Kilovoltage X X-R R Dosimetry Ray for Radiatio on Therapy C M Chharlie C.-M. h li Ma M Dept. of Radiation Oncologgy, FCCC, Philadelphia, PA Clinical Dosimetryy Meaasurements in Radiotherapy py 2009 AAPM Summer School Coloradoo College, CO June 21-25, 2009 Outlline Kil Kilovoltage lt x-ray do dosimetryi t a review i TG-61 formalism forr kilovoltage x-ray dosimetry Clinical implementat p tion of the TG-61 protocol p Summary of TG-61 recommendations r Uncertainty analysiss Therapax HF150 Superfficial ficial Unit By Pantak, Inc A X-ray X ray unit from Gulmay Gulmay Medical Ltd The physics of kV V x-ray dosimetry Very short electron rangges (< 0.5 mm water) L Large scatter tt contributio t ib tions andd SSD, SSD field fi ld size, i beam quality dependentt Kerma = dose (also Kcoll = K as negl. brem., <0.1%) Bragg Gray cavity cond Bragg-Gray ditions very difficult to fulfill - even for air-filleed ionization chambers Ionization chambers callibrated as “exposure meters” and used as “ph photon detectors” Kil Kilovoltage lt x-ray dosimetryd i t a review i Kilovoltage x-ray dosimetry is the main theme in the first 70 years following the discovvery of x-rays x rays The introduction of the roenttgen g in 1928 at Stockholm Congress of Radiology markked the beginning of precise physical measurement of raddiation exposure (dose) The universally adopted instrrument to measure exposure i the is h free f air i chamber h b (±1% % agreement between b national i l labs in 1932) Exposure, X dQ dQ X ( kg/c) d dm where dQ is the absolute valu ue of the total charge of the ions of one sign produced in (dry) air when all the electrons liberated by photon ns in air of mass dm are completely stopped in air Measurement off Exposure X Free Air Chhamber D Q AD L “Modern” Dosimetry for f Kilovoltage X-Ray ICRU Report p 23 ((1973)) significant sg changes g made 40-150 kV in-air method d, >150 kV in-phantom NCRP Report 69 (1981) only protocol for N. Ame. 10 kV and above, in in-air air method, no BSF given IAEA Report 277 (1987) significant changes made 10-100 kV in-air method d, >100 kV in-phantom “Modern” Dosimetry for f Kilovoltage X-Ray IPEMB Code of Practice (1996) with three ranges Very llow- (< V ( 1mmAl) 1 Al) iin-p phantom, h lowl (1 8 (1-8mmAl) Al) in-air, medium-energy (>0 0.5mmCu) in-phantom NCS Code of Practice (19997) two energy ranges 50 - 100 kV in-air method d, 100 - 300 kV in-phantom IAEA Code d off Practice i (20 ( 000)) - new recommendations d i Absorbed dose based, con nsistent with other beams Kilovoltage x-ray dosimetry For low low-energy energy (40 - 150 kV kV, 8mm Al HVL) x-rays - the backscaatter method F medium-energy For di y (100 - 300 kV kV, 44mm C Cu HVL) x-rays y - the in n-phantom p Method (except for NC CRP Report 69) AAPM TG G-61 Report ( Med. Phys. 28 (6) 2001 868893 ) Charles Coffey Chihray Liu Ravi Nath Jan Seuntjens Larry DeWerd Charlie Ma (chair) Stephen Seltzer What’s W at s New in AAPM A TG-61? G6 ? Use bboth U th th the in-air i i andd in-phantom i h t methods th d for f tube t b potentials 100 - 300 kV V More complete data (foor water, tissue & bone) Recommendations for relative r measurements Recommendations for QA Q and consistency check Detectors for kV k x-ray beams Air filled ion chamberrs are recommended for Air-filled absolute dose measureements Diode, film, Diode film diamond detectors for relative measurements Beam quality y specification Use a “narrow narrow beam (good beam) geometry geometry” ● Half-Value Layer exprressed in mm Ai or Cu for 40 40-150 150 kV x-rays x rayss: use mmAl for 100 - 300 kV x-raays: use mmCu Tub be poten ntial (k kV) 300 200 100 1 2 3 HVL (m mmCu) 4 Beam quality y specification Use both tube potentiaal and HVL to specify beam quality for cham mber calibration Use HVL to specify beam quality for determination of cham mber correction and conversion factors Table 1: UW ADCL and NIST beams coompared. NIST BEAM QUALITIES UW ADCL BEAM QUALITIES BEAM Code L30 L40 L50 L80 L1001 HVL (mm Al) 0.22 0.49 0.75 1.83 2.8 HC M20 M30 M40 M50 M60 0.152 0.36 0.73 1.02 1.68 M100 5.0 60 57 58 58 59 BEAM Code UW30-L UW40-L UW50-L UW80-L UW100-L HVL (mm Al) 0.22 0.49 0.75 1.83 2.80 56 60 61 58 58 79 64 66 66 68 UW20-M UW30-M UW40-M UW50-M UW60-M 72 UW80-M UW80 M2 UW100-M 0.153 0.354 0.73 1.02 1.68 2.96 4.98 6.96 10.2 14 9 14.9 18.5 79 63 64 64 66 68 72 78 87 94 98 1.86 2 82 2.82 63 76 M150 M200 M250 10.2 14 9 14.9 18.5 87 95 98 UW120-M2 UW150-M UW200 M UW200-M UW250-M S75 S60 1.86 28 2.8 63 75 UW75-S UW60 S UW60-S HC All beams are matched as closely as possible too available NIST beam qualities. I i ti Cham Ionization Ch mber b C Calibration lib ti Free-in-air Kair calibraation N K K air a /M Free-in-air X calibration n NX X / M Chamber stem ef NK N X (W / e)air (1- g) -1 Kair X (W / e)air (1- g) -1 in air Farm 1.6 RK 1.5 1.4 1.3 NACP 1.2 1.1 1.0 Cap Capin 0.9 0.8 diode 0.7 0.6 0.5 N23342 0.4 0.3 0.2 50 100 150 200 energy / kVp 250 300 Markus Farmer 1.6 RK 1.4 NACP 1.2 Diode 1.0 Capintec 0.8 0.6 N23342 0.4 Markus 0.2 50 100 150 200 250 300 Spokas Formalisms o a s s for o KV KV X-ray ay Dosimetry os et y For 40 F 40-300 300 kV bbeam ms, recommendd th the backb k scatter method if point of interest is on the surface For 100-300 kV beam ms, recommend the inphantom h method h d if point p i off interest i is i at a depth d h RK 110 NACP diode Farmer S k Spokas 100 TLD N23342 Markus 90 0 1 depth / g/cm2 2 Capintec RK NACP 100 diode 90 Farmer 80 Spokas 70 TLD N23342 60 Markus 50 2 3 4 5 6 7 depth / g/cm2 8 9 10 Capintec Th Backscatter The B k tt r (in-air) (i i ) M Method th d For surface dose deterrmination Dw MNK (en e / ) Pstem,air Bw w air ● D i ti for Derivation f the th Back B k kscatter tt (I (In-air) i ) Metho M th Determine the air kerma at a point in air in absence of the chamber inair Kair MN M K Pstem,airi i Convert air kerma to water kerma k by in-air in i w Kwini airi Kair ( / ) en air r Derive water kerma on the su urface using a backscatter factor Kw KwinairBw Derive absorbed dose to watter from water kerma assuming charged particle equilibrium Dw K w CPE exists Th IIn-Phan The Ph ntom t Method M th d For dose determinationn at a depth Dw MNK (en / ) P P w air sheath Q,cham ● D i ti for Derivation f the th In-Phantom I Ph t M Method th d Determine the air kerma at a point in water in absence of the chamber inwater Kair MN M K PQ, i Q cham h Psheath h h Convert air kerma to water kerma k by in-water w w Kw Kair (en / )air Derive absorbed dose to watter from water kerma assuming charged particle equilibrium D w K w CPE exists In-air mass energy-abso orption coefficient ratio Table 2 Ratios of mass energy-absorption coeffficients averaged over the primary photon spectrum for the beams described in Table 1. HVL (mm Al) 0.300 0.381 0.875 1.35 2.65 4.76 9.17 14.5 17.6 19.8 20.8 HVL (mm Cu) 0.010 0.012 0.027 0.422 0.090 0.195 0.574 1.71 3.01 4.32 4.92 w/air tissue/w 1.037 1.033 1.023 1.022 1.025 1.034 1.057 1.088 1.102 1.108 1.109 0.917 0.918 0.922 0.926 0.933 0.942 0.960 0.979 0.986 0.989 0.990 muscle/ w lung/w skin/w bone/w 1.016 1.020 1.030 1.032 1.032 1.029 1.018 1.003 0.996 0.993 0.992 1.031 1.035 1.045 1.047 1.046 1.040 1.026 1.005 0.997 0.993 0.992 0.890 0.893 0.902 0.909 0.920 0.934 0.956 0.979 0.985 0.988 0.989 4.20 4.28 4.51 4.45 4.25 3.82 2.885 1.741 1.276 1.080 1.032 In-water mass energy-ab bsorption coefficient ratio Table 3 Ratios of mass energy-absorption coeffficients averaged over the photon spectrum p at 2 cm depth p in water irradiated by y thhe beams described in Table 1. The field 2 size is 100 cm defined at 50 cm SSD. HVL (mm Al) 0.300 0.381 0.875 1.35 2.65 4.76 9.17 14.5 17 6 17.6 19.8 20.8 HVL (mm Cu) 0.010 0.012 0.027 0.422 0.090 0.195 0.574 1.71 3 01 3.01 4.32 4.92 w/air tissuue/w muscle/w lung/w bone/w 1.022 1.019 1.018 1.020 1.025 1.032 1.049 1.077 1 094 1.094 1.103 1.105 0.921 0.922 0.924 0.929 0.935 0.941 0.954 0.972 0 981 0.9 0.986 0.988 1.030 1.033 1.035 1.035 1.033 1.030 1.022 1.008 1 000 1.000 0.996 0.994 1.046 1.049 1.050 1.049 1.047 1.042 1.031 1.013 1 002 1.002 0.996 0.994 4.54 4.61 4.63 4.46 4.23 3.91 3.23 2.145 1 560 1.560 1.255 1.150 Water kerma based d backscatter factor Table IVb ((continued). ) Water kerma based backscatter b factors for a water pphantom as a function of field diameter (d), source surrface distance (SSD), and radiation quality Beam quality (HVL). HVL (mm Cu) SSD (cm) 10 SSD 20 30 50 100 d (cm) 1 2 3 5 10 15 20 1 2 3 5 10 15 20 1 2 3 5 10 15 20 1 2 3 5 10 15 20 1 2 3 5 10 15 20 0.1 1.062 1.120 1.159 1.210 1.269 1 287 1.287 1.292 1.061 1.116 1.158 1.214 1.290 1 320 1.320 1.333 1.063 1.120 1.164 1.220 1.297 1 330 1.330 1.348 1.065 1.121 1.163 1.225 1.308 1 345 1.345 1.361 1.062 1.121 1.163 1.224 1.310 1 353 1.353 1.373 0.2 1.057 1.118 1.161 1.224 1.306 1 335 1.335 1.344 1.058 1.118 1.164 1.232 1.331 1 377 1.377 1.397 1.060 1.122 1.168 1.242 1.348 1 401 1.401 1.426 1.059 1.121 1.169 1.240 1.350 1 408 1.408 1.439 1.059 1.121 1.169 1.239 1.349 1 413 1.413 1.446 0.3 1.056 1.119 1.161 1.226 1.316 1 348 1.348 1.361 1.055 1.119 1.168 1.242 1.352 1 407 1.407 1.434 1.056 1.119 1.169 1.242 1.363 1 417 1.417 1.446 1.054 1.118 1.170 1.247 1.367 1 433 1.433 1.471 1.055 1.117 1.170 1.245 1.370 1 447 1.447 1.490 0.4 1.054 1.113 1.155 1.221 1.313 1 348 1.348 1.362 1.054 1.114 1.161 1.238 1.353 1 412 1.412 1.441 1.054 1.113 1.161 1.239 1.366 1 429 1.429 1.464 1.053 1.114 1.163 1.244 1.372 1 443 1.443 1.486 1.053 1.114 1.165 1.243 1.378 1 456 1.456 1.502 0..5 1.05 52 08 1.10 1.15 50 17 1.21 1.31 11 1 3448 1.34 1.36 62 53 1.05 1.11 10 55 1.15 1.23 33 53 1.35 1 4115 1.41 47 1.44 1.05 52 08 1.10 1.15 55 35 1.23 1.36 67 1 4338 1.43 1.47 78 52 1.05 1.11 11 57 1.15 1.24 40 76 1.37 1 4552 1.45 99 1.49 1.05 52 11 1.11 1.16 60 41 1.24 1.38 83 1 4663 1.46 1.51 13 0.6 1.050 1.106 1.147 1.214 1.310 1 348 1.348 1.363 1.051 1.107 1.152 1.229 1.349 1 411 1.411 1.443 1.050 1.105 1.152 1.231 1.360 1 433 1.433 1.473 1.050 1.108 1.154 1.235 1.371 1 450 1.450 1.498 1.050 1.108 1.156 1.237 1.378 1 461 1.461 1.514 Applicator size s 0.8 1.046 1.103 1.143 1.209 1.307 1 347 1.347 1.364 1.048 1.102 1.147 1.219 1.339 1 403 1.403 1.436 1.047 1.101 1.146 1.221 1.347 1 422 1.422 1.464 1.047 1.103 1.148 1.226 1.360 1 446 1.446 1.495 1.047 1.104 1.150 1.227 1.369 1 458 1.458 1.516 1.0 1.043 1.097 1.135 1.199 1.294 1 332 1.332 1.349 1.045 1.097 1.140 1.209 1.326 1 389 1.389 1.421 1.044 1.096 1.139 1.211 1.332 1 405 1.405 1.446 1.045 1.097 1.140 1.214 1.344 1 428 1.428 1.478 1.045 1.098 1.142 1.217 1.353 1 441 1.441 1.499 1.5 1.037 1.081 1.116 1.170 1.254 1 289 1.289 1.303 1.038 1.084 1.122 1.184 1.291 1 350 1.350 1.381 1.038 1.084 1.121 1.184 1.292 1 360 1.360 1.399 1.038 1.084 1.121 1.184 1.304 1 379 1.379 1.428 1.038 1.085 1.122 1.188 1.311 1 393 1.393 1.447 2.0 1.033 1.071 1.102 1.151 1.227 1 260 1.260 1.273 1.033 1.074 1.107 1.164 1.260 1 316 1.316 1.345 1.033 1.073 1.107 1.164 1.263 1 327 1.327 1.364 1.034 1.073 1.106 1.163 1.274 1 346 1.346 1.391 1.034 1.074 1.107 1.167 1.278 1 356 1.356 1.406 3.0 1.026 1.057 1.081 1.122 1.186 1 213 1.213 1.225 1.024 1.056 1.082 1.127 1.204 1 251 1.251 1.278 1.024 1.056 1.084 1.130 1.214 1 270 1.270 1.302 1.025 1.056 1.084 1.131 1.222 1 285 1.285 1.325 1.025 1.057 1.085 1.132 1.226 1 291 1.291 1.334 4.0 1.021 1.046 1.067 1.101 1.154 1 178 1.178 1.188 1.020 1.046 1.067 1.104 1.168 1 207 1.207 1.230 1.020 1.046 1.068 1.106 1.177 1 226 1.226 1.254 1.020 1.047 1.069 1.108 1.184 1 237 1.237 1.272 1.020 1.047 1.070 1.109 1.188 1 244 1.244 1.282 5.0 1.017 1.038 1.054 1.082 1.126 1 146 1.146 1.155 1.018 1.039 1.057 1.088 1.141 1 174 1.174 1.194 1.018 1.038 1.055 1.087 1.147 1 189 1.189 1.213 1.018 1.040 1.057 1.089 1.152 1 195 1.195 1.226 1.018 1.040 1.057 1.090 1.155 1 204 1.204 1.237 Ratio of backscatter factors, f bone to water Table 4. Ratios of backscatter factors, bone to wateer, for photon beams 50 - 300 kV ( (0.875 - 20.8 mm All HVL)) with i h different diff field fi ld size i s defined d fi d at different diff SSD. SSD HVL (cm) 50 (mm Al) 0.875 2.65 9 17 9.17 14.5 17.6 20.8 0.875 2.65 9.17 14.5 17.6 20.8 0 875 0.875 2.65 9.17 14.5 17.6 20.8 30 10 (1 x 1 cm2) 0.943 0.972 1 022 1.022 1.039 1.036 1.022 0.943 0.973 1.023 1.039 1.037 1.023 0 943 0.943 0.973 1.023 1.039 1.037 1.022 (2 x 2 cm2) 0.916 0.938 1 015 1.015 1.065 1.069 1.048 0.916 0.935 1.017 1.067 1.067 1.046 0 916 0.916 0.941 1.017 1.064 1.066 1.044 Bbone Bw (4 x 4 cm2) 0.890 0.892 0 984 0.984 1.079 1.100 1.073 0.890 0.888 0.988 1.076 1.101 1.078 0 893 0.893 0.901 0.980 1.071 1.092 1.075 (10 x 10 cm2) 0.865 0.829 0 885 0.885 1.028 1.095 1.094 0.867 0.834 0.891 1.025 1.090 1.091 0 874 0.874 0.849 0.915 1.032 1.086 1.087 (20 x 20 cm2) 0.858 0.798 0 827 0.827 0.958 1.049 1.079 0.861 0.807 0.835 0.967 1.047 1.078 0 873 0.873 0.836 0.878 1.005 1.070 1.078 Overall chamber correction factor Table VII. VII Overall chamber correction factorrs PQ,cham for common cylindrical chambers in medium-energy x-ray beams. The data appliees to 2 cm depth in the phantom, and 100 cm2 field size. Chamber Type HVL (mmCu) 0.10 0.15 0 20 0.20 0.30 0.40 0.50 0.60 0.80 1.0 1.5 2.0 2.5 3.0 4.0 NE2571 Capintec PR06C PT TW N30001 Exradin A12 NE2581 NE2611 or NE2561 1.008 1.015 1 019 1.019 1.023 1.025 1.025 1.025 1.024 1.023 1.019 1.016 1.012 1.009 1.004 0.992 1.000 1 004 1.004 1.008 1.009 1.010 1.010 1.010 1.010 1.008 1.007 1.006 1.005 1.003 1.0004 1.0013 1 0017 1.0 1.0021 1.0023 1.0023 1.0 023 1.0022 1.0021 1.0018 1.0 015 1.0012 1.0010 1.0006 1.002 1.009 1 013 1.013 1.016 1.017 1.017 1.017 1.017 1.016 1.013 1.011 1.010 1.008 1.005 0.991 1.007 1 017 1.017 1.028 1.033 1.036 1.037 1.037 1.035 1.028 1.022 1.017 1.012 1.004 0.995 1.007 1 012 1.012 1.017 1.019 1.019 1.019 1.018 1.017 1.014 1.011 1.009 1.006 1.003 Chamber Sheath Correction C Factor Table IV: The Monte Carlo calculated correctioon factors ps for polystyrene ( = 1.06 gcm3) sleeves of thickness t. a the same as Table II II. The 11- t Other conditions are statistical uncertainties are smaller than 0.001. Beam quality B lit (mm A1) t = 0.5 mm 1.04 2.94 4.28 9 20 9.20 13.0 16.6 21 5 21.5 0.990 0.995 0.996 0 999 0.999 1.000 1.000 1 000 1.000 ps for f Pl t Polystyrene t = 1 mm t = 2 mm 0.9981 0.9990 0.9993 0 9997 0.9 0.9999 0.9999 1 0000 1.0 0.962 0.981 0.986 0 994 0.994 0.998 0.999 1 000 1.000 t = 3 mm 0.943 0.972 0.979 0 992 0.992 0.997 0.999 1 000 1.000 Consistency bettween the in-air and in-phant in phanttom methods S l a method Select h d bbased d on o point i off interest i Check consistency onlyy if PDD can be measured accurately Experimental p studies inndicated consistent results (about 1%) using both methods m at 100 and 300 kV Ma, Li and Seuntjens (19998) Med Phys 25: 2376-84 Table II Dose ratios calculated based on Eq. 12 for a 100 kV (2.43 mm Al) beam with a 100 cm2 field defined at 80 cm SSD. The chamber readings r were corrected for temperature, pressure, polarity and ion recombinatio on. The PDD curves were measured using i th the NACP chamber h b and d corrected t d using i the th Monte M t Carlo C l calculated l l t d Cz factors. f t The Th ratios of mass energy-absorption coefficients for waater to air, the backscatter factors and the chamber correction factors were taken from the ICRU3 (reference depth = 5 cm), IPEMB25 (reference depth = 2 cm) and the NCS26 (rreference depth = 2 cm) dosimetry protocols. The IAEA chamber correction factors weere taken from14 while mass-energy 2 absorption b i coefficient ffi i ratios i were from f .For F this hi wo ork, k the h correction i factors f were taken k 8 from ref . ICRU ((1973)) IAEA ((1987,, 1996)) Mair IPEMB ((1996)) NCS ((1997)) This work 27.99 1.252 27.99 1.260 27.99 1.277 27.99 1.281 27.99 1.280 13.69 1 000 1.000 13.69 1 030 1.030 25.84 1 023 1.023 25.84 1 005 1.005 25.84 0 990 0.990 1.000 1.000 1.000 0.996 1.000 PDDz=ref 0.375 0.375 0.707 0.707 0.707 R 0.960 0.938 0.956 0.976 0.990 Bw Mz=ref PQ,cham en w ,air air en w,air z ref Guidelines for dosimetry d in other phantom m materials Determine the surface dose for f other phantom materials from Dmed,z 0 C Dw,z 0 where h C med w med w Bmed med (en / )w Bw Vary significantly air i The backscatter factor ratios are significant for bone to water but close to 1.0 for soft tissu ues. Ratio of Backscatter Factors, Factors Bone to Water 1.10 10cmx10cm m 1.05 1cmx1cm 1.00 20cmx220cm 0.95 0.90 0.85 0.80 0 1 2 3 4 Beam Quallity (mm Cu) 5 Relative dosimetrry measurement L Large uncertainty t i t in i PDD measurements t Large uncertainty in profile measurements Effect of electron con ntamination Choice of detectors Choice of phantom materials m 100 90 Diode 80 70 NACP 60 RK 50 Farmer 40 30 film 20 10 0 0 2 49 10 11 al axis / cm distance from centra 12 13 (300 kkV V beam) (300 kV beam) Summary of TG-611 Recommendations Water p phantom for absolu ute dose determination, 2 cm depth for > 100 kV, plastiic phantoms for routine checks Effective point of measureement: center of air cavity 40-70 40 70 kV: parallel plate chamber 70-300 kV: cylindrical chamber Use both tube potential an nd HVL for chamber calibration A Appropriate i t b build-up ild f parallel for ll l plate l t chambers h b Summaryy of TG-611 Recommendations N Narrow beam ggeometry y for HVL V determination What method to use depen nding on beam quality and point of interest (POI) ( ) 40-100 kV : only the in n-air method should be used 100-300 kV : the in-air method if POI on surface 100-300 kV : the in-phan ntom method if POI at a depth Inter-compare chamber foor correction/conversion factors Use HVL as beam quality specifier s for conversion and correction factor (tabular data d preferred) Quality assurance (daily, (daily monthly, m monthly annually) Estimated combined standard uncertainty 33.5% 5% o surfac 4.7% a dept C lusions Conclu i Exposure/kerma basedd dosimetry procedures Backscatter method forr both low- and mediumenergy x-ray beams b Complete data set avaiilable for en/, / B, B PQ,cham Q cham and Psheath Consistent results using both formalisms Questions for kV V x-ray dosimetry 1. 2. 3 3. 4. Does a Farmer chambeer have enough buildup for kV x-ray beams? Does the Bragg-Gray cavity c theory apply to a Farmer chamber for kV V x-ray beams? Is the difference between Kcoll and K significant for kV x-ray beams? A air-filled Are i fill d ionization i i ti n chambers h b usedd as “photon “ h t detectors” or “electron detectors” for kV beams? Answ wers: 1. 2. 3. 4. Yes, electron ranges < 0.5mm of water No, significant eneergy deposition from electrons generated d in the air cavity No, g < 0.1% “Photon detectors””