4. MSc Environment & Human Health (Cornwall) Contact: Dr Alison Curnow (A.Curnow@exeter.ac.uk) Website: http://www.exeter.ac.uk/postgraduate/taught/medicine/environment-health-msc/#Overview Overview: On this programme you will consider ecological public health, the relationship of health to environment, as well as the social determinants of health and healthcare systems. By looking at current theories and concepts and through the analysis of a range of information you will develop the skills and knowledge so that on graduation you will be able to inform strategies to improve the health of communities or be well placed to continue to work towards a position of an academic researcher. Our students come from a variety of backgrounds and so the programme has been designed to give them the ability to enact meaningful change in any setting. For example, for the Ecological Public Health module our students select a country or urban/rural location to carry out an assessment of the public health profile (demographics and burden of disease/people and place) and identify the ecological foundations for that specific public health profile. They would then create a collaborative (e.g. inter-agency, community approach) action plan focused on health improvement in that particular area. Topics current students have chosen include: Public Health interventions in New Orleans Health, Wellbeing and Diet in Japan Understanding and Improving Mental Health in Indonesia Delivered at the Knowledge Spa located on the Royal Cornwall Hospital Site in Truro this research inspired programme will include contributions from the University of Exeter Medical School’s European Centre for Environment and Human Health, the Met Office, Age UK and the World Health Organisation. Students are able to access one-to-one support should they wish to undertake an internship with a Cornish business (or even further afield). They are able to take part in the Access to Internships scheme either during the course or once their studies have finished. The programme would suit graduates who are planning or already undertaking a career within public health, health promotion, environmental health and protection, occupational health, workplace wellbeing or social enterprise. The programme has been developed with reference to the training requirements of the Chartered Institute of Environmental Health and the UK Faculty of Public Health to maximise your future employability in the discipline of environment and human health sciences. Structure: The modules we outline here provide examples of what you can expect to learn on this degree course based on recent academic teaching. The precise modules available to you in future years may vary depending on staff availability and research interests, new topics of study, timetabling and student demand. Code HPDM019 HPDM020 HPDM021 HPDM022 HPDM000 20 | P a g e Module Fundamentals of environmental human health Ecological Public Heath Project design, development and knowledge transfer Environmental sciences and sustainable practice Dissertation Credits 30 30 30 30 60 2.5. MRes Health and Wellbeing Contact: pgt-shs-admissions@exeter.ac.uk Website: http://www.exeter.ac.uk/postgraduate/taught/sport/healthwellbeing/#Overview Overview: The MRes Health and Wellbeing aims to develop an interdisciplinary understanding of the social, biological and environmental drivers of individual health behaviours and interventions appropriate to develop health and wellbeing. It is designed to extend your understanding of the social science underpinning the development of effective interventions, strategies and policies aimed at sustainable improvement in health and wellbeing, and reducing physical and psychological health inequalities. The programme examines contemporary issues related to modifiable disease risk behaviours, and the determinants and correlates of these lifestyle behaviours across the lifespan. You should develop an understanding of the interdisciplinary skills and processes to translate scientific research into practical health and wellbeing applications. The MRes Health and Wellbeing forms part of the Economic and Social Research Council South West Doctoral Training Centre - a hub of world-class social science research. Structure: The MRes Health and Wellbeing is available for study 12 months full-time, studied over three terms, and is University-based throughout this time. The taught components of the programme are delivered in the first two terms; you then have the third term and a further four-month period in which to complete your dissertation. The final stages of your dissertation, between the end of the third term and the submission date in September, may be undertaken at a distance. During the programme you will study 180 credits comprised of a number of compulsory modules plus optional modules. Students can also opt to take option modules at the University of Bristol and University of Bath. Code Module Credits SSIM901a Interdisciplinary Research Design 15 SHSM025a Dissertation (Journal Article) 60 SHSM050a Contemporary Debates in Lifestyle Behaviours and Public Health 15 GEOM105Ab Research Methods in Human Geography 15 PSYM202b Behavioural Science Research Skills 15 GEOM106Ab Contemporary debates in Human Geography 30 PSYM204 Advances and Methods in Social and Organisational Psychology 30 PSYM214 Methods in Cognitive and Clinical Psychology and Neuroscience 30 SHSM014 Paediatric Exercise and Health 30 SHSM022 Physical Activity in the Prevention and Treatment of Chronic Diseases 30 a Compulsory b modules Students must chose 45 credits from GEOM105A, PSYM202 and SHSM024 21 | P a g e 2.6. MSc by Research Medical Imaging Contact: Please contact the PI of the project(s) that you are interested in directly (see portfolio of available projects below) Website: http://www.exeter.ac.uk/postgraduate/research-degrees/medicine/mscbyres-medical-imaging/ Overview: The medical imaging staff within the University of Exeter holds significant experience and expertise in the musculo-skeletal and imaging research, providing appropriate environment for your studies. The University boasts an extensive range of imaging equipment including computed radiography, which is soon to be upgraded to digital radiography equipment, an ultrasound scanner, quantitative ultrasound scanners, a magnetic resonance scanner and a dual energy x-ray absorptiometry scanner. There are staff within medical imaging who are experts in their fields and also in clinical research. Students undertaking a Master’s by research will be allocated a primary and secondary supervisor to guide them through their independent research. Structure: The Master’s by Research, not to be confused with the taught MRes degree, is offered within some Colleges. The Master’s by Research, like other research degrees, contains no taught element and offers you the opportunity to pursue a research project, without entering into the commitment of a longer-term research degree. As such, it’s ideal for those in employment who are interested in pursuing a specific shorter-term research project. A Master’s by Research degree is assessed by a written dissertation of up 40,000 words. The dissertation will not need to constitute an original contribution to knowledge but will need to provide evidence that you have worked at the current limits of understanding of the subject. Unlike a taught Master’s degree, there is no taught element, so dedication and enthusiasm for your subject are essential. 22 | P a g e 2.7. MSc by Research Medical Studies Contact: Please contact the PI of the project(s) that you are interested in directly (see portfolio of available projects below) Website: http://www.exeter.ac.uk/postgraduate/research-degrees/medicine/mscbyres-medical-studies/ Overview: The University of Exeter Medical School has a lively and innovative research environment based in Exeter and Truro, but operating across the whole of the South West. Our core themes and focus on chronic disease and applied health research align us closely with the interests of the NHS with whom we have close working relationship and our priorities will continue to reflect national needs and priorities. We have a commitment towards high-quality applied medical research spanning from the basic biomedical to applied health services. As a postgraduate student in the School you will be part of this thriving community, benefiting from quality research-led teaching and supervision and access to outstanding facilities. We can offer a wide range of supervision across our core research areas and are also involved with interdisciplinary research with other Colleges at Exeter. We offer our postgraduate students a fantastic learning environment, which includes research skills training and dedicated postgraduate facilities. The School benefits from exemplary facilities in all areas as a result of recent major investments. Our research environment spans the full spectrum, from basic biomedical discovery to clinical innovation. Our research excellence includes world-leading research in many fields and we have an increasingly recognised reputation for translating new discoveries into the clinical setting. Our research is focused around four themes: Diabetes, Cardiovascular risk and Ageing Environment and Human Health Health Services Research Neuroscience and Mental Health Structure: The Master’s by Research, not to be confused with the taught MRes degree, is offered within some Colleges. The Master’s by Research, like other research degrees, contains no taught element and offers you the opportunity to pursue a research project, without entering into the commitment of a longer-term research degree. As such, it’s ideal for those in employment who are interested in pursuing a specific shorter-term research project. A Masters by Research degree is assessed by a written dissertation of up 40,000 words. The dissertation will not need to constitute an original contribution to knowledge but will need to provide evidence that you have worked at the current limits of understanding of the subject. Unlike a taught Master’s degree, there is no taught element, so dedication and enthusiasm for your subject are essential. 23 | P a g e 2.8. MSc Paediatric Exercise and Health Contact: pgt-shs-admissions@exeter.ac.uk Website: http://www.exeter.ac.uk/postgraduate/taught/sport/paediatric/ Overview: It is well known that the first two decades of life represent an important window of opportunity to not only improve the health and well-being of young people, but also their health status into adult life. The role that physical activity and fitness can play in improving markers of health and well-being in young people is an important area of study, especially given concerns of declining fitness and increasing obesity in today’s children and adolescents. Based on the internationally-recognised research conducted at the Children’s Health and Exercise Research Centre (CHERC), our Master’s programme in Paediatric Exercise and Health offers a thorough grounding in the unique physiological responses of children and adolescents during exercise and how these responses are influenced by age, sex, and biological maturation. It provides an in depth evaluation of the relationships between physical activity, fitness and health in young people. You will gain experience of both theoretical and hands-on methods used to evaluate physical activity and fitness, plus advanced training in research methods and analytical procedures. The programme is delivered within a friendly and supportive learning environment, drawing upon innovative multi-method and multi-disciplinary research and teaching by our leading academics. You will have opportunities for involvement with on-going research projects and to develop key transferable skills beneficial for further doctoral study. Structure: The following tables describe the programme and constituent modules. Constituent modules may be updated, deleted or replaced as a consequence of the annual programme review of this programme. 180 credits of compulsory modules 24 | P a g e Code Module Credits SHSM003 Paediatric Exercise Physiology 30 SHSM006 Laboratory Techniques in Physiology 30 SHSM016 Paediatric Exercise and Health 30 SHSM024 Research Methods and Analytical Procedures 30 SHSM025 Dissertation (Journal article) 30 2.9. MSc Sports & Health Sciences Contact: pgt-shs-admissions@exeter.ac.uk Website: http://www.exeter.ac.uk/postgraduate/taught/sport/sporthealth/ Overview: With an excellent reputation for teaching quality, our MSc Sport and Health Sciences presents an exciting and challenging opportunity to develop scientific understanding of sport, exercise and health. Programme content is underpinned by past and current research from our internationally recognised research groups: Bioenergetics and Human Performance; and Physical Activity and Health Across the Lifespan. Our MSc Sport and Health Sciences provides you with a sound grounding in research methods and analytical procedures relating to sport and health sciences. The programme presents opportunities to employ theoretical concepts in applied sport, health and exercise settings and allows you to choose from a diverse range of modules allied to our research expertise. Delivered within a friendly and supportive learning environment, the programme draws upon innovative multimethod and multi-disciplinary research and teaching by our leading academics. You will have access to state-ofthe-art teaching and research facilities including modern laboratories for biomechanics, physiology and psychology. You will also have the opportunity to be involved with on-going research projects and develop key transferable skills. Structure: The following tables describe the programme and constituent modules. Constituent modules may be updated, deleted or replaced as a consequence of the annual programme review of this programme. You may take optional modules as long as any necessary prerequisites have been satisfied, where the timetable allows and if you have not already taken the module in question or an equivalent module. 90 credits of compulsory modules, 90 credits of optional modules Code Module a SHSM204a Research Methods and Analytical Procedures 30 SHSM025a Dissertation (Journal Article) 60 SHSM005 Biomechanical Aspects of Lower Limb Injury 30 SHSM006 Laboratory Techniques in Physiology 30 SHSM014 Paediatric Exercise and Health 30 SHSM022 Physical Activity in the Prevention and Treatment of Chronic Disease 30 SHSM023 Current Issues in Sport and Exercise Physiology 30 Compulsory modules 25 | P a g e Credits 2.10. MSc by Research Sport & Health Sciences Contact: Please contact the PI of the project(s) that you are interested in directly (see portfolio of available projects below) Website: http://www.exeter.ac.uk/postgraduate/research-degrees/sport/masters/#Overview Overview: The University of Exeter offers a Masters by Research in Sport and Health Sciences in an outstanding international research-active environment. Our MSc by Research can be studied in either of our research groups: Bioenergetics and human performance Physical activity and health The Bioenergetics and human performance research group adopts integrated physiological, psychological and biomechanical lines of enquiry to enhance human performance. Research specialisms include muscle metabolism and oxygen uptake, lower limb injury mechanisms, and cognitive and psychosocial determinants of human performance. The Physical activity and health research group links pre-clinical laboratory and fundamental research with epidemiological and intervention studies to enhance our understanding of the relationship between physical activity and health. One focus is on the precise measurement of physical activity to enable better quantification of movement and its relationship between physical activity and health. In addition, the Children’s Health and Exercise Research Centre (CHERC) is devoted to the study of the exercising child and adolescent and to the promotion of young people’s health and well-being, whether in relation to sport or clinical patient groups. Structure: The programme gives you the flexibility to shape your own research in an area of particular interest to you. Like other research degrees you will be required to work independently, but with the support and guidance of an appropriate supervisor. We are committed to ensuring that its research students are given the training and support to develop high-level professional skills required for careers in academia, commercial or public sectors. A wide range of training is available to Masters by Research students, including traditional, transferable skills and research specific training. This is either provided by Sport and Health Sciences staff, or by colleagues from the University's Researcher Development Programme, which offers an extensive choice of training and development events exclusively designed for our PhD students. There are a number of events, workshops and sessions available every year. These include quantitative biology and statistics, demonstrator training and various aspects of safety, research management, personal effectiveness, communication skills, networking, teamworking, and career management. Research seminars featuring internal and external speakers are organised each week during term time. You will be encouraged to attend additional optional courses, graduate schools and conferences and these are arranged through discussion with supervisors on an individual basis. You will be assessed by a written thesis or scientific paper of up to 40,000 words in length. 26 | P a g e 2.11. MSc International Management Contact: business-school-msc@exeter.ac.uk Website: http://www.exeter.ac.uk/postgraduate/taught/business/international_management/#Overview Overview: We offer three variants of our MSc International Management: a general programme plus two pathways, which are reflected in the programme title on graduation, namely: MSc International Management MSc International Management with Marketing MSc International Management with Entrepreneurship and Innovation This programme allows you to tailor your subject choices in line with your interests or planned career path. You will enrol initially on the MSc International Management, and thereafter elect a pathway depending on your particular areas of interest. We offer different optional modules depending on your pathway. This programme is an ideal route into the management of organisations working in global markets. It draws upon substantial expertise across the School in the areas of management, international business, marketing, strategy, economics, operations, accounting and finance to give you the latest ideas in management thinking and an overview of how global organisations work today. You can study the programme in an intensive nine-month format, or over 12 months. With both formats you study international business, marketing, operations, human resource management and accounting in the first term, and strategy and economics in the second term. If studying over nine months, you then select four options from the full range of management modules and complete in June. With the 12-month format you undertake three management options in the second term, and start preparation on a dissertation project which you continue to work on over the summer, completing in September. Please note that offers will be made for the 9 month pathway unless the application clearly states a preference for the 12 month pathway. In addition to top quality teaching, the School also organises dedicated careers workshops and in-company visits. If you elect to study the 12 month pathway, you can apply to spend your second semester at one of our partner institutions in either Mannheim Business School (Germany), Copenhagen Business School (Denmark) or SDA Bocconi School of Management (Italy). These institutions are recognised as among the leading institutions in Europe and are accredited by EQUIS, AACSB and AMBA: the “Triple-Crown” of business school accreditations. Spending a semester at either one of these institutions will add an extra dimension to your MSc International Management programme. Structure: The intensive nine month variant of this programme is delivered over three terms from September to June and is University-based throughout this time. During the programme you will study modules totalling 180 credits. Please note that programme structures may be subject to change. Descriptions of the individual modules are given in full on the Business School postgraduate module list. 120 credits of compulsory modules, 60 credits of optional modules 27 | P a g e Code Module Accounting for International Managers [Term 1] Managing Operations [Term 2] Marketing Strategy [Term 1] Principles of International Business [Term 1] Managing in a Multinational Context [Term 1] Strategy [Term 2] International Human Resource Management [Term 1] Sustainable Enterprise Economy [Term 2] Brand Design [Marketing] Understanding Consumer Behaviour [Marketing] Tourism and Marketing [Marketing] Sustainable Tourism Management Entrepreneurship: New Venture Development [Entrepreneurship and Innovation] Strategic Innovation Management [Entrepreneurship and Innovation] Banking and Financial Services Corporate Governance, Reporting and Regulation Credits Multinational Finance for Managers 15 BEMM126 Purchasing and Supply Chain Management [Entrepreneurship and Innovation] 15 BEMM163 Managing Projects and Programmes of Projects 15 BEAM045a BEMM114a BEMM148a BEMM116a BEMM160a BEMM119a BEMM059a BEMM161a BEMM128 BEMM120 BEMM374 BEMM375 BEMM108 BEMM118 BEAM033 BEAM026 BEMM130 BEMM169 BEAM025 BEMM129 BEMM140 BEMM170 BEMM129 a Compulsory modules 28 | P a g e Global Sourcing and Logistics Management Advanced Management Accounting [Permission needed to take this module] Digital Business Models Innovating Business Models in Emerging Economies [Entrepreneurship and Innovation] Global Career Management - Theory and Practice Digital Business Models 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 3. MSc by Research – Portfolio of Available Projects 2016-2017 All MSc by Research projects are offered by the researchers named at the top of the proposal form. Please contact the investigators directly to express an interest or to apply for their project. The investigators listed are responsible for selecting candidates from the pool of interested students but they are under no obligation to take a student if they do not feel that there are any suitable candidates. You can apply for more than one project but due to the substantial commitment associated with taking an MSc by Research student in the lab you cannot hold an MSc by Research project as a back-up for another application. If you change your mind then please inform both the ICD team and the listed investigators as soon as possible so the project can be offered to another student. 29 | P a g e 3.1. MSc by Research Medical Studies – Diabetes, Cardiovascular risk and Aging 3.1.1. Functional Characterisation of Genes Involved in Type 2 Diabetes Primary Supervisor: Name: Prof Lorna Harries Email:L.W.Harries@exeter.ac.uk Department: RNA-mediated disease mechanisms group Previous postgraduate supervision experience? Yes ☒ No ☐ Secondary Supervisor: Name: Prof Michael Weedon Email: M.N.Weedon@exeter.ac.uk Department: Complex Genetics disease group Previous postgraduate supervision experience? Yes ☒ No ☐ Programme & Theme: ☒MSc by Research Medical Studies - Diabetes, cardiovascular risk and aging Research Question/Hypothesis: Does genetic variation associated with type 2 diabetes act by disruption of sequences necessary for non-coding regulation of candidate genes? Abstract:Type 2 diabetes (T2D) is a growing public health issue, which places an increasing burden on scarce healthcare resources. Genome wide association studies (GWAS) have contributed greatly to the understanding of the genetics of T2D, with over 67 relevant genetic variants now identified. A major challenge going forward lies in identifying the causal locus in each case, and determining the mechanisms of action of each variant. The vast majority of GWAS loci for T2D are located in non-coding regions of the genome. Although these nontranslated regions produce no proteins, they are certainly functional. Thus, we have shown that GWAS variation can affect the abundance of mRNA encoding different alleles. We aim to provide comprehensive analyses of the extent to which this happens and to uncover some of the molecular mechanisms underpinning the associations with T2D. We have already identified several situations where index or proxy GWAS variation may act by disruption of normal gene regulatory processes such as alternative splicing, initiation of transcription or moderation of mRNA stability by non-coding RNA regulation. We will follow up these exciting candidates in a series of human pancreatic islet and peripheral blood lymphocyte samples to determine the basis of their association with T2D. The proposed project is likely to provide mechanistic links between genetic variation and increased risk of T2D. This will aid our understanding of this common disorder and may highlight new pathways for therapeutic intervention. Methods/techniques to be employed: Bioinformatic prediction of potential effects on mRNA splicing, long non-coding RNA regulation or miRNA regulation; RNA extraction; DNA extraction; Reverse Transcription; Quantitative real-time PCR; Allele-specific qRTPCR; Tissue culture; transfection; Site directed mutagenesis; DNA sequencing; Luciferase reporter constructs. 30 | P a g e 3.1.2. Role of STAT signalling in the regulation of pancreatic beta-cell viability Primary Supervisor: Name: Prof Noel Morgan Email: n.g.morgan@exeter.ac.uk Department: Institute of Biomedical and Clinical Science Previous postgraduate supervision experience? Yes ☒ No ☐ ☒ No ☐ Secondary Supervisor: Name: Dr Mark Russell Email: m.russell@exeter.ac.uk Department: IBCS Previous postgraduate supervision experience? Yes Programme & Theme: ☒MSc by Research Medical Studies - Diabetes, cardiovascular risk and aging Research Question/Hypothesis: In recent work, we have discovered that a series of mutations found in patients with very early onset type 1 diabetes cause the activation of one of the members of the STAT family of transcription factors in pancreatic beta-cells. We now wish to clone and express these mutant forms in pancreatic beta cells to understand how the presence of an activating mutation in a relevant STAT protein, leads to beta cell dysfunction and death. A total of 3 different mutations have been identified and the phenotype of cells expressing each of these mutations will be evaluated. Abstract: Pancreatic beta-cells are essential to the control of whole body glucose homeostasis in humans, since they are the sites of insulin synthesis and secretion. Dysfunction and/or loss of these cells leads to an inability to handle ingested nutrients appropriately and culminates in the development of diabetes mellitus. It is well known that beta-cells express surface receptors for both pro- and anti-inflammatory cytokines and there is increasing evidence that defects in cytokine signalling pathways may contribute to beta-cell dysfunction and loss in some patients with diabetes. However, the molecular mechanisms by which this occurs have not been disclosed and this remains an important topic of research. In this context, we have found that members of a family of transcription factors (the “STAT” family) play critical roles in the regulation of beta-cell viability and that a mutation in one or more of these proteins can be found in patients with an early onset form of type 1 diabetes. The present project will explore the effects of these mutations in detail to establish the molecular events that accompany STAT activation and to understand how this leads to alterations in beta-cell viability. As such, the project may define novel pathways which could be targeted in the design of new therapeutic agents for patients with diabetes. Methods/techniques to be employed: Cell culture Western blotting Analysis of protein phosphorylation Cell transfection and reporter assays Site-directed mutagenesis Cloning and transfection of expression constructs Interference RNA methods Immunoprecipitation 31 | P a g e 3.1.3. Persistent enteroviral infection as a mechanism promoting islet autoimmunity in type 1 diabetes Primary Supervisor: Name: Dr Sarah Richardson Email: s.richardson@exeter.ac.uk Department: Institute of Biomedical and Clinical Science Previous postgraduate supervision experience? Yes ☒ No ☐ ☒ No ☐ Secondary Supervisor: Name: Prof Noel Morgan Email: n.g.morgan@exeter.ac.uk Department: Institute of Biomedical and Clinical Science Previous postgraduate supervision experience? Yes Programme & Theme: ☒MSc by Research Medical Studies - Diabetes, cardiovascular risk and aging Research Question/Hypothesis: Increasing evidence indicates that type 1 diabetes might have a viral aetiology since enteroviral antigens have been detected more frequently in the pancreatic beta-cells of patients than controls. Importantly, however, the pancreatic infection appears to be atypical since it is not associated with large scale cell lysis. Rather, the infection develops persistently within beta cells and there is minimal synthesis of viral capsids. The aim of this project is to establish whether this mode of infection can be modelled in vitro such that its properties can be investigated as a means to better understand how type 1 diabetes may develop. Abstract: The incidence of Type 1 diabetes (T1D) is escalating in many Western countries and the illness currently affects more than 25000 young people under the age of 25 in the UK. T1D develops because the insulin-secreting betacells of the pancreas are selectively destroyed by immune cells but the factors that trigger this process are not known. Recent evidence has suggested that certain common strains of enterovirus might be involved and it is known that enteroviruses can infect islet cells. However, it is also clear that, in T1D, any such infection does not cause beta-cell lysis. Rather, the virus appears to establish a more unusual “persistent” infection which may then lead to abnormal processing and presentation of islet antigens. In this project, cultured pancreatic cells that have been persistently infected with model enteroviruses will be employed to study the effects of these viruses on intracellular pathways. The cells will be harvested and fixed prior to analysis. The project will then seek to establish whether antiviral pathways become activated in cells harbouring a persistent enteroviral infection or if these are subverted. The results will help define whether islet cell enteroviral infection can be implicated in the development of human type 1 diabetes. Methods/techniques to be employed: Cell culture Western blotting Analysis of protein phosphorylation Immunocytochemistry Fluorescence and confocal microscopy Image analysis Immunoprecipitation 32 | P a g e 3.1.4. Glucagon and glucose lowering therapy in type 2 diabetes Primary Supervisor: Name: Dr. Tim McDonald Email: timothy.mcdonald@nhs.net Department: Diabetes Research/Exeter NIHR Clinical Research Facility Previous postgraduate supervision experience? Yes ☒ No ☐ Secondary Supervisor: Name: Dr. Angus Jones Email: angus.jones@exeter.ac.uk Department: Diabetes Research/Exeter NIHR Clinical Research Facility Previous postgraduate supervision experience? Yes ☒ No ☐ Programme & Theme: ☒MSc by Research Medical Studies - Diabetes, cardiovascular risk and aging Research Question/Hypothesis: Is glucagon suppression important to the action of glucose lowering therapies in type 2 diabetes? Specifically: 1. Do GLP-1R analogues, DPPIV inhibitors and Sulfonylureas reduce glucagon in sustained clinical use? 2. Does response to these therapies relate to the change in glucagon with treatment? 3. Do SGLT2 inhibitors (glucose lowering agents which are known to raise glucagon) work more effectively if given in combination with agents that lower glucagon? 4. Does glucose variability relate to fasting and post meal glucagon levels? Abstract: Glucagon is thought to be an important contributory component to the raised glucose levels seen in type 2 diabetes. Several glucose lowering therapies are thought to reduce glucagon, however the magnitude of these effects in long term use and their importance to glucose lowering are unclear. Conversely, one of the most effective oral glucose lowering therapies has recently been shown to markedly raise glucagon levels. This project will use data from crossover trials, observational studies and an experimental physiological study to explore the effect of glucagon suppression by these agents and its importance to treatment response. Students will work in a highly successful clinical research group led by Professor Andrew Hattersley. While the project uses existing clinical research data students will be offered experience of all aspects of clinical research including patient recruitment and physiological tests in the NIHR Exeter Clinical Research Facility. Students will develop advanced skills in research methods and data analysis with supervision and support from the supervisors and wider research team. They should expect to publish at least one peer-reviewed article as a result of their research and will develop skills that will be valuable in both clinical and academic careers. For outstanding students there is an opportunity for further post qualification academic training in the group through our NIHR academic clinical fellow posts at F2 and ST level. Methods/Techniques: This project will use pre-existing clinical research data to answer questions directly relevant to patient care. Students will develop skills in the data analysis package STATA, SPSS or R and be taught how to systematically and robustly address research questions and hypotheses using clinical study data. Due to the nature of this project students will be expected to have evidence of good maths ability (e.g. Maths A/S or A level) and/or advanced IT skills. 33 | P a g e 3.1.5. Predicting response to treatment in Type 2 diabetes Primary Supervisor: Name: Dr. Angus Jones Email: angus.jones@exeter.ac.uk Department: Diabetes Research/Exeter NIHR Clinical Research Facility Previous postgraduate supervision experience? Yes ☒ No ☐ Secondary Supervisor: Name: Dr. Beverley Shields Email: b.shields@exeter.ac.uk Department: Diabetes Research/Exeter NIHR Clinical Research Facility Previous postgraduate supervision experience? Yes ☒ No ☐ Programme & Theme: ☒MSc by Research Medical Studies - Diabetes, cardiovascular risk and aging Research Question/Hypothesis: Can doctors use simple clinical information and blood tests to predict which patients respond well to glucose lowering treatments for type 2 diabetes? Specifically: 1. Do some agents work better at higher levels of baseline HbA1c (average glucose)? 2. Are age, gender, body mass index, renal function and diabetes duration associated with glucose lowering (glycaemic) response to commonly used glucose lowering therapies? 3. Does predicted drug steady state (based on formula that usually includes lean body weight, renal function and age) predict glycaemic response to a given dose of a therapy? 4. What proportion of drug response can be explained by measures of adherence, physical activity and change in weight? Abstract: Response to glucose lowering treatment in Type 2 diabetes is highly variable. If we could identify predictors of response to treatment we could target therapies towards those most likely to benefit, an approach called stratified or precision medicine. While large amounts of research effort go into discovering genes or other biomarkers for treatment response the relationship between simple clinical features and response has been underexplored, and use of clinical features to guide treatment choice has the potential to be a cost effective way to improve patient care. This project will use data from a number of clinical trials and observational studies to explore the relationship between clinical features and response to diabetes treatment. Students will work in a highly successful clinical research group lead by Professor Andrew Hattersley. While the project uses existing clinical research data students will be offered experience of all aspects of clinical research including patient recruitment and physiological tests in the NIHR Exeter Clinical Research Facility. Students will develop advanced skills in research methods and data analysis with supervision and support from the supervisors and wider research team. They should expect to publish at least one peer reviewed article as a result of their research and will develop skills that will be valuable in both clinical and academic careers. For outstanding students there is an opportunity for further post qualification academic training in the group through our NIHR academic clinical fellow posts at F2 and ST level. Methods/Techniques: This project will use pre-existing clinical research data to answer questions directly relevant to patient care. Students will develop skills in the data analysis package STATA, SPSS or R and be taught how to systematically and robustly address research questions and hypotheses using clinical study data. Due to the nature of this project students will be expected to have evidence of good maths ability (e.g. Maths A/S or A level) and/or advanced IT skills. 34 | P a g e 3.1.6. Pathogenesis and prediction of rapid progression to insulin requirement in Type 2 diabetes Primary Supervisor: Name: Dr. Angus Jones Email: angus.jones@exeter.ac.uk Department: Diabetes Research/Exeter NIHR Clinical Research Facility Previous postgraduate supervision experience? Yes ☒ No ☐ Secondary Supervisor: Name: Dr. Bea Knight Email: B.A.Knight@exeter.ac.uk Department: Diabetes Research/Exeter NIHR Clinical Research Facility Previous postgraduate supervision experience? Yes ☒ No ☐ Programme & Theme: ☒MSc by Research Medical Studies - Diabetes, cardiovascular risk and aging Research Question/Hypothesis: 1. What clinical, biochemical and genetic features are associated with progression of type 2 diabetes? 2. Do patients with apparent Type 2 diabetes who progress to absolute insulin deficiency have clinical, genetic and biochemical features of Type 1 diabetes? Abstract: Type 2 diabetes is characterised by progressive gradual failure of the insulin producing beta cells meaning patients need increasing amounts of treatment over time. However, rates of progression are very variable, with some needing insulin rapidly and others not needing insulin for many years. This project will use data from a study comparing 1200 patients with rapid and poorly progressing diabetes, and other data from large cross sectional datasets, to investigate the predictors and pathogenesis of rapid progression to insulin requirement and/or severe insulin deficiency. Students will work in a highly successful clinical research group lead by Professor Andrew Hattersley. While the project uses existing clinical research data students will be offered experience of all aspects of clinical research including patient recruitment and physiological tests in the NIHR Exeter Clinical Research Facility. Students will develop advanced skills in research methods and data analysis with supervision and support from the supervisors and wider research team. They should expect to publish at least one peer reviewed article as a result of their research and will develop skills that will be valuable in both clinical and academic careers. For outstanding students there is an opportunity for further post qualification academic training in the group through our NIHR academic clinical fellow posts at F2 and ST level. Methods/Techniques: This project will use pre-existing clinical research data to answer questions directly relevant to patient care. Students will develop skills in the data analysis package STATA, SPSS or R and be taught how to systematically and robustly address research questions and hypotheses using clinical study data. Due to the nature of this project students will be expected to have evidence of good maths ability (e.g. Maths A/S or A level) and/or advanced IT skills. 35 | P a g e 3.2. MSc by Research Medical Studies – Neuroscience and Mental Health 3.2.1. Systematic Review of medication adherence in children with attentiondeficit/hyperactivity disorder Primary Supervisor: Name: Darren Moore Email: d.moore@exeter.ac.uk Department: UEMS Previous postgraduate supervision experience? Yes ☐ No ☒ Secondary Supervisor: Name: Tamsin Ford Email: t.j.ford@exeter.ac.uk Department: UEMS Previous postgraduate supervision experience? Yes ☒ No ☐ Programme & Theme: ☒MSc by Research Medical Studies - Neuroscience and Mental Health Research Question/Hypothesis: To review the quantitative and qualitative literature on the prevalence, barriers and facilitators, and consequences of medication non-adherence in childhood attentiondeficit/hyperactivity disorder (ADHD). This will be organised under three research questions: 1. What is the prevalence of adherence to medication for ADHD in children? 2. What are the barriers and facilitators to medication adherence in childhood ADHD? 3. What are the consequences of not adhering to a medication programme for childhood ADHD? Research question 1 will involve a synthesis of quantitative evidence, research questions 2 and 3 will call for mixed methods synthesis. Abstract: Medication non-adherence has an important impact on treatment efficacy and healthcare burden across a range of conditions and therapeutic areas. Despite specific diagnostic criteria, published practice guidelines, and the availability of effective pharmacological treatments for children diagnosed with attentiondeficit/hyperactivity disorder (ADHD), long-term adherence to medication for ADHD is frequently poor. Nonadherence may be a problem, however, this needs to be considered in relation to evidence that reports medication may be declined, poorly tolerated, not address all the problems associated with childhood ADHD and can produce undesirable side effects. While individual studies have considered prevalence, predictors and consequences of non-adherence to ADHD medication in children with ADHD and reviews have considered these issues for adults with ADHD, there remains a gap for a systematic review of medication non-adherence for children with ADHD. A mixed methods systematic review and synthesis will be conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement guidelines. We anticipate that quantitative research will provide data that can be synthesised using meta-analysis to provide information about the level of adherence. Both qualitative and quantitative research may provide information relating to barriers and facilitators and consequences of non-adherence and we propose using either segregated or integrated methods of mixed methods synthesis to bring together this information. This review will help to establish the prevalence and impact of non-adherence to ADHD medication in childhood and can provide recommendations as to whether interventions to improve adherence are warranted and if so what barriers and facilitators ought to be targeted. Methods/techniques to be employed: We will use systematic review methodology guidelines (PRISMA, Centre for Reviews and Dissemination). A protocol will be registered on PROSPERO. Ten databases will be searched using an a priori search strategy. Studies will be selected through title and abstract, and then full text screening. Tailored data extraction forms will be piloted and used to collect relevant information, which will then be synthesised in response to the type of data and the research question. We anticipate using metaanalysis to pool data regarding the prevalence of adherence and narrative synthesis to synthesise quantitative and qualitative evidence for research question 2 and 3. 36 | P a g e 3.3. MSc by Research Medical Studies – Environment and Human Health 3.3.1. Antimicrobial resistance: a global issue, requiring cross-disciplinary research Primary Supervisor: Name: Prof Karen Mattick Email: k.l.mattick@exeter.ac.uk Department: Medical School/School of Education Previous postgraduate supervision experience? Yes ☒ No ☐ Secondary Supervisor: Name: Dr Will Gaze Email: w.h.gaze@exeter.ac.uk Department: Medical School/European Centre for Environment & Human Health Previous postgraduate supervision experience? Yes ☒ No ☐ Programme & Theme: ☒MSc by Research Medical Studies – Environment & Human Health Research Question/Hypothesis: How might we reduce the spread of antimicrobial resistance (AMR) through researching the processes by which it evolves? Abstract: The challenge of AMR is clear and its implications are daunting. In 2050, it is predicted that AMR will cause 10 million deaths globally and reduce GDP by up to 2.5%. Academic, clinical, veterinary, and farming communities, together with government and the public, have responded. Awareness and engagement is increasing (e.g. the Longitude Prize), interventions to improve AM stewardship and prevent infection are being implemented and shared, and strategies to incentivise new AM development are being devised. However, the scale and pace of the response is insufficient and disjointed, both across discipline silos and different geographical settings. Coherent, cross-discipline research is required. Dr William Gaze is a molecular microbial ecologist conducting research on the evolution of AMR in the natural and farmed environments and within the gut microbiome. Dr Karen Mattick is a microbiologist by background but now focusses on medical education research, particularly the experiences of junior doctors in prescribing antimicrobial drugs. They would be interested to supervise Masters by Research projects on the topic of AMR with an educational component. The research may take a range of perspectives on this problem (e.g. professional education, medical education, prescribing behaviours, microbiological and/or environmental) and the supervisory team and methodologies would be tailored accordingly. http://www.ecehh.org/people/dr-william-gaze/ https://medicine.exeter.ac.uk/about/profiles/index.php?web_id=Karen_Mattick Methods/techniques to be employed: The methods used would depend on the research perspective taken but might include: field work in environmental or clinical settings, observation, surveys and/or interviews. N.B. You can be based at either Exeter or Truro but some travel between the two sites is anticipated 37 | P a g e 3.3.2. Stress, sleep and the symptoms of Meniere’s disease Primary Supervisor: Name: Dr Jess Tyrrell Email: j.tyrrell@exeter.ac.uk Department: UEMS Previous postgraduate supervision experience? Yes ☒ No ☐ Secondary Supervisor: Name: Dr Benedict Wheeler Email: b.w.wheeler@exeter.ac.uk Department: UEMS Previous postgraduate supervision experience? Yes ☒ No ☐ Programme & Theme: ☒MSc by Research Medical Studies - Environment and human health Research Question/Hypothesis: Meniere’s disease is a disorder of the inner ear characterised by episodic vertigo, tinnitus, aural fullness and fluctuating hearing loss. Currently the disease is poorly understood. Using patient-generated data from the Meniere’s App, this project will investigate the role of sleep and stress in Meniere’s disease. Specifically we would investigate: 1. Does stress increase attack prevalence and worsen symptoms? Do we see cyclic effects of increased disease severity resulting in increased stress, which in turn, further exacerbates symptoms? 2. Does poor sleep influence Meniere’s influence symptoms over subsequent days? Abstract: Meniere’s disease is a chronic unpredictable condition with a prevalence of approximately 0.25% and annual costs of between £541.30-£608.70 million in the UK. Identifying factors that can influence symptom severity and attack prevalence is of crucial importance to improve our understanding of the condition and to reduce its unpredictable nature. In 2013, we launched a mobile phone application, Meniere’s Monitor, to enable daily monitoring of the symptoms of Meniere’s by patients as well as a range of other factors (including sleep and stress). The app is utilised by participants globally; and we now have a wealth of information that can be analysed to improve our understanding of the condition. We will investigate the role of stress and poor sleep on the symptoms of Meniere’s disease. Stress is hypothesised to play a major role in Meniere’s symptoms primarily based on anecdotal evidence; to date no-one has investigated whether stress is a cause and/or a consequence of symptom exacerbation. Sleep quality and duration may also be important in Meniere’s disease. One study demonstrated impaired sleep quality in Meniere’s when compared to controls, but the role of poor sleep in symptom severity has not been investigated. Using the same App data, we will investigate if sleep has a direct and/or indirect role (via stress) on the symptoms of Meniere’s. Using patient-generated data from our Meniere App longitudinal study, we will be able to perform the most comprehensive analysis to date into the complex relationship between stress, sleep and Meniere’s symptoms to date. Methods/techniques to be employed: In addition to opportunities to interact with Meniere’s patients and the Meniere’s App, this project will utilise a broad range of statistical techniques and provide experience of big data analysis. A panel data analysis framework will be utilised for investigating the longitudinal data. We will utilise linear and logistic models to determine whether sleep and/or stress influence the symptoms of Meniere’s. These models will be adjusted for a range of confounders. Lead and lag effects will be investigated to determine how for example stress influences symptoms on the following day. Students will be instructed and supervised in these analyses. N.B. You can be based at either Exeter or Truro but some travel between the two sites is anticipated 38 | P a g e 3.3.3. Do pollen levels influence symptom severity in Meniere’s disease? Primary Supervisor: Name: Dr Benedict Wheeler Email: b.w.wheeler@exeter.ac.uk Department: UEMS Previous postgraduate supervision experience? Yes ☒ No ☐ Secondary Supervisor: Name: Dr Jess Tyrrell Email: j.tyrrell@exeter.ac.uk Department: UEMS Previous postgraduate supervision experience? Yes ☒ No ☐ Programme & Theme: ☒MSc by Research Medical Studies - Environment and human health Research Question/Hypothesis: Meniere’s disease is a chronic disorder of the inner ear characterised by episodic vertigo, tinnitus, aural fullness and fluctuating hearing loss; Ménière’s is estimated to cost between £541.30-£608.70 million annually. There is currently no known cure, and our understanding of factors that trigger symptom exacerbation is limited. There is anecdotal evidence that pollen and allergies impact Meniere’s symptoms. Using Met Office pollen data and the Meniere’s App, we hypothesise that high levels of pollen and certain types of pollen will exacerbate the symptoms of Meniere’s, and increase the prevalence of attacks within the population. Abstract: The unpredictable nature of Meniere’s disease has a significant negative impact on mental health and wellbeing. A range of triggers are believed to exacerbate the symptoms of Meniere’s, including diverse environmental factors (e.g. weather and pollen levels). To date, no study has investigated the role of pollen on the symptoms of Meniere’s disease, but qualitative and anecdotal data suggest spikes in pollen may play a role. The Meniere’s Monitor is a mobile phone application that has collected daily symptom and GPS location data on Meniere’s from over 2000 participants globally. The Meniere’s Monitor data will be linked to Met Office pollen data using geographic information systems (GIS) techniques. This project will then investigate whether pollen levels and what particular types of pollen influence the symptoms of Meniere’s disease. Each individual symptom (e.g. dizziness, tinnitus, aural fullness and hearing) will be investigated as well as the prevalence of attacks. Potential confounders will be accounted for in the model, including a range of weather variables as they are associated with pollen levels and the symptoms of Meniere’s. The project will be embedded within a strategic programme of research between UEMS and the Met Office. This work will represent the most comprehensive study to date into the role of pollen in Meniere’s. If pollen was indicated to have a role in Meniere’s, then individually targeted pollen warnings from the Met Office may help individuals to better manage their condition and reduce its unpredictable nature. Methods/techniques to be employed: In addition to interacting with Meniere’s patients and the Meniere’s App, this project will utilise GIS, a broad range of statistical techniques and provide experience of big data analysis. GIS will be utilised to link Met Office pollen data to the Meniere’s app data. The analysis of pollen in Meniere’s symptoms will utilise linear and logistic models in a panel data analysis framework. These models will be adjusted for a range of confounders. Lead and lag effects will be investigated to determine if high pollen influences symptoms on the following day. Students will be instructed and supervised in these analyses. N.B. You can be based at either Exeter or Truro but some travel between the two sites is anticipated 39 | P a g e 3.3.4. Dust inhalation and the risk of rheumatoid arthritis Primary Supervisor: Name: David Hutchinson Email: david.hutchinson@rcht.cornwall.nhs.uk Department: rheumatology Previous postgraduate supervision experience? Yes ☒ No ☐ Secondary Supervisor: Name: Daniel Murphy Email: Daniel.murphy@cornwall.nhs.uk Department: rheumatology Previous postgraduate supervision experience? Yes ☐ No ☒ Programme & Theme: ☒MSc by Research Medical Studies - Environment and human health Research Question/Hypothesis: Rheumatoid arthritis is initiated by the nanoparticle silicon dioxide (silica). This occurs as a result of the induction of citrullination (post-translational modification of peptides) in the lung. It is hypothesised that inhalation of other industrial dusts (cement, wood and china clay dust) trigger seropositive rheumatoid arthritis as a consequence of increased exposure to cadmium in the lung as a consequence of inhaling cement dust, wood dust and china clay dust. Abstract: Rheumatoid arthritis in men is strongly associated with a low level of formal education. Smoking is strongly associated with male rheumatoid arthritis, however even in non-smoking cases a low level of formal education is strongly associated with male rheumatoid arthritis. I have recently hypothesised that cadmium in cigarette smoke and in the dusts of various industrial processes could potentially trigger rheumatoid arthritis. In collaboration with Trinity College Dublin we have recently shown that cadmium is a citrullinating agent. Cadmium is found in cement, wood and china clay. This project will determine if inhalation of wood dust and cement dust is a risk factor for RA by undertaking a case control study. Serology and HLADRB1 alleles will be investigated in non-smoking rheumatoid arthritis cases to determine if there is an interaction between the rheumatoid arthritis HLADRB1 “shared epitope allele” and occupational exposure to cadmium and the generation of the rheumatoid autoantibodies (rheumatoid factor and anti-citrullinated peptide antibodies). Additionally to determine if china clay dust is a risk factor for RA, a geographical prevalence study will be undertaken looking at the prevalence of RA in those working in the china clay industry compared to non-china clay workers in St Austell. Methods/techniques to be employed: A case control study comprising a data base of 700 men with rheumatoid arthritis will determine the occupation of these individuals and compared to a control group attending a GP practice in North Cornwall. This will determine the increased risk associated with exposure to wood dust, cement dust and china clay dust. The prevalence of rheumatoid will be determined around the china clay industry in St Austell. Male rheumatoid arthritis patients will be genotyped for the HLADRB1 allele and their serology checked for rheumatoid factor and anti-citrullinated peptide antibodies. It will be determined if there is an interaction between the shared epitope (a subgroup of HLADRB1 alleles) exposure to cadmium in the workplace (urinary cadmium levels will be used to confirm occupational exposure) and levels/presence of rheumatoid factor and anti-citrullinated peptide antibodies in the serum. N.B. This project is based at the Truro campus in Cornwall 40 | P a g e 3.4. MSc by Research Medical Studies – Health Services Research 3.4.1. How can medical clinical-academic practice be informed by ‘engaged scholarship’? Primary Supervisor: Name: Dr Mark Pearson Email: mark.pearson@exeter.ac.uk Department: Institute of Health Research, NIHR CLAHRC South West Peninsula Previous postgraduate supervision experience? Yes ☒ No ☐ Secondary Supervisor: Name: Dr Iain Lang Email: i.lang@exeter.ac.uk Department: Institute of Health Research, NIHR CLAHRC South West Peninsula Previous postgraduate supervision experience? Yes ☒ No ☐ Programme & Theme: ☒MSc by Research Medical Studies - Health Services Research Research Question/Hypothesis: 1. What is meant by ‘engaged scholarship’? 2. How has engaged scholarship been applied in different areas of practice within Medicine and other areas of care? 3. How can clinical-academic practice be informed by engaged scholarship? 4. What is the evidence for the effectiveness of using engaged scholarship in clinical-academic practice? Abstract: What do we mean when we talk about ‘knowledge transfer’? Some aspects of practising Medicine, such as ordering appropriate diagnostic tests and prescribing the right dose of a drug are informed by straightforward application of accepted knowledge. However, there are many other aspects of medical practice, especially when working with people with complex multi-morbidities, where knowledge is ‘co-created’ in an interactive way between doctors and patients (Wieringa & Greenhalgh 2015). In these cases, a simplistic notion of ‘knowledge transfer’ does not make sense and doctor and patient are learning together. Clinical-academic practice therefore straddles different ways of knowing and has to integrate scientific knowledge and experiential knowledge. Health care policy and practice in both the UK and USA is increasingly taking account of this (Eccles et al. 2009; Solberg et al. 2009), and in the South West the NIHR Collaboration for Leadership in Applied Health Research & Care (PenCLAHRC) endeavours to work in this way. However, our understanding of how clinical-academic practice ‘works’ and the best way to do it is limited. One promising approach is Van de Ven’s (2006) ‘engaged scholarship’ model. This uses different stakeholder perspectives to gain a more rounded understanding of complex problems, but neither the effectiveness of this approach or its application in clinical-academic practice is well understood. This research project will use the Meta-Narrative review method (Wong et al. 2013 - training materials and reporting standards) to explore how engaged scholarship has been applied in different areas, define how medical clinical-academic practice can be informed by it, and establish the effectiveness of the approach in different areas of medical clinical-academic practice. Methods/techniques to be employed: Systematic literature searching, Meta-narrative review (including analysis and synthesis of diverse types of data). 41 | P a g e 3.4.2. Accelerating the diffusion of innovations in acute medical practice: How can Normalisation Process Theory inform diffusion strategies? Primary Supervisor: Name: Dr Mark Pearson Email: mark.pearson@exeter.ac.uk Department: Institute of Health Research, NIHR CLAHRC South West Peninsula Previous postgraduate supervision experience? Yes ☒ No ☐ Secondary Supervisor: Name: Dr Iain Lang Email: i.lang@exeter.ac.uk Department: Institute of Health Research, NIHR CLAHRC South West Peninsula Previous postgraduate supervision experience? Yes ☒ No ☐ Programme & Theme: ☒MSc by Research Medical Studies - Health Services Research Research Question/Hypothesis: How can strategies for the diffusion of innovations in acute medical practice be developed using Normalisation Process Theory? Abstract: Effective innovations in medicine and health care take years to become integrated into routine practice. The diffusion of innovations, such as new diagnostic processes, ways of prescribing, or ways of organising medical care, tend to occur in an opportunistic rather than strategic way. For example, innovators rarely think in a structured way about how innovations are perceived, the characteristics of people who could use the innovation, and the organisational contexts into which innovations are introduced (Berwick 2003). This gap between what is known and what is done means patients do not benefit from improvements in health care as quickly as they should. Using theory can improve our understanding of how innovations spread (Davidoff et al. 2015) and so inform the design of strategies to increase the rate of diffusion. Normalisation Process Theory (NPT) (May et al. 2009; May 2013) has been used to investigate diffusion processes in community health care but not in acute medical settings (see McEvoy et al. 2014). This research project will use NPT to explore the literature on how an effective innovation in acute medical practice (of which details will be agreed between student and supervisors) could be made to spread more rapidly and sustainably. The use of NPT will require investigation of how collective action in complex settings takes place as well as considering the impact of individuals’ attitudes and intentions. Methods/techniques to be employed: Systematic approaches to literature searching and review Intervention Mapping 42 | P a g e 3.4.3. Accelerating the diffusion of innovations in public health: How can Normalisation Process Theory inform diffusion strategies? Primary Supervisor: Name: Dr Mark Pearson Email: mark.pearson@exeter.ac.uk Department: Institute of Health Research, NIHR CLAHRC South West Peninsula Previous postgraduate supervision experience? Yes ☒ No ☐ Secondary Supervisor: Name: Dr Iain Lang Email: i.lang@exeter.ac.uk Department: Institute of Health Research, NIHR CLAHRC South West Peninsula Previous postgraduate supervision experience? Yes ☒ No ☐ Programme & Theme: ☒MSc by Research Medical Studies - Health Services Research Research Question/Hypothesis: How can strategies for the diffusion of innovations in public health be developed using Normalisation Process Theory? Abstract: Effective innovations in public health take years to become integrated into routine practice. The diffusion of innovations, such as new public health programmes, tend to occur in an opportunistic rather than strategic way. For example, innovators rarely think in a structured way about how innovations are perceived, the characteristics of people who could use the innovation, and the organisational contexts into which innovations are introduced (Berwick 2003). This gap between what is known and what is done means patients do not benefit from improvements in health care as quickly as they should. Using theory can improve our understanding of how innovations spread (Davidoff et al. 2015) and so inform the design of strategies to increase the rate of diffusion. Normalisation Process Theory (NPT) (May et al. 2009; May 2013) has been used to investigate diffusion processes in hospitals and GP practices but not in public health (see McEvoy et al. 2014). This research project will use NPT to explore the literature on how an effective innovation in public health (of which details will be agreed between student and supervisors) could be made to spread more rapidly and sustainably. The use of NPT will require investigation of how collective action in complex settings takes place as well as considering the impact of individuals’ attitudes and intentions. Methods/techniques to be employed: Systematic approaches to literature searching and review Intervention Mapping 43 | P a g e 3.4.4. Accelerating the diffusion of innovations in surgical practice: How can Normalisation Process Theory inform diffusion strategies? Primary Supervisor: Name: Dr Mark Pearson Email: mark.pearson@exeter.ac.uk Department: Institute of Health Research, NIHR CLAHRC South West Peninsula Previous postgraduate supervision experience? Yes ☒ No ☐ Secondary Supervisor: Name: Dr Iain Lang Email: i.lang@exeter.ac.uk Department: Institute of Health Research, NIHR CLAHRC South West Peninsula Previous postgraduate supervision experience? Yes ☒ No ☐ Programme & Theme: ☒MSc by Research Medical Studies - Health Services Research Research Question/Hypothesis: How can strategies for the diffusion of innovations in surgical practice be developed using Normalisation Process Theory? Abstract: Effective innovations in surgery and health care take years to become integrated into routine practice. The diffusion of innovations, such as new surgical techniques, devices, and ways of working within teams, tend to occur in an opportunistic rather than strategic way. For example, innovators rarely think in a structured way about how innovations are perceived, the characteristics of people who could use the innovation, and the organisational contexts into which innovations are introduced (Berwick 2003). This gap between what is known and what is done means patients do not benefit from improvements in health care as quickly as they should. Using theory can improve our understanding of how innovations spread (Davidoff et al. 2015) and so inform the design of strategies to increase the rate of diffusion. Normalisation Process Theory (NPT) (May et al. 2009; May 2013) has been used to investigate diffusion processes in health care but not in acute surgical settings (see McEvoy et al. 2014). This research project will use NPT to explore the literature on how an effective innovation in acute surgical practice (of which details will be agreed between student and supervisors) could be made to spread more rapidly and sustainably. The use of NPT will require investigation of how collective action in complex settings takes place as well as considering the impact of individuals’ attitudes and intentions. Methods/techniques to be employed: Systematic approaches to literature searching and review Intervention Mapping 44 | P a g e 3.5. MSc by Research Medical Studies – Medical Education 3.5.1. How might we improve the preparedness of new medical graduates for medical practice? Primary Supervisor: Name: Prof Karen Mattick Email: k.l.mattick@exeter.ac.uk Department: Medical School/School of Education Previous postgraduate supervision experience? Yes ☒ No ☐ Secondary Supervisor: Name: TBC Email: Department: Previous postgraduate supervision experience? Programme & Theme: ☒MSc by Research Medical Studies – Medical Education Research Question/Hypothesis: How might we improve the preparedness of new medical graduates for medical practice? Abstract: Professor Karen Mattick is a medical education researcher, with a particular interest in the preparedness for practice of new medical graduates: https://medicine.exeter.ac.uk/about/profiles/index.php?web_id=Karen_Mattick She would be interested to supervise intercalated degrees students studying for a Masters By Research in Medical Education, particularly in topics aligned to her interests. This might include research into the experiences of senior medical students and junior doctors, interventions to support their learning and decision making (especially around prescribing) and / or interventions to bolster feedback and support for junior doctors, with a focus on their wellbeing and retention in the medical profession. Karen is also interested in the comparison of education, training and support for a career in medicine, with the equivalent for other professions (e.g. teaching, law) and how notions of professionalism, feedback and support might vary between professions. Methods/techniques to be employed: The methods used would depend on the specific topic area and experiences and preferences of the applicant; and the second supervisor would be selected to ensure good coverage of content and methodological expertise; but likely methodologies might include literature work, workplace based observation, surveys and/or interviews. 45 | P a g e 3.6. MSc by Research Biological Sciences – Environmental Biology 3.6.1. Colour Change and Metabolics of Chameleon Prawns Primary Supervisor: Name: Martin Stevens Email: martin.stevens@exeter.ac.uk Department: Centre for Ecology and Conservation, Penryn Campus Previous postgraduate supervision experience? Yes ☒ No ☐ Secondary Supervisor: Name: Lucy Hawkes Email: l.hawkes@exeter.ac.uk Department: Centre for Ecology and Conservation, Penryn Campus Previous postgraduate supervision experience? Yes ☒ No ☐ Programme & Theme: ☒ MSc by Research Biological Sciences – Environmental biology Research Question/Hypothesis: Many animals change colour for camouflage, using special cells called chromatophores to modify their appearance over a period of minutes, hours, days, and weeks. However, while it has been commonly assumed that colour change carries an energetic/metabolic cost, this has never been empirically tested. Using aquatic respirometry, this project will use the brightly coloured chameleon prawn (Hippolytes varians) in captive controlled conditions to test how the extent and speed of colour change incurs metabolic costs. Abstract: Colour change is found widely in nature, from reptiles and frogs through to insects and crustaceans. It can occur over varied timescales and involves changing the state of special cells called chromatophores to move coloured pigments over the body. Colour change has been commonly assumed to carry a significant metabolic cost, but this has never been tested. Chameleon prawns are a common intertidal species in the UK that vary dramatically in colour, from red to yellow to green, for camouflage on different seaweeds. They are thought to change colour over a period of hours and days. This project will analyse their change in colour using special digital imaging equipment, and model their appearance and camouflage to predator (fish vision). Concurrently, individuals will be placed in metabolic chambers to analyse the metabolic costs (measured as the rate of oxygen consumption) required to change colour over time and to different appearances. Methods/techniques to be employed: UV-human visible digital photography Image analysis Animal husbandry Aquatic respirometry Note: This project is based at the Penryn campus in Cornwall. 46 | P a g e 3.6.2. Effects of Colour Change and Rearing Conditions on Lobster Release Success Primary Supervisor: Name: Martin Stevens Email: martin.stevens@exeter.ac.uk Department: Centre for Ecology and Conservation, Penryn Campus Previous postgraduate supervision experience? Yes ☒ No ☐ Secondary Supervisor: Name: Alastair Wilson Email: a.wilson@exeter.ac.uk Department: Centre for Ecology and Conservation, Penryn Campus Previous postgraduate supervision experience? Yes ☒ No ☐ Programme & Theme: ☒MSc by Research Biological Sciences – Environmental biology Research Question/Hypothesis: Sustainable fisheries and related industries face a serious problem of depleted stocks. The National Lobster Hatchery (NLH) at Padstow has had great success at rearing and releasing juvenile lobsters into local waters to enhance wild stocks. However, juvenile hatchery lobsters vary greatly in coloration and this is likely to diminish their survival chances in the wild through lack of camouflage. This project will, in collaboration with NLH, test how lobsters change colour during development on substrates of different appearance, and how changes in background colour and lighting affect the colour and camouflage of juveniles. Abstract: Colour change is found widely in nature, from reptiles and frogs through to insects and crustaceans. It can occur over varied timescales and often involves changing appearance to better match the substrate colour and light conditions. Juvenile lobsters are one species that appear capable of colour change in line with the prevailing conditions. They are now successfully being reared and released to supplement natural stocks, which have declined dramatically over time. However, current rearing conditions do not attempt to control the colour of released individuals, which probably do not match natural substrates effectively, likely decreasing release success through increased predation. There should be value therefore in understanding how colour change in lobsters is controlled, and how to ensure rearing conditions facilitate the development of well camouflaged lobsters. This project will keep juvenile lobsters in marine tanks and vary the colour of the substrate and light conditions. Using special digital imaging equipment, the colour change and camouflage of the lobsters to predator (fish) vision will be analysed, and used to inform rearing protocols in the National Lobster Hatchery. Methods/techniques to be employed: UV-human visible digital photography Image analysis Animal husbandry Note: This project is based at the Penryn campus in Cornwall. 47 | P a g e 3.6.3. Ageing in its natural context Primary Supervisor: Name: Professor Tom Tregenza Email: t.tregenza@exeter.ac.uk Department: Centre for Ecology and Conservation, Penryn Campus Previous postgraduate supervision experience? Yes ☒ No ☐ Secondary Supervisor: Name: Dr Rolando Rodríguez Muñoz Email: R.Rodriguez-Munoz@exeter.ac.uk Department: Centre for Ecology and Conservation, Penryn Campus Previous postgraduate supervision experience? Yes ☒ No ☐ Programme & Theme: ☒MSc by Research Biological Sciences – Environmental biology Research Question/Hypothesis: Why we, and all other living things, progressively deteriorate and become more likely to die as we get older is a major unresolved question in biology. Ageing has been studied a lot in laboratories, but we have much less information about how ageing proceeds in natural populations. This project will investigate whether wild insects deteriorate in their physical performance as they age, using an individually marked natural population of crickets in a meadow in Northern Spain. This will provide essential insights into the limitations of lab studies, and into the importance of the environment in understanding ageing. Abstract: This project will address a key question in both medicine and biology – why do organisms get old and die? We will exploit the fact that we have established a comprehensive monitoring programme of an entire natural population of insects: www.WildCricketsorg. WildCrickets uses a network of 140+ day/night video cameras to record the lives of all of the adult crickets in a meadow in Northern Spain. We catch each cricket as it becomes adult, take a DNA sample, attach an individually recognisable tag and return it to live out its life which we observe using our video network. This project provides an amazing opportunity to ask questions about ageing in nature. In particular, there has been a lot of excitement generated by laboratory results which suggest that restricting diet can increase lifespan, a possibility which has already created great controversy in medicine. By providing additional food to half of an otherwise completely natural wild population, and restricting the diet of the other half, we will determine whether caloric intake has effects on ageing in the wild that are similar to those reported in the lab. We will not only monitor lifespan, but also key performance indicators such as how much movement individuals engage in and how fast they can respond to simulated predator attacks. The project will involve fieldwork in Northern Spain for between 2 weeks and 3 months depending on the preference of the candidate, and I would expect it to generate a number of publications in international scientific journals. Methods/techniques to be employed: The exact nature of the project, and the relative emphasis on different approaches will be decided in collaboration with the student. Methods and techniques employed will include: Fieldwork in a meadow in Spain, conducting assays on the physical performance of wild insects using high speed video cameras; Video analysis of the behaviour of individuals; potential for genetic analysis of parentage based on DNA data; potential for morphometric analysis of the bodies of individuals, potential for analysis of the chemical composition of the cuticle of different individuals and potential for acoustic analyses of the calling songs of male crickets. Note: This project is based at the Penryn campus in Cornwall. 48 | P a g e 3.6.4. Citizen Science – real research by real people Primary Supervisor: Name: Professor Tom Tregenza Email: t.tregenza@exeter.ac.uk Department: Centre for Ecology and Conservation, Penryn Campus Previous postgraduate supervision experience? Yes ☒ No ☐ Secondary Supervisor: Name: Dr Rolando Rodríguez Muñoz Email: R.Rodriguez-Munoz@exeter.ac.uk Department: Centre for Ecology and Conservation, Penryn Campus Previous postgraduate supervision experience? Yes ☒ No ☐ Programme & Theme: ☒MSc by Research Biological Sciences – Environmental biology Research Question/Hypothesis: “Citizen Science” in which members of the public contribute to research programmes without having extensive formal training is a rapidly expanding approach to gathering data in both biology and medicine. This project will use an experimental approach to determining the strengths and limitations of using members of the public to gather data on animal behaviour. Questions will include: What factors determine the degree of participation that is achieved by the project? Can the accuracy and reliability of data be predicted by factors such as the demography of participants, the extent of their participation, the times when they participate and suchlike? Abstract: This project will launch, develop and evaluate a major citizen science project using members of the public to collect data aimed at understanding questions about evolutionary biology. We are at an advanced stage of producing a web application that will allow members of the public to analyse the hundreds of thousands of hours of video that we have recorded from our wildcrickets.org (project pre-launch site intermittently available at: http://cricket-tales.exeter.ac.uk/). The aim of the WildCrickets project is to understand a host of question relating to evolution in its natural context, but a major impediment to realising its potential is in transcribing data from our video into a spreadsheet. You would lead the roll out of the cricket-tales citizen science project, working with us and the developer to advance the approach, analysing the effect of changes on uptake and data quality. You will research the factors that promote participation and the extent to which the quantity and quality of the data that we collect can be predicted using factors such as user characteristics and usage patterns. We expect this project to generate insights with relevance for citizen science projects across disciplines and to result in publications both in relation to this general field and using the data generated in the project itself. This work could be based in Penryn or in Exeter some visits to Penryn will be needed if an Exeter base is preferred. Methods/techniques to be employed: This project will involve working with a (very nice and very engaged) software developer and the WildCrickets research group to design and promote a web application that will allow members of the public to gather data from our video recordings of crickets in the wild. Data will be collected both through direct interactions with users via the web and at events that we will organise, and through monitoring data collected. It will be possible to conduct experiments changing aspects of the website and monitoring how this affects users and data. 49 | P a g e