RECENT TRENDS
The Impact of the NCI and NIBIB
on Medical Physics
üdoubling of the NIH budget over last 5 years;
üappointment of new heads of NIH and NCI;
ücreation of NIBIB;
übudget set-asides for the war on terrorism;
üdawning of translational research methods;
James Deye, Ph.D.
Program Director
üblurring of boundaries between disciplines;
üincreasing role for industry,
NIH ICs
Genes and the Environment
Goal: To discover genetic, environmental, and lifestyle factors and their interactions that define
cancer risk and inform strategies for cancer control.
Cancer Imaging
Goal: To accelerate discovery and development of imaging methods that will predict clinical course
and response to interventions.
Defining the Signatures of Cancer Cells: Detection, Diagnosis, and
Therapy
Goal: To catalog distinguishing molecular signatures of cells to deve lop new diagnostic and
therapeutic approaches and predict response.
Molecular Targets of Prevention and Treatment
Goal: To accelerate discovery, development, and testing of prevention and treatment agents that
target the molecular changes of cancer.
Research on Tobacco and Tobacco -Related Cancers
Goal: To understand the causes of tobacco use, addiction, and related cancers and apply this
knowledge to their prevention and treatment.
Cancer Communications
Goal: To understand and apply the most effective communications approaches to maximize access to and
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Divisions - Extramural
Division of Cancer Biology
Division of Cancer Control and Population Sciences
Division of Cancer Prevention
Division of Cancer Treatment and Diagnosis
Division of Extramural Activities
Divisions and Centers - Intramural
Center for Cancer Research
Division of Cancer Epidemiology and Genetics
WORKSHOPS sponsored by RRP (1999 – 2001)
NCI CLINICAL TRIAL GROUPS
1.Cancer and Acute Leukemia Group B (CALGB)
- TRANSLATIONAL RESEARCH IN RADIATION ONCOLOGY (published)
2.Children’s Cancer Study Group (CCSG)
- RESEARCH IN MEDICAL PHYSICS (published)
3.Eastern Cooperative Oncology Group (ECOG)
- LATE EFFECTS OF RADIATION THEARAPY (published)
4.Gynecologic Oncology Group (GOG)
5.National Surgical Adjuvant Breast and Bowel Project (NSABP)
- BRACHYTHERAPY (in press)
6.North Central Cancer Treatment Group (NCCTG)
- MONTE CARLO CALCULATIONS IN RADIATION THERAPY (draft)
7.Pediatric Oncology Group (POG)
- MOLECULAR and CELLULAR BIOLOGY of
MODERATE DOSE (1- 10 Sv) RADIATION and
POTENTIAL MECHANISMS of RADIATION PROTECTION (published)
8.Radiation Therapy Oncology Group (RTOG)
9.Southwest Oncology Group (SWOG)
10.Intergroup Rhabdomyosarcoma Study Group (IRSG)
- OPERATIONS RESEARCH APPLIED TO RADIATION THERAPY (draft)
11.National Wilms’ Tumor Study Group (NWTSG)
12.American College of Surgeons Oncology Group (ACOSOG )
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National Institute of Biomedical Imaging and
Bioengineering (NIBIB) – organization chart
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SBIR PROGRAM
ELIGIBILITY CHECKPOINTS
Extramural Programs Reserved for Small Business
ü Organized for- profit U.S. business
SMALL BUSINESS INNOVATION
RESEARCH (SBIR) PROGRAM
ü At least 51% U.S.-ownedand
independently operated
SMALL BUSINESS TECHNOLOGY
TRANSFER (STTR) PROGRAM
ü Small Business located in the U.S.
ü P.I.’s primary employment with small
business during project
“The best way to predict the future…
is to create it.”
ü 500 or fewer employees
STTR PROGRAM
ü
Faculty Partnership Opportunities
FORMAL COOPERATIVE R&D EFFORT
•
Minimum 40% by small business
Minimum 30% by research institution
ü
•
Own small firms (assign someone else PI)
Principal Investigator (w/ official permission
from University)
U.S. RESEARCH INSTITUTION (RI)
•
College or University; other non-profit research
•
organization; federal R&D center
•
ü
PRINCIPAL INVESTIGATOR FROM SMALL
BUSINESS and/or RESEARCH INST.
ü
AWARD MADE TO SMALL BUSINESS
•
SBIR/STTR
3-Phase Program
•
http://grants.nih.gov/grants/
funding/sbir.htm
PHASE I
Ü
Feasibility study (no preliminary data needed)
Ü
$100K -- 6 months (SBIR) or 12 months(STTR)
• Special Announcements (PAs and RFAs)
u
u
•
PHASE II
u
Ü
Ü
Full R/R&D
2-Year Award - - $750K (SBIR) or $500K (STTR)
u
u
u
•
Senior Personnel on SBIR
Consultants on SBIR
Subcontract on SBIR
University facilities can provide analytical
and other service support
PHASE III
Ü
Commercialization Stage
Ü
Without SBIR/STTR Support
u
u
u
Tools for Insertional Mutagenesis In The Mouse
Functional Tissue Engineering for Heart, Vascular, Lung, Blood and
Sleep Disorders and Diseases
Innovative Toxicology Models for Drug Evaluation
Innovations in Biomedical Information Science and Technology
Development of Novel Imaging Technologies
Bioengineering NanotechnologyInitiative
Protein Structure Initiative ( Structural Genomics)
Innovative Technologies for the Molecular Analysis of Cancer
Development of Digital MammographyDisplays
and Workstations
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Applications Submitted to NIH
Center for Scientific Review
• Approximately
40,000 grant
applications are
submitted to NIH
each year, of which
25-30% are funded
• Competing grant
applications are
received for three
review cycles per
year
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RADIATION ONCOLOGY
PHYSICS EFFORTS
•IMRT (Intensity Modulated Radiation Therapy)
•BRACHYTHERAPY
•RIT (Radio-Immuno-Therapy)
•MULTI-DISCIPLINARY
• NCI
has funded an Advanced Technology Radiation
Therapy QA Consortium (ATC) for Clinical Trials
- ITC and RTOG Headquarters
(itc.wustl.edu)
–
RPC
(rpc.mdanderson .org/rpc/)
–
QARC (www.qarc.org)
–
RCET (recet.health. ufl.edu)
• NCI
has also created an Imaging Trials effort along
with the ACR:
- ACRIN (www.acrin.org)
NCI:Types of Initiatives (1998-01)
• Research Centers of Excellence (Molecular Imaging)
RADIATION ONCOLOGY
PHYSICS EFFORTS
• IMRT
Questionnaire
– documentation
of institution’
institution’ s IMRT planning,
delivery, and QA capabilities
– physician
physician’’ s,
• IMRT
physicist's,… IMRT experience
physicist's,…
Dry-run (benchmark) case
Dry-
– demonstrate
• IMRT
capability and knowledge of the protocol.
Dosimetry Phantom Verification Study
• NCI/NCRR: Phased Innovation Award (R21/R33).
Specifically designed for technology development,
with provision of academic/ industry partnerships.
NCI Review:Reviewers: Academia and Industry
and small business.
• Small Animal Resource Centers (Molecular Imaging)
Applications: 1st Round 40; 4 funded, 2nd Round 70
Future: Multiple Prototypes: SB Joint Ventures
• National Distributed Research Resources
Research Interface Software ( Ultrasound).
Image Databases for Software Evaluation (Lung CT).
Platform Independent Imaging Methods (MRI).
NCI/NIBIB: Exploring new funding mechanisms
tailored for Imaging Technology
Development, including IGT/IGS
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