Abortion Control, Vaccination, and Prevention in the Ewe Suelee Robbe, DVM Veterinary Diagnostic and Production Animal Medicine Iowa State University What is a Normal Abortion Rate? Less than 1% ovine abortions • Use the diagnostic laboratory • Do not put aborted fetuses in the freezer • 60%-70% are diagnosed as infectious causes of abortion. • Toxoplasma, Chlamydia, and Campylobacter are the 3 most common causes. Toxoplasma Abortions • Ewes that are not immune to Toxoplasma are exposed during pregnancy. Cats eat tissue and defecate in sheep feed or feed bunks Animals infected with Toxo in tissue Abortion Large amounts of infected tissue for cats to eat. Ewes unknowingly eat Toxo eggs Prevention of Toxoplasma Abortions • *Avoid having a young/transient cat population. • Avoid having ewes eat where cats frequent. • Make feed storage areas cat proof (tough to do). • Maintain effective rodent control. • Prevent cats from feeding on sheep/lamb carcasses. Vaccination against Toxoplasma • There is an effective vaccine in Europe. • Feed ewe-lambs contaminated feed when they are not pregnant. • Once a ewe aborts (or exposed) she is immune. • Ionophores have been used… This is an illegal use, only partially effective. Questions??? Chlamydia Abortions • Economically a very important disease for sheep producers • Abortion occurs in the last trimester • Can be the cause of an abortion storm, but not usually • Lambs may also be carried full term, but are born dead or weak. • Can be a chronic continual problem with 15% of ewes aborting annually. (Typical) Chlamydial Abortion • Ewes can become infected during one lambing season and abort the next lambing season. • A replacement ewe lamb infected at birth can harbor the organism and abort her lambs. • Ewes carrying multiple fetuses are more likely to abort • There are flocks that are free of Chlamydia. (Or at least the strain that causes abortion.) Purchased Ewes can bring Chlamydia into a Clean Flock Infected Ewe How Chlamydia Perpetuates in a Flock Lambs from these ewes can be born infected (will be carriers) and can abort their first lambs Infects naive ewes Carrier Ewe Many of these ewes will abort at next lambing and become carrier ewes How Chlamydia Perpetuates in a Flock (cont.) Their offspring are infected and some of them will abort at subsequent lambings Infected flock of carrier ewes. These ewes don’t abort. Chlamydia is perpetuated in the flock with mostly ewe-lambs and yearlings aborting ~1-5% rate annually. Controlling Chlamydial Abortion • Use caution when selecting ewe lamb replacements. • Run ewe lambs separate from main flock. • Lamb ewe lambs away from/ after main flock. • Immediately isolate aborting ewes; consider culling them. Controlling Chlamydial Abortion • Pick up afterbirths, dead fetuses and throw barn lime down on the area if appropriate. • Do not feed on the ground in a dry lot situation. • Avoid crowding, have plenty of bunk space. • Tetracycline to help prevent shedding Vaccination against Chlamydia • Vaccines may decrease severity of initial infection. • Once a flock is infected, there is no evidence vaccine has any impact if all the studies are examined. Questions??? Campylobacter Abortions • Abortions occur in the last 6 weeks of pregnancy. • Lambs may be carried full term, but are born dead or weak. • Most common cause of abortion storms with 5-50% aborting. • Typically the disease is self-limiting. (unlike Chlamydia) Campylobacter Abortions • Many sheep carry Campylobacter as normal intestinal flora. • Ewes ingest a new strain of Campylobacter. If this happens after the 12th week of pregnancy or later, the ewe very likely aborts. • Infection is further spread by direct contact with aborted fetus/membranes. • Ewes that are not pregnant develop immunity and will not abort subsequent fetuses. Preventing Campylobacter Abortions • Have ewes thoroughly mixed before breeding. • If you don’t have a closed ewe flock, consider vaccinating. • Do not feed on the ground in a dry lot situation. • Avoid crowding, have plenty of bunk space. Campylobacter Vaccination • One of the poorest vaccines routinely recommended by sheep health experts. • At best 80% efficacy, probably closer to 0%. • Efficacy depends on strain of campylobacter. • Don’t rely on vaccination in place of good management. Lamb/Sheep Quality Assurance Suelee Robbe, DVM Veterinary diagnostic and Production Animal Medicine Iowa State University Quality Assurance Programs • Standardized methods of handling, treating, and processing food animals to help ensure quality and wholesomeness to the consumer. Where is the sheep industry in this picture? Goals of a Quality Assurance program for Sheep • Keep muscle damage down to a minimum. (Injection sites, bruises, etc…) • Eliminate illegal drug residues and foreign objects. • Prudent use of extra-label drugs. • Consistent meat “eating quality” • Wool QA. Minimizing Injection Site Damage • Syringe handling and care Rinse after each use. Allow syringe to dry thoroughly. Do not use soap to clean. (unless NO MLV products are used) Lube plungers with approved products. Minimizing Injection Site Damage • Needle handling – Stainless Steel, Disposable – Different needle for drawing out of a multidose bottle. – Change after bent, burred needles. Needles (SQ) • Acceptable needles 18 gauge by ½ inch (5/8 inch in disposable) 20 gauge by ½ inch • Acceptable areas Neck (preferred) Behind elbow Inside loose skin of the flank (Only on lambs) Needles (IM) • (Avoid if possible) – 16 gauge by ¾ inch – 18 gauge by ¾ inch – 20 gauge by ¾ inch • Neck only! QA Guidelines (cont.) • Follow Label instructions. • Never mix products in one injection. • Never put more than 10 cc’s per site in adult ewes, 5 cc’s in lambs, feeder lambs. • Know the Products you are using. • Follow common sense. Goals of a Quality Assurance program for Sheep • Keep muscle damage down to a minimum. (Injection sites, bruises, etc…) • Eliminate illegal drug residues and foreign objects. • Prudent use of extra-label drugs. • Consistent meat “eating quality” • Wool QA. Eliminating Drug Residues • Understand and adhere to withdrawal times. • Do not use drugs that are not approved for use in sheep without veterinary approval. – This includes topical insecticides, over the counter human remedies, etc… What are the sheep Approved Antibiotics? • Erythromycin/ Gallimycin – Unacceptable Tissue reactivity. • Penicillin – 3000 units per pound of body weight or 1.0 ml (cc) for each 100 lbs. once daily. • Naxcel (ceftiofur) (prescription use only) – 0.5-1 mg/lb. IM (If reconstituted per label directions, 1-2 cc/100 lbs.) • If these drugs are used any way other than the label, it must be done with veterinary approval. When can we use Drugs that are Not Approved for Sheep? • This is addressed in a law that was passed called AMDUCA (Animal Medicinal Drug Use Clarification Act). • This act gives veterinarians the right to use and recommend the use of drugs that are not approved for use in sheep. (ONLY under certain circumstances) AMDUCA • A valid VCPR exists. • The health of the animal is at immediate risk and suffering or death would result if a drug were not used. • There is not an approved drug on the market for that particular condition. • Accurate records of usage are kept • Treated animals can be easily identified for an extended period. • An extended withdrawal time is used to assure that no illegal residue occurs. AMDUCA (cont.) • The veterinarian and producer accept full responsibility for any illegal residue that occurs. Recommendations to Producers for Prudent Antibiotic Use • Before treatment is given, a diagnosis must be made by you, or your veterinarian. • Use a sheep veterinarian that gives you treatment protocols. (preferably written) • Follow your sheep veterinarian’s advice and give feedback. • Every time you give an antibiotic understand and adhere to the withdrawal time. • Keep Appropriate Records Veterinarians Role in the Sheep Industry • We must be able to justify ourselves economically. • Medicine on a Flock basis – QA, Protocols, outbreak treatments, diagnostic assistance. • Prevention of Disease on a Flock basis. – Biosecurity Protocols, Risk Assessments Parasite Control Programs Suelee Robbe, DVM, MS Diagnostic and Production Animal Medicine, Iowa State University Typical parasitic lifestyle Adults-Hang out in the GI tract • Abomasum – Haemonchus , Ostertagia, some Trichostrongylus • Small intestine – Trichostrongylus, Nematodirus • May live for longer than a year, but usually egg production peaks ~ 3 months Typical parasitic lifestyle Eggs: Development from egg to infective (L3) larvae can occur as early as 6 days Molt into L1’s in the egg then hatch Nematodirus develop into L3’s in the egg, then hatch Most ova do not survive very cold ambient temperatures Typical parasitic lifestyle • L3’s - infective stage • Thick cuticle protects them from drying – Cannot feed - finite life span – Warm temperatures increase their metabolic rate. • Can survive some freezing Typical parasitic lifestyle • L3’s molt in to L4’s soon after their ingestion where they may “rest for a time” • Hypobiosis • occurs in most species of worms Haemonchus • Adults live in abomasum – ingest 0.05ml blood/worm/day – 5000 worms will remove 250 ml of blood. • Adults are very prolific egg layers • Haemonchus L3’s are not as cold hardy as others • Most L3’s live for 1-3 months Others parasites • Nematodirus • Ostertagia • Trichostrongylus • Plan your parasite program to control haemonchus Coccidia • All sheep shed coccidia • Clinical signs – Sudden death – Scouring lambs – weight loss Prevention • Keep environment clean and dry • Design feed and water bunks so lambs cannot step in them • Feed coccidiostats – Decox – Bovatec Treatment • Amprolium • Sulfa drugs Parasite control • Control of L3’s on pasture is critical, and is related to number of adults in the animal. • A parasite program that: Targets L3’s controls the parasite burdens in grazing sheep. Targets L4’s and adults in the animal does not necessarily control L3’s on pasture. Example Sheep flock Remote Pasture Moves here in the summer. Working facility/barns Close Pasture Winter close up pasture. Example Sheep and goat flock Remote Pasture Flock here since June 20 FEC Aug 1st. Dewormed Dectomax Sept 2 Working facility/barns Close Pasture Wants to move here Sept. 30 last sheep/goat July 4th Example Sheep and goat flock Remote Pasture Working facility/barns Close Pasture L3 Burden in Oct? L3 Burden in Sept/Oct? HIGH LOW Parasite control programs • Development and survival of infective larvae depend on temperature and moisture. • Optimums vary with worm species. Parasite control • Host Resistance depends on – Age – Vigor – Genetic constitution – Presence or absence of established parasite infections – Acquired immunity Parasite control • Maturation of 4th stage larvae in host may be arrested. Anthelmentics Long acting • ivermectin-larvicidal ~10 days • doramectin -larvicidal ~20 days • eprinomectin • moxidectin Pour-ons do not work in sheep Disadvantages: Parasite resistance, cost, WDT, Not Ovicidal Anthelmentics Short acting or purge • levamisole – relatively poor against immature or arrested L4 larvae – Low margin of safety • benzimidazoles (fenbendazole, oxfendazole, albendazole) These products are ovicidal Host resistance issues • kids typically more susceptible • goats producing more milk typically have higher parasite burdens • animals under stress/have pre-existing conditions are more likely have higher parasite burdens Parasite Resistance • The best way to avoid resistance to an anthelmintic is not to use it. • If you rely on just anthelmintics as your sole parasite control program you WILL get resistance. • There never has been and most likely never will be an anthelmintic that won’t have resistance problems