AAAI Technical Report SS-12-05 Self-Tracking and Collective Intelligence for Personal Wellness Self-Tracking Mindfulness Incorporating a Personal Genome Takashi Kidoa,b,c a RikenGenesis Co., Ltd., Taito-ku, Taito, 1-5-1, Tokyo, Japan. Stanford University School of Medicine, 1265 Welch Road, Stanford, CA, 94305-5479. c Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST). b takashi.kido@rikengenesis.jp personal genome applications for medical purposes have been widely discussed, there has been little discussion on its applications for other purposes (Inoue and Muto, 2011). In this paper, we discuss the possibility of designing new personal genome applications using QS technologies in the non-medical domain of mental performance. We also propose the concept of the MyFinder project and discuss the ongoing challenges regarding the application of the personal genome in non-medical domains. Abstract This paper introduces the ongoing MyFinder project, which was launched in October 2010. The goals of this project are: (1) to propose an intimate personal genome information environment, MyFinder, which supports the search for our inborn talents and maximizes our potential for a meaningful life; and (2) to contribute to scientific discoveries in the biomedical or psychological research domains through intelligent community computing, or in other words, citizen science. This paper describes our research framework and the ongoing challenges to achieving these two goals. We also discuss the technical and social issues related to possible personal genome applications in non-medical domains. The Concept of MyFinder The MyFinder project is a novel research framework for the personal genome environment. It combines the notion of an intelligent agent in the Artificial Intelligence (AI) community and personal genome research in the biomedical community (Kido, 2011). The concept of MyFinder is represented visually in Figure 1. While traditional personal genome services primarily aim to establish personalized medicine, such as disease treatment or drug response, MyFinder focuses more on wellness, psychiatry, and behavioral sciences. The MyFinder project has two goals. The first is to provide a personal genome environment that enables us to find our inborn nature, strengths, and talents, and to maximize our potential. The second is to provide a research platform for scientific discovery with community computing. By observing and analyzing our daily behaviors, such as diet, sleep, working style, time management, social interactions, and individual preferences, we can monitor our daily physical, chemical, and mental stress levels. Quantified Self (QS) technologies and intelligent software agent technologies may be useful for learning a user’s behavioral trends and analyzing stress states. Recent studies have suggested that individual mental performance and psychological recognition may be influenced by genetic factors. More interestingly, the influence of genetic factors is not deterministic, as genetic activity may be controlled by environmental factors, such as physical, chemical, and psychological stress levels. For example, some recent studies have reported that laughing is very effective in the treatment of type 2 diabetes (Hayashi, 2006), which suggests that the positive mental Introduction The Quantified Self (QS) community, in which people inspire one another to share ideas on self-tracking systems for sleep, activity, location, heart rate, facial expressions, mood, diet, productivity, and cognition, has recently emerged (Quantified Self, 2011). Conventional health care records were thought to be useful only to physicians and researchers. However, the QS movement may change the notion of conventional health care, in the same way as the emergence of personal computers changed the traditional notion of computers. Although biomedical scientists have attempted to build a database of human traits and disease to realize data-driven personalized medicine (Butte, 2008), non-medical applications for healthy people are rarely discussed. A particularly ambitious movement in the biomedical community is the personal genome. The price for obtaining one’s personal genome sequence – a comprehensive map of the 3 billon bases in our DNA – has been falling rapidly, from $2 billion in 2000 to around $1,000 within the next few years (Davies, 2010). Personal genome sequencing and its medical interpretation will play very important roles in realizing personalized medicine (Ashley, 2010). While Copyright © 2012, Association for the Advancement of Artificial Intelligence (www.aaai.org). All rights reserved. 31 state induced by laughter activates genetic triggers of cellular activity. By incorporating such observations with personal genome data and self-tracked data of individual daily behaviors, MyFinder may learn a user’s behavioral trends (for example, learning by a psychological theory, such as the enneagram theory) and suggest some findings for users so that the user’s unique behavior trend could be influenced by his/her inborn genetic variance. This finding may be valuable for users to rediscover their inborn potential and for the scientific community to share new scientific evidence. Important questions in this concept are: (1) How can we design the scheme to discover these findings? and (2) How do people feel about these findings? To answer these questions, we must understand what people would really want to do with their personal genome. mindfulness meditation training has also been investigated (Hudlicka, 2011). Brain wave and heart wave analyses may be useful for characterizing an individual’s mental status. Brain training research such as Lumosity (Lumosity, 2011) or Compassion and Altruism Research (CCARE, 2011) may provide good tools and platforms for designing mindfulness technologies. We are currently developing a cloud computing environment for the self-tracking of brain wave and heart wave data. (2) Personal Genome Interpretation While the costs associated with obtaining genetic information have fallen sharply, the medical interpretation of genetic risk remains unclear (Ashley, 2011). Research into the medical interpretation of personal genome data is currently a very hot topic in genetics. In addition to medical interpretations, personal genome interpretation for psychological resources is also an interesting and important challenge. For example, genetic associations have recently been reported between the oxytocin receptor single-nucleotide polymorphism rs53576 and psychological resources such as optimism, mastery, and self-esteem (Saphire-Bernstein, 2011). This genetic variation may influence social behavior and personality. Approaches based on brain science and neuroimaging technologies integrated with a personal genome may therefore be useful for understanding the diversity of human cognition and behavior. However, further investigation is necessary. (3) Behavior Pattern Analyses on Human Attitude It is important to understand how a new personal genome application can be designed to influence and change human behavior. Investigating how knowledge of genetic risk affects people is a major challenge. Social psychological experiments may be useful for understanding various attitudes (Elliot, 2003). Learning about human attitudes in various cultural contexts and classifying the genetic knowledge with several measures (such as credibility, harmfulness, seriousness, usefulness, and interest factors) will be useful for designing intimate and persuasive interactive computer systems. Figure 1: The Concept of MyFinder MyFinder provides a personal genome environment that enables us to find our inborn nature, strengths, and talents, and to maximize our potential. MyFinder also provides a research platform for scientific discovery with community computing. Challenge Problems Self-Tracking of Mental Status in Daily Activity We are designing and implementing a daily self-tracking environment for monitoring individual mental status with daily event logs. The first challenge is to investigate what kind of data would be useful for understanding how people feel about their daily experience and how we can effectively collect the data in intimate and persuasive ways. (1) Design Mindfulness Technologies One of the major challenges is the self-tracking of individual mental performance. Mindfulness, a form of Buddhist meditation, is a good example of mental performance monitoring. Modern clinical psychology and psychiatry have developed a number of therapeutic applications based on the concept of mindfulness (Kabat-Zinn, 1990). Virtual coaching to provide 32 We came up with ideas on mental state tracking in everyday life from the “flow theory” proposed by Csikszentmihalyi (1998). Csikszentmihalyi developed the “Experience Sampling Method” (ESM) to determine how people actually spend their ordinary days. For the ESM, the participants of a study are required to report what they are doing and how they are feeling whenever they receive a pocket pager’s signal, at random intervals, eight times a day for a week. By statistically analyzing ESM responses, researchers try to measure “flow” (in other words, “zone”) state. The “flow” state is defined as a mental state of operation in which a person in an activity is fully immersed in a feeling of energized focus, fully involved, and successfully performing the activity. our personal mental profile, (Figure 3), we may learn how to be more mindful of our psychological state. Our challenge is to design a new ESM environment that incorporates new mobile health technology. Recent innovations in portable devices for brain wave and heart rate detection may provide a new objective definition of the “flow” state in addition to the traditional subjective self-reported ESM description. Figure 2A: Self-tracking the emotional states associated with daily events. The user chooses the visual symbols in each category (Food, Relationships, Work, and Health) for self-tracking the user’s emotional states or physical conditions. Each symbol represents the user’s mental or physical conditions in several daily events. The user can easily choose the appropriate visual symbols (with short comments, if necessary) and quickly upload them to the server. Current System Design and Implementation We have been developing a self-tracking environment for collecting data on a person’s daily events and mental status. Some example images of the tracking and displaying of daily events data are shown in Figure 2A and Figure 2B. We designed a system in which users can easily self-track their daily events and their emotional feelings by choosing predefined visual symbols (Fig. 2A). If necessary, the user can upload some short text messages to trace what events caused the feelings. The system allows connection of the portable brain wave sensors developed by Neurosky Inc., and heart wave sensors developed by HeartMath. Accumulated symbols, messages, and sensory data can be displayed in daily, weekly, and monthly aggregates. We expect users to have some sense of new awareness by observing the time series of their self-tracking records and to build up their own subtle habits for self-discovery. Collected symbols, messages, and sensory data can be analyzed and correlated. The results are expected to provide good resources for advancements in the social sciences and wellness medicine. Figure 2B: Quantified Self-User Event Timeline. The daily self-tracking data can be visualized in a timeline format. Self-tracking data may include visual symbols of daily events, short comments, pictures, and stress status (relaxed or focused) data captured by devices that record brain waves and heart rate. The user can trace back his/her mental or physical conditions in daily, weekly, and monthly aggregates. Figure 3 shows an example of self-tracking history of brainwave signals with NeuroSky’s sensor. Time series of brainwave signals are recorded with personal actions. We expect to discover some unique relationships between signal patterns and actions. Observing how the actions influence the brainwave patterns demonstrates how actions potentially influence our mental activity. By recognizing 33 Figure 3: An example of self-tracking history of brainwave signals with NeuroSky’s sensor. The X-axis shows the time (minutes) and the Y-axis shows the brainwave signal intensity defined by NeuroSky’s algorithm. The red line indicates “Attention” signal and blue line indicates “Meditation” signal calculated by NeuroSky’s algorithm. Three events, (A) talking on the phone, (B) working on the computer and (C) playing a video game, are labeled. In this example, playing a video game increases the both of “Attention” and “Meditation” levels. Table 1: Genes and SNPs that have previously been reported for cognitive or psychological phenotypes. CANTAB, Cambridge Neuropsychological Test Automated Battery. L&M, learning and memory. 34 How can we design a scheme to discover our unique potential? We have been designing a scheme for supporting self-discovery processes in two ways. The first way is the Quantified Self (QS) approach. We assume that self-tracking our daily events with emotions may be useful for discovering our unique trend of behavior patterns, feeling patterns, and thinking patterns. Our technical challenges are how to collect various data in an easy way, how to find the essential variables, and how to analyze data for finding meaningful patterns. We are currently investigating what kind of data collection would be useful for the self-discovery process; for example, self-tracking data may include a diary, social network interactions, self-reporting messages, diagnosis type questionnaires, and body sensors to measure physical parameters such as heart rate and brain wave pattern. We expect to find some statistical correlations between subjective variables and objective ones, but some interventions may be necessary to prove their causal relationships. Personal Genome for Understanding Human Mind Understanding how our human mind evolved remains a challenge. Minsky (2006) proposed the concept of an emotion machine, offering a new model for how our minds work. Minsky argues persuasively that emotion, intuition, and feeling are not distinct things, but different ways of thinking. We are interested in understanding how various ways of thinking evolve how complex diversity of personalities emerges. Mental performance genomics is an important new area of research and many links between personal genetic profiles and mental performance have been recently reported. Table 1 shows the genes and SNPs that have previously reported associations with cognitive or psychological phenotypes. Recent papers report some genetic variances associated with optimism and empathy, extraversion, and altruism (Saphire-Bernstein, 2011). We have been collaborating with DIYgenomics (DIYgenomics, 2011) and are planning to conduct a social intelligence study assessing genotype-phenotype linkage in optimism, empathy, extraversion, and altruism. The second way is a citizen science approach, in which non-expert volunteers are willing to share their data and participate in community computing projects for scientific discovery. We have been designing citizen science genetics projects for social intelligence research in which we test a hypothesis of whether some type of genetic variances are significantly correlated with mental performance traits of social intelligence, such as optimism, empathy, extraversion, and altruism. Our hypothesis is that individuals with certain genetic profiles may have greater natural capacity for characteristics of social intelligence. Recognized standard online survey instruments can also be prepared for the phenotypic assessments of these mental traits. We will investigate whether the findings of previous studies are replicated in our citizen science cohort and then explore the potential causes and influences of these social intelligence traits. We will also investigate whether social intelligence skills may be improved through intervention via mobile application and other methods. In both the QS and citizen science approaches, the key success factor is the synergy of science, technology, and social movement. Science success is new discovery, technological success is new technological innovation, and social movement success is motivation of people. These challenges open up new interdisciplinary research paradigms in science, technology, and society. Discussion How do people feel about new findings on themselves? We have discussed the methodologies for finding our unique potential and describe technological and scientific challenges in QS and citizen science genetic approaches. Another important question is how people feel when they know their inborn genetic destiny. This topic is more related to social psychology than to technology. Even if genetic factors are not deterministic and environment factors have larger influences than genetic factors, some people may have a concern about knowing their innate strengths and weaknesses. Cultural differences may also affect people’s attitude on knowing their inborn talents or flaws. We will continue to investigate these topics by conducting behavior pattern analyses on people’s attitudes. We have described our goals, concepts, challenges, system designs, and study designs for our ongoing project, MyFinder. While the mainstream goal of personal genome application is considered to be the realization of personal medicine, we focus much more attention on other possibilities in non-medical domains. We have been trying to design self-tracking environments for capturing our mental status with our daily events, in subjective and objective ways. We then try to incorporate these self-tracking data, especially mental performance data, with the personal genome. Our ongoing challenges pose new types of questions on how to live our own life, which open up new interdisciplinary research paradigms in science, technology, and society. 35 [14] The Center for Compassion and Altruism Research and Education (CCARE). http://ccare.stanford.edu/, 2011. [15] Inoue, Y, and Muto, K. "Children and genetic identification of talent." The Hastings Center Report 41, no. 5, 2011. [16] Csikszentmihalyi, M. Finding Flow: The Psychology of Engagement with Everyday Life (Masterminds Series) , Basic Books, 1998. 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Investigating the genetic basis of altruism: the role of the COMT Val158Met polymorphism. Soc Cogn Affect Neurosci. 2011 Oct;6(5):662-8. [23] Klein TA, Neumann J, Reuter M, Henning J,, von Cramon DY, Ullsperger M, Genetically determined differences in learning from errors. Science, 2007 Dec 7; 318 (5856): 1642-5 Summary In this paper, we introduced the ongoing MyFinder project and described three significant challenges. We also introduced our system for the self-tracking of mental performance, along with our personal genome approach for understanding the human mind. Acknowledgement The project described was supported by a grant from the JST Sakigake program. I thank the following individuals: Melanie Swan, a founder of DIYgenomics for citizen science collaboration; Atul J. Butte and Keiichi Kodama, Stanford University School of Medicine; Jin Yamanaka, an independent software creator; and Minae Kawashima, Graduate School of Medicine, Tokyo University. References [1] Aronson, E. 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