Chapter 31
Stroke and Cerebrovascular Disease
Alison Baird
Questions
1. Immune cells involved in the evolution of ischemic brain lesions include:
a. Microglia
b. Neutrophils
c. Monocytes
d. Lymphocytes
e. All of the above
2. Immune cells involved in stroke-related inflammation stroke are predominantly derived
from the circulating blood.
True/False
3. The first immune cell responders after ischemic stroke are the brain microglia.
True/False
4. Leukocyte infiltration across the blood brain barrier after ischemic stroke is dependent on
the expression of adhesion molecules on leukocytes and endothelial cells.
True/False
5. Molecular mediators of inflammation after ischemic stroke include
a. cytokines
b. chemokines
c. complement
d. a and b
e. a, b and c
6. The neurovascular unit is comprised of the following:
a. astrocytes
b. neurons
c. smooth muscle cells
d. endothelial cells
e. all of the above
7. The effects of ischemic stroke on the systemic circulation include:
a. increased susceptibility to infection
b. sensitization of circulating lymphocytes to brain antigens
c. both a and b
d. neither a or b
8. Atherosclerosis is now regarded as a chronic inflammatory disorder as opposed to one of
lipid storage.
True/False
9. Neutrophils are the major inflammatory cells contained within atherosclerotic plaques.
True/False
10. Features of the vulnerable plaque include:
a. more prone to rupture
b. heavy inflammatory cell infiltrate
c. thin fibrous cap
d. a, b and c
e. a and c
31. Stroke and Cerebrovascular Disease
Alison Baird
2
11. Discuss the role of the immune system before and after ischemic and hemorrhagic stroke.
12. Discuss the potential of immunomodulatory approaches for stroke treatment and
prevention.
31. Stroke and Cerebrovascular Disease
Alison Baird
Answers
1.
e
2.
True
3.
True
4.
True
5.
e
6.
e
7.
c
8.
True
9.
False
10.
d
3