Full publication list
1. Yeganeh B, Jäger R, Gorman AM, Samali A, Ghavami S (2014) Induction of autophagy: Role of
endoplasmic reticulum stress and unfolded protein response. In AUTOPHAGY. CANCER,
OTHER PATHOLOGIES, INFLAMMATION, IMMUNITY AND INFECTION, Volume 7 (MA Hyatt,
ed) Elsevier Inc ISBN: 978-0-12-405530-8, In press
2. Mnich K, Carleton LA, Kavanagh ET, Doyle KM, Samali A, Gorman AM. (2014) Nerve growth
factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active
caspase-3 in a lysosome-dependent manner. Cell Death and Disease May 1;5:e1202. doi:
10.1038/cddis.2014.173.
3. Moloney TC, Hyland R, O’Toole D, Paucard A, Kirik D, O’Doherty A, Gorman AM, Dowd E.
(2014) Heat shock protein 70 reduces α-synuclein-induced predegenerative neuronal
dystrophy in the α-synuclein viral gene transfer rat model of Parkinson’s disease. CNS
Neuroscience & Therapeutics 20(1):50-8
4. Logue SE, Gorman AM, Keogh N, Cleary P, Samali A (2013) Current concepts in ER stressinduced apoptosis Journal of Carcinogenesis and Mutagenesis S6
5. Toner AP, McLaughlin F, Giles FJ, Sullivan FJ, O’Connell E, Carleton LA, Breen L, Dunne G,
Gorman AM, Lewis JD, Glynn SA. (2013) The toluidine sulphonamide EL102 enhances
docetaxel pre-clinical activity against prostate cancer and circumvents MDR1 resistance. Br J
Cancer 109:2131-41
6. Donnelly N, Gorman AM, Gupta G, Samali A (2013) The eIF2α kinases: their structures and
functions. Cell Mol Life Sci Oct;70(19):3493-511
7. Cawley K, Logue SE, Gorman AM, Zeng Q Patterson J, Gupta S, Samali A. (2013) Disruption of
microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the
mitochondrion, PLoS One 8(8):e73870. doi: 10.1371/journal.pone.0073870
8. Deegan S, Saveljeva S, Gorman AM and Samali A (2013) Stress-induced self-cannibalism: on
the regulation of autophagy by endoplasmic reticulum stress. Cell Mol Life Sci
Jul;70(14):2425-41. doi: 10.1007/s00018-012-1173-4. Epub 2012 Sep 28.
9. Gorman AM, Healy SJM, Jäger R, Samali A (2012) Stress management at the ER: Regulators
of ER stress-induced apoptosis. Pharmacol Ther. 134, 306-16
10. Jaeger R, Bertrand MJM, Gorman AM, Vandenabeele P and Samali A (2012) The unfolded
protein response at the crossroads of cellular life and death during endoplasmic reticulum
stress. Biol. Cell 104, 1–12
11. Cawley K, Sugrue T, Samali A, Gupta S, Gorman AM (2012) MicroRNA regulation of apoptosis
in breast cancer. Cancer Reports 2, 1-8
12. Doyle KM, Kennedy D, Gorman AM, Gupta S, Samali A (2011) Unfolded proteins and
Endoplasmic Reticulum stress in neurodegenerative disorders. J Cell Mol Med 15, 2025-2039
13. Molloy NH, Read DE, Gorman AM (2011) Nerve growth factor in cancer cell death and
survival. Cancers 3, 510-530; doi:10.3390/cancers3010510
14. Walsh S, Gorman AM, Finn D, Dowd E (2010) The effects of cannabinoid drugs on abnormal
involuntary movements in dyskinetic and nondyskinetic 6-hydroxydopamine lesioned rats.
Brain Res 1363, 40-48
15. Fulda S, Gorman AM, Osamu H, Samali A (2010) Cellular Stress Responses: cell survival and
cell death. Int J Cell Biol 2010, 214074
16. Mnich K, Dowd E, Finn D, Gorman AM (2010) Inhibition by anandamide of 6hydroxydopamine-induced cell death. Int J Cell Biol 2010, 818497
17. Walsh S, Mnich K, Gorman AM, Finn D, Mackie K, Dowd E (2010) Loss of cannabinoid CB1
receptor expression in the 6-hydroxydopamine-induced nigrostriatal terminal lesion model
of Parkinson’s disease. Brain Res Bull 81, 543-548
18. Yao L, Damodaran G, Nikolskaya N, Gorman AM, Windebank A, Pandit A (2010) The effect of
laminin peptide gradient in enzymatically cross-linked collagen scaffolds on neurite growth. J
Biomed Mater Res 92, 484-492
19. Samali A, Fulda S, Gorman AM, Hori O, Srinivasula SM (2010) Cell stress and cell death. Int J
Cell Biol (Editorial for Special Issue on Cell Stress and Cell Death) Article ID 245803,
doi:10.1155/2010/245803
20. Healy SJM, Gorman AM, Mousavi-Shafaei P, Gupta S, Samali A (2009) Targeting the
endoplasmic reticulum-stress response as an anti-cancer strategy. Eur J Pharmacol 625, 234246 (Special Issue 'New vistas in anti-cancer therapy')
21. Read DE, Gorman AM (2009) Involvement of Akt in neurite outgrowth. Cell Mol Life Sci 66,
2975-2984
22. Read DE, Gorman AM (2009) Heat shock protein 27 in neuronal survival and neurite
outgrowth. Biochem Biophys Res Commun 382, 6-8
23. Doyle KM, Gorman AM (2009) Considerations and recent advances in neuroscience.
Meeting report of 2nd Neuroscience Ireland Conference Biochem Soc Trans. 37(1), 299-302
24. Yao L, Wang S, Cui W, Sherlock R, O’Connell C, Damodaran G, Gorman A, Windebank A,
Pandit A (2009) Effect of functionalised micropatterned PLGA on guided neurite growth.
ACTA Biomater 5, 580-588
25. Gorman AM (2008) Neuronal cell death in neurodegenerative diseases: recurring themes
around protein handling. J Cell Mol Med 12(6A), 2263-2280
26. Szegezdi E, Reed Herbert K, Kavanagh ET, Samali A and Gorman AM (2008) Nerve growth
factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation
of Bim. J Cell Mol Med 12(6A), 2482-2496
27. Read DE, Reed Herbert K, Gorman AM (2008) Heat shock enhances NGF-induced neurite
elongation which is not mediated by Hsp25 in PC12 cells. Brain Res 1221, 14-23
28. Reed Herbert K, Samali A, Gorman AM. (2007) The role of heat shock proteins in neuronal
differentiation and development. In Heat Shock Proteins in Neural Cells, Chapter 3
(Christiane Richter-Landsberg, ed.), Landes Bioscience, TX, USA. ISBN: 0-387-39952-6, pp 2537
29. Fitzgerald, U, Gorman AM, Samali A. (2007) Heat shock proteins and the regulation of
apoptosis. In Heat Shock Proteins in Neural Cells, Chapter 5 (Christiane Richter-Landsberg,
ed.), Landes Bioscience, TX, USA. ISBN: 0-387-39952-6, pp 53-66
30. Kavanagh ET, Loughlin JP, Herbert KR, Dockery P, Samali A, Doyle KM, and Gorman AM
(2006) Functionality of NGF-protected PC12 cells following exposure to 6-hydroxydopamine.
Biochem Biophys Res Commun 351, 890-895
31. Szegezdi E, Logue SE, Gorman AM and Samali A (2006) Mediators of ER stress-induced
apoptosis. EMBO Reports 7, 880-885
32. Ní Chonghaile T, Concannon CG, Szegezdi E, Gorman AM, Samali A (2006) Dexamethasone
inhibits apoptosis in C6 glioma cells through increased expression of Bcl-XL. Apoptosis 11,
1247-1255
33. Gorman AM (2006) Helping keep our neurons alive with neurotrophins. The Irish Scientist
Yearbook, No. 14, p69
34. Gorman AM, Szegezdi E, Quigney DJ, Samali A (2005) Hsp27 inhibits 6-hydroxydopamineinduced cytochrome c release and apoptosis in PC12 cells. Biochem Biophys Res Commun
327, 801-810
35. O’Driscoll CM, Gorman AM (2005) Hypoxia induces neurite outgrowth in PC12 cells that is
mediated through adenosine A2A receptors. Neuroscience 131, 321-329
36. Concannon CG, Gorman AM, Samali A (2003) On the role of Hsp27 in regulating apoptosis.
Apoptosis 8, 61-70
37. Quigney DJ, Gorman AM, Samali A. (2003) Heat shock protects PC12 cells against MPP+
toxicity. Brain Research 993, 133-139
38. Wu J, Gorman A, Xinghua Z, Ceccatelli S, Chen E. (2002) Involvement of caspase-3 in
photoreceptor cell apoptosis induced by in vivo blue light exposure. Investigative
Ophthalmology and Visual Science 43, 3349-3354
39. Bree RT, Stenson C, Grealy M, Byrnes L, Gorman AM, Samali A (2002) Cellular longevity: role
of apoptosis and replicative senescence. BioGerontology 3, 195-206
40. Daré E, Gorman AM, Ahlbom E, Götz M, Momoi T, Ceccatelli S (2001) Apoptotic morphology
does not always require caspase activity in rat cerebellar granule neurons. Neurotoxicity
Research 3, 501-514
41. Gorman AM, Hirt UA, Orrenius S, Ceccatelli S (2000) Dexamethasone pre-treatment
interferes with apoptotic death in glioma cells. Neurosci. 96, 417-425
42. Gorman AM, Ceccatelli S, Orrenius S (2000) Role of mitochondria in neuronal apoptosis Dev.
Neurosci. 22, 348-358
43. Gorman AM, Heavey B, Creagh EM, Cotter TG, Samali A (1999) Antioxidant-mediated
inhibition of the heat shock response leads to apoptosis. FEBS Lett. 445:98-102.
44. Gorman AM, Zhivotovsky B. (1999) Challenging the dogmas... Cell Death Diff. 6, 207-211
(Report on the 6th Euroconference on Apoptosis)
45. Gorman AM, Bonfoco E, Zhivotovsky B, Orrenius S, Ceccatelli S (1999) Cytochrome c release
and caspase-3 activation during colchicine-induced apoptosis of cerebellar granule cells. Eur.
J. Neurosci. 11:1067-1073
46. Gorman AM, Hirt UA, Orrenius S, Ceccatelli S. (1999) Application of a fluorometric assay to
detect caspase activity in thymus tissue undergoing apoptosis in vivo. J. Immunol. Methods.
226:43-48
47. Gorman AM, Orrenius S, Ceccatelli S (1998) Apoptosis in neuronal cells: Role of caspases.
NeuroReport 9:R49-R55
48. Gorman AM, Samali A, McGowan AJ, Cotter TG (1997) The use of flow cytometry techniques
in studying mechanisms of apoptosis in leukemic cells Cytometry 29, 97-105
49. Samali A, Gorman AM, Cotter TG (1997) Role of Bcr-abl in resistance to apoptosis. Adv.
Pharmacol. 41, 533-552
50. Gorman A, McGowan A, Cotter TG (1997) Role of peroxide and superoxide anion during
tumour cell apoptosis. FEBS Lett. 404:27-33
51. Samali A, Gorman AM, Cotter TG (1996) Apoptosis: The story so far... Experientia 52, 933941
52. Gorman AM, McGowan A, O’Neill C, Cotter TG (1996) Oxidative stress and apoptosis in
neurodegeneration. J. Neurol. Sci. 139:(Suppl) 45-52
53. McGowan A, Ruiz-Ruiz MC, Gorman AM, Lopez-Rivas A, Cotter TG (1996) The role of
proteases, PARP and free radicals during apoptosis of several leukemic cell lines FEBS Lett.
392, 299-303
54. Fernandes RS, Gorman AM, McGahon A, Lawlor M, McCann S, Cotter TG (1996) The
repression of apoptosis by activated abl oncogenes in chronic myelogenous leukaemia
Leukaemia 10, (Suppl) S17-S21
55. Gorman A, McCarthy J, Finucane D, Reville W, Cotter T. (1996) Morphological assessment of
apoptosis In Techniques in Apoptosis: A User's Guide pp 1-20 (Cotter, T.G. and Martin, S.J.
eds.), Portland Press.
56. Gorman AM, Grieve A, Griffiths R (1995) Modulation by ionotropic excitatory amino acids
and K+ of trans-ACPD stimulated phosphoinositide hydrolysis in mouse cerebellar granule
cells. J. Neurochem. 65:2473-2483.
57. Gorman AM, Scott MP, Rumbsby PC, Meredith C, Griffiths R (1995) Excitatory amino acidinduced cytotoxicity in primary cultures of mouse cerebellar granule cells correlates with
elevated, sustained c-fos protooncogene expression. Neurosci. Lett. 191:116-120.
58. Gorman A, Griffiths R (1994) Sulphur-containing excitatory amino acid-stimulated inositol
phosphate formation in primary cultures of cerebellar granule cells is mediated
predominantly by N-methyl-D-aspartate receptors. Neuroscience 59:299-308.
59. Griffiths R, Dunlop J, Gorman A, Senior J, Grieve A. (1994) L-Trans-pyrrolidine-2,4dicarboxylate and cis-1-aminocyclobutane-1,3-dicarboxylate behave as transportable,
competitive inhibitors of the high-affinity glutamate transporters. Biochem. Pharmacol.
47:267-272
60. Zisterer DM, Gorman AM, Williams DC, Murphy MP (1992) The effects of the peripheraltype benzodiazepine acceptor ligands, Ro-5-4864 and PK-11195, on mitochondrial
respiration. Methods and Findings in Experimental and Clinical Pharmacology. 14:85-90
61. Regan CM, Gorman AM, Larsson OM, Maguire C, Martin ML, Schousboe A, Williams DC
(1990) In vitro screening for anticonvulsant-induced teratogenesis in neural primary cultures
and cell lines. Preliminary observations. Int. J. Devl. Neuroscience. 8:143-150
62. Gorman AM, O'Beirne G, Regan C, Williams DC (1989) Antiproliferative actions of
benzodiazepines in cultured brain cells is not mediated through the peripheral-type
benzodiazepine acceptor. J. Neurochem. 53:849-855