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ANNOUNCING
The American Physiological
Society (APS) announces
the Publication of a
Resource Book for the
Design of Animal Exercise
Protocols intended for
researchers, Institutional
Animal Care and Use
Committees (IACUCs), and
those involved with research
oversight. The authoring
committee, which was
comprised of exercise
physiologists and laboratory
animal veterinarians,
reviewed reference material
and drew upon their own
experience to compile
suggestions about how to
design, review, and
implement experimental
paradigms involving animals
and exercise.
The APS Resource Book is
intended to promote an
informed dialogue that can
help researchers and their
IACUCs arrive at
satisfactory answers to
questions about how to
assure the welfare of
animals in exercise
research protocols.
Topics addressed in the
APS Resource Book include
general concerns such as
selecting appropriate animal
models for exercise
research, study design
considerations, animal
stress, working with
compromised animals, and
the impact of surgery on
exercise. (See excerpts
from the Table of Contents
at the right).
American Physiological Society
Resource Book for the Design
of Animal Exercise Protocols
In addition to some 400
citations, the book includes
appendices on hind limb
suspension and
immobilization of rats and
mice and a set of sample
animal exercise protocol
review scenarios.
TO ORDER: NIH’s
Office of Laboratory Animal
Welfare (OLAW) sponsored
the development of the APS
Resource Book, and single
copies are available free of
charge from OLAW while
supplies last. Contact
OLAW@od.nih.gov to
request a free copy.
TABLE OF CONTENTS
(excerpts)
CHAPTER 1. INTRODUCTION AND OVERVIEW
I. Scope of the Document
II. Why Study Exercise?
III. Why Use Animals to Study Exercise?
IV. Animal Research Oversight
CHAPTER 2. GENERAL ASPECTS OF ANIMAL CARE AND THE
DEVELOPMENT OF ANIMAL USE PROTOCOLS
I. Overview
II. Selecting Animal Models for Exercise Research
III. Study Design Considerations
A. Protocol Development
B. General Considerations for Exercise Study Design
IV. Animal Stress and Humane Study Design
A. Stress and Exercise
B. Subject and Stressor Characteristics
C. Indexes of Acute and Chronic Stress Responses
V. Working with Compromised Animals: Animal Models of Disease
that Limit Exercise Performance
A. Special Considerations for Training Compromised Animals
B. Disease Models that Limit Exercise Capabilities
VI. Impact of Surgery on Exercise
A. Surgical Procedures on Animals Used in Exercise Studies
B. Selecting Anesthesia for Animals in Surgery
CHAPTER 3. EXERCISE PROTOCOLS USING RATS AND MICE
CHAPTER 4. EXERCISE PROTOCOLS USING LARGE ANIMALS
CHAPTER 5. EXERCISE PROTOCOLS USING OTHER SPECIES
Chapters 3, 4, and 5 include modalities such as treadmill,
swimming, and exercise wheels.
Copies may also be
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The PDF of the book is
available online at
http://www.theaps.org/pa/action/exercise/
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