AbstractID: 7354 Title: Independent Monitor Unit Calculation for Serial Tomotherapy A self-consistent monitor unit (MU) calculation method has been developed which provides a quick and independent verification of the MUs calculated by the Corvus inverse planning system for Nomos serial tomotherapy. The method takes into account the two unique features of Nomos serial tomotherapy: the dynamic arc delivery of intensity modulated beams and the slice-by-slice multiple-table-position treatment of large tumor volumes. At each table position, the method converts the intensity modulated beam profiles planned at fixed gantry angles into conventional beam apertures at each elemental arc segment corresponding to the arc delivery. The MU calculation is then made equivalent to that for a conventional arc with gantry-angle dependent beam apertures. The dose contribution from each elemental arc segment is calculated by using the Clarkson scatter summation technique based on measured tissue-maximum-ratio and output factors. For treatments requiring multiple table positions, the MU for each table position is dependent on the MUs given at other table positions, as the additional scattered dose from adjacent table positions is proportional to the MU given at those table positions. The current method takes into account the off-slice scatter contribution selfconsistently by solving a set of coupled linear equations for the MUs of all involved table positions. The off-slice scatter contribution is also calculated by using the Clarkson scatter summation technique. Comparison of the MUs calculated by the current method and the Corvus planning system as well as that deduced from direct measurements will be discussed for different treatment conditions.