AbstractID: 6542 Title: New transfer relation describing non-elementary stages in medical imaging detectors Linear systems cascade analysis is a useful tool to study the imaging characteristics of medical x-ray detectors. In this analysis, the interactions of imaging quanta with the detector are broken down into a series of stages. The propagation of signal and noise through each stage can then be calculated using suitable transfer relations. Transfer relations have been developed for elementary stages: an amplification stage, where each quantum creates multiple quanta with no change in location, and a dislocation stage, where each quantum is moved to a new location (but the total number of quanta is conserved). These elementary stages have been successful in describing various detectors in medical imaging. In general, however, a quantum can create many secondary quanta, each dislocated to a different location. In some cases it may be impossible to further subdivide these interactions into elementary stages. For this reason we derive a new transfer relation which governs stages with multiple correlated amplifications and dislocations. We illustrate the use of this relation with an example: megavoltage imaging with a metal/phosphor detector. In this case, many optical photons are created at various positions along the tracks of ionizing radiation, which undergoes significant lateral transport at megavoltage energies. We calculate the detective quantum efficiency (DQE) using the new cascade equation and Monte Carlo techniques, and show good agreement with experimental data.