Warwick Clinical Trials Unit:
Emergency and Critical Care Research
www.warwick.ac.uk/go/ctu
Selected Publications
Overview
Selected Publications
Nakash RA, Lamb SE, Fisher J, Gates S, Hutton JL (2008) Response & nonresponse to postal questionnaires in a clinical trial - a qualitative study of the
patient's perspective, Journal of Evaluation in Clinical Practice, 14(2) 226-35.
Warwick Clinical Trials Unit is an academic unit undertaking clinical
trials addressing real issues of local, national and international
importance.
Lamb SE, Marsh JL, Hutton JL, Nakash R, Cooke MW (2009) Mechanical supports
for acute, severe ankle sprain. A multi-centre randomised controlled trial, Lancet ,
373, 575-581
We lead or support the development of high quality randomised
controlled trials in selective, focused areas that are consistent with the
research strategy of Warwick Medical School, and in which the
University of Warwick has a key stake in the intellectual property.
Cooke MW, Nakash R, Jarvis RM, Szczepura A, Clarke M, Hutton JA, Marsh J,
Lamb SE on behalf of the CAST (2007) A randomised controlled trial of
mechanical supports for the management of severe ankle sprains in the
emergency department, Health Technology Assessment
OSCAR
High Frequency OSCillation in ARDS
•This trial is a multi-centre, randomised controlled trial
funded by the Health Technology Assessment programme
and sponsored by the University of Oxford
•It compares high frequency oscillatory ventilation (HFOV)
with conventional ventilator for adults with acute
respiratory distress syndrome
•Data collected on patients: (a) in intensive care units
(ICU) (b) through to hospital discharge (c) at follow-up at 6
and 12 months after randomisation
•Primary outcome: Mortality at 30 days after
randomisation
•Secondary outcomes: ICU, hospital discharge and
follow-up data, as well as an economic evaluation
•The total sample size required is 1006 patients
•The trial has currently recruited 132 patients in 12 ICUs
Our main research themes include Emergency and Critical Care,
Rehabilitation, Cancer, and Methodology. This poster provides an
overview of our Emergency and Critical Care research.
BALTI-2
BALTI-2 (Beta Agonist Lung Injury Trial 2)
•This is a large scale multi-centre clinical trial funded by
the UK Medical Research Council (MRC).
•Patients with Acute respiratory distress syndrome
(ARDS) are randomised to receive IV infusion of
Salbutamol or placebo for 7 days (maximum).
•Survivors are followed by at 1 year.
•Primary outcome: mortality at 28 days after
randomisation
•Secondary outcomes: mortality (at 1 year), quality of
life (at 1 year), hospital and ICU length of stay, adverse
events, health economic evaluation.
•1, 334 patients recruited from 50 intensive care units
(ICUs)
•Trial started in September 2008 and currently has
recruited 82 patients from 15 participating ICUs
Lamb SE, Gates S, Underwood MJ, Cooke MW, et al (2007) Managing Injuries of
the Neck Trial (MINT): design of a randomised controlled trial of treatments for
whiplash associated disorders, BMC Musculoskeletal Disorders; 8:7. PMID:
17257408
Williamson E, Williams M, Gates S, Lamb SE (2007) A systematic literature review
of psychological factors and the development of Late Whiplash Syndrome, Pain;
Pain. 2008 Mar;135(1-2):20-30.
Williams M, Williamson E, Gates S, Lamb S (2007) A systematic literature review
of physical prognostic factors for the development of Late Whiplash Syndrome,
Spine 32; (25): E764-780
MINT
MINT Trial (Managing Injuries of the Neck Trial)
• A multi-centre randomised controlled trial funded by
the NIHR Health Technology Assessment Programme.
• Primary aim : to estimate the clinical and cost
effectiveness of a stepped care approach for whiplash
injuries
•Two stages to the trial:
Stage 1: Cluster randomised trial, where NHS
Emergency Departments (ED) were randomised to either
a Whiplash Book or usual advice
Stage 2: Patient still experiencing problems approx. 3
weeks after their initial neck injury were randomised to
either physiotherapy or a single advice session (reenforcing the advice given in AD department)
•3533 patients recruited to Stage 1; 599 patients
recruited to Stage 2
•Patients followed–up at 12 months.
CAST
Collaborative Ankle Support Trial (CAST)
•This trial was a multi-centre randomised trial funded by the UK
Department of Health through its Health and Technology
Assessment Programme
•It estimated the clinical and cost effectiveness of three different
methods of mechanical support (below knee cast, an Aircast brace
and Bledsoe boot) compared with Tubigrip in the treatment of
severe ankle sprains
•600 patients were randomised to one of the four treatment groups
and followed up at 1, 3 and 9 months after injury.
•Primary outcome : return to function (Foot and Ankle Outcome
Score questionnaire)
•Results: At 1 month, knee cast gave the best results and by 9
months there was no difference in the treatments. Knee cast was
the most cost effective
•The study suggests that choice of treatment may affect speed of
recovery but not long-term outcome.
•Trial has finished- results are currently under review.
Contact
Dr Ranjit Lall (02476 574649)
r.lall@warwick.ac.uk
POSTER TEMPL ATE BY:
www.PosterPresentations.com
Contact
Dr Simon Gates (02476 575850)
S.Gates@warwick.ac.uk
Contact
Contact
Mark Williams (02476 574648)
M.A.Williams.3@warwick.ac.uk
Professor Sallie Lamb (02476 574658)
S.Lamb@warwick.ac.uk