Site Planning and Radiation Safety for the PET Facility Point of View Jon A. Anderson Department of Radiology The University of Texas Southwestern Medical Center at Dallas This presentation addresses practical design issues for PET and PET/CT facilities that - are involved in cancer imaging of the whole-body with 18F FDG, - use unit doses of FDG obtained from an external radiopharmacy, and - use dedicated PET or PET/CT scanners. Cyclotrons, radiopharmacies, and isotope generators are not considered except peripherally. AAPM Annual Meeting, 7/07 J. Anderson 1 PET and PET/CT Imaging Conventional PET - uses rotating isotopic sources for acquiring transmission image - 70 % E/30% T time split AAPM Annual Meeting, 7/07 J. Anderson 2 Current PET/CT Implementations Siemens/CPS Biograph Series - typically, 15 cm axial FOV - 2D or 3D acquisitions - newer crystals allow lower noise, shorter acquisition times - uses coupled x-ray CT scanner to acquire transmission image for attenuation correction - provides auto registration of anatomic CT and functional PET - faster scans through reduced transmission image time AAPM Annual Meeting, 7/07 PET/CT J. Anderson 3 GE Discovery Series apologies to any vendor that was inadvertently omitted! AAPM Annual Meeting, 7/07 Philips GEMINI J. Anderson 4 1 Workflow at the PET Center (FDG Whole Body Scans) What Is Different When You Have PET in Your Practice? Arrival of patient 1) Requirements for patient handling during injection and uptake phase Receive doses 10 min Position Pt 10-60 min Scan Release Pt * steps with highest technologist exposure QA Check of Scan Read study 5 AAPM Annual Meeting, 7/07 J. Anderson 6 PET Facility: University of Texas Southwestern Medical Center at Dallas 1 Hour Uptake, 30 M inute Scan 16 Radioactive Materials This facility needs two uptake areas Dock Laundry J. Anderson PET Facility Throughput Example: Scan Utility Future Camera Office 1 Room Reading Room East Corridor 10 Phase 7 Uptake 4 Hot Toilet Scanning Hot Lab Injection Scan Room 1 #2 Injection #1 1 Scan Room 2 Control South Corridor Patient Number * * Print for file and referring; distribute to PACS Maximum Workload Estimation 8:00 Assay of dose Have Pt empty bladder Transport Pt to scanner 3) Combined modality scanners (PET/CT) require consideration of both gamma-ray and x-ray hazard 13 * Uptake of pharmaceutical 30-60 min 2) 511 keV energy -increases exposure rate from doses, patients -greatly increases thickness of required shielding (hence, use time and distance when possible) AAPM Annual Meeting, 7/07 Injection of Pt Pt instruction and prep West Corridor Time of Day #pts/day = (Twork - Tuptake)/Tscan_rm AAPM Annual Meeting, 7/07 Break Room Office 2 Patients 9:00 10:00 11:00 12:00 13:00 14:00 15:00 16:00 17:00 Storage Office 3 Business Office Reception & Waiting # uptake areas = Tuptake/Tscan_rm J. Anderson 7 AAPM Annual Meeting, 7/07 J. Anderson 8 2 Hot Lab Details: Dose Storage Area Notes: 1) Floor protection (containers weigh 66 lbs) 2) Space needed depends on how often deliveries are made; may have >100 mCi here at a time, even for one scanner 3) Not much waste accumulation (2 hr half-life) AAPM Annual Meeting, 7/07 J. Anderson 9 Hot Lab Details Hot Lab Details: Dose Assay and Preparation Area Notes: 1) Calibrator convenient to dose storage 2) L Block close to calibrator 3) Note use of special PET carrier for syringe 4) Note L Block: thick window, 2" lead, 2" lead wrap-around AAPM Annual Meeting, 7/07 J. Anderson 10 Injection Room Details Notes: 1) Injection room Hot lab PET/CT bay are most likely areas to need shielding Notes: 1) All this lead requires solid support -- have a heart-toheart talk with the cabinet maker 2) Counter mount of calibrator decreases tech exposure 3) Extra shielding required on well counter to shield from sources in scanner, calibration sources, patient in scanner, etc. 4) Use tungsten syringe shields for dose reduction to fingers. AAPM Annual Meeting, 7/07 J. Anderson 11 2) To minimize anomalous uptake -minimize external stimuli -keep patient quiet and still on gurney or in injection chair 3) Need adjacent hot toilet for patients to use after uptake period. AAPM Annual Meeting, 7/07 4) Indirect lighting,curtains, noise control are desirable J. Anderson 12 3 PET and PET/CT Imaging Suites PET/CT Specifics: Scanner Bay and Control Rooms Suggestions Temperature control is vital in both areas -- make sure HVAC plan is adequate (equipment may shut down automatically when temperature goes high!); make sure HVAC is zoned so that uptake areas are separate from scanner/control rooms Control room (never too many network drops!) (Console, HIS/RIS, PACS station/DICOM interface) Conventional PET Provide for IV contrast injector/ injector control unit Technologist spends a lot of time here -- evaluate the shielding to maintain ALARA. AAPM Annual Meeting, 7/07 J. Anderson 13 Views from Control Room AAPM Annual Meeting, 7/07 J. Anderson 14 Specifics and Suggestions: Utility Rooms Required for Some Equipment Note: orientation of PET/CT required use of closed circuit TV to keep patient under observation. May be required to hold - Heat exchangers for cooling the gantry (some gantries exhaust heat into the scan room instead) - Uninterruptible power supplies - Surge suppressors and other power conditioning equipment One technologist can monitor both scanners at the same time. AAPM Annual Meeting, 7/07 Note: Equipment from some vendors may shut down if temperature here exceeds specifications! Consider making your own heat load calculations and asking for extra capacity. J. Anderson 15 AAPM Annual Meeting, 7/07 J. Anderson 16 4 Site Details: How Much Space is just examples from planning guides! Required for a Scanner? site check with the vendor Example Site Plan for a PET/CT Scanner: Siemens Biograph Vendor /Equipment Siemens Biograph 16 PET/CT GE Discovery ST PET/CT Philips Gemini PET/CT Scanner [m] ([ft]) Control [m] ([ft]) Utility [m] ([ft]) Total 2 2 [m ] ([ft ]) 4.57 x 7.55 (15 x 24.8) 3.20 x 4.00 (10.5 x 13) 3.20 x 2.14 (10.5 x 7) 54 (582) 5.00 x 7.10 3.81 x 2.67 not required (12.3 x 9.0) (16.3 x 23.3) 4.8 x 7.9 (16 x 26) 3.6 X 4.8 (12 X 16) not required 46 (491) 55 (608) personal advice: get more space to reduce shielding requirements AAPM Annual Meeting, 7/07 J. Anderson 17 Miscellaneous Personal Advice on Facility Planning and Start-up -Keep the hot areas in interior of space, away from adjacent, uncontrolled occupancies -Buy enough specialty workstations in original purchase to allow techs, docs, researchers enough access (general purpose PACS stations and older NM workstations are inadequate for evaluating, processing, or reading these studies) J. Anderson 19 J. Anderson 18 Radiation Protection Goals: Regulations Limitations per 10CFR20 Radiation workers Pregnant worker's fetus -For multiple scanners, use a common control room AAPM Annual Meeting, 7/07 AAPM Annual Meeting, 7/07 (in terms of effective dose equivalent) 50 mSv/yr 5000 mrem/yr 5 mSv/9 mo 500 mrem/9 mo Members of public 1 mSv/yr in any hour, not to exceed .02 mSv (from each licensed operation) 100 mrem/yr 2 mrem GUIDANCE: ALARA -- As Low As Reasonably Achievable AAPM Annual Meeting, 7/07 J. Anderson 20 5 Radiation Protection Goals: NCRP The Old Standbys of Radiation Protection Are Still There: TDS Recommendations per NCRP 116 (in terms of effective dose) Radiation workers 50 mSv/yr 5000 mrem/yr with lifetime limit of Age x 10 mSv new facilities designed to limit exposure to "a fraction of the 10 mSv/yr implied by the lifetime dose limit." Pregnant worker's fetus 0.5 mSv/mo 50 mrem/mo Members of public 1 mSv/yr 100 mrem/yr (All sites or sources! Either limit single-site contribution to 25% of this, or demonstrate that maximally exposed individual will not exceed 1 mSv for all contributions.) AAPM Annual Meeting, 7/07 J. Anderson 21 Shielding and the PET Center Common Viewpoint: Nuclear medicine departments don't need shielding Under older regulatory limits of 5 mSv/yr for members of the public, little or no additional shielding would be needed in many cases. This needs to be re-evaluated under new 1 mSv/yr limits. (5 times less dose allowed) Another way of putting this: much of the shielding required in practice is on the order of 2 to 3 half-value layers (factor of 4-8). Each half value layer is about 1/8” of lead! AAPM Annual Meeting, 7/07 J. Anderson 23 Time Distance Shielding Shielding is just harder to come by. AAPM Annual Meeting, 7/07 J. Anderson 22 Practice of PET Shielding Is Not Highly Standardized Yet Excerpts from a web discussion thread on shielding control areas at PET facilities (from 2000, but the same discussions are held today): "...requirements were determined to be 1" and 1/2" of lead..." "...we don't have any special shielding..." "...most do not shield the control room..." "...this leads to lead thicknesses...of about 2 cm..." "...we don't have any lead shielding..." "...we have 2 mm Pb in the walls..." "... we have ...a lead glass window ... 1/4" of lead shielding on this wall..." AAPM Annual Meeting, 7/07 J. Anderson 24 6 Radiation Sources to Include in the Shielding Plan AAPM Task Group on PET Facility Shielding Mark Madsen Members: Jon Anderson Doug Simpkin Jeff Kleck Mike Yester Richard (Bud) Wendt John Votaw Jim Halama Doses (pre-injection) on hand Calibration sources for scanner Patient (in scanner, hot toilet) J. Anderson 25 Photon (511 keV) Intensity per Decay [%] Positron Energy [MeV] -Ray Dose µ Sv/hr)/MBq] [(µ ([(mrem/hr)/mCi]) at 1 meter 11 C 20.3 200 0.961 0.194 (0.717) 13 N 9.97 200 1.19 0.194 (0.717) 15 O 2.03 200 1.72 0.194 (0.717) 194 0.635 0.188 (0.695) 18 F 110. 68 Ge 4.1e5 68 Ga (288 d) 180 82 192 Rb 1.25 AAPM Annual Meeting, 7/07 1.9, 0.8 3.35,2.5 Care must be exercised to understand the dose rate constants. These values, from Unger and Trubey (ORNL/RSIC-45) are given in µSv of deep dose as defined in 10CFR20. The air kerma values for 18F at 1 m are 0.179 (0.662) 0.132 (µ µGy/hr)/MBq 0.210 (0.778) (0.56 (mR/hr)/mCi) J. Anderson CT x-ray source (for PET/CT) AAPM Annual Meeting, 7/07 J. Anderson 26 The 18F-Injected Patient as a Source (retained activity) Dose Rate Constants from Point Source Positron Emitters HalfLife [min] require CT x-ray workload factors, including additional (nonPET) CT work TX Sources in scanner (PET) Report is hoped for by end of 2004. Because this work is unfinished, today's talk, except when noted, reflects the author's opinions, not the committee's conclusions. AAPM Annual Meeting, 7/07 require isotopic workload parameters Patient (post-injection) Dose Rate from Injected Patient at 1 m 0.600 Dose Rate [(µ Sv/hr)/MBq] [(mrem/hr)/mCi] Chairman: 0.500 0.400 sources of variation: delay time to measurement, micturation status, exposure-to-dose conversion, etc. 0.300 0.200 0.100 0.000 Kearfott 1992 Chisea 1997 Cronin 1999 Benetar 2000 White 2000 Massoth 2003 SI Units 0.075 0.055 0.100 0.150 0.137 0.097 Conventional Units 0.279 0.203 0.370 0.553 0.508 0.359 Source AAPM 2003 poster about 20% of dose will be in bladder after 1-2 hours 27 AAPM Annual Meeting, 7/07 J. Anderson 28 7 The 18F-Injected Patient as a Source (average of different investigators) µSv/hr)/MBq Superior 0.075 (µ 0.279 (mrem/hr)/mCi Isodose Curves from Vendor all at 1 m from surface of body, average value from all applicable reports Lateral Anterior 0.104 (µ µSv/hr)/MBq 0.383 (mrem/hr)/mCi 0.103 (µ µSv/hr)/MBq 0.383 (mrem/hr)/mCi not as anisotropic as is might seem 0.018 (µ µSv/hr)/MBq Inferior 0.065 (mrem/hr)/mCi AAPM Annual Meeting, 7/07 compare this to 0.014 (µ µSv/hr)/MBq or 0.05 (mrem/hr)/mCi 99m for Tc J. Anderson with phantom in place 29 Half-Value Layer at 511 keV Narrow Beam Conditions [mm] 3 Lead (11.4 g/cm ) 3.98 3 34 3 43 Concrete (2.35 g/cm ) Concrete (1.84 g/cm ) with transmission rods extended Caveat Shieldor: The phantoms for PET and for CT isodose curves do not look very much like patients! Shielding Materials Material 3 (density in [g/cm ] with line source in place AAPM Annual Meeting, 7/07 J. Anderson 30 More Precise Shielding Calculation Approaches Correct curves for 511 keV are not in NCRP 49; new NCRP 147 will not include isotopic information Alternatives: - Interpolate between existing curves from NCRP 49 Caveat Shieldor: These are narrow beam values; the observed attentuation will be less than this in real shielding geometries. - Use gamma-transport codes (example: Courtney, Health Phys. 81, S24S28 (2001)) Low density concrete is often used for poured-in-place floors over steel decking, a common construction technique. - Use buildup or other semi-empirical approach; buildup formalism µx)e-µ x, where B(µ µx) is the buildup function models the intensity as I = IoB(µ (must use correct factors) Gypsum wallboard has been investigated (Courtney, Health Phys. 81, S24-S28 (2001)) but provides little attenuation at reasonable thickness. - Wait until AAPM Task Group report is issued AAPM Annual Meeting, 7/07 J. Anderson 31 AAPM Annual Meeting, 7/07 J. Anderson 32 8 Information to Collect for Shielding Evaluation A Shielding Paradigm for Mixed PET/CT Applications (Just a personal opinion) Uses of adjacent spaces (including above and below) and occupancy factors for them # patients/week isotopes to be used, activity/pt types of PET studies to be performed (heads, WB, cardiac) uptake time; scan time dose delivery schedule; maximum activity on hand CT technique factors (kVp, mAs/scan [depends of # beds]) # scans per patient amount of "non-PET" CT workload expected AAPM Annual Meeting, 7/07 J. Anderson Identify magnitude and location (x,y) of all sources, including CT. Integrate over appropriate decay period that source is in location. Express as dose/wk or dose/hr at one meter, given workload. Identify all barriers that will contribute to shielding, including pigs, shipping containers, etc. Establish test points (x,y) at perimeter, sensitive locations. Identify which barriers will shield each point. 33 AAPM Annual Meeting, 7/07 A Shielding Paradigm (cont) J. Anderson 34 Effects of Adding Corrections to Dose Calculation Calculate doses (summed over all sources, including CT) without attenuation. Dose at 1 m from 10 mCi F-18Activity Start adding lead or concrete as necessary to the barriers, recalculating the doses as you go. 6 Include physical decay Dose [mrem] 5 Stop when you have met goals (100 mrem/yr, 2 mrem/hr) Include self-shielding Include self-shielding, voiding 4 3 2 1 A spreadsheet can do all of this (including corrections for anisotropic sources). Special purpose programs can be developed to do the same. Pencil and paper can be used, but it is tedious! AAPM Annual Meeting, 7/07 J. Anderson 35 0 0 20 40 60 80 100 120 140 Time [min] AAPM Annual Meeting, 7/07 J. Anderson 36 9 Calculation Grid for PET/CT Calculations 8 7 9 10 11 12 50 13 14 15 16 17 18 Example Spreadsheet Verification that no member of the public will avg per hour Input Data Source XRate@1m 1 scan1 3.15 2 scan2 2.6 3 inj 1 3.8 4 inj 2 3.8 5 phan 1 1.1 6 phan 2 1.1 7 lab 54 8 hot_ws 0.13 9 bath 0.45 10 CT NPETSources 9 19 49 48 66 47 6 20 65 64 23 22 s7 s8 3 s6 s1 s4 45 27 s9 44 s3 43 51 42 41 52 40 39 53 38 54 37 36 35 34 55 60 56 33 32 57 test point results 28 63 62 61 31 30 58 29 59 PathID 1 2 3 4 AAPM Annual Meeting, 7/07 J. Anderson Sy 10.49 8.6 7.77 8.81 8.58 9.88 11 11 6.56 9.11 Total Target mR/wkmR/wk Loc_ID Occupancy Status Area 1 1 OK control 12.66 2 1 OK control 9.05 3 0.25 OK hot lab 7.61 4 1 OK reading room 3.62 5 1 OK reading room 2.03 6 1 OK reading room 2.44 7 1 OK E wall 1.97 8 1 OK E wall 1.81 9 1 OK E wall 1.97 10 1 OK E wall 1.97 11 1 OK E wall 1.74 12 1 OK E wall 1.70 13 1 OK E wall 1.56 14 1 OK E wall 1.41 15 1 OK E wall 1.28 16 1 OK E wall 1.14 17 1 OK E wall 1.13 26 s2 s10 2 s5 21 24 1 46 Sx -14.4 -4.43 -17.6 -17.6 -15.9 -8.83 -18.7 -17.8 -22.8 -5.04 source definitions 5 4 be exposed to more than 100 mrem/yr 37 Where to Put the Lead: Shadow vs Complete Coverage XConst Source Area 3.15 scan1 control 2.60 scan2 control 3.80 inj 1 control 3.80 inj 2 control 100 100 100 100 100 100 2 2 2 2 2 2 2 2 2 2 2 511 Calculation Buildup Factor Coefficients Matl Mu/Rho Rho Mu B2 B1 B0 Concrete 0.0877 1.84 0.1614 0.049 0.473 0.994 Lead 0.161 11.34 1.8257 -0.01 0.198 1.05 Lead tranmissions for CT Calc (NCRP49) d[cm] B 0 1 Exposure Tolerance: 0.159 2.63E-03 0.3180 5.47E-05 0.4760 1.09E-06 0.6350 1.00E-06 shielding material definitions Tot/Targ Ratio 0.12664 0.09049 0.0761 0.03618 0.02026 0.02444 0.98403 0.90567 0.98286 0.98251 0.86885 0.85039 0.77788 0.70582 0.64054 0.57104 0.56277 Tx -10.83 -9.60 -17.84 -12.80 -10.99 -9.60 -20.12 -18.29 -16.46 -14.63 -12.80 -10.97 -9.14 -7.32 -5.49 -3.66 -1.83 Ty 10.06 8.23 11.52 15.55 17.36 15.55 18.29 18.29 18.29 18.29 18.29 18.29 18.29 18.29 18.29 18.29 18.29 Barrier# Thick Orient q[rad] n [cm] Loc_IDOccupancy Length TotReqL,WS TotL, NS d(concrete) d(lead)B1 B2 B3 [rad] 1 1 3.57595 3.021053 1.02 1.12 0 0.16 1 1 1 6.56442 6.058898 0.92 1.02 0 0.163 2 1 1 7.12787 3.468667 0.66 1.23 0 0.84 5 1 1 1 6.86477 3.324703 0.68 1.23 0 0.809 4 1 AAPM Annual Meeting, 7/07 -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7 8 0 0 0 0 2.54 3.105 2.54 0 0.159 0.159 0.636 0.636 0.636 0.159 0.318 0.636 0 0 0 0 0 0 0 0 0 0 0 90 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.571 B7 B8 barrier definitions B4 J. Anderson B5 B6 CT Calculation CT Angle 320 degrees CT mAs/hr 40000 mAs 1 Comment 1 1 4 4 4 1 2 4 L-Block PET-Net shipping case + local shielding 1" lead storage case no barriers counted n control s control s hot lab s inj 2 s inj 1 n inj area s scan 2 e hot lab barriers for each test point 38 Examples of Shadow Shields Alternatives: Complete coverage -- like most x-ray shielding -contractors are familiar with technique -facility previously shown had lead thicknesses of 1.6 mm to 6.3 mm, easily managed - makes sense for PET/CT where CT must be shielded Shadow shielding -- big slabs next to trouble spots -can reduce overall cost when thick shield needed - provides flexibility when remodeling old work AAPM Annual Meeting, 7/07 J. Anderson 39 from JA Anderson, RJ Massoth, and LL Windedahl, 2003 AAPM AAPM Annual Meeting, 7/07 J. Anderson 40 10 Calculation Formalism Proposed by Task Group AAPM Task Group on PET Facility Shielding -- In Progress B, the barrier transmission factor, will be calculated as 1) Evaluating recommended dose rate constants from the literature for both point sources and the patient as a source. B= 2) Creating, by Monte Carlo simulation, a set of broad-beam attenuation graphs/tables for appropriate shielding materials. Archer equation fits will be given to allow straightforward calculation of shield thickness from the required barrier transmission factor 3) Promulgating a set of consistent recommendations on shielding issues such as those discussed in this talk (the conclusions may be different, you have heard only the author's opinion today!) AAPM Annual Meeting, 7/07 J. Anderson 41 Magnitude of Technologist Consistent with conventional nuclear medicine Exposure practice, most of technologist dose comes from positioning, transport, and injection. Dose/Activity Handled µ Sv/MBq (mrem/mCi) Technologist Doses 0.100 average dose/procedure < 10 µSv (1 mrem) 0.080 0.060 0.040 0.020 0.000 Benetar Chisea Chisea McElroy UTSW Average SI Units 0.018 0.012 0.023 0.019 0.019 0.018 Conventional Units 0.067 0.044 0.085 0.069 0.069 0.067 Reference AAPM Annual Meeting, 7/07 J. Anderson 43 T * d2 * P * A0 * t * Rt * N T = occupancy factor d = distance to protected point P = target dose in protected area (per week, hour, etc.) = dose rate factor A0 = initial activity contained in patient entering the area at start of integration time t = integration time Rt = reduction factor for integration time N = number of patients per time period corresponding to P AAPM Annual Meeting, 7/07 J. Anderson 42 More on Technologist Exposure 1) It is often seen that the technologist dose per mCi handled drops as a function of experience in the PET clinic. An update to the previous UTSW data for the same two technologists as shown on preceding slide shows a normalized WB dose of 0.011 µSv/MBq (0.041 mrem/mCi), down by 40% since 2002. 2) Assuming an average dose of 0.07 mrem/mCi injected, 10 pt/day and 10 mCi injected/pt, this would yield a yearly dose of 1750 mrem, within regulation but above most ALARA investigational limits. Over nine months, it would be 1300 mrem, well above the declared pregnancy limit. AAPM Annual Meeting, 7/07 J. Anderson 44 11 Operating Suggestions to Minimize Technologist Dose Use unit doses. Short half-life allows release of patient with normal (1015 mCi) amounts of administered FDG activity, even under conservative assumptions. Use syringe shields, syringe carriers, carts, etc. to reduce exposure during dose transport, injection. Complete patient instruction, interaction before injection. Minimize time near patient after injection. Establish IV access with butterfly infusion set before injection. Use other personnel for patient transport. J. Anderson 45 Whole Body Scan, HR+ in 2D mode 1.3 rem (average exposure of 56 mR on axis, free air, 6 bed scan, 8 min/bed,) Whole Body Scan, Biograph 10 mCi 18F FDG WB CT scan (130 kVp, 120 mAs, 5 mm, p = 1.5) Total AAPM Annual Meeting, 7/07 J. Anderson Breast-feeding mothers may expose infants through proximity rather than through milk until activity has died away; instruction may be needed (Hicks, J. Nucl. Med. 42(8), 1238-1242 (2001)) AAPM Annual Meeting, 7/07 J. Anderson 46 Acknowledgements Effective Dose Comparison: Conventional PET vs PET/CT 12 mCi 18F FDG transmission scan 10CFR35.75 and Regulatory Guide 8.39 Release allowed: unlikely others receive > 5 mSv Instructions needed: likely to expose others to > 1 mSv Lay out hot lab to minimize handling time. AAPM Annual Meeting, 7/07 Release of Radioactive Patients • • • • • • • • Tammy Pritchett, RT, CNMT Michael Viguet, CNMT Dana Mathews, MD Thomas Lane, PhD Richard Massoth, PhD Larry Windedahl Doug Simpkin, PhD Mark Madsen, PhD 1.1 rem 1.3 rem 2.4 rem 47 AAPM Annual Meeting, 7/07 J. Anderson 48 12 The End AAPM Annual Meeting, 7/07 J. Anderson 49 13