AbstractID: 7315 Title: Robotic Variable SAD for Frameless Functional Radiosurgery Functional radiosurgery requires the delivery of a very high single dose resulting in long beam-on times. A smaller lesion size delivered in a shorter time is better. Unlike the isocentric gantry, the robotic arm mounted linac of the Cyberknife may utilize a variable source target distance. This study investigates with Monte Carlo simulations the effect of a robotic variable SAD delivery technique to produce a smaller lesion volume while simultaneously achieving a higher dose rate for functional radiosurgery. An isocentric 80 cm SAD treatment plan from a trigeminal neuralgia patient was utilized. Each beam location was moved along the central axis to provide 5, 10, 15, and 20 cm clearance between the collimator and the patient’s skin resulting in separate plans with 45, 50, 55, and 60 cm SSD for both 5 mm and 7.5 mm collimators. A 3.25 mm collimator was simulated using EGS4/BEAM and utilized to generate a comparison dose distribution. The EGS4/MCDOSE code was used to simulate the treatment plans. The required monitor units to achieve 80 Gy peak dose was determined from the simulations for each configuration. The beam-on time for a 300 MU/minute output was calculated. The 5 mm collimator at 45 cm SSD achieves the smallest target isodose volume (3.03 times reduction) and the 7.5 mm collimator at 45 cm SSD achieves the highest dose rate (2.49 times increase). This technique provides dose distributions equivalent to those from smaller collimators while simultaneously achieving higher dose rates. Research supported by Accuray Oncology, Inc.