Antiretroviral Drug Resistance Growing for Africa AIDS Cases...
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Mpumelele, 18-months-old, receives antiretroviral treatment from his cousin, as his grandmother holds his hand.
July 23, 2012
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By DONALD G. McNEIL Jr.
Published: July 23, 2012
In a worrying sign for the course of the AIDS epidemic, resistance to
antiretroviral drugs is increasing in parts of Africa, according to a
new study by the World Health Organization and University College
London.
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The report, published online Monday
Related
by The Lancet, summarized data from
Health Guide: AIDS
more than 200 smaller studies
performed in Africa, Asia, Latin
America and the Caribbean. Drug resistance was serious only in
eastern and southern Africa, and mostly involved a class of
medications called non-nucleoside reverse transcriptase inhibitors.
(The most common are nevirapine and efavirenz, sold as Viramune
and Sustiva.)
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Eight years after affordable generic AIDS drugs were introduced in east Africa, 7.4 percent
of viral strains tested were drug-resistant; in southern Africa, the hardest-hit part of the
world, the figure was 3 percent.
The authors said resistance was “not unexpected,” since nearly eight million poor people
have received the drugs in the past decade. But it is still worrisome; while generic
manufacturers make some modern AIDS drugs with fewer side effects, only a few classes
are made in generic form. Drug companies fight hard to keep exclusive control over their
newest inventions so prices and profits remain high.
The authors of the new report suggested strengthening pharmacy supply chains to prevent
shortages — a chronic problem in poor countries. They also called for better tracking of
patients for whom drugs are prescribed. Anyone who stops therapy, even briefly, is much
more likely to develop a drug-resistant strain.
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25/07/2012 14:10
Antiretroviral Drug Resistance Growing for Africa AIDS Cases...
http://www.nytimes.com/2012/07/24/health/antiretroviral-drug...
A version of this article appeared in print on July 24, 2012, on page D6 of the New York edition with the headline: AIDS:
Drug Resistance Growing in Parts of Africa For Antiretroviral Treatment, a Study Says.
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25/07/2012 14:10