AbstractID: 6910 Title: The N-Dimensional Image Noise-Power Spectrum Estimation of the image noise-power spectrum (NPS) is fundamental to objective characterization of the performance of novel imaging systems. Advanced digital x-ray imaging technologies (e.g., flat-panel imagers) are under development for numerous applications, including: projection radiography [2-D data in the spatial domain (x,y)]; real-time fluoroscopy [2-D data in (x,y) as a function of time, t – essentially constituting 3-D data]; and cone-beam CT [3-D data in (x,y,z)]. Accurate estimation of the NPS in each case requires that the analysis knowledgeably account for signal correlation in each of the n dimensions. For example, it is well known that analysis of a central slice of the 2-D NPS (e.g., using a “synthesized slit”) must account for correlation (blur) in the orthogonal direction. Analogously, the 2-D NPS (e.g., from fluoroscopic data) is affected by correlation (image lag) in the temporal domain, and failure to account for such results in underestimation of NPS (overestimation of DQE). Similarly, the 3-D NPS in cone-beam CT depends on correlation (blur) in the 3-D spatial domain, which is known to be highly asymmetric. This paper presents on a general framework for NPS analysis in n dimensions, highlighting the important aspects of n-D correlation and sampling (i.e., n-D aliasing of the NPS). The issues of NPS convergence and stationarity are addressed, and a general form for NPS normalization is given. The framework is applied to real and simulated n-D image data, reducing to the familiar cases of 1-D and 2D NPS analysis, but extending generally to 3-D and higher-order domains.