Application for Promotion to Associate Professorship Dr. Angela Savage
PEER REVIEWED PUBLICATIONS
1.
G.G.S. Dutton, K.L. Mackie, A.V. Savage & M.D. Stephenson,"Structural investigation of the capsular polysaccharide of Klebsiella serotype K23", Carbohydr. Res . (1978) 66, 125-31.
2.
G.G.S. Dutton & A.V. Savage, "Structural investigation of the capsular polysaccharide of
Klebsiella serotype K12", Carbohydr. Res . (1980) 83, 351-362.
3.
G.G.S. Dutton & A.V. Savage, "Structural investigation of the capsular polysaccharide of
Klebsiella serotype K58", Carbohydr. Res . (1980) 84, 297-305.
4.
G.G.S. Dutton, K.L. Mackie, A.V. Savage, D. Rieger-Hug & S. Stirm, "Preparation of oligosaccharides by bacteriophage degradation of polysaccharides from Klebsiella serotypes
K21 and K32", Carbohydr. Res . (1980) 84, 161-170.
5.
G.G.S. Dutton, A.V. Savage & M. Vignon, "Use of bacteriophage to depolymerise a
1 polysaccharide to an oligosaccharide; comparison of the H- and
13
C-NMR spectra of the polysaccharide and its hexasaccharide repeating unit", Can. J. Chem . (1980) 58, 2588-2591.
6.
A.V. Savage, R. Geyer, S. Stirm, E. Reinwald & H-J. Risse, "Structural studies on the major oligosaccharides in a variant surface glycoprotein of Trypanosoma congolense ", Mol.
Biochem. Parasitol . (1984) 11, 309-328.
7.
P.R. Farrell, D.A. Applegarth, J.R. Toone, P.M. McLeod & A.V.Savage, "Pseudo arylsulfatase A deficiency in the neurologically impaired patient", Can. J. Neurol. Sc . (1985)
12, 274-277.
8.
A.V. Savage & D.A. Applegarth, "Diagnosis of mucopolysaccharidoses using 1H-NMR spectroscopy of glycosaminoglycans". Carbohydr.Res
. (1986) 148, 471-474.
9.
A.V. Savage, H. van Halbeek, J.F.G. Vliegenthart, P.L. Koppen, W.E.C.M. Schiphorst,
L.A.W. Trippelvitz & D.H.van den Eijnden, "Porcine submaxillary mucin contains
α
2-3 and
α
2-6 linked N-acetyl and N-glycolylneuraminic acid", Eur. J. Biochem . (1986) 160, 123-129.
10.
A.V. Savage, S.M. D'Arcy, C.M. Donoghue, C.A.M. Koeleman & D.H. van den Eijnden,
“
1
H-NMR of NeuAc- and NeuGc-containing trisaccharides with novel core 5 isolated from bovine submaxillary mucin", in R. Schauer and T. Yamakawa (eds.), Sialic acids (1988) pp
90-91, Kiel, Kieler Verlag.
1.
C.M. Donoghue, S.M. D'Arcy & A.V. Savage, "1H-NMR Study of a Sialo-tetrasaccharide
Isolated from Bovine Submaxillary Mucin", Proceed. Royal Irish Acad. (1989) 89B, 125-134.
Festschrift: Prof. Eva Philbin.
1.
S.M.T. D'Arcy, C.M. Donoghue, C.A.M. Koeleman, D.H. van den Eijnden & A.V. Savage,
"Structure Determination of a Novel Acidic Oligosaccharide with Blood-group Activity
Isolated from Bovine Submaxillary Mucin", Biochem. J.
(1989) 260, 389-393.
13.
M. Beurret, J.-P. Joseleau, G.G.S. Dutton & A.V. Savage, "Homologous and Heterologous
Reaction of Bacteriophages
φ
41 and
φ
12 on the Capsular Polysaccharides from Klebsiella
K41 and K12". Carbohydr. Res . (1989) 189, 237-246.
14.
M. Beurret, J.-P. Joseleau, G.G.S. Dutton & A.V. Savage, “Proof of the occurrence of 5,6-O-
(1-Carboxyethylidene)-D-Galactofuranose in the Capsular Polysaccharide of Klebsiella K12 as shown by Analysis of the N.M.R. Spectra of the Phage-produced Oligosacharides",
Carbohydr. Res. (1989) 189, 247 -260.

Application for Promotion to Associate Professorship Dr. Angela Savage
15.
A.V. Savage, C.M. Donoghue, S.M. D'Arcy, C.A.M. Koeleman, & D.H. van den Eijnden.
"Structure determination of five sialylated trisacharides with core types 1, 3, or 5 isolated from bovine submaxillary mucin", Eur J. Biochem. (1990) 192, 427-432
16.
A.V. Savage, J.J. Donohue, C.A.M. Koeleman, & D.H. van den Eijnden. "Structural characterization of sialylated tetrasacharides and pentasaccharides with blood group H and
Lex activity isolated from bovine submaxillary mucin", Eur J. Biochem . (1990) 193, 837-843.
17.
A.V. Savage, S.M. D'Arcy, & C.M. Donoghue. "Structural characterization of neutral oligosaccharides with blood-group A and H activity isolated from bovine submaxillary mucin", Biochem. J. (1991) 279, 95-103
18.
K.O. Lloyd & A.V. Savage. "High performance anion exchange chromatography of reduced oligosaccharides from sialomucins", Glycoconjugate J.
(1992) 8, 493-498.
19.
M.M. Brooks, M.G. Tuohy, A.V. Savage, M. Claeyssens, & M.P. Coughlan. "The stereochemical course of reactions catalysed by the cellobiohydrolases produced by
Talaromyces emersonii ". Biochem. J.
(1992) 283, 31-34.
20.
P. Wong, H. Vallance, A.V. Savage, A.G.F. Davidson & D. Applegarth. "Oral Zinc therapy in the treatment of
α
-Mannosidosis". American J. Medical Genetics, (1993) 46, 410-414.
21.
T. Hayase, M. Sheykhanazari. V.P. Bhavanandan, A.V. Savage, & Y.C. Lee. "Separation and
Identification of O-linked Oligosaccharides derived from Glycoproteins by High-pH Anion-
Exchange Chromatography. Anal. Biochem. (1993) 211, 72-80.
22.
P.M. Mathias, K Bailey, J.J. McEvoy, M. Cuffe, A.V. Savage & A.A. Allen “Studies on the amylotytic breakdown of damaged starch in cereal and non-cereal flours using high performance liquid chromatography and scanning electron microscopy” in Starch: Structure and Functionality. Eds P.J. Frazier, A.M. Donald and P. Richmond. Proceedings Royal
Society of Chemistry Food Chemistry Group / Inst. Food Science and Technology Research
Group: Starch and Starch Function. Churchill College, Cambridge, April 1996. pp 129-140.
23.
M.M. Brooks & A.V. Savage “The substrate specificity of the enzyme endo-
α
N -acetyl-Dgalactosaminidase from Diplococcus pneumonia ”, Glycoconjugate J . (1997) 14, 183-190.
24.
O.M. Hanniffy, A.S. Shashkov, S.N. Senchenkova, S.V. Tomshich, N.A. Komandrova, L.A.
Romanenko, Y.A. Knirel, & A.V. Savage. “Structure of a highly acidic O-specific polysaccharide of lipopolysaccharide of Pseudoalteromonas haloplanktis KMM 23 (44-1) containing L-iduronic acid and D-QuiNHb4NHb” Carbohydr. Res.
(1998) 307, 291-298.
25.
C. Burger, M.J.T. Carrondo, J. Cruz, M. Cuffe, E. Dias, J.B. Griffiths, K. Hayes, J. Hauser, D.
Looby, C. Mielke, J.-L. Moreira, E. Reike, A.V. Savage, G.N. Stacey, & T. Wedge “An integrated strategy for the process development of a recombinant antibody-cytokine fusion protein expressed in BHK cells”, Applied Microbiol. and Biotech.
, (1999) 52, 345 – 353.
26.
O.M. Hanniffy, A.S. Shashkov, A.P. Moran, M.M. Prendergast, S.N. Senchenkova, Y.A.
Knirel, & A.V. Savage “Chemical structure of a polysaccharide from Campylobacter jejuni
176.83 (serotype O:41) containing only furanose sugars” Carbohydr. Res.
(1999) 319, 124-
132.
2

Application for Promotion to Associate Professorship Dr. Angela Savage
27.
O.M. Hanniffy, A.S. Shashkov , S.N. Senchenkova, S.V. Tomshich, N.A. Komandrova, L.A.
Romanenko, Y.A. Knirel, & A.V. Savage. “Structure of an acidic O-specific polysaccharide of Pseudoalteromonas haloplanktis type strain ATCC 14393 containing 2-acetamido-2deoxy-D- and -L-galacturonic acids and 3-( N -acetyl-D-alanyl)amino-3,6-dideoxy-D-glucose”,
Carbohydr. Res.
(1999) 321, 132-138.
28.
J. Pfetzing, D. B. Stengel, M. M. Cuffe, A. V. Savage & M. D. Guiry. “Effects of temperature and prolonged emersion on photosynthesis, carbohydrate content and growth of the brown intertidal alga Pelvetia canaliculata ” Botanica Marina , (2000) 43, 399-407.
29.
J. Muldoon, A.S. Shashkov, S.N. Senchenkova, S.V. Tomshich, N.A. Komandrova, L.A.
Romanenko, Y. A. Knirel, & A.V. Savage “Structure of an acidic polysaccharide from a marine bacterium Pseudoalteromonas distincta KMM 638 containing 5-acetamido-3,5,7,9tetradeoxy-7-formamido-Lglycero -Lmanno -nonulosonic acid”, Carbohydr. Res.
(2001)
330, 231-239.
30.
O.M. Hanniffy, A.S. Shashkov, A.P. Moran, M.M. Prendergast, S.N. Senchenkova, Y.A.
Knirel, & A.V. Savage “Chemical structure of the core region of Campylobacter jejuni serotype O:2 aerotolerant lipopolysaccharide”, Carbohydr. Res.
(2001) 330, 223-229.
31.
J. Muldoon, A.V. Perepelov, A.S. Shashkov, R.P.Gorshkova, E.L. Nazarenko, V.A. Zubkov,
E.P. Ivanova, Y.A. Knirel, & A.V. Savage “Structure of a colitose-containing O-specific polysaccharide of the marine bacterium Pseudoalteromonas haloplanktis ssp. tetraodonis type strain IAM 14160”, Carbohydr. Res.
(2001) 333, 41-46.
32.
P.G. Murray, A. Grassick, C.D. Laffey, M.M. Cuffe, T.M. Higgins, A.V. Savage, A. Planas &
M.G. “Tuohy Isolation and characterisation of a novel, thermostable endo-
β
-glucanase active on 1,3-1,4-
β
-D-glucans from the aerobic fungus Talaromyces emersonii CBS 814.70”,
Enzyme Microbial Technol.
(2001) 29, 90-98.
33.
A.J. Power, B.F. Keegan, K. Nolan, & A.V. Savage. “The seasonality and role of the neurotoxin tetramine in the salivary glands of the red whelk Neptunea antiqua (L.)”. Toxicon ,
(2002) 40, 419–425.
34.
M.G. Tuohy, D.J. Walsh, P.G. Murray, M.Claeyssens, M.M. Cuffe, A.V. Savage & Michael
P. Coughlan. “Kinetic parameters and mode of action of the cellobiohydrolases produced by
Talaromyces emersonii”, Biochim. Biophys. Acta, (2002)1596, 366-380.
35.
M. Kilcoyne, A.S. Shashkov, S.A. Senchenkova, Y.A. Knirel, E.V. Vinogradov,
J.Radziejewska-Lebrech, R. Galimska-Stypa, & A.V. Savage. “Structural investigation of the
O-specific polysaccharides of Morganella morganii consisting of two higher sugars”,
Carbohydr. Res.
(2002) 337, 1697-1702.
36.
J.Muldoon, A.S. Shashkov, A.P. Moran, J.A. Ferris, S.N. Senchenkova, & A.V. Savage.
“Structures of two extracellular polysaccharides of Campylobacter jejuni 81116”, Carbohydr.
Res.
(2002) 337, 2223-2229.
37.
J. Muldoon, A.V. Perepelov, A.S. Shashkov, E.L. Nazarenko, V.A. Zubkov, R.P. Gorshkova,
E.P. Ivanova, N.M. Gorshkova, Y.A. Knirel, & A.V. Savage. “Structure of an acidic polysaccharide from the marine bacterium Pseudoalteromonas flavipulchra NCIMB 2033
T
” .
Carbohydr. Res.
(2003) 338, 459-462.
3

Application for Promotion to Associate Professorship Dr. Angela Savage
38.
S. E. Ryan, K. Nolan, R. Thompson, G. M. Gubitz, A.V. Savage & M. G. Tuohy.
“Purification and characterization of a new low molecular weight endoxylanase from
Penicillium capsulatum”, Enzyme and Microbial Technology , (2003) 33, 775-785.
39.
T. McCarthy, O. Hanniffy, A. V. Savage & M. G. Tuohy. “Catalytic properties and mode of action of three endo-
β
-glucanases from Talaromyces emersonii on soluble
β
-1,4 and
β
-
1,3;1,4-linked glucans”, Intl. J. Biolog. Macromolecules . (2003) 33, 141 - 148.
40.
Y. Wang, M. Zhang, D. Ruan, A. S. Shashkov, M. Kilcoyne, A. V. Savage, & L. Zhang .
“ Chemical components and molecular mass of six polysaccharides isolated from the sclerotium of Poria cocos ”, Carbohydr. Res.
(2004) 338, 327 - 334.
41.
M. Kilcoyne, A. S. Shashkov, A. V. Perepelov, Y. A. Knirel, S. V. Tomshich, N. A.
Komandrova, L. A. Romanenko, A. V. Savage “Structure of the O-polysaccharide of
Idiomarina zobellii KMM 231
T
containing two unusual amino sugars, 4-amino-4,6-dideoxy-
D -glucose and 2-amino-2-deoxyL -guluronic acid, with the free amino group”. Carbohydr.
Res.
(2004) 339, 477-482.
42.
M. Kilcoyne, A. V. Perepelov, A. S. Shashkov, E.L. Nazarenko, V.A. Zubkov, E.P. Ivanova,
N.M. Gorshkova, R.P. Gorshkova, AV. Savage “Structure of an acidic O-specific polysaccharide from marine bacterium Shewanella fidelis KMM 3582
T
containing N
ε
-[( S )-1carboxyethyl]N
α
-(D-galacturonoyl)-L-lysine” Carbohydr. Res.
(2004) 339, 1655-1661.
43.
X. Xu, D. Ruan, Y. Jin, A. S. Shashkov, S. N. Senchenkova, M. Kilcoyne, A. V. Savage, L.
Zhang “ Chemical structure of aeromonas gum - extracellular polysaccharide from Aeromonas nichidenii 5797”. Carbohydr. Res.
(2004) 339, 1631-1636.
44.
Y. Wang, M. Zhang, D. Ruan, A. S. Shashkov, M. Kilcoyne, A. V. Savage, L. Zhang
“ Chemical components and molecular mass of six polysaccharides isolated from the sclerotium of Poria cocos ” Carbohydr. Res.
(2004) 338, 327 - 334.
45.
M. Kilcoyne, A. S. Shashkov, A. V. Perepelov, Y. A. Knirel, S. V. Tomshich, N. A.
Komandrova, L. A. Romanenko, A. V. Savage “Structure of the O-polysaccharide of
Idiomarina zobellii KMM 231
T
containing two unusual amino sugars, 4-amino-4,6-dideoxy-
D -glucose and 2-amino-2-deoxyL -guluronic acid, with the free amino group”. Carbohydr.
Res.
(2004) 339, 477-482.
11.
T. C. McCarthy, E. Lalor, O. Hanniffy, A.V. Savage, and M.G. Tuohy. Comparison of wild type and UV-mutant
β
-glucanase-producing strains of Talaromyces emersonii with potential in brewing applications. J. Industrial Microbiol. & Biotechnol.
(2005) 32, 125-134.
49.
T. McCarthy, O. Hanniffy, E. Lalor, A.V. Savage and M.G. Tuohy. Evaluation of the potential of three thermostable fungal endo-
β
-glucanases for brewing and food applications using viscometric analysis and Dionex HPAEC. Process Biochem . (2005) 40, 1741-1748.
50.
M. Kilcoyne, A. S. Shashkov, A. V. Perepelov, E. L. Nazarenko, R.P. Gorshkova, E. P.
Ivanova, G. Widmalm, A. V. Savage. Structure of the O-specific polysaccharide from
Shewanella japonica type strain KMM 3299
T containing three amino sugars: FucNAc,
Fuc4NAc and QuiNAc4NAc. Carbohydr. Res.
(2005) 340, 1557-1561.
51.
M. Kilcoyne, A. S. Shashkov, Y.A. Knirel, R.P. Gorshkova, E. L. Nazarenko, E. P. Ivanova,
N.M. Gorshkova, S.N. Senchenkova, A. V. Savage. Structure of the O-polysaccharide of the
Pseudoalteromonas rubra ATCC 29570
T
lipopolysaccharide containing a keto sugar.
Carbohydr. Res.
(2005) 340, 2369-2375.
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Application for Promotion to Associate Professorship Dr. Angela Savage
52.
M. Kilcoyne, A.S. Shashkov, S.N. Senchenkova, J.A. Ferris, A. Corcoran, A. P. Moran, and
A. V. Savage, “Separation and identification of the origins of a polysaccharide and a lipopolysaccharides isolated from C. jejuni 81116.” FEMS Letts, (ms. submitted).
1.
E. L. Nazarenko, N. A. Komandrova, R. P.Gorshkova, S. V. Tomshich, V. A. Zubkov, M.
Kilcoyne, & A. V. Savage. Review : “Structures of polysaccharides and oligosaccharides of some Gram-negative marine Proteobacteria”. Carbohydr. Res.
(2003) 338, 2449 - 2457.
2.
A.V. Savage, “Glycosylation: A Post-translational Modification”, in Mammalian Cell
Biotechnology in Protein Production (H. Hauser & R. Wagner, eds) Walter de Gruyter,
Berlin, pp 233 - 276, April 1997.
3.
A.V. Savage, “Sugars: Sweet, strong and very smart!”, Technology Ireland (1994) 26 14-16.
4.
A.V. Savage, “Sugars: Intelligent as well as sweet”, The Irish Scientist Year Book, 1997.
•
Glycoimmunology 2: Advances in Experimental Medicine and Biology. Vol 435. Ed John S.
Axford, published by Plenum Press, New York and London, 1997, 284 pp.
Carbohydr. Res.
, 314 (1998) 293-294.
•
Glycoproteins New Comprehensive Biochemistry Vol 29a
J. Montreuil, J.F.G. Vliegenthart, H. Schacter Eds. 1995 Elsevier, Amsterdam.
Carbohydrates in Europe , May 1996, pp 44-45.
•
Glycopeptides and Related Compounds: Synthesis, Analysis, and Applications. David Large and Christopher Warren Eds, Carbohydr. Res.
, 306, (1998) 587-588
Royal Society of Chemistry Carbohydrate Group and Biochemical Society Glycobiology Group
Joint Spring Meeting: Complex Carbohydrates: Structure, Recognition and Synthesis, University of St. Andrews, March 1996. Glycoconjugate J ., (1996) 13, ix-x.
5