AbstractID: 8121 Title: Intensity modulated proton therapy delivery system with a synchrotron Since its inception in 1946, approximately 49000 patients have been treated worldwide with proton therapy. Of these patients a small number, less than 3%, have been treated using spot scanning techniques. There is, however, mounting evidence that proton therapy will reach its full potential benefit through spot scanning, which offers some distinct advantages over other proton therapy delivery techniques. We discuss the promises and challenges inherent in the spot scanning technique. We review the approach taken at MD Anderson Cancer, where the proton accelerator is a synchrotron. Topics of discussion include treatment delivery hardware, treatment control systems, treatment planning, and beam measurements. Educational Objectives: 1. To understand the potential benefits and challenges scanning beam proton therapy and intensity modulated proton therapy offer relative to other modes of proton therapy. 2. To understand various features of proton beam therapy with a scanned proton beam at MD Anderson Cancer Center in Houston. 3. To understand how spot scanning proton therapy with a synchrotron differs from spot scanning proton therapy with other proton accelerators.