Early Fall 2009 New Member of the DSLS Team! Dr. Virginia ‘Ginger’ Wotring recently joined the DSLS Team as Senior Scientist. She now works under the leadership of Dr. Scott Smith. Ginger received her PhD in Pharmacological and Physiological Sciences at Saint Louis University after earning a BS in Chemistry at Florida State University. She has experiences studying drug mechanisms of action, drug receptor structure/function relationships, and gene and protein expression. Ginger has her office in Building 37, Room 164, and can be reached at (281) 483-6332 or at virginia.e.wotring@nasa.gov. Please join us in welcoming Ginger to the team! Ginger Wotring, PhD DSLS Newsletter UNIVERSITIES SPACE RESEARCH ASSOCIATION Congratulations to the Happy Couple! In a ceremony at Friendswood Church of Christ, Lori Jackson and John Michael Chappell were united in marriage on May 23. All of us at DSLS extend our very best wishes for a wonderful life together to Lori and John. We are very happy for you! Honors and Awards Jancy McPhee, PhD, was elected to full membership in the International Academy of Astronautics. Regina Buccello-Stout, PhD, was named adjunct professor of Psychology at the University of Houston Clear Lake. Jean Sibonga, PhD, was named adjunct professor of Health and Human Performance at the University of Houston. Jancy McPhee, PhD Regina BuccelloStout, PhD Jean Sibonga, PhD Lori Ploutz-Snyder, PhD, was recently named adjunct professor of Health and Human Performance at the University of Houston. Lori Ploutz-Snyder, PhD Introducing: SMAR! Have you heard about SMAR yet? Even if you missed the kick-off meeting, you can still participate in DSLS’ new series of professional development workshops on Statistical Methods and Applications Review. In response to our recent survey, members and colleagues of the JSC Biostatistics lab have started this new series for researchers who want to gain a better understanding of some of the common (and not-socommon!) statistical techniques to obtain the most information possible from SLSD research data. The series will meet on the 2nd and 4th weeks of every month - watch your email Inbox for the next event announcement! Then join us in lively discussions about statistics and a wide variety of statistical approaches to gain knowledge from data. The DSLS Newsletter is published on a bi-monthly basis. Dagmar Morgan—Editor Division of Space Life Sciences Universities Space Research Association, 3600 Bay Area Boulevard, Houston, TX 77058 Grant Proposals Submitted Byerly D, Arndt D, Sognier MA: “Using focused microwave energy for sterilizing water systems”, for funding through the NASA Innovation Fund. Clement G, Clarke A, McIntyre J, Denise P, Cheron G, Wuyts F, Wood SJ: Letter of intent to propose “Multidimensional perception in microgravity - An integrated approach” in response to ILSRA-2009, International Life Sciences Research Announcement. Huff JL, Rustgi AK, Patel ZS, Hada M: Step-2 proposal for “Impact of radiation quality on cancer development processes studied in a 3-D human esophageal cell model system” in response to NNJ09ZSA001N: Ground-Based Studies in Radiobiology. Smith SM, Zwart SR, Jessup JM: “Characterization of oxidative damage during a saturation dive”, to the HRP Science Management Office. Smith SM, Zwart SR, Perchonok M, Kloeris V, Lupton J, Heer M: “Multi-nutrition countermeasure”, to the NASA 2009 Innovation Fund call for proposals. Sognier MA (co-investigator): “Southeast Regional T-STEM Center Teach and Student Professional Development”, to Texas Education Agency. Wood SJ, Denise P, Makishima T, Clement G: Letter of intent to propose “Effects of vestibular dysfunction on musculoskeletal alterations in mice following exposure to acute and chronic gravitational changes”, in response to NASA Research Announcement NNH09ZTT003N, Fundamental Space Biology - Animal Physiology. Research Grant Awarded Byerly D, Arndt D, Sognier MA: Seal and heal: Microwave-based emergency would treatment. Funded through the NASA Innovation Fund. What’s Going On With …. Lealem Mulugeta worked with JSC, Glenn Research Center, and University of Mississippi Medical Center investigators to develop a user’s guide and a verification and validation plan for the Digital Astronaut computational model. He now serves as liaison between the NASA team and the UMMC development team to advance several of the Digital Astronaut project processes. Camille Shea worked with DSLS staff to plan and execute the working group meeting of the Behavioral Health and PerformCamille Shea, PhD ance element, and assisted Dr. Christian Otto with organizing the Antarctic findings. Megumi Hada completed the mFISH analysis of control samples of a JapaE A R L Y F A L L 20 0 9 nese ISS experiment in collaboration with Nara Medical University in Japan, and is discussing future collaboration plans with Drs. Takahashi and Ohnishi. Frank Sulzman presented a lecture at the NASA Space Radiation Summer School and represented NASA at the Radiobiology Bioterrorism Research and Training Group (RABRAT) interagency teleconference. Frank Sulzman, PhD Yvonne Roed completed training on processing CR-39 detectors. Her training and her written “Summary on test etching of five CR39 detector plates” have Yvonne Roed, MS qualified her to process CR-39 detectors independently. Johnny Conkin was invited by Dr. Tom Newman to contribute (as second author) a chapter on Johnny Conkin, PhD Aerospace Decompression Sickness to the 6th edition of Bennett and Elliott’s The Physiology and Medicine of Diving. Chris Westby was certified as a dorsal vein operator and will now be the Chris Westby, PhD primary person overseeing all dorsal hand and foot vein infusions for the Gender Differences Bed Rest Study. Continued on page 7 Page 2 SPOTLIGHT ON: Ianik Plante, MD PhD! lations of ionizing radiations, notably heavy ions tracks, to calculate energy deposition and creation of reactive oxygen species. These Ianik Plante, MD PhD simulations will help our understanding of radiobiological * Tell us briefly about yourself and effects of space radiation and improve your family. models of radiation risk. I was born in Sherbrooke, Québec, which is the French speaking province * What is really important to you regarding your work at JSC? of Canada. I lived in Québec and Understanding the risk of ionizing studied at the University of Sherradiation is a combrooke. I just completed my Ph.D. in plicated problem radiobiology. One year and half ago I which has several moved to Houston to work at JSC. aspects. Therefore, What a change of culture and people from differweather! Most of my family is in Canent facilities ada at this moment. around the world * What are you presently working on working in differat JSC? ent fields such as Presently I am working in the NASA biologists, bioSpace Radiation Project as a research chemists, chemscientist. Our goal is to improve our ists, computer prounderstanding of the radiation risk in grammers, mathespace, mostly regarding heavy ions, to maticians, physieventually develop effective and efficists and physicient countermeasures to protect cians, are all inastronauts from the effects of radiavolved in this of the Space Radiation tion . For this project I conduct simu- Logo Project (Courtesy of NASA) problem. So team Ianik Plante, MD PhD, works for the JSC Space Radiation Project, which aims to achieve human exploration and development of space without exceeding an acceptable level of risk from exposure to space radiation. Recently, Ianik was interviewed for this edition’s Spotlight Article. work is very important to exchange ideas of people from different fields. The collaboration between experimentalists and modelers is also of crucial importance. * What are your goals for this year? I am working on several projects at this moment. One of these projects is to study the role of the molecule TGFβ in the radiation response of cell culture or tissue. TGFβ is very important because it is activated by ionizing radiation and interacts with cells to modify their responses. This project is also a great opportunity to link results from previous work such as calculations of radiation tracks with the radiation response of cells in tissue culture. I will also work on some parts of the radiation transport codes, notably on light ions. Thank you so much for being our Spotlight Scientist for this edition of the DSLS newsletter, Ianik! For the most recent issue of the Space Radiation Newsletter, please go to http://spaceradiation.usra.edu/ newsletter/archive/2009/spring/. 6th ISLSWG Working Group’s Microbiology Workshop The International Space Life Sciences Working Group (ISLSWG) is chartered with bringing agencies together to provide coordination of international development and use of spaceflight and special ground research facilities. In late August, the group held a workshop focused on Space Microbiology in Sonoma County, California. Organized by Dr. C. Mark Ott and Dr. Duane Pierson and coordinated by DSLS’ very own Gail Pacetti, the workGail Pacetti shop aimed to provide a fruitful discussion of current and future research aboard the International Space Station. 34 researchers from NASA Headquarters, Johnson Space Center, Ames Research Center and the Jet Propulsion Lab, as well as from international partners such as Japan The ISLSWG 2009 Microbiology Workshop Attendees (JAXA), Canada (CSA), Russia (IBMP), and Belgium (SCK-CEN), participated in the three-day event. All workshop presentations and a final meeting report will soon be available on a passwordprotected section of the DSLS website. Congratulations on a very successful meeting! E A R L Y F A L L 20 0 9 Page 3 New Publications by DSLS Scientists Kim M-HY, Hayat MJ, Feiveson AH, Cucinotta FA. 2009. Prediction of frequency and exposure level of solar particle events. Health Physics Myung Kim, PhD Journal 97(1), 66-81. http:// dx.doi.org/10.1097/01.HP.0000346799 .65001.9c George KA, Hada M, Jackson L, Elliott T, Kawata T, Pluth JM, Cucinotta FA. 2009. Dose response of γrays and iron nuclei induction of chromosomal aberrations in normal and repair deficient cell lines. Radiation Research 171, 752-763. Baynard T, Carhart RL Jr, PloutzSnyder LL, Weinstock RS, Kanaley JA. 2008. Short-term training effects on diastolic function in obese persons with the metabolic syndrome. Obesity 16(6): 1277-1283. http:// dx.doi.org/10.1083/oby.2008.212 Nounu HN, Kim M-HY, Ponomarev AL, Cucinotta FA. 2009. The use of Pro/Engineer CAD Hatem Nounu, PhD software and fishbowl tool kit in ray-tracing analysis. NASA Technical Publication NASA/TP-2009 214788. Conkin J, Wessel JH III. 2009, July. A model to predict acute mountain sickness in future spacecraft. NASA Technical Publication NASA/TP 2009214791. Plante I, Cucinotta FA. 2009. Cross sections for the interaction of 10 eV100MeV electrons in liquid water and application to Monte-Carlo simulation of HZE radiation tracks. New Journal of Physics 11, 060347. http://dx.doi.org/10.1088/13672630/11/6/063047. Zwart SR, Wolf M, Rogers A, Rodgers S, Gillman PL, Hitchcox K, Ericson KL, Smith SM. 2009. Stability of analytes related to Sara Zwart, PhD clinical chemistry and bone metabolism in blood specimens after delayed processing. Clin Biochem 42(9), 907-910. http:// dx.doi.org/10.1016/ j.clinbiochem.2009.02.010 Matthew G, Zwart SR, Smith SM. 2009. Stability of blood analytes after storage in BD SST TM tubes for 12 mo. Clinical Biochem. Jul 22 2009 [Epub ahead of print]. http:// dx.doi.org/10.1016/ j.clinbiochem.2009.07.015 Education and Public Outreach Roni Cromwell mentored graduate student Ashley Purgason for a lab rotation as part of her UTMB doctoral degree requirements. Roni was also interRoni Cromwell, PhD viewed by Wired.com about the lunar head-up tilt studies. Lori Ploutz-Snyder mentored Syracuse University’s graduate student Kyle Hackney, resulting in a presentation for the National Strength and Conditioning Association’s Annual Meeting in Las Vegas. She attended Syracuse University’s graduate student Summer Cook’s dissertation defense; and she mentored NSBRI intern and UTMB graduate student Brandon Marcias. She also presented “Exercise Prescriptions for Spaceflight” for the UTMB Space Physiology Course. In addition, Lori facilitated the HHC Element’s review of an unsolicited E A R L Y F A L L 20 0 9 grant proposal; and met the dean, assistant dean, and exercise science faculty at Syracuse University to discuss possible NASA collaborations. Professoriate Summer Research Student Lecture Series. Jean Sibonga mentored HarvardMIT Health Sciences and Technology graduate students Rachel Ellman and Jordan Spatz and facilitate meetings with researchers for both. She also served as an ad hoc member of the NIH Special Emphasis Panel study section (ZRG1F10B-2(20)) in Bethesda, Maryland. Ramona Gaza mentored summer intern Camille Smith from Prairie View University Research Center and led several SRAG lab tours. Patrice Yarbough mentored FAP summer intern Cheryl Goetz and presented “Hepatitis E Vaccine Discovery and Development” to University of Houston and Rice University students Patrice Yarbough, PhD as part of the Alliances for Graduate Education and Sara Zwart mentored DeBakey High School student Sharon Mathew. Ramona Gaza, PhD Scott Wood mentored USRA College Career Exploration Program participant Krystin Ramos, Dr. T. Makishma of UTMB Otolaryngology, and NSBRI summer intern J. Kayanickupuram. Scott also reviewed articles for Acta Oto-Laryngologica and Acta astronautica. (Cont. on Page 6) Page 4 Recent Scientific Presentations Batki S, Dimmock J, Ploutz-Snyder R, Carey K, Maisto S, Cavallerano M, Meszaros Z, Leontieva L, Canfield K, DeRycke S. Dirctly monitored naltrexone reduces drinking in schizophrenia: Preliminary analysis of a controlled trial. 32nd Annual Research Society on Alcoholism Conference, June 2024, 2009. San Diego, CA. Conkin J, Wessel JH III. Alternative to the equivalent air altitude model to predict acute mountain sickness. 2009 Scientific Meeting of the Undersea and Hyperbaric Medical Society, June 2428, 2009. Las Vegas, NV. Conkin J. Environmental Physiology at the NASA Johnson Space Center. Lecture for the Introduction to Aerospace Medicine Course for the UTMB Aerospace Medicine Residency Program. June 30, 2009. Galveston, TX. Cromwell RL, Buccello-Stout R, Yarbough P. Standardization of the bed rest analog. 17th IAA Humans in Space Symposium, June 7-11, 2009. Moscow, Russia. Ploutz-Snyder LL, Cook SB. Low load resistance training with blood flow restriction as a countermeasure to disuse atrophy. 17th IAA Humans in Space Symposium. June 7-11, 2009. Moscow, Russia. Gaza R. SRAG Operational Radiation Measurements. Habitability and Environmental Factors Division Management Team Meeting, June 25, 2009. NASA JSC. Meszaros Z, Dimmock J, Ploutz-Snyder R, Batki S. Safety of naltrexone directly administered 3 times per week for alcohol dependence in schizoRob Ploutz-Snyder, PhD phrenia. 32nd Annual Research Society on Alcoholism Conference. June 20-24, 2009. San Diego, CA. Ploutz-Snyder R. Effect size, statistical power, and sample size calculations for proposing new studies at NASA. DSLS Brown Bag Seminar June 25, 2009. USRA Houston. Stress Response Upregulation. Aerospace Medicine Grand Rounds, July 28, 2009. USRA Houston. Hackney KJ, Keller AR, PloutzSnyder LL. Timing amino-acid carboPonomarev A. Energy deposition hydrate with consecutive bouts of reand foci formation. Invited talk at the sistance training ELEVATES resting NASA Space Radiation Summer energy expenditure. National Strength School, June 2, 2009. Brookhaven and Conditioning Association 2009 National Lab, Upton, NY. Annual Meeting, July 9-11, 2009. Las Vegas, NV. Shea C, Slack KJ, Keeton KE, Palinkas LA, Leveton LB. Antarctica Hada M, George KA, Patel Z, Huff J, Meta Analysis: Psychosocial factors Pluth JM, Cucinotta FA. DNA repair related to long-duration isolation and defects and chromosomal aberrations: confinement. 17th IAA Humans in Comparisons after low and high dose Space Symposium, June 7-11, 2009. irradiation. 9th International SympoMoscow, Russia. sium on Chromosomal Aberrations (ISCA), July 11-12, 2009. St. Goar, Sibonga J. Bone health in space: What do we need to know in order to Germany. preserve it? Invited talk at the Space Hada M, Cucinotta FA, Life Sciences Summer Institute, June Wu H. mBAND study of 25, 2009. NASA JSC. radiation-induced chromosome aberrations in Vanhavere F, Zhou D, Spurny F, human epithelial cells. Yukihara E, O’Sullivan D, Schoon9th International Sympojans W. Genicot J-L. Passive dosium on Chromosomal simetry at the International Space Megumi Hada, PhD Station (ISS) in the framework of the Aberrations (ISCA), July 11-12, 2009. St. DOBIES Project. 17th IAA Humans Goar, Germany. in Space Symposium, June 7-11, 2009. Moscow, Russia. Wood SJ. Sensorimotor adaptation during g-transitions. Invited talk at the Space Life Sciences Summer Institute, June 4, 2009. NASA JSC. Zhou D, O’Sullivan D, Semones E, Gaza R, Roed Y, Johnson S, Zapp N, Lee K. Radiation measured during ISS-Expedition 15 space mission with different dosimeters. 17th IAA Humans in Space Symposium, June 7-11, 2009. Moscow, Russia. Buccello-Stout R. Flight Analogs Project. Lecture at the Space Life Sciences Summer Institute, July 23, 2009, NASA JSC. Gillis DB, Zanello SB. Potential Transformational Mission Health and Performance Benefits of Cell Kim MY, Cucinotta FA. Probabilistic assessment of cancer risk for astronauts on lunar missions. Heavy Ions in Therapy and Space Symposium 2009 / 20th Annual NASA Space Radiation Investigators’ Workshop (SRIHW), July 6-10, 2009. Cologne, Germany. Mulugeta L, Bodkin D, Chasseigne R, Lealem Mulugeta, M.Sc. Demel M, Jagula D, Turnock M. Proposed standards and tools for risk analysis and allocation of robotic systems to enhance crew safety during surface exploration missions. 39th International Conference on Environmental Systems, July 12-16, 2009. Savannah, GA. Page 5 Recent Presentations (cont.) Mulugeta L, Chappell S, Skytland N. The effect of center of gravity and anthropometrics on human performance in simulated lunar gravity. 39th International Conference on Environmental Systems, July 12-16, 2009. Savannah, GA. Sibonga J. Evaluations of Hip Morphology by QCT in Long-Duration Crewmembers. Medical Operations Board Special Topics Lecture, July 15, 2009, NASA JSC. Patel ZS, Grugan KD, Rustgi AK, Cucinotta FA, Huff JL. Esophageal epithelial cells exhibit increased migration and invasion in two- and threeZarana Patel, PhD dimensional cell culture models as triggered by irradiated fibroblasts. Heavy Ions in Therapy and Space Symposium / 20th Annual NASA Space Radiation Investigators’ Workshop, July 6-10, 2009. Cologne, Germany. Poster received first place in the Student Poster Contest! Ploutz-Snyder L. Blood Flow Restricted Exercise: Fact or Fiction? National Strength and Conditioning Association 2009 Annual Meeting, July 9-11, 2009. Las Vegas, NV. Tian L, Huff JL, Patel Z, Wang M, Cucinotta FA, Wang H. Effect of epidermal growth factor and its receptor on DNA damage response. Heavy Ions in Therapy and Janice Huff, PhD Space Symposium / 20th Annual NASA Space Radiation Investigators’ Workshop, July 6-10, 2009. Cologne, Germany. Zhou D, O’Sullivan D, Semones E, Gaza R, Roed Y, Zapp N. Radiation measured in low Earth orbit for GCR heavy ions near solar minimum. Heavy Ions in Therapy and Space Symposium / 20th Annual NASA Space Radiation Investigators’ Workshop, July 6-10, 2009. Cologne, Germany. Zhou D, O’Sullivan D, Semones E, Johnson S, Lee K, Zapp N. Radiation of cosmic rays measured in low Earth orbit with active and passive detectors. 31st International Cosmic Ray Conference, July 7-15, 2009. Lodz, Poland. Cucinotta FA, Ponomarev AL, Plante I, Carra C, Kim MY. Development of a GCR event-based risk model. Heavy Ions in Therapy and Space Artem Ponomarev, PhD Symposium 2009 / 20th Annual NASA Space Radiation Investigators’ Workshop (SRIHW), July 6-10, 2009. Cologne, Germany. Save the Date for the DSLS Halloween Picnic! When: October 28, 2009 Where: USRA Great Room and Backyard Who: All DSLS employees and their families How: Let’s ‘fall’ into the Halloween spirit together! Stay tuned for more info! Education & Public Outreach (cont.) Marguerite Sognier reviewed NIH challenge grants, presented Marguerite Sognier, PhD an all-day “Make It, Take It” and a “Science Share-a-thon” teacher workshop, and trained Galveston County teachers to use the NSTA online learning center. Further, she presented “Star Trekkies”, a variety of hands-on space-related educaE A R L Y F A L L 20 0 9 tional activities, at the 15th Annual Texas Regional Collaboratives Conference in Austin, and an invited talk entitled “Successful pipeline programs for health careers” at the Health Science Technology Conference in Houston. Susi Zanello wrote a letter of support for the GenMAPP team of the J. David Gladstone Institutes, University of Susi Zanello, PhD California San Francisco, for their pursuit of grant funding from NIH for further enhancement of GenMAPP, a publicly available tool. Larry Kuznetz advised University of South Alabama graduate student Tom Miller on a progress report for the new human body thermal model. Chris Westby volunteered as a test subject for three ongoing studies in the Cardiovascular Lab. Page 6 What’s Going On With ... (cont.) Larry Kuznetz responded to a call from the Mission Management Team during STS-127 to determine possible causes of high Larry Kuznetz, PhD Larry Kuznetz, PhD CO2 levels in the EVA suits. Using LEGACI data compiled on one of the STS-127 astronauts during the Integrated Suit Test Program last year, he was able to trace the problem to liquid cooled garment overcooling (low inlet temperatures). The overcooling caused a low sweat rate that impacted the lithium hydroxide canister, which in turn resulted in the high CO2 levels and in early termination of the EVAs. Dazhuang Zhou submitted a draft of the chapter “Methods Using CR-39 Plastic Nuclear Track Detectors in Radiation Research” for the book Nuclear Track Dazhuang Zhou, PhD Detectors: Design, Methods and Application to Nova Science Publishers. ScottDazhuang WoodZhou, re-PhD cently hosted a public affairs outreach for the ESA experiments ZAG and Otolith with Swedish astroScott Wood, PhD, on the Swedish National TV news naut and STS-128 crew member Swedish Astronaut Christer Fuglesang, PhD, in the ISS Harmony node together with ESA astronaut Frank De Winne, Exp 20 Flight Engineer (left). (Photo Courtesy of NASA) Christer Fuglesang. Over 20 media representatives from all over Europe were in attendance. Jean Sibonga recruited postdoctoral candidates for a three-month internship in the Bone and Mineral Lab this fall. She worked with graduate student Rachel Ellman on pQCT modes for evaluating cross-sectional area of bone marrow canal and whole bone of tibia, and initiated communications between Rachel and DLR investigators in the Berlin bed rest study. DSLS Scientists to Participate in First Suborbital Space Scientist Training Course In a press release dated July 14, 2009, Environmental Tectonics Corporate (ETC) announced that its National AeroSpace Training and Research (NASTAR) Center will host its inaugural Suborbital Space Scientist Training Course in conjunction with Southwest Research Institute in January 2010. ing Course will be taught to a select group of a dozen scientists, graduate students and educators from U.S. research and educational institutions and is designed to acquaint individuals with the physiological rigors of suborbital human spaceflight. Institutions sending participants to the inaugural program include Southwest Research Institute, Boston University, the Denver Museum of Natural SciThe NASTAR Center offers training ences (DMNS), the Johns Hopkins and research capabilities to governUniversity Applied Physics Laborament, private and international space tory (APL), the Massachusetts Instiindustries. Through academic instruc- tute of Technology (MIT), the Unition and leading-edge simulation tech- versity of Central Florida, and the nology, individuals can explore susUniversity Space Retained elevated G exposure, altitude search Association exposure, spatial disorientation, and (USRA). other physiological effects of entering Chosen from among the the space environment. USRA scientists were The Suborbital Space Scientist Train- DSLS team members Scott Wood and Scott Wood, PhD Ramona Gaza, PhD Ramona Gaza. Their class will include space flight training and altitude physiology, as well as classroom work, centrifuge flights, altitude chamber runs and other training elements. Congratulations, Ramona and Scott! We can’t wait to hear about your experience at a Brown Bag Luncheon Seminar early next year! For more information about the NASTAR Center and for the press release in its entirety, please visit http:// www.nastarcenter.com/index.php. DSLS Newsletter U N I V E R S I T I E S S P A C E R E S E A R C H A S S O C I A T I O N Page 7