AbstractID: 7121 Title: Evaluation of Quality Assurance by Utilizing Positional Variation in IMRT The stated objective of delivering an accurate maximum radiation dose to a tumor site with the maximum sparing effects on the normal tissues requires tremendous efforts on the part of planning a treatment in Intensity Modulated Radiation Therapy(IMRT). This challenge requires extreme accuracy when the target volume consists of smaller irregular nodules wrapped around critical structures coupled with positional uncertainties. We have observed that moving the couch in a symmetrical order does not produce symmetrical results in dose. Such a misleading scenario may result in unwanted outcome. A study was carried out to evaluate the effects of symmetrical changes in couch movement on a 15 MV Linac with a multi-leaf collimator at SSD =100. The detector was placed at 10 cm below the surface in a Lucite phantom. Measurements were made with gantry both at 900 and 2700 and a difference of only 0.2% was found in dose for the symmetrical gantry rotation. With the gantry position fixed at 2700 the couch was raised 1 millimeter (mm) above its central axis and measurements were made. It was observed that there was only 2.30% change in dose. Then the couch was lowered 1 mm below the central axis and measurements were made again. A change of 7.65% in dose difference was observed. This shows that a symmetrical change in target position with fixed SSD does not necessarily result in a symmetrical change in dose. Technique developed along these lines may be incorporated into regular QA program.