NASA Human Research Program Investigators' Workshop 2012
sess451.pdf
Wednesday, February 15, 2012
ACUTE EFFECTS, RADIATION DOSIMETRY, TRANSPORT, AND SHIELDING
8:00 a.m. West Alabama Room
Chairs:
Ann Kennedy
Keith Cengel
8:00 a.m.
Kennedy A. R. Weissman D. Freund G. G. McDonough J. Seykora J. T. Mick R.
Diffenderfer E. S. Sanzari J. K. Romero-Weaver A. L. Punekar S. Krigsfeld G. S.
York J. M. Blevins N. A. Peterlin M. B. Zhou Y. Ni H. Li M. Cengel K. A.
Acute Radiation Effects Resulting from Exposure to Solar Particle Event-Like Radiation [#4227]
The NSBRI-funded Center of Acute Radiation Research (CARR) will be described. The CARR grant
is focused on the adverse health effects resulting from exposure to solar particle event radiation and the
development of countermeasures for those risks.
8:12 a.m.
Cengel K. A. Sanzari J. Punekar S. Diffenderfer E. S. Gridley D. Wroe A.
Weissman D. Kennedy A. R.
Skin Toxicity of Solar Particle Event Radiation: Dependence on Dose-Distribution Rather than
Particle Identity [#4219]
Our results suggest that major skin toxicity could be a significant clinical problem in astronauts
exposed to solar particle event radiation and that understanding the specific dose distribution within an
astronaut will be clinically valuable.
8:24 a.m.
Zhou Y. Ni H. Li M. Sanzari J. K. Kennedy A. R. Weissman D.
Identification of a Mechanism for Immune Dysfunction Induced by Solar Particle Event Radiation and
Hindlimb Suspension [#4194]
We demonstrate that SPE-like radiation with hindlimb suspension results in increased levels and
duration of immune activation. This immune dysfunction could place astronauts at increased risk on
missions with exposure to significant SPE radiation.
8:36 a.m.
Diffenderfer E. S. Kennedy A. R. Cengel K. A.
Implementing CT-Based Monte Carlo Simulation Tools for Solar Particle Event Dosimetry [#4218]
To investigate dose patterns due to SPE radiation, we construct simulations from CT image sets by
converting each image voxel into a material with specific atomic composition and accumulating dose
voxel-by-voxel during radiation transport simulation.
8:48 a.m.
Theriot C. A. Briers D. Wu H.
DF-1 Treatment Prior to Irradiation Leads to Altered Gene Expression Profiles in
Human Fibroblasts [#4254]
This research focuses on characterizing the molecular mechanism of the radioprotective effects of a
functionalized non-toxic carbon nanoparticle called DF-1.
9:00 a.m.
Cox B. Theriot C. A. Rohde L. H. Wu H.
Computational Transport Modeling of High-Energy Neutrons Found in the
Space Environment [#4215]
High-energy neutrons are produced during fragmentation interactions of HZE ions traversing shielding
materials and the human body. Neutron dosimetry is explored through simulations using the Particle
and Heavy Ion Transport Code System (PHITS).
NASA Human Research Program Investigators' Workshop 2012
sess451.pdf
9:12 a.m.
Johnson E. B. Chen X. J. Whitney C. Stapels C. J. Shirwadkar U. van Loef E. Glodo J.
Shah K. Benton E. Prettyman T. Christian J. F.
Recent Developments on a Fast Neutron Dosimeter for the Space Environment [#4262]
The space environment is inherently complicated with multiple sources of radiation, and within a space
craft, these radiation fields are further complicated.
9:24 a.m.
DISCUSSION
9:30 a.m.
Coffee Break