AbstractID: 9140 Title: A comparison between Direct Aperture Optimization and two commercial IMRT systems Recently, significant attention has been paid to aperture-based optimization for IMRT. These methods deviate from traditional IMRT techniques in that apertures are determined using a rulebased algorithm or automatically using computer optimization Direct Aperture Optimization (DAO) is a method that utilizes the latter technique and simultaneously optimizes the relative aperture weights. With DAO, the user pre-specifies the maximum number of segments to deliver from each beam direction, resulting in a significant reduction in the number of segments as compared with conventional IMRT techniques. Some skepticism has developed regarding the proposal that similar treatment plans can be generated with DAO using a significantly smaller number of segments as compared with conventional IMRT techniques. In this talk, we attempt to dispel some of this skepticism by performing a rigorous comparison between DAO and two commercial inverse treatment planning systems, Pinnacle and Corvus. Since different systems use different dose calculation algorithms, doubt can be cast on comparisons between the systems. To minimize this, we extract the final fluence maps from all three systems and use them as input to a home-grown dose calculation algorithm to perform the final dose calculation. Using the three systems, we tuned the optimization parameters to create similar plans for five cases: lung, head-neck, breast, prostate, and pancreas. Identical angles and beam energies were used for each case for all systems. For the DAO plans, we specified a maximum of five apertures per beam direction. The results demonstrate that DAO can produce comparable plans using 50-90% fewer segments.