[2012]

Lincoln KM, Richardson TE, Rutter L, Gozalez P, Simpkins JW, Green KN. An Nheterocyclic amine chelate capable of antioxidant capacity and amyloid disaggregation.
ACS Chem Neurosci (2012 Nov 21) 3(11): 919-27
.

Richardson TE, Simpkins JW. R- and S-equol have equivalent cytoprotective effects in
Friedreich's ataxia. BMC Pharmacol Toxicol (2012 Oct 22) 13:12
.

Gatson JW, Liu MM, Abdelfattah K, Wigginton JG, Smith S, Wolf S, Simpkins JW,
Minei JP. Estrone is neuroprotective in rats after traumatic brain injury. J Neurotrauma
(2012 Aug 10) 29(12): 2209-19.

Nixon E, Simpkins JW. Neuroprotective effects of nonfeminizing estrogens in retinal
photoreceptor neurons. Invest Ophthalmol Vis Sci (2012 Jul 12) 53(8):4739-47.

Luedtke RR, Perez E, Yang SH, Liu R, Vangveravong S, Tu Z, Mach RH, Simpkins
JW. Neuroprotective effects of high affinity Σ1 receptor selective compounds. Brain Res
(2012 Mar 2) 1441:17-26.

Jung ME, Ju X, Metzger DB, Simpkins JW. Ethanol withdrawal hastens the aging of
cytochrome c oxidase. Neurobiol Aging (2012 Mar) 33(3): 618.e21-32.

Simpkins JW, Singh M, Brock C, Etgen AM. Neuroprotection and estrogen receptors.
Neuroendocrinology (2012) 96(2): 119-30.

Poteet E, Winters A, Yan LJ, Shufelt K, Green KN, Simpkins JW, Wen Y, Yang SH.
Neuroprotective actions of methylene blue and its derivatives. PLoS One (2012)
7(10):e48279
.

Richardson TE, Yu AE, Wen Y, Yang SH, Simpkins JW. Estrogen prevents oxidative
damage to the mitochondria in Friedreich's ataxia skin fibroblasts. PLoS One (2012)
7(4):e34600
[2011]

Jung ME, Ju X, Simpkins JW, Metzger DB, Yan LJ, Wen Y. Ethanol withdrawal acts as
an age-specific stressor to activate cerebellar p38 kinase. Neurobiol Aging (2011 Dec)
32(12): 2266-78.

Simpkins JW, Swenberg JA, Weiss N, Brustick D, Eldridge JC, Stevens JT, Handa RJ,
Hovey RC, Plant TM, Pastoor TP, Breckenridge CB. Atrazine and breast cancer: a
framework assessment of the toxicological and epidemiological evidence. Toxicol Sci
(2011 Oct) 123(2): 441-59.

Nguyen HP, Tedmon L, Li L, Wigginton JG, Maass D, Gatson JW, Simpkins JW, Schug
KA. Investigation of the temperature stability of premarin intravenous using liquid
chromatography-mass spectometry. J Pharm Biomed Anal (2011 Jul 15) 55(5): 1218-22.

Richardson TE, Yang SH, Wen Y, Simpkins JW. Estrogen protection in Friedreich's
ataxia skin fibroblasts. Endocrinology (2011 Jul) 152(7): 2742-9.

Wen Y, Li W, Poteet EC, Xie L, Tan LJ, Ju X, Liu R, Qian H, Marvin MA, Goldberg
MS, She H, Mao Z, Simpkins JW, Yang SH. Alternative mitochondrial electron transfer
as a novel strategy for neuroprotection. J Biol Chem (2011 May 6) 286(18): 16504-15.

Logan SM, Sarkar SN, Zhang Z, Simpkins JW. Estrogen-induced signaling attenuates
soluable ΑΒ peptide-mediated dysfunction of pathways in synaptic plasticity. Brain Res
(2011 Apr 6) 1383:1-12.

Nguyen HP, Li L, Gatson JW, Maass D, Wigginton JG, Simpkins JW, Schug KA.
Simultaneous quantification of four native estrogen hormones at trace levels in human
cerebrospinal fluid using liquid chromatography-tandem mass spectrometry. J Pharm
Biomed Anal (2011 Mar 25) 54(4): 830-7.

Walf AA, Paris JJ, Rhodes ME, Simpkins JW, Frye CA. Divergent mechanisms for
trophic actions of estrogens in the brain and peripheral tissues. Brain Res (2011 Mar 16)
1379: 119-36.

Yi KD, Perez E, Yang S, Liu R, Covey DF, Simpkins JW. The assessment of nonfeminizing estrogens for use in neuroprotection. Brain Res (2011 Mar 16) 1379: 61-70.

Gatson JW, Simpkins JW, Yi KD, Idris AH, Minei JP, Wigginton JG. Aromatase is
increased in astrocytes in the presence of elevated pressure. Endocrinology (2011 Jan)
152(1): 207-13.
[2010]

Sarkar SN, Smith LT, Logan SM, Simpkins JW. Estrogen-induced activation of
extracellular signal-regulated kinase signaling triggers dendritic resident mRNA
translation. Neuroscience (2010 Nov 10) 170(4): 1080-5.

Zhang Z, Simpkins JW. An okadaic acid-induced model of tauopathy and cognitive
deficiency. Brain Res (2010 Nov 4) 1359: 233-46.

Simpkins JW, Yi KD, Yang SH, Dykens JA. Mitochondrial mechanisms of estrogen
neuroprotection. Biochem Biophys Acta (2010 Oct) 1800(10): 1113-20.

Xie L, Poteet EC, Li W, Scott AE, Liu R, Wen Y, Ghorpade A, Simpkins JW, Yang SH.
Modulation of polymorphonuclear neutrophil functions by astrocytes. J
Neuroinflammation (2010 Sep 9) 7:53.

Simpkins JW, Wood BE, Balin BJ. Alzheimer disease: the crisis is upon us. J Am
Osteopath Assoc (2010 Sep) 110(9 Suppl 8): Sii-2.

Zhang Z, Simpkins JW. Okadaic acid induces tau phosphorylation in SH-SY5Y cells in
an estrogen-preventable manner. Brain Res (2010 Jul 23) 1345: 176-81.

Liu R, Liu Q, He S, Simpkins JW, Yang SH. Combination therapy of 17beta-estradiol
and recombinant tissue plasminogen activator for experimental ischemic stroke. J
Pharmacol Exp Ther (2010 mar) 332(3):1006-12.

Nguyen HP, Yang SH, Wigginton JG, Simpkins JW, Schug KA. Retention behavior of
estrogen metabolites on hydrophilic interaction chromatography stationary phases. J Sep
Sci (2010 Mar) 33(6-7): 793-802.

Ill-Raga G, Ramos Fernández E, Guix FX, Tajes M, Borsch-Morató M, Palomer E,
Godoy J, Belmar S, Cerpa W, Simpkins JW, Inestrosa And NC, Muñoz FJ. Amyloid-Β
peptide fibrils induce nitro-oxidative stress in neuronal cells. J Alzheimers Dis (2010)
22(2): 641-52.
[2009]

Gatson JW, Maass DL, Simpkins JW, Idris AH, Minei JP, Wigginton JG. Estrogen
treatment following severe burn injury reduces brain inflammation and apoptitic
signaling. J Neuroinflammation (2009 Oct 22) 6:30.

Simpkins JW. Commentary on "Alzhemier's Disease Drug Development and the
Problem of the Blood-Brain Barrier". Alzheimers Dement (2009 Sep) 5(5): 433-4.

Simpkins JW, Brown K, Bae S, Ratka A. Role of ethnicity in the expression of features
of hot flashes. Maturitas (2009 Aug 20) 63(4):341-6.

Simpkins JW, Yi KD, Yang SH. Role of protein phosphatases and mitochondria in the
neuroprotective effects of estrogens. Front Neuroendocrinol (2009 Jul) 30(2):93-105.

Prokai-Tatrai K, Prokai L, Simpkins JW, Jung ME. Phenolic compounds protect
cultured hippocampal neurons against ethanol-withdrawal incuded oxidative stress. Int J
Mol Sci (2009 Apr 20) 10(4): 1773-87.

Yang SH, Sarkar SN, Liu R, Perez EJ, Wang X, Wen Y, Yan LJ, Simpkins JW.
Estrogen receptor beta as a mitochondrial vulnerability factor. J Biol Chem (2009 Apr 3)
284(14): 9540-8.

Simpkins JW, Gatson JW, Wigginton JG. Commentary on "a roadmap for the
prevention of dementia II. Leon Thal Symposium 2008." Rationale and recommendations
for first evaluating anti-Alzheimer's disease medications in acute brain injury patients.
Alzheimers Dement (2009 Mar) 5(2): 143-6.

Khachaturian ZS, Snyder PJ, Doody R, Aisen P, Comer M, Dwyer J, Frank RA,
Holzapfel A, Khachaturian AS, Korczyn AD, Roses A, Simpkins JW, Schneider LS,
Albert MS, Egge R, Deves A, Ferris S, Greenberg BD, Johnson C, Kukull WA, Poirer J,
Schenk D, Thies W, Gauthier S, Gilman S, Bernick C, Cummings JL, Fillit H, Grundman
M, Kaye J, Mucke L, Reisberg B, Sano M, Pickeral O, Petersen RC, Mohs RC, Carillo
M, Corey-Bloom JP, Foster NK, Jacobsen S, Lee V, Potter WZ, Sabbagh MN, Salmon D,
Trojanowski JQ, Wexler N, Bain LJ. A roadmap for the prevention of demenita II: Leon
Thal Symposium 2008. Alzheimers Dement (2009 Mar) 5(2): 85-92.

Jung ME, Wilson AM, Ju X, Wen Y, Metzger DB, Simpkins JW. Ethanol withdrawal
provokes opening of the mitochondrial membrane permeability transition pore in an
estrogen-preventable manner.J Pharmacol Exp Ther (2009 Mar) 328(3): 692-8.

Yi KD, Covey DF, Simpkins JW. Mechanism of okadaic acid-induced neuronal death
and the effect of estrogens. J Neurocem (2009 Feb) 108(3): 732-40.

Simpkins JW, Perez E, Wang X, Yang S, Wen Y, Singh M. The potential for estrogens
in preventing Alzheimer's disease and vascular dementia. Ther Adv Neurol Disord (2009
Jan) 2(1): 31-49.