Program Synopsis
21st Annual NASA Space Radiation Investigators’ Workshop
May 16 – 19, 2010
Danfords Hotel and Marina
Port Jefferson Village Center
Port Jefferson, New York
Sunday, May 16
1:30 p.m. – 3:30 p.m.
3:30 p.m. – 7:00 p.m.
4:50 p.m. – 5:15 p.m.
7:00 p.m.
Monday, May 17
7:45 a.m. – 8:30 a.m.
8:30 a.m. – Noon
10:00 – 10:20 a.m.
Noon – 1:30 p.m.
12:45 p.m. – 1:30 p.m.
1:30 p.m. – 6:10 p.m.
3:05 p.m. – 3:30 p.m.
6:30 p.m. – 8:00 p.m.
Tuesday, May 18
7:30 a.m. – 8:30 a.m.
8:00 a.m. – 8:30 a.m.
Registration
Poster Set Up
Port Jefferson Village Center, 3rd
Floor
Bayles and Willse Rooms
Opening Session
Break
Adjourn
Village Center, 3rd Floor
Registration and Continental
Breakfast
Scientific Sessions
Break
Lunch
THREE Project Meeting
Scientific Sessions
Break
Poster Session/Reception
Village Center, 3rd Floor
8:30 a.m. – Noon
10:00 a.m. – 10:30 a.m.
12:10 p.m. – 1:30 p.m.
1:30 p.m. – 2:30 p.m.
2:30 p.m. – 2:50 p.m.
2:50 p.m. – 4:30 p.m.
4:30 p.m. – 5:15 p.m.
5:15 p.m. – 6:30 p.m.
Continental Breakfast
Roundtable Discussion on
Sample Sharing Issues
Scientific Sessions
Break
Lunch
Memorial Session
Break
Scientific Session
Poster Summaries
Poster Session II
7:00 p.m. – 9:30 p.m.
Dinner/Awards Banquet
Wednesday, May 19
7:30 a.m. – 8:30 a.m.
8:30 a.m. – Noon
10:00 a.m. – 10:30 a.m.
12:10 p.m. – 1:30 p.m.
1:30 p.m.
Continental Breakfast
Scientific Sessions
Break
Lunch and Closing Remarks
Adjourn
i
Village Center, 3rd Floor
Danfords Hotel, Brookhaven Room
Brookhaven Room
Village Center, 3rd Floor
Bayles and Willse Rooms
Village Center, 3rd Floor
Village Center, 3rd Floor
Village Center, 3rd Floor
Brookhaven Room
Village Center, 3rd Floor
Village Center, 3rd Floor
Village Center, 3rd Floor
Bayles and Willse Rooms
Village Center, 3rd Floor
Brookhaven Room
Village Center, 3rd Floor
Village Center, 3rd Floor
Brookhaven Room
Sunday, May 16, 2010
1:30 p.m. – 3:30 p.m.
Registration
Port Jefferson Village Center, 3rd Floor
1:30 p.m. – 3:30 p.m.
Poster Set Up
Bayles and Willse Rooms
Port Jefferson Village Center, 3rd Floor (Student Posters)
SESSION I:
3:30 p.m. – 7:00 p.m.
OPENING SESSION
Port Jefferson Village Center, 3rd Floor
Chairs: Lynn Hlatky
Robert Ullrich
3:30 p.m. – 3:40 p.m.
Introductions and Greetings
3:40 p.m. – 4:15 p.m.
Durante M. *
Space Radiobiology in Space? [#1094] .....................................................................................................**2
4:15 p.m. – 4:35 p.m.................. Balmain A.
Costes S.V.
Demaria S.
Mao J.H.
Barcellos-Hoff M.H. *
NASA Specialized Center of Research: The Contribution of Non-Targeted Effects in HZE Cancer Risk
[#1106] ......................................................................................................................................................................13
4:35 p.m. – 4:55 p.m.
Meador J. A.
Amundson S. A. *
HZE-Induced Mammary Cancer Development Processes in Murine and "Humanized"Models, and their
Influence on Radiation Quality Functions [#1057] ...................................................................................................12
4:55 p.m. – 5:15 p.m.
Break
5:15 pm. – 5:50 p.m.
Zhu X. W.*
Two Hit Hypothesis of Alzheimer's Disease [#1067] ......................................................................................4
5:50 p.m. – 6:20 p.m.
Li F.
Li C-Y. *
The “Phoenix Rising” Pathway of Apoptosis-mediated Wound Healing and Tissue Regeneration and Its
Potential Roles in Space Radiation Induced Carcinogenesis [#1046] ..........................................................................5
6:20 p.m. – 6:50 p.m.
Hlatky L.*
Hahnfeldt P.
Sachs R. K.
Abdollahi A.
Girdhani S.
Beheshti A.
Enderling H.
Lamont C.
Solid Tumor Risk Estimation: Incorporating Intercellular Interaction Effects [#1098] .................................6
7:00 p.m.
Adjourn for Local Attractions and Restaurants
*Presenting Author
**Page Number
ii
Monday, May 17, 2010
7:45 a.m. – 8:30 a.m.
Registration and Continental Breakfast
Port Jefferson Village Center, 3rd Floor
SESSION II:
8:30 a.m. – 9:00 a.m.
RED AND BLUE TEAM OVERVIEW
Port Jefferson Village Center, 3rd Floor
Chairs: Polly Chang
Michael Weil
8:30 a.m. – 9:00 a.m.
Cucinotta F. A.
NASA Self-Assessment of Space Radiation Research [#1099]
SESSION III:
9:00 a.m. – 12:00 p.m.
....................................................................8
TISSUE MODELS OF CANCER RISKS
Port Jefferson Village Center, 3rd Floor
Chairs: Polly Chang
Michael Weil
9:00 a.m. – 9:20 a.m.
Datta K.
Trani D.
Moon B-H.
Sun J.
Fornace A. J. Jr.*
Space Radiation and Intestinal Tumorigenesis Risk Assessment [#1030].....................................................10
9:20 a.m. – 9:40 a.m.
Kronenberg A. * Gauny S.
Kwoh E.
Dan C.
Turker M.
Autosomal mutations in murine kidney epithelial cells exposed to energetic protons [#1011].....................11
9:40 p.m. – 10:15 a.m.
Wang T.*
Inflammation, Stem Cells, and GI Cancer .....................................................................................................3
10:15 a.m. – 10:40 a.m. Break
10:40 a.m. – 11:00 a.m. ....... Hang H.
Magpayo N.
Rusek A.
Chiang I.-H.
Sivertz M.
Held K. D. *
Effects of Very Low Particle Fluences on Irradiated and Bystander Cells [#1056] ...................................14
11:00 a.m. – 11:20 a.m. ....... Azzam E. I. * de Toledo S. M.
Buonanno M.
Li M.
Autsavapromporn N.
Gonon G. Zhang J.
Shim G.
The Role of Gap-Junction Communication and Oxidative Metabolism in the Biological Effects of Space
Radiation [#1092] ......................................................................................................................................................15
11:20 a.m. – 11:40 a.m.
Morgan M. N.M.
Goetz W.
Baulch J. E. *
High LET Effects on DNA Methylation Profiles [#1058] ............................................................................16
11:40 a.m. – 12:00 p.m.
Templin T.
Paul S.
Amundson S. A.
Smilenov L. B. *
miRNA profiling of radiation response: A systems biology approach to understanding regulation of
proton and heavy ion dose effects [#1022] ................................................................................................................17
12:00 p.m. – 1:30 p.m.
Lunch
Danfords Hotel, Brookhaven Room
12:45 p.m. – 1:30 p.m.
Meeting, THREE Project Committee
Danfords Hotel, Brookhaven Room
iii
SESSION IV:
1:30 p.m. – 3:05 p.m.
MECHANISMS OF RADIATION CARCINOGENESIS
Port Jefferson Village Center, 3rd Floor
Chairs: Mary Helen Barcellos-Hoff
Philip Hahnfeldt
1:30 p.m. – 2:00 p.m.
Minna J. D. * Story M. D.
Delgado O.
Chen D.
Richardson J.
Xie Y.
Xie X. J.
Shay J. W.
Development of a Risk Assessment Model for Lung Cancer Pathogenesis after Exposure of Human and
Mouse Lung Epithelial Cells to HZE Particle Radiation [#1078] .............................................................................19
2:00 p.m. – 2:20 p.m.
Weil M. M.
Bedford J. S.
Peng Y.
Ray F. A.
Steffen L.
Bacher J. W.
Ding L.
Story M. D.
Bielefeldt-Ohmann H.
Fallgren C. F.
Genik P. C.
Ullrich R. L.*
Radiation Carcinogenesis NSCOR: Tumors Arising in 56Fe Ion Irradiated Mice [#1072] .......................20
2:20 p.m. – 2:35 p.m.
Peng Y.
Nagasawa H.
Warner C.
Bedford J. S. *
Dose Rate Effects for Protons and Gamma-rays for Chromosome Aberration Induction in Four Human
Cell Strains [#1020] ...................................................................................................................................................21
2:35 p.m. – 2:50 p.m.
Loucas B. D.
Eberle R. L.
Cornforth M. N. *
Chromosome Aberrations Formed in Response to Changes in Proton Energy and Dose Rate [#1065] .....22
2:50 p.m. – 3:05 p.m.
Rithidech K. * Reungpatthanaphong P.
Honikel L.
Golightly M.
Anderson C. W.
Dose-rate Effects of Protons on the Induction and Repair of Chromosome Aberrations In Vivo [#1035] .23
3:05 p.m. – 3:30 p.m.
Break
SESSION V:
3:30 p.m. – 5:05 p.m.
DEGENERATIVE TISSUE RISKS
Port Jefferson Village Center, 3rd Floor
Chairs: Claudia Wiese
Gregory Nelson
3:30 p.m. – 4:05 p.m.
Little M.P.
Cardiovascular Disease and Radiation: A Summary of What We Know from the Low-Dose Epidemiology
and Radiobiology [#1102] .........................................................................................................................................26
4:05 – p.m. – 4:25 p.m. Grabham P.
Sharma P.
Geard C. *
Effects of Ionizing Radiation on 3-Dimensional Human Vessel Models: Differential Effects According to
LET and Cellular Development. [#1073] ..................................................................................................................27
4:25 p.m. – 4:45 p.m.
Chang P. Y. * Bakke J.
Wang A.
Impact of sequential exposure to protons and iron ions in vivo. [#1045] ...................................................28
4:45 p.m. – 5:05 p.m.
Yoshida K.
Yoshida S.
Eguchi-Kasai K.
Morita T. *
Study on the Effect of Space Radiation to Mammalian ES and iPS Cells to Their Development [#1023] ..29
iv
SESSION VI:
5:05 p.m. – 6:10 p.m.
ACUTE EFFECTS AND SPACE PHYSICS
Port Jefferson Village Center, 3rd Floor
Chairs: Kathryn Held
Edouard Azzam
5:05 p.m. – 5:25 p.m.
Zeitlin C. *
Hassler D.
Wimmer-Schweingruber R. F.
Boehm E.
Boettcher S.
Burmeister S.
Cucinotta F.
Kortmann O.
Martin C.
Posner A.
Rafkin S.
Precursor Measurements of the Mars Surface Radiation Environment with the Radiation Assessment
Detector (RAD) on the Mars Science Laboratory (MSL) [#1041] .............................................................................32
5:25 p.m. – 5:45 p.m.
Reitz G.*
Report on International Space Station Results of the Matroshka Experiment
..............................................
5:45 p.m. – 6:10 p.m.
Kennedy A. R. * Weissman D.
King G.
Freund G.
Woods J.
Wagner E.
McDonough J.
Miller A.
Gewirtz A.
Mick R.
Wilson J. M.
Cengel K.
Acute Radiation Effects Resulting from Exposure to Solar Particle Event-Like Radiation [#1070] ...........33
6:10 p.m. – 6:30 p.m.
Chiang I-H.
Lowenstein D. I.
Rusek A. * Sivertz M.
NSRL Overview and Update [#1013] ..........................................................................................................34
6:30 p.m. – 8:00 p.m.
8:00 p.m.
Poster Session I, Danfords Hotel, Bayles and Willse Rooms
Adjourn
CANCER/GENOMIC INSTABILITY POSTER SESSION
6:30 p.m. – 8:00 p.m.
Bayles and Willse Rooms
Poster Number precedes authors’ names
C-1
Asaithamby A.*
Hu B.
Delgado O.
Minna J. D.
Shay J. W.
Chen D. J.
DNA double-strand break repair is attenuated in three-dimensional human lung epithelial cell culture
exposed to ionizing radiation [#1021] .......................................................................................................................36
C-2
Bacher J.*
Bourdeau-Heller J.
Leisemann Immel R.
Halberg R.
Steffen L.
Storts D.
Microsatellite Mutations in Mouse Tissues Induced by Low and High LET Radiation [#1051] .................37
C-3
Bailey S. M.*
Dregalla R.
Idate R. R.
Battaglia C. L. R.
Liber H. L.
Tankyrase 1 influences telomeric recombination and stability of the NHEJ protein DNA-PKcs [#1080] ..38
C-4
Bennett P. V.*
Abele W. H.
Keszenman D. J.
Stisova V.
Sutherland B. M.
Human Cell Neoplastic Transformation and Clustered DNA Damage Induced by HZE Particles and SPE
Protons [#1089] .........................................................................................................................................................39
C-5
Camacho C. V.
Mukherjee B.
McEllin B.
Ding L-H.
Xie X-J.
Nirodi C.
Saha D.
Story M.
Boothman D.
Bachoo R. M.
Burma S.*
Loss of p15/Ink4b accompanies tumorigenesis triggered by particle radiation [#1003] ............................40
C-6
Dziegielewski J.*
Valerie N. C. K.
Parsons S. J.
Larner J. M.
Carcinogenic Transformation and Neuroendocrine Differentiation Induced by Space Radiation in Human
Prostate Cells [#1054] ...............................................................................................................................................41
C-7
Becker D.
Bauer L.
Tonn T. PD Seifried E. Prof.
Ritter S. Dr. Durante M. Prof.
Fournier C. Dr.*
Response of Human Hematopoietic Stem and Progenitor Cells to Energetic Carbon Ions [#1006] ..........42
v
C-8
George K.*
Hada M.
Cucinotta F. A.
Silicon Ions Have a Significantly Higher Biological Effectiveness than Iron Ions for the Induction of
Chromosome Damage in Human Lymphocytes [#1027] ...........................................................................................43
C-9
Patel Z. S.
Grugan K. D.
Rustgi A. K.
Cucinotta F. A.
Huff J. L.*
Modulation of Esophageal Epithelial Cell Behavior by Irradiated Stromal Fibroblast: Effects of Radiation
Quality [#1093] .........................................................................................................................................................44
C-10
Kosmacek E. A.
Napoli E.
Mackey M. A.
Colwell E. A.
Ianzini F.*
Dose-Response and Time-Course Expression of Cancer Cell Markers in Adult Human Fibroblast and
Epithelial Cells Exposed to Light and Heavy Ions. [#1014] ......................................................................................45
C-11
Keszenman D. J.*
Stisova V.
Abele W. H.
Sutherland B. M.
Bennett P. V.
Immediate and Delayed Cellular Effects of Single or Sequential Exposures to Low Doses of X-rays in
Human Skin Fibroblasts [#1038] ...............................................................................................................................46
C-12
Liber H. L.*
Bailey S. M.
Radiation Quality and the Relationship between Induced Telomere Aberrations
and Mutagenesis [#1060] ........................................................................................................................................48
C-13
Miller A. C.*
Stewart M.
Rivas R.
Cohen S.
Merlot R.
Lison P.
Use of a Non-targeted Radiation Leukemogenesis Model for a Mechanistic Understanding of Radiation
Quality Effects for NASA Relevant Radiations [#1008] .............................................................................................49
C-14
Jones T.
Ortloff L.
Perez C.
Nelson G.*
In vivo Bystander Signaling in the Nematode C. elegans [#1074] ..............................................................51
C-15
Whalen M. W.
Sridharan D. M.
Chappell L. J.
Cucinotta F. A.
Pluth J. M.*
Radiation Quality Dependent Effects on Phospho-protein Kinetics and Surrogate Cancer Endpoints
[#1100] ......................................................................................................................................................................52
C-16
Ray F. A.*
Hailu F.
Liu X.
Lehman J. M.
Weil M. M.
Goodwin E. H.
Progress Towards Development of a New Technique to Detect Recurrent Point Mutations; Intended Use in
a Murine Model of Radiation-Induced AML. [#1079] ...............................................................................................53
C-17
Redpath J. L.*
Elmore E.
Neoplastic Transformation In Vitro by High Energy Protons and Iron Ions [#1028] .................................54
C-18
Yamamoto M.L.
Reliene R.
Hacke K.
Hafer K.
Westbrook A.
Bral M.
Kelly O.
Trouiller B.
Schiestl R.H.*
Effects of Space Radiation on Genetic Instability, Neuromotor Function, Carcinogenesis and Longevity in
Ataxia Telangiectasiia Deficient Mice [#1105] .........................................................................................................55
C-19
Kim S. B.
Eskiocak U.
Roig A. I.
Delgado O.
Kitten E.
Batten K.
Wright W. E. Shay J. W.*
Bardoxolone Methyl (BARD) is Both a Countermeasure and Mitigator of Radiation-induced Neoplastic
Transformation of Normal Human Epithelial Cells [#1024] .....................................................................................56
C-20
Park S.
Ding L.
Xie Y.
Xie X.-J.
Minna J. D.
Story M. D.*
Discerning the Cellular and Molecular Events Associated with Lung Carcinogenesis after Exposure to
HZE Particles Using the Human Bronchial Epithelial Cell Line HBEC3-KT and Its Isogenic Variants [#1069] ....57
vi
C-21
Tafrov S. T.*
Discrete Sets of Histone Acetyltransferase 1 (Hat1) Isoforms Expressed by Normal Human Fibroblasts and
Keratinocytes [#1009] ...............................................................................................................................................58
C-22
Wang H.-Y.
Zhang X.-M.
Wang P.
Yu X.-Y.
Essers J.
Chen D.-J.
Kanaar R.
Takeda S.
Wang Y.*
Characteristics of DNA Binding Proteins Determine the Biological Sensitivity to High Linear Energy
Transfer Radiation [#1002] .......................................................................................................................................59
C-23
Carra C.
Wang M.*
Huff J. L.
Hada M.
Pluth J. M.
O'Neill P.
Cucinotta F. A.
Pathway Model of the Kinetics of the TGFbeta Antagonist Smad7 and Cross-Talk with the ATM and WNT
Pathways [#1096] ......................................................................................................................................................60
C-24
Snijders A. M.
Kronenberg A.
Schild D.
Wiese C.*
HZE-Induced Skin Carcinoma: an In-Vivo-Like Multi-Cellular Epithelial Model System for Analysis of
Radiation Quality Effects and DSB Repair Processes [#1095] .................................................................................61
C-25
Hada M.
Zhang Y.
Feiveson A.
Cucinotta F. A.
Wu H.*
Distributions of low- and high-LET radiation-induced breaks in chromosomes are associated with interand intrachromosome exchanges [#1034] .................................................................................................................63
C-26
Yaswen P.*
Parvin B.
Kronenberg A.
Kaur G.
Epigenetic Effects of Radiation on Epithelial Cell Self-renewal [#1091] ...................................................64
C-27
Yatagai F.*
Honma H.
Omori K.
Ukai A.
Suzuki H.
Shimazu T.
Takahashi A.
Ohnishi T.
Sugasawa K.
Dohmae N.
Ebisuzaki T.
Ishioka N.
An ISS Experiment: Biological Influences of Space Environments
(Radiation and Microgravity) [#1025] ......................................................................................................................65
C-28
Zhu Y.*
Yu X.-Y.
Fu HJ.
Wang HY.
Wang P.
Zheng XF.
Wang Y.
MicroRNA-21 involves radiation-promoted liver carcinogenesis [#1005] .................................................66
C-29
Weil M. M.*
Bedford J. S.
Peng Y.
Ray F. A.
Steffen L.
Bacher J. W.
Ding L.
Story M. D.
Bielefeldt-Ohmann H.
Fallgren C. F.
Genik P. C.
Ullrich R. L.
Radiation Carcinogenesis NSCOR: Tumors Arising in 56Fe Ion Irradiated Mice [#1072] .......................20
C-30
Ding L.-H.*
Perez V.
Hu B. Verma G.
Minna J.D. Story M.D.
The Role of Mir-107 in the Cellular Response to Ionizing Radiation Exposure ...........................................
CNS POSTER SESSION
6:30 p.m. – 8:00 p.m.
Bayles and Willse Rooms
CNS-1 Rivera P. D.
Shih H.
LeBlanc J. A.
Amaral W. Z.
DeCarolis N. A.
Chen B. P. C.*
Eisch A. J.*
Silicon-rich HZE Particle Irradiation Dynamically Impacts Adult Hippocampal
Neurogenesis [#1084] ................................................................................................................................................68
CNS-2 Sharma P.
Grabham P.*
Development and use of Human 3-Dimensional Tissue Culture Models for the study of Space Radiation
Effects on the Degeneration of the Central Nervous System and other Tissues. [#1075] ..........................................69
CNS-3 Naidu M. D.*
Sanchez Z. S.
Pena L. A.
Apurinic Endonuclease-1 (Ape1) Protein in Glial Progenitor Cells is Highly Induced by Fractionated as
compared to Single Low Dose of X-rays [#1016] ......................................................................................................70
vii
CNS-4 Neill J. C.*
Gatley S. J.
HZE Irradiation Impairs Auditory Quality Discrimination and Decreases Brainstem Auditory Evoked
Potential Latency [#1087] .........................................................................................................................................71
CNS-5 Sanchez M. C.*
Nelson G. A.
Vlkolinsky R.
Green L. M.
Mechanisms of Low Dose HZE Alteration of Neuronal-Astrocytic Coupling: The Role of Purinergic
Receptors and Calcium Signaling [#1068] ................................................................................................................72
CNS-6 Wang M.
Tian L.
Tang X.
Wang H.*
Interaction of PARP-1 and CDK5 in DNA Damage Response in Neural Cells Exposed to Space Radiation
[#1037] ......................................................................................................................................................................73
NON-CANCER EFFECTS POSTER SESSION
6:30 p.m. – 8:00 p.m.
Bayles and Willse Rooms
NCE-1 Chang P. Y.*
Rosen C. J.
Bjornstad K. A.
Moncaster J. A.
Casey N. F.
Thompson A. C.
Fraine A.
Kempf O.
Goldstein L. E.
Blakely E. A.
Non-Invasive Quasi-Electric Light Scattering (QLS) Assessment of Pre-Cataractous Lenticular Changes
after Exposure to Particle Radiations [#1103] ........................................................................................................75
NCE-2 Dynlacht J. R.*
Valluri S.
Henderson M. Garrett J.
Lopez J.
Caperell-Grant A.
Mendonca M. S.
Bigsby R. M.
Age, Gender, and Hormones as Determinants of Cataractogenesis Induced by Low and High LET
Radiation [#1062] ......................................................................................................................................................76
NCE-3 Globus R. K.*
Alwood J.
Almeida E. A. C.
Searby N. D.
Yumoto K.
Limoli C. L.
HZE and Skeletal Recovery from Simulated Weightlessness [#1085] .........................................................77
NCE-4 Gridley D. S. Ph.D.* Green L. M. Ph.D.
Bianski B. B.S. Stodieck L. S. Ph.D.
Ferguson V. L. Ph.D. Slater J. M. M.D. Pecaut M. J. Ph.D.
STS-118 Spaceflight Effects on Expression of Liver Genes Associated with Metabolism and Tissue
Remodeling [#1019] ..................................................................................................................................................78
NCE-5 King G. L.*
Maks C. J.
Gridley D. S.
Kennedy A. R.
Miller A.
Space Radiation and Emesis Studies in the Ferret Model - Preliminary Results [#1053] ..........................47
NCE-6 Kleiman N. J.*
Smilenov L. B.
Elliston C. D.
Brenner D. J.
Hall E. J.
Mechanisms of Ocular Cataracts [#1059] ..................................................................................................79
NCE-7 Yu T.
Khaled S.
Gupta K.
Wu X.
Parks B. W.
Srivastava R.
Yu S.
Chang P. Y.
Kabarowski J. H. S.
Kucik D. F.*
56Fe Radiation Increases Adhesiveness of Aortic Endothelium and Accelerates Development of
Atherosclerosis [#1032] .............................................................................................................................................80
NCE-8 Li X.*
Liu Y. H.
Jiménez J. A.
Kao C.
TRAIL Is a Sensitizer for Prostate Cancer Cells to Radiation Therapy [#1031] ........................................82
viii
Tuesday, May 18, 2010
7:45 a.m. – 8:00 a.m.
Registration and Continental Breakfast
Port Jefferson Village Center, 3rd Floor
SESSION VII:
8:00 a.m. – 8:40 a.m.
TUESDAY OPENING SESSION
Port Jefferson Village Center, 3rd Floor
8:00 a.m. – 8:30 a.m.
Round Table Discussion on Sample Sharing Issues
8:30 a.m. – 8:40 a.m.
Schimmerling W.*
THREE [#1017] ...........................................................................................................................................84
SESSION VIII:
8:30 a.m. – 10:00 a.m.
CENTRAL NERVOUS SYSTEM RISKS I
Port Jefferson Village Center, 3rd Floor
Chairs: K. Noy Rithidech
Bernard Rabin
8:40 a.m. – 9:00 a.m.
Nelson G. A. * Chang P.
Favre C.
Fike J.
Kamarova N.
Limoli C.
Mao X. W.
Obenaus A.
Raber J.
Spigelman I.
Soltesz I.
Song S. K.
Stampanoni M.
Vlkolinsky R.
Wodarz D.
CNS NSCOR in Transition: Charged Particle Radiation & Resultant Oxidative Stress Elicit Deleterious
Functional Changes in the CNS [#1077] ...................................................................................................................86
9:00 a.m. – 9:15 a.m.
Britten R. A. * Johnson A. J.
Davis L.
Parris B.
Lonart G.
Green-Mitchell S.
Sanford L.
Singletary S. J.
Drake R. R.
Spatial Memory and Attentional Set Shifting are Significantly Impaired Following Exposure to 20 cGy Hze
Particles. [#1052] ......................................................................................................................................................87
9:15 a.m. – 9:30 a.m.
Hienz R. D. Ph.D.*
Davis C. M. Ph.D. Weed M. R. Ph.D. Guida P. M. Ph.D.
Gooden V. L.
Brady J. V. Ph.D. Roma P. M. Ph.D.
Neurobehavioral Effects of Space Radiation on Psychomotor Vigilance Tests [#1033] .............................88
9:30 a.m. – 9:45 a.m.
Rabin B. M. * Joseph J. A.
Shukitt-Hale B.
Carrihill-Knoll K.
Operant Responding in Rats as a Function of Age and Irradiation [#1012] ..............................................89
9:45 a.m. – 10:00 a.m.
Lowe X. R.
Rabin B. M.
Marchetti F.
Bhatnagar S.
Snijders A.
Wyrobek A. J. *
Persistent Signature and Cellular Defects in the Choroid Plexus of Rats with Persistent Cognitive Defects
long after Cranial Exposure to Space Radiation [#1101] .........................................................................................90
10:00 a.m. – 10:30 a.m. Break
SESSION IX:
CENTRAL NERVOUS SYSTEMS RISKS II
10:30 a.m. – 11:30 a.m. Port Jefferson Village Center, 3rd Floor
Chairs: Susan Bailey
M. Kerry O'Banion
10:30 a.m. – 10:50 a.m.
Fike J. R. * Rosi S.
Raber J.
Alterations in Cognition and Expression of the Behaviorally-Induced Immediate Early Gene Arc Due to
Traumatic Brain Injury are Ameliorated by a Previous Exposure to 56Fe [#1026] ................................................. 92
ix
10:50 a.m. 11:10 a.m.
Tseng B. P.
Tran K.
Lan M. L.
Giedzinski E.
Limoli C. L. *
Low dose charged particle effects in rodent and human neural stem cells [#1010] ....................................93
11:10 a.m. – 11:30 a.m.
O'Banion M. K. * Welle S. L.
Hurley S. D.
Olschowka J. A.
Williams J.
Low Dose HZE Particle Effects on Adult Hippocampal mRNA Expression
and Neurogenesis [#1061] .........................................................................................................................................94
SESSION X:
NEW INVESTIGATOR REPORTS SESSION
11:30 a.m. – 12:10 p.m. Port Jefferson Village Center, 3rd Floor
Chairs: Janice Pluth
Peter Guida
12:10 p.m. – 1:30 p.m.
Lunch
Danfords Hotel, Brookhaven Room
SESSION XI:
1:30 p.m. – 2:30 p.m.
TRIBUTES SESSION
Port Jefferson Village Center, 3rd Floor
Chairs: Francis Cucinotta
Remembering John Ainsworth
Remembering Lora Green
Remembering John Lett
Remembering Betsy Sutherland
Amy Kronenberg
Gregory Nelson
Christopher Lange
Noelle Metting
2:30 p.m. – 2:50 p.m.
Break
SESSION XII:
2:50 p.m. – 4:30 p.m.
CANCER RISKS: RED AND BLUE TEAM DEBATE
Port Jefferson Village Center, 3rd Floor
Dudley Goodhead, Moderator
Blue Team
Mary Helen Barcellos-Hoff, Lynn Hlatky, Jerry Shay, Robert Ullrich
Red Team
Albert J. Fornace, Jr., Kathryn Held, John Minna, Michael Weil
SESSION XIII:
4:30 p.m. – 5:15 p.m.
SUMMARIES OF STUDENT POSTERS
Port Jefferson Village Center, 3rd Floor
Chairs: Francis Cucinotta
Jerry Shay
5:15 p.m. – 6:30 p.m.
Poster Session II
Student Posters, Port Jefferson Village Center, 3rd Floor
Models and Physics Posters, Bayles and Willse Rooms
x
STUDENT POSTER SESSION
5:15 p.m. – 6:30 p.m.
Port Jefferson Village Center, 3rd floor
S-1
Autsavapromporn N.*
De Toledo S. M.
Harris A. L.
Jay-Gerin J.- P.
Azzam E. I.
The role of gap junction communication in the propagation of stressful or protective effects between human
cells exposed to space radiation [#1055] ................................................................................................................100
S-2
Bourdeau-Heller J.*
Leisemann Immel R.
Halberg R.
Steffen L.
Storts D.
Bacher J.
Microsatellite–Based Biodosimetry [#1050] .............................................................................................101
S-3
Buonanno M.*
de Toledo S. M.
Azzam E. I.
The Effect of Linear Energy Transfer in Induction of Non-targeted Effects of
Space Radiations [#1043] ......................................................................................................................................102
S-4
Delgado O.*
Richardson J. A.
Xie X-J.
Wright W. E.
Story M. D.
Minna J. D.
Shay J. W.
Invasive Cancer Induced by Radiation in the LA1 K-ras Mouse Model of Lung Cancer [#1082] ............103
S-5
Girdhani S.*
Hahnfeldt P.
Lamont C.
Anaya Z.
Peluso M.
Szelag H.
Weremowicz J.
Abdollahi A.
Hlatky L.
Proton Suppression of Angiogenesis as a Progression Phase Modulator of
Carcinogenesis Risk [#1076] ...................................................................................................................................104
S-6
Gonon G.*
de Toledo S. M.
Fromm M.
Azzam E. I.
A Tissue Culture Strategy to Identify Irradiated and Bystander Cells in Monolayer Cell Cultures Exposed
to Low Fluences of HZE Particles at the NSRL [#1044] .........................................................................................105
S-7
Illa-Bochaca I.*
Fernandez-Garcia I.
Mahoney V.
Barcellos-Hoff M. H.
The Contribution of Non-Targeted Effects in HZE Cancer Risk: Impact on Tissue Stem Cells [#1088] ..106
S-8
Kuo M. M.*
Soucy K. G.
Shoukas A. A.
Berkowitz D. E.
Time and Dose Effects of Low-Dose Iron Radiation on Vascular Function [#1090] ................................107
S-9
Li H.
Li M.*
Feng D.
de Toledo S. M.
Zhang J.
Donnelly R. J.
Barnes B.
Azzam E. I.
Rabin B. M.
In Vivo Bystander Effects Induced by Heavy Particle Irradiation [#1042] ...............................................108
S-10
McEllin B.*
Boies L.
Camacho C. V.
Nannepaga S.
Mashimo T.
Vemireddy V.
Sirasanagandla S.
Bachoo R. M.
Burma S.
Generation of a novel mouse model system to study HZE particle-induced gliomagenesis [#1086] ........109
S-11
Plante I.*
Cucinotta F. A.
Monte-Carlo simulation of radiation track structure and calculation of dose deposition in nanovolumes
[#1064] ....................................................................................................................................................................110
S-12
Rivera P. D.*
Shih H.
LeBlanc J. A.
Amaral W. Z.
DeCarolis N. A.
Chen B. P. C.
Eisch A. J.
Silicon-rich HZE Particle Irradiation Dynamically Impacts Adult Hippocampal Neurogenesis [#1084] 111
S-13
Sridharan D. M.*
Whalen M. W.
Cucinotta F. A.
Pluth J. M.
Phosphorylation Kinetics of Proteins involved in Early Response to HZE Exposure are Modified by
Radiation Quality [#1097] .......................................................................................................................................112
xi
S-14
Stisova V.*
Abele W. H.
Bennett P. V.
Sutherland B. M.
Effect of Low-LET Solar Particle Event Protons and X-rays on Transformation and Survival of Primary
Human Fibroblasts [#1015] ....................................................................................................................................113
S-15
Tang J.*
Chen C.
Barcellos-Hoff M. H.
Costes S. V.
In Silico Mammary Gland: An Agent-Based Systems Biology Model of Mammary Gland Carcinogenesis
Following Ionizing Radiation [#1048] ....................................................................................................................114
S-16
Trani D.*
Datta K.
Li H.
Moon B. H.
Sun J.
Kallakury B.
Fornace A. J. Jr.
Enhanced Intestinal Tumor Multiplicity and Grade in vivo after HZE and Proton Exposure: Mouse Models
for Radiation Risk Estimates [#1071] ......................................................................................................................115
MODELS POSTER SESSION
5:15 p.m. – 6:30 p.m.
Bayles and Willse Rooms
M-1
Burns F. J.*
Tang M.-S.
Wu F.
Cancer Yield Prediction on the Basis of DNA Double Strand Breaks [#1029] .........................................117
M-2
Cengel K. A.*
Wilson J.
Diffenderfer E.
Seykora J. T.
Senzari J. K.
Maks C.
Avery S.
Yee S.
Ware J.
McDonough J.
Kennedy A. R.
Techniques and Biological Effects of Simulating the Whole Body Dose Distribution from a Solar Particle
Event Using a Porcine Model [#1081] ....................................................................................................................118
M-3
Chappell L. J.*
Cucinotta F. A.
Non-Targeted Effects and the Dose Response for Heavy Ion Tumorigenesis [#1049] ..............................119
M-4
Neumaier T.
Yang B.
Costes S. V.*
High-LET ionizing radiation reveal DSB clustering into common nuclear subunits [#1047] ..................120
M-5
Kim M. Y.*
Cucinotta F. A.
Overview of the Graphical User Interface for the GERMcode (GCR Event-based Risk Model) [#1036] .121
M-6
Ponomarev A. L.*
Cornforth M. N.
Loucas B. D.
Cucinotta F. A.
The Distribution of Small Ring Products and Associated Deletions In Human Chromosomes as Predicted
by a Generalized Model of Radiation-Induced Aberration Formation [#1083] ......................................................122
M-7
Saganti P.B.*
Cucinotta F.A.
Expansions of "QMSFRG" Model Calculations in the Context of Current GCR [#1104] ........................123
M-8
Sowa M. B.*
Lewis A. J.
Chrisler W. B.
Castillo S.
Koehler P.
Shankaran H.
Integrated Experimental and Computational Strategy to Develop a Predictive Understanding of Radiation
Induced Matrix Remodeling in a Human Skin Tissue Model [#1040] .....................................................................124
PHYSICS POSTER SESSION
5:15 p.m. – 6:30 p.m.
Bayles and Willse Rooms
P-1
Dingfelder M.*
Jorjishvili I. G.
Toburen L. H.
Patterns of Energy Deposition by HZE Particles in Cellular Targets [#1063] .........................................126
P-2
Lin Z. W.*
Jia Y.
The Radiation Environment from Galactic Cosmic Rays in a Habitat on the Lunar Surface [#1018] .....127
xii
P-3
Di Fino L.
Casolino M.
De Santis C.
Larosa M.
La Tessa C.
Narici L.*
Picozza P.
Zaconte V.
Angular distribution of the charged radiation in the ISS: evidence for an anisotropy in the radiation flux of
heavy ions [#1004] ...................................................................................................................................................128
P-4
Pisacane V. L.*
Dolecek Q. E.
Malak H.
Dicello J. F.
Calibration and End-to-End System Test of Solid-State Microdosimeters [#1007] ..................................129
P-5
Straume T.*
Borak T.
Braby L. A.
Lusby T.
Warner D.
Tran H.
Oertli D.
Liu H.
Murakami T.
Iwata Y.
Active EVA Radiation Monitor [#1039] ....................................................................................................130
P-6
Wilkins R. T.*
Aghara S. K.
Gersey B.
Kirby K. K.
Saganti P. B.
Zhou J.
NASA Center for Radiation Engineering and Science for Space Exploration at Prairie View A&M
University [#1066] ...................................................................................................................................................131
7:00 p.m. – 9:00 p.m.
Dinner and Awards Banquet
Danfords Hotel, Brookhaven Room
xiii
Wednesday, May 19, 2010
7:30 a.m. – 8:00 a.m.
Continental Breakfast
Port Jefferson Village Center, 3rd Floor
SESSION XIV:
8:30 a.m. – 10:00 a.m.
CNS RISKS: RED AND BLUE TEAM DEBATE
Port Jefferson Village Center, 3rd Floor
Walter Schimmerling, Moderator
Blue Team
Charles Limoli, Gregory Nelson, Bernard Rabin
Red Team
Amelia Eisch, John Fike, Kerry O’Banion
10:00 a.m. – 10:30 a.m. Break
SESSION XV:
DEGENERATIVE AND ACUTE RISKS: RED AND BLUE TEAM DEBATE
10:30 a.m. – 12:00 p.m. Port Jefferson Village Center, 3rd Floor
Derek Lowenstein, Moderator
Blue Team
Polly Chang, Ann Kennedy, Mark Little
Red Team
Joel Bedford, Charles Geard, Jacqueline Williams
12:00 p.m. – 12:10 p.m. Yuki Uchihori
Announcing the 6th International Workshop on Space Radiation Research
12:10 p.m. – 1:30 p.m.
Lunch and Closing Remarks
Danfords Hotel, Brookhaven Room
1:30 p.m.
Adjourn
xiv