UH-COP Research Collaborations Texas Medical Center Collaborations University of Texas Health Science Center 1. 2. 3. 4. 5. 6. PI Ming Hu Samina Salim Kevin Garey Ke-He Ruan Ke-He Ruan Diana Chow 7. Rajender Aparasu Collaborator(s) Pramod Dash Raymond J. Grill Herbert DuPont Ron Wang Yong-Jian Geng James Shuo-Hsiu Chang Sushovan Guha Project Reducing Memory Dysfunction Following Brain Injury Technical expertise in brain imaging State-wide Assessment of Environmental C. difficile Colonization The relationship of inflammation and Prostate cancer Human Stem Cells Mechanisms of neuromusculoskeletal plasticity in humans Non-Evidence Based Proton Pump Inhibitor Use Among Elderly Nursing Home Residents The Methodist Hospital PI 8. Diana Chow Collaborator(s) Vadim Sherman 9. Diana Chow Robert Grossman 10. 11. 12. 13. Vincent Tam Vincent Tam Michael Johnson Michael Johnson Luan Troung Valerie Belden Joshua Swan Barbara Bass Project Pharmacokinetic/Pharmacodynamic (PK/PD) Study of Metformin and Rosuvastatin with Gastric Bypass Surgery A Multi-Center, Randomized, Placebo-Controlled, Double-Blinded, Trial of Efficacy and Safety of Riluzole in Acute Spinal Cord Injury Nephrotoxicity of polymyxin B Pharmacokinetics of cefepime in patients undergoing CRRT Risk of Acute Kidney Injury in Patients undergoing Elective Surgery Center for Outcomes Research University of Texas Medical Branch (UTMB) PI 14. Bradley McConnell Collaborator(s) Kenichi Fujise 15. Bradley McConnell Celeste Finnerty 16. Ke-He Ruan Ken Fujise Project Role of Anti-Apoptotic Protein Fortilin in Cardiac Contractility and Signaling Effects of Chronic Catecholamine Exposure on Post-Burn Wound Healing and Scarring Fortilin-p53 interaction Texas Heart Institute PI 17. Ke-He Ruan Collaborator(s) Richard Dixon and James Willerson Project Prostacyclin-Secreting Cells as Therapy for Pulmonary Artery Hypertension Texas Children’s Hospital PI 18. Jason Eriksen 19. Diana Chow Collaborator(s) Ananth Annapragada Daniella Rios 20. Diana Chow Carmela Gironella Project Imaging Technologies for Alzheimer's Disease Dopamine Versus Vasopressin for Cadiovascular Support in Low Birth Weight Infants: A Randomized, Blinded Pilot Study Clinical Pharmacology of Mycophenolate Mofetil and Its Relations to Therapeutic Responses in Childhood-Onset Systemic Lupus Erythematosus Baylor College of Medicine PI 21. Kevin Garey Collaborator(s) Todd Lasco 22. Joy Alonzo Carl Tapia 23. Joy Alonzo Thomas Kosten 24. Rustin Crutchley Christina Nance 25. Joydip Das 26. Marc Fleming B.V.V. Prasad George Taffet 27. Catherine Hatfield 28. Claire Mach LaChauncy Woodard Matthew Anderson 29. Claire Mach 30. Claire Mach Matthew Anderson Matthew Anderson 31. Claire Mach Matthew Anderson 32. Bradley McConnell Corey Reynolds 33. Ke-He Ruan 34. Sujit Sansgiry Jie Cheng Shubhada Sansgiry 35. Meghana Trivedi Rachel Schiff Project Accelerate ID/AST System vs. Conventional Methods for Identification and Susceptibility of Gram-positive Bacteria A Social Network Theory Guided Intervention to Improve Guideline Concordant Physician Prescribing Behavior Novel Contingency Management in Prescription Drug Abuse in Adolescents: Use of Virtual Reality Phone App Phase 1 Study to Evaluate Safety and Toxicity of EGCG in HIV-1 Infected Subjects Role of Munc 13-1 as am effector of ethanol action Impact of Hydrocodone Rescheduling on Geriatric Patients Undergoing Transition of Care Center of Excellence in Primary Care Education Assessing a Novel Synthetic Lethal Phenotype Sensitizing Ovarian Cancer to Chemotherapy Project Viral microRNAs in Ovarian Cancer Project Evaluation of mannitol and furosemide use in cervical cancer patients receiving cisplatin (retrospective) Development of a nanoparticle based delivery system for small RNA therapies Gravin Scaffold Protein Regulation of Cardiac Hypertrophy and Function Structure and function of VIP receptor Development and validation of a prognostic tool to identify diabetes patients at high risk for non-adherence to medications 1. Circulating tumor cell-based model to test efficacy of novel anticancer drugs in breast cancer 2. Novel G protein-coupled receptor discovery in breast cancer 36. Meghana Trivedi Mothaffar Rimawi 3. Understanding mechanism of drug resistance in breast cancer 1. Circulating tumor cell-based model to test efficacy of novel anticancer drugs in breast cancer 2. Novel G protein-coupled receptor discovery in breast cancer 3. Clinical/translational research in breast cancer 37. Meghana Trivedi 38. Matthew Wanat Polly Niravath Kaushal Patel 39. Joy Alonzo 40. Vincent Tam Rich De La Garza, Thomas Kosten and Carl Tapia Lynn Zechiedrich 41. Michael Johnson Joseph Coselli 42. Michael Johnson Scott Lemaire 43. Michael Johnson Mark Kunik 44. Romi Ghose 45. Amelia Sofjan 46. Julianna Fernandez B. Moorthy Raymond Yau and Todd Lasco George Taffet 47. Julianna Fernandez George Taffet 48. Hua Chen Carl Tapia Clinical research in breast cancer Risk of Thrombosis and Bleeding in Patients on Warfarin or TSOACs and Concurrent Anti-Arrhythmic Medications Novel Contingency Management in Prescription Drug Abuse in Adolescents: Use of Virtual Reality Phone App Molecular and Temporal Characterization of fluoroquinolone resistance mechanisms in E. Coli under a selective pressure Aortic root aneurysm surgery and Marfan Syndrome: preserve or replace the valve? Aortic root aneurysm surgery and Marfan Syndrome: preserve or replace the valve? Antihypertensive agents and risk of dementia in patients with diabetes Regulation of Cytochrome P450 enzymes Changing Epidemiology in Cirrhotic Patients with Spontaneous Bacterial Peritonitis Impact of Hydrocodone Rescheduling on Geriatric Patients Undergoing Transition of Care Caregiver type and knowledge of medication management for geriatric patients: a prospective study Texas Medicaid managed care quality improvement project for improving prescribing for children with mental disorders Johns Hopkins University PI 49. Bradley McConnell 50. Bradley McConnell Collaborator(s) Genaro RamirezCorrea Weidong Gao 51. Vincent Tam Lynn Zechiedrich Project Scaffolding Protein Interaction Network Regulates Cardiac Cell Signaling Force Development and Intracellular Ca2+ in Intact Cardiac Muscles Molecular and Temporal Characterization of fluoroquinolone resistance mechanisms in E. Coli under a selective pressure MD Anderson Cancer Center PI 52. Rajender Aparasu Collaborator(s) 53. Marc Fleming Holly Holmes Knox Todd, Larry Driver and Todd Pickard 54. Michael Johnson 55. Michael Johnson 56. Michael Johnson Holly Holmes Holly Holmes Maria Suarez-Almazor Project Comparative Effectiveness Of Second Generation Antidepressants On Cognition And Dementia In The Elderly Texas Prescribers’ Attitudes and Predicted Pain Management Based on Rescheduling Hydrocodone Combination Products Association of Physician Payments from Pharma and Prescription of Drugs of Uncertain Medical Benefit in Medicare Part D Costs of Oral Chemotherapy drugs in Medicare Part D Comparative Effectiveness Research Training and Instruction (R25) and Sharon H. Giordano 57. Santhi Masilamani Lorna McNeill 58. Randall Prince Kenneth Tolston 59. Randall Prince 60. Maria Tejada-Simon 61. Meghana Trivedi 62. Anne Tucker Kenneth Tolston Kun-Sang Chang David Hong Joseph Nates and Sharla Tajchman 63. Elizabeth Coyle K. Rolston - Observational Research Module, Longitudinal Data Analysis Physician-Pharmacist Model for Increasing Physical Activity in Safety Net Clinics In-Vitro Activity of Ceftaroline and Comparative Agents against Bacterial Pathogens Isolated from Patients with Cancer In-Vitro Activity of Ceftaroline and Comparative Agents against Bacterial Pathogens Isolated from Patients with Cancer Learning and memory in PML knockout mice Clinical/translational research in oncology Oncological Critical Care Outcomes Research Project 1. Telavancin versus Gram Positive Isolates from a Comprehensive Cancer 2. Dalbavancin versus Gram Positive Isolates from a Comprehensive Cancer Center University of Houston Collaborations PI 64. 65. 66. 67. 68. 69. 70. 71. 72. Kevin Garey Maria Bondesson Maria Bondesson Maria Bondesson Joydip Das Joydip Das Jason Eriksen Jason Eriksen Jason Eriksen Collaborator(s) Long Chan Ioannis Kakadiaris Fatima Merchant Chandra Mohan Gregg Roman Leigh Leasure David Mayerich Badri Roysam Steve Bark 73. Marc Fleming Kathleen Reeve 74. Kevin Garey Ioannis Kakadiaris 75. Michael Johnson Ioannis Kakadiaris 76. Bradley McConnell Robert Schwartz 77. Bradley McConnell 78. Bradley McConnell 79. Bradley McConnell Yu Liu David Stewart Li Chen 80. 81. 82. 83. 84. 85. Bradley McConnell Maria Tejada-Simon Maria Tejada-Simon Maria Tejada-Simon Samina Salim Samina Salim Ravi Birla Thomas Lowder Gregg Roman Leigh Leasure Peter Norton Tahir Hussain Project Immunomodulatory activity of SMT19969, a novel agent for Clostridium difficile Development of segmentation and atlas methods for zebrafish Analysis of vasculogenesis in zebrafish Immunotoxicology in zebrafish Role of Munc 13-1 as am effector of ethanol action Role of Munc 13-1 as am effector of ethanol action Tissue Modeling in Mouse Models of Neurodegeneration Blood vessel pathology in neurodegenerative disorders Mechanisms of Antigen Retrieval Texas Prescribers’ Attitudes and Predicted Pain Management Based on Rescheduling Hydrocodone Combination Products Immunomodulatory activity of SMT19969, a novel agent for Clostridium difficile Developing a risk index for prediction of C Difficile in hospitalized patients Generation of Mesendoderm Stem Cell Progenitors in the ISS National Laboratory Mesp1 Marked Cardiac Progenitor Cells Repair Infarcted Mouse Hearts Cardiomyopathy in the Absence of Histone Chaperone HIRA Mesp1 Regulation of Pancreatic Regeneration Bioengineering Three Dimensional Heart Muscle using Adult Cardiomyocytes Immune system in Fragile X syndrome Biology of Behavior Institute Scholars Biology of Behavior Institute Scholars Understanding anxiety disorders : a translational approach Anglotensin signaling in anxiety disorders 86. Vincent Tam Michael Nickolaou 87. Douglas Eikenburg Jokubas Ziburkus 88. Julianna Fernandez Marc Fleming Modeling of combination antimicrobial therapy Effects of inescapable stress on neuronal network activity in locus coeruleus Impact of Hydrocodone Rescheduling on Geriatric Patients Undergoing Transition of Care Other Domestic Institutions PI 89. Diana Chow 90. Susan Abughosh 91. Susan Abughosh 92. Rajender Aparasu Collaborator(s) Jamie Renbarger Omar Serna and Tara Esse Marcia McDonnell Holstad Ryan Carnahan 93. Kim Birtcher Ali Mortazavi Richard Finnell and Robert 94. Maria Bondesson Cabrera Thomas Knudsen, Tamara Tal and Nicole 95. Maria Bondesson Kleinstreuer 96. Rustin Crutchley 97. Rustin Crutchley 98. Greg Cuny 99. Greg Cuny Institution Indiana University School of Medicine Cigna-Health Spring Kelsey-Seybold Clinic A Motivational Interviewing Pharmacy Student Intervention to Improve Medication Adherence Anticholinergics and Cognitive Decline in the Elderly with Depression Compliance With National Guidelines In Patients at Very High-Risk for Future Cardiovascular and/or Stroke Event University of Texas at Austin Identification of vascular and neuronal disruptors Emory University University of Iowa Joseph Gathe Environmental Protection Agency Therapeutic Concepts Joseph Gather Liz Hedstrom Liz Hedstrom Therapeutic Concepts Brandeis University Brandeis University 100. Greg Cuny Alexei Degterev Tufts University 101. Greg Cuny Alexei Degterev 102. Greg Cuny Paul Yu Tufts University Brigham and Women's Hospital 103. Greg Cuny Guan Zhu 104. 105. Greg Cuny Joydip Das Amin Arnaout Peter M. Project Clinical Pharmacology of Mycophenolate Mofetil in Hematopoietic Stem Cell Transplantation (HSCT) Patients as a Graft-versus-host disease (GVHD) prophylaxis A Motivational Interviewing Pharmacy Student Intervention to Improve Medication Adherence Texas A&M University Massachusetts General Hospital NCI/NIH Toxicity testing of potential vascular disruptors Real-world use of crofelemer in HIV patients on HAART with treatment failure to other anti-diarrheals Assessing the effects of lopinavir/ritonavir monotherapy on changes in serum 25-hydroxyvitamin D levels in treatment-naïve HIV-infected patients over 48 weeks IMPDH-targeted antibiotics for select agents Optimizing IMPDH inhibitors for select agents New approaches to development of selective type 2 inhibitors of RIP kinase family Coupling binding affinity and reactivity in covalent kinase inhibitors Probes to elucidate the role of BMP signaling in vasculature calcification Developing therapeutics against Giardia and other anaerobic protozoa by targeting parasite fatty acylCoA synthetase (ACS) Integrins and kidney disease Structure and Function of PKC thata Blumberg 106. Jason Eriksen Iris Lindberg University of Maryland 107. James Essien Marcia Holstad Emory University 108. Marc Fleming 109. Mustafa Lokhandwala 110. Bradley McConnell 111. Bradley McConnell 112. Bradley McConnell 113. Sujit Sansgiry 114. Sujit Sansgiry 115. Anne Tucker 116. Anne Tucker Jamie Barner Nosratola Vaziri Celeste Finnerty Kenichi Fujise Jonathan and Christine Seidman Omar Serna and Nelson Fernandez Omar Serna and Nelson Fernandez Renee Walker Renee Walker and Lauren Probsfield 117. Gomika Udugamasooriya Rolf Brekken 118. Gomika Udugamasooriya Mark Henkemeyer 119. Yang Zhang Pin-Lan Li 120. Ming Hu Xiaoqiang Wang 121. Samina Salim 122. Richard Bond Kendal Blumer Julia Walker and Robert Lefkowitz 123. Richard Bond 124. Brian Knoll Ray Penn Julia Walker and Robert Lefkowitz 125. Brian Knoll Ray Penn University of Texas at Austin University of California University of Texas Medical Branch University of Texas Medical Branch Harvard Medical School Cigna Health Springs Cigna Health Springs Michael E. DeBakey VA Medical Center Bioactive Molecules in Alzheimer's Disease Motivating HIV positive women for safer sex and ART adherence Survey of Pharmacists’ Perceptions Pharmacist’s Perceptions Regarding the Impact of Hydrocodone Rescheduling on Work Flow Management, Revenue, and Patient Outcomes Role of renal inflammation in hypertension Effects of Chronic Catecholamine Exposure on PostBurn Wound Healing and Scarring Role of Anti-Apoptotic Protein Fortilin in Cardiac Contractility and Signaling Cardiac Myosin Binding Protein C Regulates Postnatal Myocyte Cytokinesis Development and validation of a prognostic tool to identify diabetes patients at high risk for nonadherence to medications Impact of Medicare Advantage Prescription Drug Coverage GAP Among COPD patients: Analysis of Risk of Hospitalization Does Hang Height Influence the Accuracy of Enteral Nutrition Provision Michael E. DeBakey VA Medical Center University of Texas Southwestern Medical Center University of Texas Southwestern Medical Center Virginia Commonwealth University University of North Texas Washington University School of Medicine Nutritional Requirements in Patients with Late Stage Huntington Disease Duke University Thomas Jefferson Medical School Optimizing beta-2 AR signaling in asthma Duke University Thomas Jefferson Medical School Optimizing beta-2 AR signaling in asthma Validation of phosphatidylserine targeted peptidomimetics Peptoid ligands that target the pro-¬synaptic EphB2 receptor Lysosome trafficking dysfunction of arterial myocytes in atherogenesis UGT Engineering for Detoxifying Anticancer Drug SN38 RGS Proteins Optimizing beta-2 AR signaling in asthma Optimizing beta-2 AR signaling in asthma 126. Joy Alonzo Robert Hunter 127. Kevin Garey Luis Ostroksy Texas Children's Health Plan University of Texas Medical School 128. Hua Chen Melissa OchoaPerez Legacy Health Services 129. Hua Chen Vinod Bhatara University of South Dakota 130. Hua Chen 131. Hua Chen Heidi Schwarzwald Kayo Fujimoto and Wenyaw Chan Texas Children’s Health Plan University of Texas School of Public Health Vinod Bhatara University of South Dakota Kayo Fujimoto University of Texas School of Public Health 132. 133. Hua Chen Hua Chen Novel Contingency Management in Prescription Drug Abuse in Adolescents: Use of Virtual Reality Phone App Effect of Antifungals on the Performance of the T2Cnadida Assay Texas Medicaid managed care quality improvement project for improving prescribing for children with mental disorders Texas Medicaid managed care quality improvement project for improving prescribing for children with mental disorders Texas Medicaid managed care quality improvement project for improving prescribing for children with mental disorders Texas Medicaid managed care quality improvement project for improving prescribing for children with mental disorders A Social Network Approach to Understanding the Diagnosis and Treatment of ADHD: The effect of delivery system design and the moderating role of care coordination A Social Network Approach to Understanding the Diagnosis and Treatment of ADHD: The effect of delivery system design and the moderating role of care coordination International Institutions PI Collaborator(s) 134. Susan Abughosh 135. Mustafa Lokhandwala 136. Maria Tejada-Simon Feras Hawari Bernardo Rodriquez-Iturbe Yolanda de Diego-Otero 137. Maria Tejada-Simon Gunter Eckert 138. Samina Salim Iris Hovatta 139. Samina Salim Yu-Lin Wu 140. 141. Richard Bond Richard Bond Michael Bouvier Paul Leff 142. 143. Brian Knoll Brian Knoll Michael Bouvier Paul Leff Institution King Hussein Cancer Center Hospital Universitaio University of Malaga, Spain University of Frankfurt Am Main, Germany University of Helskinki National Yang-Ming University University of Montreal Manchester University of Montreal Manchester Project Smoking cessation support among oncology practitioners in a regional cancer center in the Middle East – improving a critical service for cancer care Oxidative stress, inflammation and transcription factors in hypertension Oxidative stress in Fragile X syndrome Isoprenylation defects related to impaired cognition Oxidative Stress and Genomics RGS Proteins Optimizing beta-2 AR signaling in asthma Optimizing beta-2 AR signaling in asthma Optimizing beta-2 AR signaling in asthma Optimizing beta-2 AR signaling in asthma 144. Mustafa Lokhandwala 145. James Essien Franceso Amenta Emmanual Ezedinachi 146. Vincent Tam Dala Fisher University of Camerino University of Calabar National University of Singapore Dopamine receptor interactions within the brain and kidney The Center of Excellence in Infectious Diseases Program Continuous infusion of vancomycin