Journal Club Articles 1. Twenty-five year follow up for breast cancer incidence and mortality of the Canadian National Breast Screening Study: Randomized Screening Trial Miller et.al; BMJ 2014 2. Effect of ACEI and ARB on All-Cause Mortality, Cardiovascular Death and Cardiovascular Events in Patients with Diabetes Mellitus. A Meta-Analysis Cheng et.al; JAMA 2014 3. Age-Adjusted D-Dimer Cutoff Levels to Rule out Pulmonary Embolism. The ADJUST-PE Study Righini, Van Es et. Al.; JAMA 2014 4. Changes in Mortality after Massachusetts Health Care Reform Sommers, Long et. Al; Annals of Internal Medicine; May 6th, 2014 5. Health Care-Associated Infection after Red Blood Cell Transfusion. A Systematic Review and Meta-Analysis Rohde et.al; JAMA 2014 6. Aspirin in Patients Undergoing Noncardiac Surgery Devereaux et al; NEJM April 2014 7. Albumin Replacement in Patients with Severe Sepsis or Septic Shock Caironi et al; NEJM April 2014 8. A Randomized Trial of Protocol-Based Care for Early Septic Shock The ProCESS Investigators; NEJM March 18th, 2014 9. High versus Low Blood-Pressure Target in Patients with Septic Shock Asfar et.al; NEJM March 18th, 2014 10. Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock Rivers et.al; NEJM Nov 8th, 2001 11. Cost-Effectiveness of Genotype-Guided and Dual Antiplatelet Therapies in Acute Coronary Syndrome. Kazi MD, et. Al. Annals of Internal Medicine, Feb 2014 12. Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation (The CURE Trial). NEJM 2001 13. Long Term Mortality after Screening for Colorectal Cancer. Shaukat A, Mongin SJ, Geisser MS, et al. NEJM 2013 14. Upper Airway Stimulation for Obstructive Sleep Apnea. Strollo, Soose, Maurer et al. NEJM 2014 15. Bariatric Surgery vs. non-surgical treatment for obesity. Gloy, Bhatt, et al. BMJ 2013 16. Use of procalcitonin to reduce patients’ exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial Bouadma et al; Lancet, 2010 17. Body-Mass Index and Mortality among Adults with Incident Type 2 Diabetes Tobias et al; NEJM Jan 16th, 2014 18. 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults. Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8) JAMA December 2013 19. Heart Association Task Force on Practice Guidelines Cardiovascular Risk in Adults: A Report of the American College of Cardiology/American 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Circulation 2013 20. Worsening Trends in the Management and Treatment of Back Pain JAMA 2013 21. Effects of Vitamin D supplements on bone mineral density: A systematic review and meta-analysis 22. Combined Angiotensin Inhibition for the Treatment of Diabetic Nephropathy (NEJM). November 2013 23. Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy. REENAL Study (NEJM) 2001 24. Combined Angiotensin Inhibition for the Treatment of Diabetic Nephropathy (NEJM). November 2013 25. Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy. REENAL Study (NEJM) 2001 26. Aggressive Fluid and Sodium Restriction in Acute Decompensated Heart Failure JAMA, June 2013 27. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF) The Lancet, June 1999 28. Short-term vs Conventional Glucocorticoid Therapy in Acute Exacerbations of Chronic Obstructive Pulmonary Disease. The REDUCE Randomized Clinical Trial. JAMA, May 2013 29. Effect of Home Blood Pressure Telemonitoring and Pharmacist Management on Blood Pressure Control: A Cluster Randomized Clinical Trial Margolis et. al; JAMA July 3, 2013 30. Therapies for Active Rheumatoid Arthritis after Methotrexate Failure O’Dell et al; NEJM July 25, 2013 31. Diagnostic Blood Loss From Phlebotomy and Hospital-Acquired Anemia During Acute Myocardial Infarction Salisbury et al; Arch Intern Med; October 10, 2011 32. “Effect of hormone replacement therapy on cardiovascular events in recently postmenopausal women” BMJ 33. “Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women” (results from the Women’s Health Initiative) JAMA 34. “Associations Between Reduced Hospital Length of Stay and 30 Day Readmission Rate & Mortality” Annals of Internal Medicine 35. Dietary and Supplemental Calcium Intake and Cardiovascular Disease Mortality The National Institutes of Health 36. Blood Pressure and Mortality in U.S. Veterans with Chronic Kidney Disease Annals of Internal Medicine 37. Cardiovascular Effects of Intensive Lifestyle Intervention in Type 2 Diabetes The New England Journal of Medicine 38. Association Between Chlorthalidone Treatment of Systolic Hypertension and Long-term Survival JAMA, December 21, 2011 39. Screening for Lung Cancer with Low-Dose Computed Tomography: A Systematic Review to Update the U.S. Preventive Services Task Force Recommendation Annals of Internal Medicine 40. Twenty-five year follow up for breast cancer incidence and mortality of the Canadian National Breast Screening Study: Randomized Screening Trial Miller et.al; BMJ 2014 41. Effect of ACEI and ARB on All-Cause Mortality, Cardiovascular Death and Cardiovascular Events in Patients with Diabetes Mellitus. A Meta-Analysis Cheng et.al; JAMA 2014 42. Twenty-five year follow up for breast cancer incidence and mortality of the Canadian National Breast Screening Study: Randomized Screening Trial Miller et.al; BMJ 2014 43. Effect of ACEI and ARB on All-Cause Mortality, Cardiovascular Death and Cardiovascular Events in Patients with Diabetes Mellitus. A Meta-Analysis Cheng et.al; JAMA 2014 44. Simvastatin for the Prevention of Exacerbations in Moderate-to-Severe COPD Criner et. al NEJM June 14, 2014 45. Atrial Fibrillation in Patients with Cryptogenic Stroke Gladstone et. al NEJM June 26, 2014 46. Once weekly Dalbvancin versus conventional therapy for skin infection Boucher, et. al NEJM June 5th, 2014 47. Pregnancy Incidence and Outcomes Among Women Receiving Pre-exposure Prophylaxis for HIV Prevention: A Randomized Clinical Trial Nelly R. Mugo, MBChB, MPH1,2,3; et. al http://jama.jamanetwork.com/article.aspx?articleid=1889140&resultClick=3 48. Telecare Collaborative Management of Chronic Pain in Primary Care: A Randomized Clinical Trial Kurt Kroenke, MD1,2,3; Erin E. Krebs, MD4,5; Jingwei Wu, MS6; Zhangsheng Yu, PhD6; Neale R. Chumbler, PhD7; Matthew J. Bair, MD1,2,3 http://jama.jamanetwork.com/article.aspx?articleid=1887761&resultClick=3 49. Efficacy of Varenicline Combined With Nicotine Replacement Therapy vs Varenicline Alone for Smoking Cessation: A Randomized Clinical Trial Coenraad F. N. Koegelenberg, MD, PhD1; et.al http://jama.jamanetwork.com/article.aspx?articleid=1886188 50. Early Palliative Care for Patients with Metastatic Non–Small-Cell Lung Cancer Jennifer S. Temel, M.D., Joseph A. Greer, Ph.D., et.al N Engl J Med 2010; 363:733-742August 19, 2010DOI: 10.1056/NEJMoa1000678 http://www.nejm.org/doi/full/10.1056/NEJMoa1000678 51. Dabigatran versus Warfarin in Patients with Atrial Fibrillation (RE-LY Trial) Stuart J. Connolly, M.D., Michael D. Ezekowitz, M.B., Ch.B., et.al and the RE-LY Steering Committee and Investigators N Engl J Med 2009; 361:1139-1151 September 17, 2009 52. Vancomycin, Metronidazole, or Tolevamer for Clostridium difficile Infection: Results from Two Multinational, Randomized, Controlled Trials Stuart Johnson, Thomas Louie, et. al for the Polymer Alternative for CDI Treatment (PACT) investigators Clinical Infectious Diseases; July 2014 53. The CHA2DS2-VASc score identifies those patients with atrial fibrillation and a CHADS2 score of 1 who are unlikely to benefit from oral anticoagulant therapy Michiel Coppens, John W. Eikelboom et. Al European Heart Journal, September 2012 54. The Risk of Melanoma in Airline Pilots and Cabin Crew Martina Sanlorenzo, MD et.al JAMA Dermatol. Published online September 03, 2014 55. Cardiovascular Risk and Events in 17 Low, Middle and High-Income Countries S. Yusuf et.al NEJM, August 28, 2014 56. Angiotensin-Neprilysin Inhibition versus Enalapril in Heart Failure J.J. McMurray et. al NEJM, September 11th, 2014 57. The Risk of Melanoma in Airline Pilots and Cabin Crew Martina Sanlorenzo, MD et. al JAMA Dermatol. Published online September 3, 214 58. Cardiovascular Risk and Events in 17 Low, Middle and High-Income Countries S. Yusuf et. al NEJM, August 28, 2014 59. Angiotensin-Neprilysin Inhibition versus Enalapril in Heart Failure J.J. McMurray et. al NEJM, September 11, 2014 60. A Controlled Trial of Renal Denervation for Resistant Hypertension Deepak L. Bhatt, M.D., M.P.H., David E. Kandzari, M.D et.al for the SYMPLICITY HTN-3 Investigators NEJM, March 29th, 2014 61. Canagliflozin Compared With Sitagliptin for Patients With Type 2 Diabetes who do not have Adequate Glycemic Control With Metformin Plus Sulfonylurea G. Schernthaner, J. Gross et.al Diabetes Care, April 5, 2013 62. Bariatric Surgery versus Intensive Medical Therapy for Diabetes — 3-Year Outcomes Philip R. Schauer, M.D., Deepak L. Bhatt, M.D., M.P.H., et.al for the STAMPEDE Investigators NEJM, March 31, 2014 63. Multitarget Stool DNA Testing for Colorectal-Cancer Screening Thomas F. Imperiale, et. Al NEJM April 3rd, 2014 64. A Randomized Trial of Rectal Indomethacin to Prevent Post-ERCP Pancreatitis B. Joseph Elmunzer, et. al NEJM April 12, 2012 65. Ledipasvir and Sofosbuvir for 8 or 12 Weeks for Chronic HCV without Cirrhosis Kris V. Kowdley, et. al NEJM May 15, 2014 66. Goal-Directed Resuscitation for Patients with Early Septic Shock The ARISE Investigators and the ANZICS Clinical Trials Group* October 1st, 2014 67. Fractional Flow Reserve–Guided PCI for Stable Coronary Artery Disease Bernard De Bruyne, M.D., Ph.D. et.al NEJM September 2014 68. Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients The HPS2-THRIVE Collaborative Group* NEJM July 2014 69. Low-Dose Aspirin for Primary Prevention of Cardiovascular Events in Japanese Patients 60 years or Older with Atherosclerotic Risk Factors Y. Ikeda et. al, JAMA, November 17, 2014 http://jama.jamanetwork.com/article.aspx?articleid=1936801 70. Tamoxifen for prevention of breast cancer: extended long-term follow-up of the IBIS-I breast cancer prevention trial J. Cuzick et.al, Lancet, December 2014 http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(14)71171-4/abstract 71. A Randomized Trial of Low-Dose Aspirin in the Primary Prevention of Cardiovascular Disease in Women P. Ridker et.al, NEJM, March 200 http://www.nejm.org/doi/full/10.1056/NEJMoa050613 72. The Effectiveness and Risks of Long-Term Opioid Therapy for Chronic Pain: A Systematic Review for a National Institutes of Health Pathways to Prevention Workshop Roger Chou, MD et. Al Annals of Internal Medicine, Feb 17th, 2015 73. Cost-Effectiveness of Hypertension Therapy According to 2014 Guidelines Andrew E. Moran, M.D., M.P.H., Michelle C. Odden, Ph.D., et.al N Engl J Med January 29, 2015 74. Perioperative Atrial Fibrillation and the Long-term Risk of Ischemic Stroke Gino Gialdini, MD1; Katherine Nearing, MD2; et.al JAMA, August 13th, 2015 75. Continuous Proton Pump Inhibitor Therapy and the Associated Risk of Recurrent Clostridium difficile Infection Emily G. McDonald, MD et.al JAMA, March 2, 2015 76. Association of NSAID Use With Risk of Bleeding and Cardiovascular Events in Patients Receiving Antithrombotic Therapy After Myocardial Infarction Anne-Marie Schjerning Olsen, MD et.al JAMA Feb 24, 2015 77. Thrombolysis for Pulmonary Embolism and Risk of All-Cause Mortality, Major Bleeding, and Intracranial Hemorrhage A Meta-analysis Saurav Chatterjee, MD et.al JAMA, June 18, 2014 78. Antibiotic Treatment Strategies for Community-Acquired Pneumonia in Adults Douwe F. Postma, M.D et. Al NEJM, April 2nd, 2015 79. Trial of Early, Goal-Directed Resuscitation for Septic Shock Paul R. Mouncey, M.Sc., Tiffany M. Osborn, M.D et.al NEJM, April 2nd, 2015 80. Outcomes of Anatomical versus Functional Testing for Coronary Artery Disease Pamela S. Douglas, M.D., et.al NEJM, April 2nd, 2015 81. Prednisolone or Pentoxifylline for Alcoholic Hepatitis Mark R. Thursz, M.D et.al NEJM, April 23rd, 2015 82. Association of Early Imaging for Back Pain with Clinical Outcomes in Older Adults Jeffrey Jarvik, MD et.al JAMA March 17, 2015 83. Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials Gustavo C Machado, PhD, et.al BMJ, March 2015 84. Clindamycin versus Trimethoprim–Sulfamethoxazole for Uncomplicated Skin Infections Loren G. Miller, M.D., M.P.H., et.al NEJM March 19, 2015 85. Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease. Walters JA et.al Cochrane Database Syst Rev. 2014. 86. Second-generation drug-eluting stent implantation followed by 6- versus 12month dual antiplatelet therapy: The SECURITY randomized clinical trial. Colombo A, Chieffo A, Frasheri A, et al. J Am Coll Cardiol. 2014 87. Effect of a retrievable inferior vena cava filter plus anticoagulation vs anticoagulation alone on risk of recurrent pulmonary embolism: a randomized clinical trial. Mismetti P et. al JAMA. 2015 Apr 28;313(16):1627-35. 88. Bleeding, Recurrent Venous Thromboembolism, and Mortality Risks During Warfarin Interruption for Invasive Procedures Nathan P. Clark, PharmD1,2; Daniel M. Witt, PharmD1,3; et.al JAMA Intern Med. Published online May 26, 2015 89. Antibiotic treatment for 6 weeks versus 12 weeks in patients with pyogenic vertebral osteomyelitis: an open-label, non-inferiority, randomised, controlled trial Louis Bernard, Aurélien Dinh, Idir Ghout, David Simo, Valerie Zeller, et.al on behalf of the Duration of Treatment for Spondylodiscitis (DTS) study group* Lancet, Vol 385 March 7, 2015 90. A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management Xavier Pi-Sunyer, M.D., Arne Astrup, M.D., D.M.Sc., Ken Fujioka, M.D., Frank Greenway, M.D.,et.al for the SCALE Obesity and Prediabetes NN8022-1839 Study Group* NEJM, July 2, 2015 91. Effects of intensive blood-pressure control in type 2 diabetes mellitus Cushman WC, Evans GW, Byington RP, et al. N Engl J Med. 2010;362(17):1575-1585. 92. Blood-pressure control for renoprotection in patients with non-diabetic chronic renal disease (REIN-2): Multicentre, randomised controlled trial Ruggenenti P, Perna A, Loriga G, et al. Lancet. 2005;365(9463):939-946 93. Telmisartan, ramipril, or both in patients at high risk for vascular events. Yusuf S, Teo KK, Pogue J, et al. N Engl J Med. 2008;358(15):1547-1559. 94. Early Palliative Care for Patients with Metastatic Non–Small-Cell Lung Cancer Jennifer S. Temel, M.D., Joseph A. Greer, Ph.D., et.al N Engl J Med August 19, 2010; 363:733-742 95. Patients’ Expectations about Effects of Chemotherapy for Advanced Cancer Jane C. Weeks, M.D, et. al N Engl J Med 2012;367:1616-25. 96. Chemotherapy Use, Performance Status, and Quality of Life at the End of Life Holly G. Prigerson, PhD et. Al JAMA Oncol. July 23, 2015. 97. Six Months vs Extended Oral Anticoagulation After a First Episode of Pulmonary Embolism: The PADIS-PE Randomized Clinical Trial Francis Couturaud, MD, PhD; Olivier Sanchez, MD, PhD et.al JAMA July 7 2015 98. Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection The INSIGHT START Study Group NEJM August 27, 2015 99. Screening for Occult Cancer in Unprovoked Venous Thromboembolism Marc Carrier, M.D., Alejandro Lazo-Langner, M.D., et.al NEJM August 20, 2015 100. Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation James D. Douketis, M.D., Alex C. Spyropoulos MD, et.al NEJM August 27, 2015 101. Terlipressin Plus Albumin Versus Midodrine and Octreotide Plus Albumin in the Treatment of Hepatorenal Syndrome: A Randomized Trial Marta Cavallin, et. Al Hepatology, August 2015 102. Intravascular Complications of Central Venous Catheterization by Insertion Site Jean-Jacques Parienti, et. al NEJM, September 25, 2015 103. Effect Of Intravenous Albumin On Renal Impairment and Mortality in Patients With Cirrhosis And Spontaneous Bacterial Peritonitis Pau Sort, et.al NEJM, 1999 104. Calcium intake and risk of fracture: systematic review. Bolland MJ, Leung W, Tai V, et al. BMJ. 2015 Sep 29 105. Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes Zinman B, Wanner C, Lachin JM, et al. N Engl J Med. 2015 Sep 17 106. Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2 Williams B, MacDonald TM, Morant S, et al. Lancet. 2015 Sep 18 107. Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain Benjamin W. Friedman, MD et.al JAMA October 20, 2015 108. Beta-Blocker-Associated Risks in Patients With Uncomplicated Hypertension Undergoing Noncardiac Surgery. Jorgensen ME, Hlatky MA, Kober L, et al. JAMA, October 5, 2015 109. A Randomized Trial of Intensive versus Standard Blood-Pressure Control The SPRINT Research Group NEJM, November 26, 2015 110. Effect of PCI on Long-Term Survival in Patients with Stable Ischemic Heart Disease Steven P. Sedlis, M.D. et.al NEJM, November 12, 2015 111. Stroke and recurrent hemorrhage associated with antithrombotic treatment after gastrointestinal bleeding in patients with atrial fibrillation: nationwide cohort study. Staerk L, Lip GY, Olesen JB, et al. BMJ Nov 2015 112. Comparative Performance of ATRIA, CHADS2, and CHA2DS2-VASc Risk Scores Predicting Stroke in Patients With Atrial Fibrillation: Results From a National Primary Care Database. van den Ham HA, Klungel OH, Singer DE, et al. J Am Coll Cardiol. 2015 Oct 113. A Comparison of Rate Control and Rhythm Control in Patients with Atrial Fibrillation The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Investigators N Engl J Med 2002 114. Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes (RABBIT 2 trial) Umpierrez GE1, Smiley D, Zisman A, Prieto LM, Palacio A, Ceron M, Puig A, Mejia R Diabetes Care. 2007 Sep;30(9):2181-6. Epub 2007 May 18. 115. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33) UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998 Sep 12 116. Follow-up of Glycemic Control and Cardiovascular Outcomes in Type 2 Diabetes Rodney A. Hayward, M.D., Peter D. Reaven, M.D., et.al for the VADT Investigators NEJM June 4, 2015 117. Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection The INSIGHT START Study Group NEJM August 27, 2015 118. Assessment of the Safety and Immunogenicity of 2 Novel Vaccine Platforms for HIV-1 Prevention A Randomized Trial Lindsey R. Baden, MD; Etienne Karita, MD et.al Annals of Internal Medicine Feb 2016 119. Timing of Antiretroviral Therapy after Diagnosis of Cryptococcal Meningitis David R. Boulware, M.D., M.P.H., et.al for COAT Trial Team NEJM June 26 2014 120. Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection The INSIGHT START Study Group NEJM August 27, 2015 121. Assessment of the Safety and Immunogenicity of 2 Novel Vaccine Platforms for HIV-1 Prevention A Randomized Trial Lindsey R. Baden, MD; Etienne Karita, MD et.al Annals of Internal Medicine Feb 2016 122. Timing of Antiretroviral Therapy after Diagnosis of Cryptococcal Meningitis David R. Boulware, M.D., M.P.H., et.al for COAT Trial Team NEJM June 26 2014 123. Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection The INSIGHT START Study Group NEJM August 27, 2015 124. Assessment of the Safety and Immunogenicity of 2 Novel Vaccine Platforms for HIV-1 Prevention A Randomized Trial Lindsey R. Baden, MD; Etienne Karita, MD et.al Annals of Internal Medicine Feb 2016 125. Timing of Antiretroviral Therapy after Diagnosis of Cryptococcal Meningitis David R. Boulware, M.D., M.P.H., et.al for COAT Trial Team NEJM June 26 2014 126. Validation of the International Medical Prevention Registry on Venous Thromboembolism Bleeding Risk Score MAJ David C. Hostler et.al Chest 2015 127. Trimethoprim–Sulfamethoxazole versus Placebo for Uncomplicated Skin Abscess David A. Talan et.al NEJM March 3, 2016 128. HbA1c over-testing and overtreatment among US adults with controlled type 2 diabetes, 2001-13: observational population based study Rozalina G McCoy et.al BMJ 2015 129. Validation of the International Medical Prevention Registry on Venous Thromboembolism Bleeding Risk Score MAJ David C. Hostler et.al Chest 2015 130. Trimethoprim–Sulfamethoxazole versus Placebo for Uncomplicated Skin Abscess David A. Talan et.al NEJM March 3, 2016 131. HbA1c over-testing and overtreatment among US adults with controlled type 2 diabetes, 2001-13: observational population based study Rozalina G McCoy et.al BMJ 2015 132. Validation of the International Medical Prevention Registry on Venous Thromboembolism Bleeding Risk Score MAJ David C. Hostler et.al Chest 2015 133. Trimethoprim–Sulfamethoxazole versus Placebo for Uncomplicated Skin Abscess David A. Talan et.al NEJM March 3, 2016 134. HbA1c over-testing and overtreatment among US adults with controlled type 2 diabetes, 2001-13: observational population based study Rozalina G McCoy et.al BMJ 2015 135. Warfarin in the Prevention of Stroke Associated with Nonrheumatic Atrial Fibrillation (SPINAF) Michael D. Ezekowitz, M.D., Ph.D., Samuel L. Bridgers, M.D. et.al NEJM 1992 136. Rivaroxaban versus Warfarin in Non-Valvular Atrial Fibrillation (ROCKET AF) Manesh R. Patel, M.D., Kenneth W. Mahaffey, M.D. et.al NEJM Sept 8, 2011 137. Warfarin in the Prevention of Stroke Associated with Nonrheumatic Atrial Fibrillation (SPINAF) Michael D. Ezekowitz, M.D., Ph.D., Samuel L. Bridgers, M.D. et.al NEJM 1992 138. Rivaroxaban versus Warfarin in Non-Valvular Atrial Fibrillation (ROCKET AF) Manesh R. Patel, M.D., Kenneth W. Mahaffey, M.D. et.al NEJM Sept 8, 2011 139. Coronary-Artery Bypass Surgery in Patients with Ischemic Cardiomyopathy Eric J. Velazquez, M.D., Kerry L. Lee, Ph.D., et.al for the STICHES Investigators* NEJM April 21, 2016 140. Cholesterol Lowering in Intermediate-Risk Persons without Cardiovascular Disease Yusuf S, Bosch J, Dagenais G, et al. for the HOPE-3 Investigators NEJM April 2, 2016 141. Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes Christopher P. Cannon, M.D., Michael A. Blazing, M.D., et.al for the IMPROVE-IT Investigators NEJM June 18, 2015 142. Coronary-Artery Bypass Surgery in Patients with Ischemic Cardiomyopathy Eric J. Velazquez, M.D., Kerry L. Lee, Ph.D., et.al for the STICHES Investigators* NEJM April 21, 2016 143. Cholesterol Lowering in Intermediate-Risk Persons without Cardiovascular Disease Yusuf S, Bosch J, Dagenais G, et al. for the HOPE-3 Investigators NEJM April 2, 2016 144. Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes Christopher P. Cannon, M.D., Michael A. Blazing, M.D., et.al for the IMPROVE-IT Investigators NEJM June 18, 2015 145. Coronary-Artery Bypass Surgery in Patients with Ischemic Cardiomyopathy Eric J. Velazquez, M.D., Kerry L. Lee, Ph.D., et.al for the STICHES Investigators* NEJM April 21, 2016 146. Cholesterol Lowering in Intermediate-Risk Persons without Cardiovascular Disease Yusuf S, Bosch J, Dagenais G, et al. for the HOPE-3 Investigators NEJM April 2, 2016 147. Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes Christopher P. Cannon, M.D., Michael A. Blazing, M.D., et.al for the IMPROVE-IT Investigators NEJM June 18, 2015 148. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Mervyn Singer, MD, FRCP1; Clifford S. Deutschman, MD, MS et. Al JAMA Feb 23 2016 149. Nutritional Support and Outcomes in Malnourished Medical Inpatients: A Systematic Review and Meta-analysis Bally MR1, Blaser Yildirim PZ2, et. Al JAMA Jan 2016 150. Blood-Pressure Lowering in Intermediate-Risk Persons without Cardiovascular Disease Eva M. Lonn, M.D., Jackie Bosch, Ph.D et.al NEJM April 2016 151. Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients Martin B. Leon, M.D., Craig R. Smith NEJM April 2016 152. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Mervyn Singer, MD, FRCP1; Clifford S. Deutschman, MD, MS et. Al JAMA Feb 23 2016 153. Nutritional Support and Outcomes in Malnourished Medical Inpatients: A Systematic Review and Meta-analysis. Bally MR1, Blaser Yildirim PZ2, et. Al JAMA Jan 2016 154. Blood-Pressure Lowering in Intermediate-Risk Persons without Cardiovascular Disease Eva M. Lonn, M.D., Jackie Bosch, Ph.D et.al NEJM April 2016 155. Transcatheter or Surgical Aortic-Valve Replacement in IntermediateRisk Patients Martin B. Leon, M.D., Craig R. Smith NEJM April 2016 156. Invasive versus conservative strategy in patients aged 80 years or older with NSTEMI or unstable angina pectoris (After Eighty study) Nicolai Tegn, Michael Abdelnoor, et.al Jan 12, 2016 (Lancet) 157. Ticagrelor versus Aspirin in Acute Stroke or Transient Ischemic Attack S. Claiborne Johnston, M.D., Ph.D., Pierre Amarenco, M.D., et. Al for the SOCRATES Steering Committee and Investigators May 10, 2016 (NEJM) 158. Invasive versus conservative strategy in patients aged 80 years or older with NSTEMI or unstable angina pectoris (After Eighty study) Nicolai Tegn, Michael Abdelnoor, et.al Jan 12, 2016 (Lancet) 159. Ticagrelor versus Aspirin in Acute Stroke or Transient Ischemic Attack S. Claiborne Johnston, M.D., Ph.D., Pierre Amarenco, M.D., et. Al for the SOCRATES Steering Committee and Investigators May 10, 2016 (NEJM)