AbstractID: 9637 Title: Implementation of an algorithm for fast DRR calculation and estimation of a beam source from a radiograph We present an implementation of an algorithm for fast calculation of DRR from a CT based volume. We also present a theoretical and computational method to utilize our fast DRR computation algorithm to calculate the beam source orientation from a given radiograph. The fast DRR algorithm involves decomposing the 3D volume data into a set of basis functionals that are invariant in one dimension. To generate a DRR when the beam source rotates around an axis, the appropriate functional set is cylindrical harmonics. Each cylindrical harmonic functional is projected into the projection plane from the source. The projection of the volume into the projection plane involves an appropriate summation of all projections. Since the cylindrical harmonic functionals are invariant of beam source axial rotation, new projection of the volume, as a result of the beam rotation, can be recomputed by an appropriate phase shifting and summing the basis functionals projection sets. Using this method in recalculating DRR of a volume, after the initial decomposition, offers a significant advantage in computational speed with respect to other methods, such as ray casting or shear-warp factorization algorithms. However, the main advantage of this algorithm is for source localization and patient orientation and motion compensation. One can apply an inverse process (back-projection) to evaluate the orientation of the beam source from a projected image. This information is used in computing the patient re-positioning for treatment delivery, using a neural network estimator algorithm.