Back to Contents Page 1 I. Imaging of Spine Disorders In Children: Dysraphism and Scoliosis. II. Authors L. Santiago Medina, MD, MPH Diego Jaramillo, MD, MPH Esperanza Pacheco-Jacome, MD Martha Ballesteros, MD Tina Young Poussaint, MD Brian E. Grottkau MD 2 KEY POINTS ISSUES A. Spinal Dysraphism: 1. How accurate is imaging in occult spinal dysraphism? 2. Defining risk of occult spinal dysraphism (OSD) 3. What is the natural history and role of surgical intervention in occult spinal dysraphism (OSD)? 4. What is the cost-effectiveness of imaging in occult spinal dysraphism? B. Scoliosis 1. How should the radiographic evaluation of scoliosis be performed? 2. What radiation-induced complications result from radiographic monitoring of scoliosis? 3. What is the use of MRI for severe idiopathic scoliosis? 4. What is the use of MRI for high-risk subgroups of scoliosis? 3 IV Key Points: Spinal Dyraphism •The prevalence of OSD ranges from as low as 0.34% in children with intergluteal dimples to as high as 46% in newborns with cloacal malformation. (Moderate Evidence). •MRI and ultrasound have better overall diagnostic performances (ie, sensitivity and specificity) than plain radiographs (Moderate Evidence) in children with suspected occult spinal dysraphism •Early detection and prompt neurosurgical correction of occult spinal dysraphism may prevent upper urinary tract deterioration, infection of dorsal dermal sinuses, or permanent neurologic damage (Moderate and Limited Evidence). •Cost-effectiveness analysis suggests that, in newborns with suspected OSD, appropriate selection of patients and diagnostic strategy may increase quality-adjusted life expectancy and decrease cost of medical workup (Moderate Evidence). Scoliosis • Radiographic measurements of scoliosis are reproducible, particularly when the levels of the end plates measured are kept constant (Moderate Evidence). Unexpected findings on radiographs are unusual (Limited Evidence). • Radiographic monitoring of scoliosis results in a clear increase in the radiation-induced cancer risk, particularly to the breast (Moderate Evidence). It also results in a high dose of radiation to the ovaries and worsens reproductive outcome in females (Moderate Evidence). Therefore, it is very important to reduce the radiation exposure. Postero-anterior projection greatly reduces exposure, and some digital systems also decrease radiation. 4 • Minimal tonsillar ectopia (< 5mm) is significantly prevalent in scoliosis and correlates with abnormalities in somatosensory-evoked potential and with the severity of scoliosis (Moderate Evidence). Otherwise, a paucity of significant findings on MR images of patients evaluated for idiopathic scoliosis is noted, even in severe cases. • Unlike adolescent idiopathic scoliosis, juvenile and infantile idiopathic scoliosis and congenital scoliosis have a high incidence of neural axis abnormalities (Limited Evidence). Increase incidence of neural axis abnormalities have also been seen with atypical idiopathic scoliosis and left (levoconvex) thoracic scoliosis (Limited Evidence). IX. Issues in Spinal Dysraphism Issue 1: How accurate is Imaging? Summary Several studies have shown that MRI and ultrasound have better overall diagnostic performances (ie, sensitivity and specificity) than plain radiographs (Moderate Evidence). The sensitivity of spinal MRI and ultrasound has been estimated at 95.6% and 86.5%, respectively. The specificity of spinal MRI and ultrasound has been estimated at 90.9% and 92.9%, respectively. Conversely, the sensitivity and specificity of plain radiographs have been estimated at 80% and 18%, respectively. Issue 2: Defining risk of occult spinal dysraphism. Summary The prevalence of OSD ranges from as low as 0.34% in children with intergluteal dimples to as high as 46% in newborns with cloacal malformation. (Moderate Evidence). Table 2 summarizes the spectrum of occult spinal dysraphism into low, intermediate and high risk groups. 5 Issue3 : What is the natural history and role of surgical intervention in occult spinal dysraphism? Summary Early detection and prompt neurosurgical correction of occult spinal dysraphism may prevent upper urinary tract deterioration, infection of dorsal dermal sinuses, or permanent neurologic damage (Moderate and Limited Evidence). Several studies have demonstrated that motor function, urologic symptoms, and urodynamic patterns may be improved, stabilized or prevented by early surgical intervention in patients with occult spinal dysraphism (Moderate and Limited Evidence). The surgical outcome may be better if intervention occurs before the age of 3 years (Moderate and Limited Evidence). Spinal neuroimaging, therefore, has the important role of determining the presence or absence of an occult spinal dysraphic lesion so that appropriate surgical treatment can be instituted in a timely manner. At our institution, occult dysraphic lesions diagnosed in the newborn period are usually operated at age 2-3 months. Therefore, if ultrasound is indicated, it is performed in the early newborn and infancy period to avoid a limited sonographic window from posterior element mineralization. If MRI is required, it is usually performed a few days before surgery. 6 Issue 4:What is the cost-effectiveness of imaging in children with occult spinal dysraphism? Summary Cost-effectiveness analysis suggests that, in newborns with suspected OSD, appropriate selection of patients and diagnostic strategy may increase quality-adjusted life expectancy and decrease cost of medical workup. Issues in Scoliosis Issue 1 : How should the radiographic evaluation of scoliosis be performed? Summary Radiographic measurements of scoliosis are reproducible, particularly when the levels of the end plates measured are kept constant (Moderate Evidence). Unexpected findings on radiographs are unusual (Limited Evidence). Issue 2: What radiation-induced complications result from radiographic monitoring of scoliosis? Summary Patients with severe scoliosis are monitored with the use of serial radiographs that expose the body to radiation. Radiographic monitoring of scoliosis results in a clear increase in the radiationinduced cancer risk, particularly to the breast (Moderate Evidence). It also results in a high dose of radiation to the ovaries and worsens reproductive outcome in females (Moderate Evidence). 7 Therefore, it is very important to reduce the radiation exposure. Posteroanterior projection greatly reduces exposure, and some digital systems also decrease radiation. Issue 3: What is the use of magnetic resonance imaging for severe idiopathic scoliosis? Summary There is increasing concern about the association of idiopathic scoliosis with structural abnormalities of the neural axis. Minimal tonsillar ectopia (< 5mm) is significantly prevalent in scoliosis and correlates with abnormalities in somatosensory-evoked potential and with the severity of scoliosis (Moderate Evidence). Otherwise, a paucity of significant findings on MR images of patients evaluated for idiopathic scoliosis is noted, even in severe cases. Issue 4 : What is the use of magnetic resonance imaging for high-risk subgroups of scoliosis? Summary Unlike adolescent idiopathic scoliosis, juvenile and infantile idiopathic scoliosis and congenital scoliosis have a high incidence of neural axis abnormalities (Limited Evidence). Increase incidence of neural axis abnormalities have been seen with atypical idiopathic scoliosis and left (levoconvex) thoracic scoliosis (Limited Evidence). 8 Table 2. Risk Groups for Occult Spinal Dysraphism Variable Baseline Value Reference Low Risk Group Offsprings of diabetic mothers Intergluteal dimples Lumbosacral dimple 0.3% 0.34% 3.8% 63-66 25,63 29 Intermediate Risk Groups Low anorectal malformation Intermediate anorectal malformation Complex skin stigmata a 27% 33% 36% 67 67 29 High Risk Group High anorectal malformation Cloacal malformation Cloacal exstrophy 44% 46% 100% 67 21 21 a = hemangiomas, hairy patches, and subcutaneous masses Back to Article Back to Contents Page